Dr Stuart Jenkins

Title: Lecturer in Neurobiology
Phone: +44 (0)1782 733874
Email: s.i.jenkins@keele.ac.uk
Location: Huxley Building : 225
Role: ISTM Research Themes: Therapeutics, Regenerative Medicine
Contacting me: Try my office, or arrange an appointment by email or phone
Stuart Jenkins

Following degrees in Computer Science (University of Essex) and Biochemistry & Neuroscience (Keele), I earned my PhD in Biomedical Engineering, studying under Prof Divya Chari (Keele, 2013). During my PhD, I was awarded an EPSRC E-TERM Landscape Fellowship, also hosted in Prof Chari’s lab (2013-15). I then held a postdoc position with Dr David Morgan (Keele, School of Pharmacy; 2015-16), before becoming a Lecturer at Keele’s School of Medicine (Nov 2016-).

I am interested in improving preclinical models of neurodegeneration in the central nervous system, particularly for screening nanomaterials with therapeutic potential for tissue engineering/regenerative medicine (TERM).

I mainly work with glial cells (astrocytes, oligodendrocytes, OPCs and microglia), but also embryonic stem cells (ESCs) and neurons (particularly dopaminergic).

I am associated with two themes at the Institute for Science and Technology in Medicine (ISTM):

atreum conference

I am organising the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)

 

preclinical workshop

In Feb 2014, I organised a Preclinical Modelling Workshop for Regenerative Medicine at Keele Hall.

 

I am a member of the British Neuroscience Association (BNA) and the British Society for Immunology (BSI).

Selected Publications

  • Jenkins SI, Weinberg D, Al-Shakli AF, Fernandes AR, Yiu HHP, Telling ND, Roach P, Chari DM. 2016. 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release, vol. 224, 136-145. link> doi>
  • Weightman AP, Jenkins SI, Chari DM. 2016. Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research. doi> link>
  • Jenkins SI, Roach P, Chari DM. 2015. Development of a nanomaterial bio-screening platform for neurological applications. Nanomedicine, vol. 11(1), 77-87. link> doi>
  • Jenkins SI, Pickard MR, Furness DN, Yiu HHP, Chari DM. 2013. Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond), vol. 8(6), 951-968. link> doi>
  • Jenkins SI, Pickard MR, Granger N, Chari DM. 2011. Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies. ACS Nano, vol. 5(8), 6527-6538. link> doi>

Full Publications List show

Journal Articles

  • Evans MG, Shakli A, Jenkins SI, Chari DM. 2017. Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles. Nano Research. doi> link>
  • Evans MG, Al-Shakli A, Jenkins SI, Chari DM. 2017. Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles. NANO RESEARCH, vol. 10(8), 2881-2890. link> doi>
  • Tickle JA, Jenkins SI, Polyak B, Pickard MR, Chari DM. 2016. Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. Nanomedicine (Lond), vol. 11(4), 345-358. link> doi>
  • Jenkins SI, Weinberg D, Al-Shakli AF, Fernandes AR, Yiu HHP, Telling ND, Roach P, Chari DM. 2016. 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release, vol. 224, 136-145. link> doi>
  • Weightman AP, Jenkins SI, Chari DM. 2016. Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research. doi> link>
  • Jenkins SI, Roach P, Chari DM. 2015. Development of a nanomaterial bio-screening platform for neurological applications. Nanomedicine, vol. 11(1), 77-87. link> doi>
  • Jenkins SI, Yiu HHP, Rosseinsky MJ, Chari DM. 2014. Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Mol Cell Ther, vol. 2, 23. link> doi>
  • Tickle JA, Jenkins SI, Pickard MR, Chari DM. 2014. Influence of amplitude of oscillating magnetic fields on magnetic nanoparticle-mediated gene transfer to astrocytes. nanoLife. doi>
  • Jenkins SI, Pickard MR, Khong M, Smith HL, Mann CLA, Emes RD, Chari DM. 2014. Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS Chem Neurosci, vol. 5(1), 51-63. link> doi>
  • Weightman A, Jenkins S, Pickard M, Chari D, Yang Y. 2014. Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine, vol. 10(2), 291-295. link> doi>
  • Jenkins SI, Pickard MR, Furness DN, Yiu HHP, Chari DM. 2013. Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond), vol. 8(6), 951-968. link> doi>
  • Jenkins SI, Pickard MR, Chari DM. 2012. Magnetic nanoparticle mediated gene delivery in oligodendroglial cells: a comparison of differentiated versus precursor forms. NanoLIFE, vol. 3(1243001).
  • Jenkins SI, Pickard MR, Granger N, Chari DM. 2011. Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies. ACS Nano, vol. 5(8), 6527-6538. link> doi>
  • Pickard MR, Jenkins SI, Koller CJ, Furness DN, Chari DM. 2011. Magnetic nanoparticle labeling of astrocytes derived for neural transplantation. Tissue Eng Part C Methods, vol. 17(1), 89-99. link> doi>
  • Rafiq QA, Ortega I, Jenkins SI, Wilson SL, Patel AK, Barnes AL, Adams CF, Delcassian D, Smith D. 2015. The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regen Med, vol. 10(8), 989-1003. link> doi>

I teach at Keele University Medical School, and am currently involved in curriculum development (MBChB).

Postgraduate Supervision:LSC-40043, MSc in Scientific Research Training

Links, Resources, News

atreum conference

  • I am organising the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)

School of Life Sciences, Huxley003, Weds 09:00-10:00

Informal seminars discussing recent and proposed research in Neuroscience-related subjects, including Computer Science.

Please contact me if you are interested in presenting, or would like to join the mailing list.

  • I have contributed to the HEART (Healthcare Engineering & Regenerative Therapies) blog, aimed at teenagers interested in science

Are nanoparticles too small to be seen interacting with cells? [Jun 2014]

Can ‘stealth’ nanoparticles deliver medicine to the brain? [Apr 2014]

News, Events

 

 

  • Three of my publications have featured as journal covers

covers

  • Videos, produced using time-lapse fluorescence microscopy

Fluorescent magnetic nanoparticles being internalised by brain cells

Lab members, opportunities

  • Emma Green, PhD student (2016-)

Vitamin driven generation of dopaminergic neurons as cell replacement therapy for Parkinson’s disease

  • Michael Santer, MSc Scientific Research Training (2016-)

Serum-free media for neural cell culture

  • Shida “Tiggs” Gholamian, Keele medical student, INSPIRE Summer Studentship (2016, with Dr David Morgan)

Eight week project: “Does repeated activation generate an ‘experienced’ microglial phenotype, with altered pro-inflammatory responses?”

Anna Biju won a place in the national finals of the National Science + Engineering Competition (British Science Association, BSA), presenting our work at The Big Bang Fair. Covered in The Sentinel.

student

  • Students wanted:

I welcome applications to undertake postgraduate (PhD or MPhil) studies in my laboratory. Please contact me directly (s.i.jenkins@keele.ac.uk) to discuss potential projects and the application process. See the "Research and Scholarship" tab for my research interests.