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    Dr S Glazewski

    Dr S Glazewski

    Title
    Lecturer in Neuroscience
    Location
    Huxley Building : 164
    Role

    Second Year Tutor for Neuroscience Study Abroad Tutor for Neuroscience Honorary Research Fellow – Cardiff School of Biosciences, Cardiff University, U.K. (Feb. 1st. 2002-present). Visiting Research Scholar – Department of Biological Sciences, Carnegie-Melon University, Pittsburgh, USA (June 15th 2004 – present). Member of the Advisory Board of the Nencki Institute PhD Programme.
    Contact me
    Try my office or email me
    Phone
    +44 (0)1782 733029
    Email
    s.glazewski@keele.ac.uk

    Biography

    I have been at Keele since 2002. My first degree (Msc), in Molecular Biology from the University of Warsaw was followed by the PhD in Neuroscience and habilitation in Neurobiology from the Nencki Institute, Warsaw.

    I was working in several scientific institutions in Poland before departing to the U.S (Georgetown University, Washington, D.C.; University of Minnesota, Minneapolis and Washington University, St. Louis) before coming to the UK (Cardiff University).

    Research and scholarship

    barrel cortex A great deal of progress has been made in our understanding of brain function, in recent years, but we still do not know precisely how this organ acquires, stores and recalls information.

    A common assumption is, that it is done somehow via changes in synaptic weights and connectivity between neurons (plastic changes). Studying changes in neuronal transmission and connectivity in intact animals during learning it is quite a big task as we usually do not know, where these changes take a place, nor what they mean and whether they are specifically related to learning and memory or not.

    Those are the main reasons for studying mechanisms of plastic changes using model systems. For example, the barrel cortex of rodents, where vibrissae are represented. The unique anatomical organisation of this cortical area enables quantitative and very accurate measurement of plasticity induced by change in experience. For instance, due to changing vibrissae complement for some period of time.

    My research aims to understand how experience induces neuronal plasticity in the neocortex and how this plasticity is maintained; namely, to discover the physiological mechanisms of synaptic potentiation and depression, how these changes are stabilised during development and the molecules involved. Recently, I am also interested in the mechanisms underlying simple forms of learning that may be induced in the barrel cortex with use of whiskers, synaptic changes driven by circadian rhythms and the consequences of demyelination.

    Teaching

    • Second Year tutor
    • LSC-10029 – Introduction to Neuroscience
    • LSC-10040  - Introduction to Human Physiology
    • LSC-10028 - Cell and Molecular Neuroscience
    • LSC-20005 - Endocrinology and Signalling
    • PHA-20004 - Principles of Pharmacology
    • LSC-20027 - From Neurone to Brain (module manager)
    • LSC-20023 - Development and Evolution of  Nervous System
    • LSC-30021 – Research Project in Neuroscience (module manager)
    • LSC30022- Non-Experimental Project in Neuroscience (module manager)
    • LSC-30023 - Final Year Dissertation in Neuroscience (module manager)

    Selected Publications

    • Glazewski S and Barth AL. 2015. Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates. EUROPEAN JOURNAL OF NEUROSCIENCE, 410-419, vol. 41(4). link> doi> full text>
    • Glazewski S, Greenhill S, Fox K. 2017. Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philos Trans R Soc Lond B Biol Sci, vol. 372(1715). link> doi> full text>
    • Sims RE, Butcher JB, Parri HR, Glazewski S. 2015. Astrocyte and Neuronal Plasticity in the Somatosensory System. Neural Plast, 732014, vol. 2015. link> doi>
    • Dachtler J, Hardingham NR, Glazewski S, Wright NF, Blain EJ, Fox K. 2011. Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. J Neurosci, 11220-11230, vol. 31(31). link> doi>
    • Jasinska M, Siucinska E, Cybulska-Klosowicz A, Pyza E, Furness DN, Kossut M, Glazewski S. 2010. Rapid, learning-induced inhibitory synaptogenesis in murine barrel field. J Neurosci, 1176-1184, vol. 30(3). link> doi> full text>

