Prof Simon J Davies

Title: Professor of Nephrology
Consultant Nephrologist and Clinical Director, Department of Nephrology UHNM
Phone: +44 (0)1782 676387 or 676346
Email: s.j.davies@keele.ac.uk
Location: 1. Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire ST4 7QB
2. University Hospitals of North Midlands, Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent, ST4 6QG
Role: Clinical Co-Director of ISTM
ISTM Research theme: Health Services Research (Theme lead)

Contacting me: By phone or e-mail please
Prof Simon Davies

Prof. Simon Davies is a consultant nephrologist at the University Hospitals of North Midlands and Professor of Nephrology and Dialysis Medicine in the Institute for Science and Technology in Medicine at Keele University. His principal research interests are in peritoneal dialysis and the evaluation of fluid status in advanced renal failure.

Prof. Davies  is responsible for the Stoke PD Study, now the largest single centre study of long-term membrane function and clinical outcomes in peritoneal dialysis patients and was one of the lead investigators of the European Automated Peritoneal Dialysis Outcome Study (EAPOS). Other international collaborations have included studies evaluating the effects of polyglucose and low sodium solutions on fluid status in PD patients. He is currently developing new techniques in bedside body composition using breath analysis for deuterium abundance with the physicist Prof. David Smith FRS, for application in the haemodialysis unit, intensive care setting and in heart failure. This research is supported by Kidney Research UK, the Wellcome Trust and the Baxter Renal Discoveries Extra-mural grant programme.

Prof. Davies is a member of the UK Renal Registry Dialysis group, the Renal Association standards committee and author of the UK peritoneal dialysis guidelines. He is also chair of the International Society of Peritoneal Dialysis Research Committee and associate editor of Peritoneal Dialysis International.

Previous appointments held:

1993-2001      

Senior Lecturer, School of Postgraduate Medicine, Keele University
Consultant Renal Physician, North Staffordshire Hospital

1989-93      Lecturer, School of Postgraduate Medicine, Keele University and Senior Registrar, Nephrology, North Staffordshire Hospital.
1985-87 Research Registrar, Renal Research Laboratories, Renal Unit, Guy’s Hospital, London
Doctoral Thesis “Peritoneal defence mechanisms in patients treated with Continuous Ambulatory Peritoneal Dialysis”Supervisor: Professor J Stewart Cameron

Education:

BSc (1st Class Honours) 
Pharmacology and Basic Medical Science King’s College, University of London 1978
MBBS     King’s College Hospital University of London 1981
MRCP (UK)    Royal College of Physicians 1984
MD      University of London  1989

 

ISTM Research theme: Health Services Research (Theme lead)

Prof Davies' principal research interests are in peritoneal dialysis and the evaluation of fluid status in advanced renal failure.

Selected Publications

  • Zavvos V, Buxton AT, Evans C, Lambie M, Davies SJ, Topley N, Wilkie M, Summers A, Brenchley P, Goumenos DS, Johnson TS. 2017. A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney Int, vol. 92(4), 988-1002. link> doi>
  • Lambie M and Davies SJ. Are Peritoneal Dialysis Center Characteristics a Modifiable Risk Factor to Improve Peritoneal Dialysis Outcomes?. Clin J Am Soc Nephrol, vol. 12(7), 1032-1034. link> doi>
  • Lopez-Anton M, Lambie M, Lopez-Cabrera M, Schmitt CP, Ruiz-Carpio V, Bartosova M, Schaefer B, Davies S, Stone T, Jenkins R, Taylor PR, Topley N, Bowen T, Fraser D. 2017. miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. Am J Pathol, vol. 187(7), 1537-1550. link> doi>
  • Davies SJ, Caskey FJ, Coyle D, Lindley E, Macdonald J, Mitra S, Wilkie M, Davenport A, Farrington K, Dasgupta I, Ormandy P, Andronis L, Solis-Trapala I, Sim J. 2017. Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrol, vol. 18(1), 138. link> doi>
  • Jha V, Martin DE, Bargman JM, Davies S, Feehally J, Finkelstein F, Harris D, Misra M, Remuzzi G, Levin A, International Society of Nephrology Ethical Dialysis Task Force. 2017. Ethical issues in dialysis therapy. Lancet, vol. 389(10081), 1851-1856. link> doi>

Full Publications List show

Books

  • Davies S. The Dialysis Decision Aid Booklet: Making The Right Choices For You. Kidney Research UK.

