Dr Chris Adams

Title: Lecturer in Neuroscience
Phone: +44 (0)1782 733943
Email: c.adams@keele.ac.uk
Location: Huxley Building : 226
Role: Lecturer in Neuroscience
Contacting me: By phone or email please
Christoper_Adams_200x200

Current post:
Lecturer in Neuroscience

Scientific career:

2015-2017:  Research Fellow (Engineering: Tissue Engineering and Regenerative Medicine Landscape), Keele University
Project title: Engineering neural bridges to promote repair in spinal cord injury.

2015:  PhD in Cellular and Neural Engineering, Keele University
Title: Magnetic particles for neural stem cell-based therapies
Supervisor: Professor Divya Chari
A four year EPSRC PhD studentship within the internationally recognised CDT in Regenerative Medicine.

2010:  MSc in Bioscience Technology (awarded distinction), University of York

2007:  BSc in Biochemistry (2:1), University of Bristol

Neural cell transplantation shows significant promise to promote regeneration of the central nervous system (CNS) post-disease or injury but still requires further optimisation before being adopted globally in healthcare practice. My research aims are to investigate a range of nanotechnology platforms which could improve effectiveness of neural cell transplantation therapies, whilst maintaining a high safety profile. As successful translation of this technology requires a highly multidisciplinary environment, our laboratory has setup a diverse range of collaborators including clinicians, industry and basic scientists. My current work is divided into the following areas:

1. Examining the use of multifunctional magnetic nanoparticles to facilitate noninvasive cell tracking and safe genetic engineering of neural cells in collaboration with Professor Jean-Paul Lellouche, Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, Israel.

2. Optimising neural cell culture in hydrogels for implantation into sites of neurological injury. This includes (i) 3-D culture of multiple neural cell types with control over their cytoarchitecture within the gel for directed regeneration applications in collaboration with a number of industrial partners: BiogelX Ltd, PeptigelDesign Ltd and Jellagen Pty Ltd and (ii) Investigating ease of implantation and non-invasive monitoring of hydrogel-cell constructs in vivo in collaboration with Dr Nicolas Granger, School of Veterinary Sciences, University of Bristol and Professor Nicholas  Jeffery, Texas A&M University, USA.

3. Proteomics based analysis of the safety of nanoparticle platforms for neural stem cells with Dr Sarah Hart, Keele University and Professor Richard Emes, Director of the Advanced Analysis Centre, Nottingham University.

Selected Publications

  • Adams C, Israel LL, Ostrovsky S, Taylor A, Poptani H, Lellouche J-P, Chari D. 2016. Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells. ADVANCED HEALTHCARE MATERIALS, vol. 5(7), 841-849. link> doi>
  • Adams CF, Rai A, Sneddon G, Yiu HHP, Polyak B, Chari DM. 2015. Increasing magnetite contents of polymeric magnetic particles dramatically improves labeling of neural stem cell transplant populations. Nanomedicine, vol. 11(1), 19-29. link> doi>
  • Adams CF, Pickard MR, Chari DM. 2013. Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields. Nanomedicine, vol. 9(6), 737-741. link> doi>
  • Delaney AM, Adams CF, Fernandes AR, Al-Shakli AF, Sen J, Carwardine DR, Granger N, Chari DM. 2017. A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells. Nanoscale, vol. 9(25), 8560-8566. link> doi>
  • Pickard MR, Adams CF, Chari DM. 2017. Magnetic Nanoparticle-Mediated Gene Delivery to Two- and Three-Dimensional Neural Stem Cell Cultures: Magnet-Assisted Transfection and Multifection Approaches to Enhance Outcomes. Curr Protoc Stem Cell Biol, vol. 40, 2D.19.1-2D.19.16. link> doi>

