Dr Julien Pelletier

Title: Teaching Fellow in Biosciences
Phone: +44 (0)1782 733671
Email: j.pelletier@keele.ac.uk
Location: Huxley Building : 304
Role:
Contacting me: Try my office or arrange an appointment by e-mail.
Julien Pelletier

I studied for my BA at University Paris-6 where I started to develop an ever-growing interest for the field of insect physiology. Then, I completed a PhD in molecular biology at INRA (Institut National de la Recherche Agronomique) in Versailles, France, working on the characterization of olfactory proteins involved in the antennal reception of pheromone in the silkmoth. After graduating, I joined Walter Leal’s laboratory for a first postdoctoral experience at the University of California-Davis, USA. There, I employed a combination of molecular, bioinformatics and functional approaches to study different families of mosquito olfactory proteins. I returned to Europe for a second postdoctoral experience at SLU (Sveriges Lantbruks Universitet), Sweden, where I received two competitive grants to continue my research on the molecular mechanisms of olfaction in mosquitoes. I joined the faculty at Keele in November 2013 as a Lecturer in Vector Biology.

My research, conducted from an evolutionary and functional perspective, involves elucidating molecular mechanisms of olfaction in mosquitoes. Adaptation of mosquitoes within different ecological niches (e.g. host preference) relies on a diversified set of olfactory proteins necessary to detect semiochemicals critical for survival. Thus far, only a small subset of these proteins has been functionally characterized. In this context, I am employing conventional techniques of molecular biology and electrophysiology in addition to emerging tools such as transgenesis-mediated knockout in order to translate genomic and transcriptomic data into functional evidence. My main objective is to get insights into the evolutionary and molecular mechanisms of mosquito odorant reception as well as to provide relevant information regarding the design of new strategies for vector control.

Further details (CAEP Homepage)

Selected Publications

  • Rogerson E, Pelletier J, Acosta-Serrano A, Rose C, Taylor S, Guimond S, Lima M, Skidmore M, Yates E. 2018. Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. Pathogens, vol. 7(1). link> doi> full text>
  • Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E. Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Res, vol. 140, 13-17. link> doi> full text>
  • Hughes DT, Pelletier J, Rahman S, Chen S, Leal WS, Luetje CW. 2017. Functional and non-functional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus. Chemical Senses, vol. 42(4), 333-341. doi> link>
  • Pelletier J, Xu P, Yoon KS, Clark JM, Leal WS. 2015. Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, vol. 66, 103-109. doi> link> full text>
  • Choo Y-M, Pelletier J, Atungulu E, Leal WS. 2013. Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm. PLoS One, vol. 8(6), e67794. link> doi>

Full Publications List show

Journal Articles

  • Rogerson E, Pelletier J, Acosta-Serrano A, Rose C, Taylor S, Guimond S, Lima M, Skidmore M, Yates E. 2018. Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. Pathogens, vol. 7(1). link> doi> full text>
  • Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E. Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Res, vol. 140, 13-17. link> doi> full text>
  • Hughes DT, Pelletier J, Rahman S, Chen S, Leal WS, Luetje CW. 2017. Functional and non-functional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus. Chemical Senses, vol. 42(4), 333-341. doi> link>
  • Pelletier J, Xu P, Yoon KS, Clark JM, Leal WS. 2015. Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, vol. 66, 103-109. doi> link> full text>
  • Choo Y-M, Pelletier J, Atungulu E, Leal WS. 2013. Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm. PLoS One, vol. 8(6), e67794. link> doi>
  • Xu P, Choo Y-M, Pelletier J, Sujimoto FR, Hughes DT, Zhu F, Atungulu E, Cornel AJ, Luetje CW, Leal WS. 2013. Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito. J Insect Physiol, vol. 59(9), 961-966. link> doi>
  • Pelletier J and Leal WS. 2011. Characterization of olfactory genes in the antennae of the Southern house mosquito, Culex quinquefasciatus. J Insect Physiol, vol. 57(7), 915-929. link> doi>
  • Syed Z, Pelletier J, Flounders E, Chitolina RF, Leal WS. 2011. Generic insect repellent detector from the fruit fly Drosophila melanogaster. PLoS One, vol. 6(3), e17705. link> doi>
  • Pelletier J, Hughes DT, Luetje CW, Leal WS. 2010. An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants. PLoS One, vol. 5(4), e10090. link> doi>
  • Pickett JA, Birkett MA, Dewhirst SY, Logan JG, Omolo MO, Torto B, Pelletier J, Syed Z, Leal WS. 2010. Chemical ecology of animal and human pathogen vectors in a changing global climate. J Chem Ecol, vol. 36(1), 113-121. link> doi>
  • Pelletier J, Guidolin A, Syed Z, Cornel AJ, Leal WS. 2010. Knockdown of a mosquito odorant-binding protein involved in the sensitive detection of oviposition attractants. J Chem Ecol, vol. 36(3), 245-248. link> doi>
  • Hughes DT, Pelletier J, Luetje CW, Leal WS. 2010. Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole. J Chem Ecol, vol. 36(8), 797-800. link> doi>
  • Pelletier J and Leal WS. 2009. Genome analysis and expression patterns of odorant-binding proteins from the Southern House mosquito Culex pipiens quinquefasciatus. PLoS One, vol. 4(7), e6237. link> doi>
  • Leal WS, Ishida Y, Pelletier J, Xu W, Rayo J, Xu X, Ames JB. 2009. Olfactory proteins mediating chemical communication in the navel orangeworm moth, Amyelois transitella. PLoS One, vol. 4(9), e7235. link> doi>
  • Merlin C, Rosell G, Carot-Sans G, François M-C, Bozzolan F, Pelletier J, Jacquin-Joly E, Guerrero A, Maïbèche-Coisne M. 2007. Antennal esterase cDNAs from two pest moths, Spodoptera littoralis and Sesamia nonagrioides, potentially involved in odourant degradation. Insect Mol Biol, vol. 16(1), 73-81. link> doi>
  • Pelletier J, Bozzolan F, Solvar M, François M-C, Jacquin-Joly E, Maïbèche-Coisne M. 2007. Identification of candidate aldehyde oxidases from the silkworm Bombyx mori potentially involved in antennal pheromone degradation. Gene, vol. 404(1-2), 31-40. link> doi>
  • de Santis F, François M-C, Merlin C, Pelletier J, Maïbèche-Coisné M, Conti E, Jacquin-Joly E. 2006. Molecular cloning and in Situ expression patterns of two new pheromone-binding proteins from the corn stemborer Sesamia nonagrioides. J Chem Ecol, vol. 32(8), 1703-1717. link> doi>