Journal Articles

  • Zavvos V, Buxton AT, Evans C, Lambie M, Davies SJ, Topley N, Wilkie M, Summers A, Brenchley P, Goumenos DS, Johnson TS. 2017. A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney Int, vol. 92(4), 988-1002. link> doi>
  • Lambie M and Davies SJ. Are Peritoneal Dialysis Center Characteristics a Modifiable Risk Factor to Improve Peritoneal Dialysis Outcomes?. Clin J Am Soc Nephrol, vol. 12(7), 1032-1034. link> doi>
  • Lopez-Anton M, Lambie M, Lopez-Cabrera M, Schmitt CP, Ruiz-Carpio V, Bartosova M, Schaefer B, Davies S, Stone T, Jenkins R, Taylor PR, Topley N, Bowen T, Fraser D. 2017. miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. Am J Pathol, vol. 187(7), 1537-1550. link> doi>
  • Davies SJ, Caskey FJ, Coyle D, Lindley E, Macdonald J, Mitra S, Wilkie M, Davenport A, Farrington K, Dasgupta I, Ormandy P, Andronis L, Solis-Trapala I, Sim J. 2017. Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrol, vol. 18(1), 138. link> doi>
  • Jha V, Martin DE, Bargman JM, Davies S, Feehally J, Finkelstein F, Harris D, Misra M, Remuzzi G, Levin A, International Society of Nephrology Ethical Dialysis Task Force. 2017. Ethical issues in dialysis therapy. Lancet, vol. 389(10081), 1851-1856. link> doi>
  • Kwok CS, Wong CW, Rushton CA, Ahmed F, Cunnington C, Davies SJ, Patwala A, Mamas MA, Satchithananda D. 2017. Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. Int J Cardiol, vol. 228, 122-128. link> doi>
  • Wilkie M and Davies SJ. Technique Failure - Talking a Common Language. Peritoneal Dialysis International, vol. 36(6), 583-584. doi> link>
  • Davies SJ. 2016. Normalizing the peritoneal dialysis dose-have we got it right?. Kidney Int, vol. 90(6), 1162-1163. link> doi>
  • Davies SJ. 2016. Unraveling the mechanisms of progressive peritoneal membrane fibrosis. Kidney International, vol. 89(6), 1185-1187. doi>
  • Lambie MR, Chess J, Do JY, Noh H, Lee HB, Kim YL, Summers A, Williams PF, Davison S, Dorval M, Topley N, Davies S. 2016. Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL fluid cohort study. PLoS One. doi> link>
  • Dasgupta I, Farrington K, Davies SJ, Davenport A, Mitra S. 2016. UK National Survey of Practice Patterns of Fluid Volume Management in Haemodialysis Patients: A Need for Evidence. Blood Purif, vol. 41(4), 324-331. link> doi>
  • Lambie MR, Chess J, Summers AM, Williams PF, Topley N, Davies SJ, GLOBAL Fluid Study Investigators. 2016. Peritoneal inflammation precedes encapsulating peritoneal sclerosis: results from the GLOBAL Fluid Study. Nephrol Dial Transplant, vol. 31(3), 480-486. link> doi>
  • Davies SJ. 2014. Peritoneal solute transport and inflammation. Am J Kidney Dis, vol. 64(6), 978-986. link> doi>
  • Davies SJ and Davenport A. 2014. The role of bioimpedance and biomarkers in helping to aid clinical decision-making of volume assessments in dialysis patients. Kidney Int, vol. 86(3), 489-496. link> doi>
  • Kratochwill K, Boehm M, Herzog R, Kuster L, Gleiss A, Aufricht C, Vychytil A, Prasad N, Singh K, Prasad K, Gupta A, Bhadauria D, Pérez J, Selgas R, Prieto M, Sánchez JA, Remón C, Latus J, Habib SM, Kitterer D, Korte M, Ulmer C, Fritz P, Davies S, Lambie M, Alscher MD, Betjes M, Segerer S, Braun N, Kitterer D, Latus J, Ulmer C, Alscher MD, Segerer S, Braun N, Herzog R, Glüxam T, Becker J, Vychytil A, Aufricht C, Kratochwill K. 2014. Peritoneal dialysis. Nephrol Dial Transplant, vol. 29 Suppl 3, iii16-iii18. link> doi>
