Selected Publications

  • Amith SR and Fliegel L. 2017. Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Semin Cancer Biol, 35-41, vol. 43. link> doi> full text>
  • Amith SR, Vincent KM, Wilkinson JM, Postovit LM, Fliegel L. 2017. Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. Cell Signal, 69-77, vol. 29. link> doi> link> full text>
  • Amith SR, Wilkinson JM, Fliegel L. 2016. KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochem Pharmacol, 31-39, vol. 118. link> doi> full text>
  • Amith SR and Fliegel L. 2016. The Na+/H+ exchanger in metastasis. Aging (Albany NY), 1291, vol. 8(7). link> doi> link> full text>
  • Amith SR, Wilkinson JM, Fliegel L. 2016. Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells. Oncotarget, 21091-21113, vol. 7(16). link> doi> full text>

Full Publications Listshow

Journal Articles

  • Amith SR and Fliegel L. 2017. Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Semin Cancer Biol, 35-41, vol. 43. link> doi> full text>
  • Amith SR, Vincent KM, Wilkinson JM, Postovit LM, Fliegel L. 2017. Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. Cell Signal, 69-77, vol. 29. link> doi> link> full text>
  • Amith SR, Wilkinson JM, Fliegel L. 2016. KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochem Pharmacol, 31-39, vol. 118. link> doi> full text>
  • Amith SR and Fliegel L. 2016. The Na+/H+ exchanger in metastasis. Aging (Albany NY), 1291, vol. 8(7). link> doi> link> full text>
  • Amith SR, Wilkinson JM, Fliegel L. 2016. Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells. Oncotarget, 21091-21113, vol. 7(16). link> doi> full text>
  • Amith SR, Wilkinson JM, Fliegel L. 2016. Assessing Na+/H+ exchange and cell effector functionality in metastatic breast cancer. Biochim Open, 16-23, vol. 2. link> doi>
  • Amith SR, Fong S, Baksh S, Fliegel L. 2015. Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?. Int J Dev Biol, 367-377, vol. 59(7-9). link> doi> full text>
  • Amith SR, Wilkinson JM, Baksh S, Fliegel L. 2014. The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget, 1262-1275, vol. 6(2). link> doi> full text>
  • Alghamdi F, Guo M, Abdulkhalek S, Crawford N, Amith SR, Szewczuk MR. 2014. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. Cell Signal, 1355-1368, vol. 26(6). link> doi>
  • Amith SR and Fliegel L. 2013. Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis. Cancer Res, 1259-1264, vol. 73(4). link> doi>
  • Abdulkhalek S, Guo M, Amith SR, Jayanth P, Szewczuk MR. 2012. G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling. Cell Signal, 2035-2042, vol. 24(11). link> doi>
  • Abdulkhalek S, Amith SR, Franchuk SL, Jayanth P, Guo M, Finlay T, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. 2011. Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. J Biol Chem, 36532-36549, vol. 286(42). link> doi>
  • Amith SR, Jayanth P, Finlay T, Franchuk S, Gilmour A, Abdulkhalek S, Szewczuk MR. 2010. Detection of Neu1 sialidase activity in regulating Toll-like receptor activation. J Vis Exp. link> doi>
  • Finlay TM, Abdulkhalek S, Gilmour A, Guzzo C, Jayanth P, Amith SR, Gee K, Beyaert R, Szewczuk MR. 2010. Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo. Glycoconj J, 583-600, vol. 27(6). link> doi>
  • Jayanth P, Amith SR, Gee K, Szewczuk MR. 2010. Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling. Cell Signal, 1193-1205, vol. 22(8). link> doi>
  • Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. 2010. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J, 329-348, vol. 27(3). link> doi>
  • Amith SR, Jayanth P, Franchuk S, Finlay T, Seyrantepe V, Beyaert R, Pshezhetsky AV, Szewczuk MR. 2010. Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling. Cell Signal, 314-324, vol. 22(2). link> doi>
  • Amith SR, Jayanth P, Franchuk S, Siddiqui S, Seyrantepe V, Gee K, Basta S, Beyaert R, Pshezhetsky AV, Szewczuk MR. 2009. Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase. Glycoconj J, 1197-1212, vol. 26(9). link> doi>
  • Woronowicz A, Amith SR, De Vusser K, Laroy W, Contreras R, Basta S, Szewczuk MR. 2007. Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase (vol 17, pg 10-14, 2007). GLYCOBIOLOGY, 1030, vol. 17(10). link>
  • Woronowicz A, Amith SR, Davis VW, Jayanth P, De Vusser K, Laroy W, Contreras R, Meakin SO, Szewczuk MR. 2007. Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells. Glycobiology, 725-734, vol. 17(7). link> doi>
  • Jumaa PA, Sonnevend A, Pàl T, El Hag M, Amith R, Trad O. 2006. The molecular epidemiology of Stenotrophomonas maltophilia bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000-2004. Ann Clin Microbiol Antimicrob, 32, vol. 5. link> doi> full text>
  • Woronowicz A, Amith SR, De Vusser K, Laroy W, Contreras R, Basta S, Szewczuk MR. 2007. Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase. Glycobiology, 10-24, vol. 17(1). link> doi>
  • Dissanayake S, Amith RS, Shahin A. 2004. Taenia crassiceps carbohydrates stimulate IL-6 expression in naïve murine macrophages via Toll-like receptors (TLRs). Mol Immunol, 391-398, vol. 41(4). link> doi>