Full Publications List show

Journal Articles

  • Delaney AM, Adams CF, Fernandes AR, Al-Shakli AF, Sen J, Carwardine DR, Granger N, Chari DM. 2017. A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells. Nanoscale, vol. 9(25), 8560-8566. link> doi>
  • Pickard MR, Adams CF, Chari DM. 2017. Magnetic Nanoparticle-Mediated Gene Delivery to Two- and Three-Dimensional Neural Stem Cell Cultures: Magnet-Assisted Transfection and Multifection Approaches to Enhance Outcomes. Curr Protoc Stem Cell Biol, vol. 40, 2D.19.1-2D.19.16. link> doi>
  • Adams CF, Dickson AW, Kuiper J-H, Chari DM. 2016. Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. Nanoscale, vol. 8(41), 17869-17880. link> doi>
  • Adams C, Israel LL, Ostrovsky S, Taylor A, Poptani H, Lellouche J-P, Chari D. 2016. Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells. ADVANCED HEALTHCARE MATERIALS, vol. 5(7), 841-849. link> doi>
  • Weinberg D, Adams CF, Chari DM. 2015. Deploying clinical grade magnetic nanoparticles with magnetic fields to magnetolabel neural stem cells in adherent versus suspension cultures. RSC ADVANCES, vol. 5(54), 43353-43360. link> doi>
  • Pickard MR, Adams CF, Barraud P, Chari DM. 2015. Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes. J Funct Biomater, vol. 6(2), 259-276. link> doi>
  • Fernandes AR, Adams CF, Furness DN, Chari DM. 2015. Early Membrane Responses to Magnetic Particles are Predictors of Particle Uptake in Neural Stem Cells. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, vol. 32(6), 661-667. link> doi>
  • Adams CF, Rai A, Sneddon G, Yiu HHP, Polyak B, Chari DM. 2015. Increasing magnetite contents of polymeric magnetic particles dramatically improves labeling of neural stem cell transplant populations. Nanomedicine, vol. 11(1), 19-29. link> doi>
  • Adams CF, Pickard MR, Chari DM. 2013. Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields. Nanomedicine, vol. 9(6), 737-741. link> doi>
  • Rafiq QA, Ortega I, Jenkins SI, Wilson SL, Patel AK, Barnes AL, Adams CF, Delcassian D, Smith D. 2015. The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regen Med, vol. 10(8), 989-1003. link> doi>

October 2017

£51k for Medical Research Council Confidence in Concept funding “Protective matrices for delivery of genetically augmented canine olfactory ensheathing cell transplants”. Co-applicant with Professor Divya Chari (Keele University), 12 months.

Faculty of Natural Sciences fully funded PhD studentship “Investigating the chick embryo as a neurological injury model for screening new nanotherapies” (3 years, ca £80k).  

Aug 2017

Best Poster Presentation prize for ASPIRE funded, summer placement medical student Georgios Solomou. He presented “Therapeutic gene delivery to neural stem cell transplants using multimodal magnetic particles” at the British Society of Nanomedicine Early Career Researchers Meeting (Belfast, UK).

July 2017

£1.8k British Neuropathological Society Small Grant “Investigating the feasibility of using the chick embryo as a neurological injury model for screening new nanotherapies”.

£1.5k for three ASPIRE Summer Studentships to support training placements for medical students in the laboratory (School of Medicine, Keele University).

November 2016

Oral Presentation Prize for best presentation at The Academy of Medical Sciences’ Daniel Turnberg Travel Fellowship Scheme Alumni Conference 2016.

May 2016

£2.9k Personal award of a Daniel Turnberg Travel Fellowship from the Wellcome Trust for secondment “Developing next generation nanoparticles for neural cell therapies” in the Department of Chemistry, Bar-Ilan University, Israel.

February 2016

£20k Pump-priming Research Award from the North Staffordshire Medical Institute.

Project title: Assessing human brain slices as ‘benchtop’ injury models. Co-applicant with Professor Chari (Keele University) and Mr Tzerakis (Consultant Neurosurgeon, University Hospitals of North Midlands).

January 2015

£250,000 Engineering: Tissue Engineering and Regenerative Medicine Landscape Research Fellow Fellowship funded by the EPSRC via the Centre for Doctoral Training (CDT) in Regenerative Medicine.

Project title: Engineering neural bridges to promote repair in spinal cord injury.