  • Davies SJ, Španěl P, Smith D. 2014. Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis. Bioanalysis, vol. 6(6), 843-857. link> doi>
  • Davies S, Lally F, Satchithananda D, Kadam U, Roffe C. 2014. Extending the role of peritoneal dialysis: can we win hearts and minds?. Nephrol Dial Transplant, vol. 29(9), 1648-1654. link> doi>
  • Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao C-T, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity, vol. 40(1), 40-50. link> doi>
  • Latus J, Habib SM, Kitterer D, Korte MR, Ulmer C, Fritz P, Davies S, Lambie M, Alscher MD, Betjes MGH, Segerer S, Braun N, European EPS study group. 2014. Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study. PLoS One, vol. 9(8), e106511. link> doi>
  • Van Biesen W, van der Veer SN, Murphey M, Loblova O, Davies S. 2014. Patients' perceptions of information and education for renal replacement therapy: an independent survey by the European Kidney Patients' Federation on information and support on renal replacement therapy. PLoS One, vol. 9(7), e103914. link> doi>
  • Yu Z, Lambie M, Davies SJ. 2014. Longitudinal study of small solute transport and peritoneal protein clearance in peritoneal dialysis patients. Clin J Am Soc Nephrol, vol. 9(2), 326-334. link> doi>
  • Davies SJ, Engel B, Chan C, Tan BK, Yu Z, Asghar R, John B, Spanel P, Smith D. 2013. Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution - Applications in the Dialysis Clinic. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 593-599. link>
  • Lambie M, Chess J, Donovan KL, Kim YL, Do JY, Lee HB, Noh H, Williams PF, Williams AJ, Davison S, Dorval M, Summers A, Williams JD, Bankart J, Davies SJ, Topley N, Global Fluid Study Investigators. 2013. Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. J Am Soc Nephrol, vol. 24(12), 2071-2080. link> doi>
  • Davies SJ. 2013. What has balANZ taught us about balancing ultrafiltration with membrane preservation?. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 28(8), 1971-1974. link> doi>
  • Davies SJ. 2013. Peritoneal dialysis--current status and future challenges. Nat Rev Nephrol, vol. 9(7), 399-408. link> doi>
  • Lambie M, Braun N, Davies SJ. 2013. TOWARDS STANDARDIZED REPORTING IN STUDIES OF ENCAPSULATING PERITONEAL SCLEROSIS. PERITONEAL DIALYSIS INTERNATIONAL, vol. 33(5), 482-486. link> doi>
  • Tan BK, Davies SJ, Spaněl P, Smith D. 2012. Injection of deuterated water into the pulmonary/alveolar circulation; measurement of HDO in exhaled breath and implications to breath analysis. J Breath Res, vol. 6(3), 036005. link> doi>
  • Dunn WB, Summers A, Brown M, Goodacre R, Lambie M, Johnson T, Wilkie M, Davies S, Topley N, Brenchley P. 2012. Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 27(6), 2502-2510. link> doi>
  • Yu Z, Tan BK, Dainty S, Mattey DL, Davies SJ. 2012. Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients. Nephrol Dial Transplant, vol. 27(12), 4437-4445. link> doi>
  • Garcia-Lopez E, Lindholm B, Davies S. 2012. An update on peritoneal dialysis solutions. NATURE REVIEWS NEPHROLOGY, vol. 8(4), 224-233. link> doi>
  • Briggs V, Davies S, Jenkins S, Wilkie M. 2011. Getting more out of clinical practice guidelines. Perit Dial Int, vol. 31(6), 631-635. link> doi>
  • Davies SJ. 2011. L-carnitine: more than just an alternative to glucose as an osmotic agent for peritoneal dialysis?. Kidney Int, vol. 80(6), 565-566. link> doi>
  • Coelho S, Yu Z, Davies S. 2011. Do we really know the meaning of sodium removal?. Perit Dial Int, vol. 31(4), 383-386. link> doi>