    Full Publications Listshow

    Journal Articles

    • Glazewski S, Greenhill S, Fox K. 2017. Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philos Trans R Soc Lond B Biol Sci, vol. 372(1715). link> doi> full text>
    • Sims RE, Butcher JB, Parri HR, Glazewski S. 2015. Astrocyte and Neuronal Plasticity in the Somatosensory System. Neural Plast, 732014, vol. 2015. link> doi>
    • Glazewski S and Barth AL. 2015. Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates. EUROPEAN JOURNAL OF NEUROSCIENCE, 410-419, vol. 41(4). link> doi> full text>
    • Dachtler J, Hardingham NR, Glazewski S, Wright NF, Blain EJ, Fox K. 2011. Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. J Neurosci, 11220-11230, vol. 31(31). link> doi>
    • Jasinska M, Siucinska E, Cybulska-Klosowicz A, Pyza E, Furness DN, Kossut M, Glazewski S. 2010. Rapid, learning-induced inhibitory synaptogenesis in murine barrel field. J Neurosci, 1176-1184, vol. 30(3). link> doi> full text>
    • Nowicka D, Soulsby S, Skangiel-Kramska J, Glazewski S. 2009. Parvalbumin-containing neurons, perineuronal nets and experience-dependent plasticity in murine barrel cortex. Eur J Neurosci, 2053-2063, vol. 30(11). link> doi>
    • Benedetti BL, Glazewski S, Barth AL. 2009. Reliable and precise neuronal firing during sensory plasticity in superficial layers of primary somatosensory cortex. J Neurosci, 11817-11827, vol. 29(38). link> doi>
    • Wright N, Glazewski S, Hardingham N, Phillips K, Pervolaraki E, Fox K. 2008. Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nat Neurosci, 1140-1142, vol. 11(10). link> doi>
    • Glazewski S, Benedetti BL, Barth AL. 2007. Ipsilateral whiskers suppress experience-dependent plasticity in the barrel cortex. J Neurosci, 3910-3920, vol. 27(14). link> doi>
    • Jasińska M, Siucińska E, Głazewski S, Pyza E, Kossut M. 2006. Characterization and plasticity of the double synapse spines in the barrel cortex of the mouse. Acta Neurobiol Exp (Wars), 99-104, vol. 66(2). link>
    • Fox K, Wright N, Wallace H, Glazewski S. 2003. The origin of cortical surround receptive fields studied in the barrel cortex. Journal of Neuroscience, 8380-8391, vol. 23(23). doi>
    • Hardingham N, Glazewski S, Pakhotin P, Mizuno K, Chapman PF, Giese KP, Fox K. 2003. Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation. J Neurosci, 4428-4436, vol. 23(11). link> doi>
    • Fox K, Wallace H, Glazewski S. 2002. Is there a thalamic component to experience-dependent cortical plasticity?. Philos Trans R Soc Lond B Biol Sci, 1709-1715, vol. 357(1428). link> doi>
    • Glazewski S, McKenna M, Jacquin M, Fox K. 1998. Experience-dependent depression of vibrissae responses in adolescent rat barrel cortex. Eur J Neurosci, 2107-2116, vol. 10(6). link> doi>
    • Glazewski S, Bejar R, Mayford M, Fox K. 2001. The effect of autonomous alpha-CaMKII expression on sensory responses and experience-dependent plasticity in mouse barrel cortex. Neuropharmacology, 771-778, vol. 41(6). link> doi>
    • Wallace H, Glazewski S, Liming K, Fox K. 2001. The role of cortical activity in experience-dependent potentiation and depression of sensory responses in rat barrel cortex. J Neurosci, 3881-3894, vol. 21(11). link> doi>
    • Glazewski S, Giese KP, Silva A, Fox K. 2000. The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nat Neurosci, 911-918, vol. 3(9). link> doi>
    • Fox K, Glazewski S, Schulze S. 2000. Plasticity and stability of somatosensory maps in thalamus and cortex. Curr Opin Neurobiol, 494-497, vol. 10(4). link> doi>
    • Barth AL, McKenna M, Glazewski S, Hill P, Impey S, Storm D, Fox K. 2000. Upregulation of cAMP response element-mediated gene expression during experience-dependent plasticity in adult neocortex. J Neurosci, 4206-4216, vol. 20(11). link> doi>
    • Skibinska A, Glazewski S, Fox K, Kossut M. 2000. Age-dependent response of the mouse barrel cortex to sensory deprivation: a 2-deoxyglucose study. Exp Brain Res, 134-138, vol. 132(1). link> doi>
    • Głazewski S, Kossut M, Skangiel-Kramska J. 1995. NMDA receptors in mouse barrel cortex during normal development and following vibrissectomy. Int J Dev Neurosci, 505-514, vol. 13(6). link> doi>
    • Glazewski S, Barth AL, Wallace H, McKenna M, Silva A, Fox K. 1999. Impaired experience-dependent plasticity in barrel cortex of mice lacking the alpha and delta isoforms of CREB. Cereb Cortex, 249-256, vol. 9(3). link> doi>