Other

  • Amith R, Wilkinson JM, Baksh S, Fliegel L. 2014. Deletion of the Na+/H+ exchanger results in decreased invasiveness of MDA-MB-231 breast cancer cells. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE (p. 594, vol. 92). link>
  • Amith SR, Wilkinson JM, Fliegel L. 2013. Inhibition of the Na+/H+ exchanger (NHE1) increases susceptibility to paclitaxel in invasive breast cancer cells. MOLECULAR CANCER RESEARCH (vol. 11). link> doi>
  • Abdulkhalek S, Amith SR, Jayanth P, Guo M, Szewczuk M. 2011. Dependence of G-Protein Coupled Receptor Agonists Transactivation of Trk Tyrosine Kinase and TOLL-Like Receptors on Neuraminidase-1 and Matrix Metalloproteinase-9 Cross-Talk. GLYCOBIOLOGY (p. 1490, vol. 21). link>
  • Abdulkhalek S, Amith SR, Franchuk SL, Jayanth P, Finlay T, Gilmour A, Guo M, Guzzo C, Gee K, Beyaert R, Szewczuk M. 2010. Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-Talk: a Novel Molecular Signalling Platform for Cell Surface and Intracellular TOLL-Like Receptors. GLYCOBIOLOGY (p. 1461, vol. 20). link>
  • Jayanth P, Amith SR, Szewczuk MR. 2009. Neu1 Sialidase Regulates Nerve Growth Factor-Induced Trka Receptor Activation. GLYCOBIOLOGY (p. 1363, vol. 19). link>
  • Franchuk SL, Amith SR, Jayanth P, Finlay T, Szewczuk MR. 2009. Neu1 and Mmp-9 Cross-Talk Regulates Pathogen Molecule Induced Tlr Activation to Generate a Functional Receptor. GLYCOBIOLOGY (p. 1343, vol. 19). link>
  • Amith SR, Jayanth P, Franchuk S, Siddiqui S, Seyrantepe V, Gee K, Basta S, Beyaert R, Pshezhetsky A, Szewczuk M. 2009. Pathogen Molecule-Induced Toll-Like Receptor Activation and Cell Function is Dependent on Neu1 Sialidase. GLYCOBIOLOGY (p. 1290, vol. 19). link>
  • Jayanth P, Amith SR, Beyaert R, Szewczuk MR. 2008. Essential Role of alpha 2,3 Sialyl Residues in MyD88/TLR4 Interaction and NFkappaB Activation. GLYCOBIOLOGY (p. 988, vol. 18). link>
  • Amith SR, Jayanth P, Szewczuk MR, Finlay TM. 2008. The Pro-Inflammatory Effects of Thymoquinone. GLYCOBIOLOGY (p. 987, vol. 18). link>
  • Amith SR, Jayanth P, Finlay T, Franchuk S, Gilmour A, Abdulkhalek S, Szewczuk MR. Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation. link>