    • Glazewski S, Herman C, McKenna M, Chapman PF, Fox K. 1998. Long-term potentiation in vivo in layers II/III of rat barrel cortex. Neuropharmacology, 581-592, vol. 37(4-5). link> doi>
    • Glazewski S. 1998. Experience-dependent changes in vibrissae evoked responses in the rodent barrel cortex. Acta Neurobiol Exp (Wars), 309-320, vol. 58(4). link>
    • Glazewski S, Wallace H, Silva A, Fox K. 1998. Experience-dependent plasticity in the barrel cortex of adolescent alpha/delta-CREB deficient mice. EUROPEAN JOURNAL OF NEUROSCIENCE, 436, vol. 10. link>
    • Skibinska A, Glazewski S, Fox K, Kossut M. 1998. Metabolic activation and receptive field properties in barrel cortex of vibrissa deprived rodents. EUROPEAN JOURNAL OF NEUROSCIENCE, 227, vol. 10. link>
    • Fox K and Glazewski S. 1997. Evidence for heterosynaptic depression of vibrissae responses in rat barrel cortex. JOURNAL OF PHYSIOLOGY-LONDON, P94, vol. 501P. link>
    • Fox K, Schlaggar BL, Glazewski S, O'Leary DD. 1996. Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex. Proc Natl Acad Sci U S A, 5584-5589, vol. 93(11). link> doi>
    • Glazewski S, Chen CM, Silva A, Fox K. 1996. Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science, 421-423, vol. 272(5260). link> doi>
    • Glazewski S and Fox K. 1996. Time course of experience-dependent synaptic potentiation and depression in barrel cortex of adolescent rats. J Neurophysiol, 1714-1729, vol. 75(4). link> doi>
    • Fox K, Glazewski S, Chen CM, Silva A, Li X. 1996. Mechanisms underlying experience-dependent potentiation and depression of vibrissae responses in barrel cortex. J Physiol Paris, 263-269, vol. 90(3-4). link> doi>
    • GLAZEWSKI S, REMISZEWSKA M, WUTKIEWICZ M, JASTRZEBSKI Z, DANYSZ W. 1995. ON THE ROLE OF NMDA RECEPTORS IN BLOOD-PRESSURE REGULATION IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR). AMINO ACIDS, 379-383, vol. 8(4). link> doi>
    • Li X, Glazewski S, Lin X, Elde R, Fox K. 1995. Effect of vibrissae deprivation on follicle innervation, neuropeptide synthesis in the trigeminal ganglion, and S1 barrel cortex plasticity. J Comp Neurol, 465-481, vol. 357(3). link> doi>
    • SKANGIELKRAMSKA J, GLAZEWSKI S, JABLONSKA B, KOSSUT M. 1994. NMDA AND AMPA RECEPTORS IN THE DEVELOPMENT AND PLASTICITY OF THE BARREL CORTEX OF THE MOUSE. JOURNAL OF NEUROCHEMISTRY, S50, vol. 63. link>
    • Skangiel-Kramska J, Głazewski S, Jabłońska B, Siucińska E, Kossut M. 1994. Reduction of GABAA receptor binding of [3H]muscimol in the barrel field of mice after peripheral denervation: transient and long-lasting effects. Exp Brain Res, 39-46, vol. 100(1). link> doi>
    • Głazewski S, Skangiel-Kramska J, Kossut M. 1993. Development of NMDA receptor-channel complex and L-type calcium channels in mouse hippocampus. J Neurosci Res, 199-206, vol. 35(2). link> doi>
    • Kossut M, Głazewski S, Siucińska E, Skangiel-Kramska J. 1993. Functional plasticity and neurotransmitter receptor binding in the vibrissal barrel cortex. Acta Neurobiol Exp (Wars), 161-173, vol. 53(1). link>
    • Danysz W, Dyr W, Jankowska E, Glazewski S, Kostowski W. 1992. The involvement of NMDA receptors in acute and chronic effects of ethanol. Alcohol Clin Exp Res, 499-504, vol. 16(3). link> doi>
    • GLAZEWSKI S, SKANGIELKRAMSKA J, KOSSUT M. 1992. IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS IN DEVELOPING MOUSE BARREL CORTEX. EUROPEAN JOURNAL OF NEUROSCIENCE, 122. link>
    • Skangiel-Kramska J, Głazewski S, Siucińska E, Kossut M. 1992. Ontogenesis of muscarinic cholinergic receptor binding in the barrel cortex of mice. Acta Neurobiol Exp (Wars), 48, vol. 52(1). link>
    • Michalik M, Głazewski S, Bryła J. 1989. Effect of various aminoglycoside antibiotics on glucose formation in isolated rabbit kidney-cortex tubules. Pharmacol Res, 405-414, vol. 21(4). link> doi>

    Other

    • Fox NW, Wallace H, Glazewski S. 2004. The origin of cortical surround receptive fields studied in the barrel field.
    • Glazewski S, Giese KP, Fox K. 2003. Effect of a point mutation at the Thr-286 site of alpha-CaMKII on plasticity measured by sensory evoked field EPSPs. Neural Mechanisms of Learning and Memory.
    • Glazewski S, Sprengel R, Fox K. 2003. The effect of deleting AMPA receptor subunit GluR A on experience-dependent plasticity in mouse barrel cortex.
    • Głazewski S, Kossut M, Siucińska E, Skangiel-Kramska J. 1990. Cholinergic markers in the plasticity of murine barrel field. Acta Neurobiol Exp (Wars) (pp. 163-172, vol. 50). link>