  • Summers AM, Abrahams AC, Alscher MD, Betjes M, Boeschoten EW, Braun N, Brenchley PEC, Davies S, Dunn L, Engelsman L, Fieren M, Garosi G, Goffin E, Heuveling L, Korte M, Lindholm B, Rutherford P, Struijk D, Verduijn M, Verger C, Westerhuis R. 2011. A COLLABORATIVE APPROACH TO UNDERSTANDING EPS: THE EUROPEAN PERSPECTIVE. PERITONEAL DIALYSIS INTERNATIONAL, vol. 31(3), 245-248. link> doi>
  • Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC, Chess JA, Toleman MA, Gahan CG, Hill C, Parish T, Williams JD, Davies SJ, Johnson DW, Topley N, Eberl T. 2011. Human Neutrophil Clearance of Bacterial Pathogens Triggers Anti-Microbial γδ T Cell Responses in Early Infection. PLoS Pathogens, vol. 7(5). doi>
  • Rippe B and Davies S. 2011. Permeability of peritoneal and glomerular capillaries: what are the differences according to pore theory?. Perit Dial Int, vol. 31(3), 249-258. link> doi>
  • Davies SJ, Mushahar L, Yu Z, Lambie M. 2011. Determinants of peritoneal membrane function over time. Semin Nephrol, vol. 31(2), 172-182. link> doi>
  • Davies SJ. 2011. Peritoneal dialysis research in the UK: the Cardiff contribution. Perit Dial Int, vol. 31 Suppl 2, S39-S42. link> doi>
  • Lindholm B and Davies S. 2011. Timing of dialysis initiation and choice of dialysis modality. NATURE REVIEWS NEPHROLOGY, vol. 7(2), 66-68. link> doi>
  • Woodrow G and Davies S. 2011. Renal Association Clinical Practice Guideline on Peritoneal Dialysis. NEPHRON CLINICAL PRACTICE, vol. 118, C287-C310. link> doi>
  • Mactier R, Davies S, Dudley C, Harden P, Jones C, Kanagasundaram S, Lewington A, Richardson D, Taal M, Andrews P, Baker R, Breen C, Duncan N, Farrington K, Fluck R, Geddes C, Goldsmith D, Hoenich N, Holt S, Jardine A, Jenkins S, Kumwenda M, Lindley E, MacGregor M, Mikhail A, Sharples E, Shrestha B, Shrivastava R, Steddon S, Warwick G, Wilkie M, Woodrow G, Wright M. 2011. Summary of the 5th Edition of the Renal Association Clinical Practice Guidelines (2009-2012). NEPHRON CLINICAL PRACTICE, vol. 118, C27-C70. link> doi>
  • Tan BK, Chan C, Davies SJ. 2010. Achieving euvolemia in peritoneal dialysis patients: a surprisingly difficult proposition. Semin Dial, vol. 23(5), 456-461. link> doi>
  • John B, Tan BK, Dainty S, Spanel P, Smith D, Davies SJ. 2010. Plasma volume, albumin, and fluid status in peritoneal dialysis patients. Clin J Am Soc Nephrol, vol. 5(8), 1463-1470. link> doi>
  • Lambie M, John B, Mushahar L, Davies SJ. 2010. Characterisation of the Natural History of Peritoneal Dialysis prior to Encapsulating Peritoneal Sclerosis. SCOTTISH MEDICAL JOURNAL, vol. 55(3), 48. link>
  • Lambie M, Chess J, Huckvale K, Topley N, Davies SJ. 2010. IL-6, Peritoneal Solute Transport Rate and Inflammation: Results from GLOBAL. SCOTTISH MEDICAL JOURNAL, vol. 55(3), 48. link>
  • Lindholm B and Davies S. 2010. END-STAGE RENAL DISEASE A new comorbidity index for estimating mortality risk in ESRD. NATURE REVIEWS NEPHROLOGY, vol. 6(7), 391-393. link> doi>
  • Lambie ML, John B, Mushahar L, Huckvale C, Davies SJ. 2010. The peritoneal osmotic conductance is low well before the diagnosis of encapsulating peritoneal sclerosis is made. Kidney Int, vol. 78(6), 611-618. link> doi>
  • Tan BK, Smith D, Spanel P, Davies SJ. 2010. Dispersal kinetics of deuterated water in the lungs and airways following mouth inhalation: real-time breath analysis by flowing afterglow mass spectrometry (FA-MS). J Breath Res, vol. 4(1), 017109. link> doi>
  • Smith D, Spaněl P, Enderby B, Lenney W, Turner C, Davies SJ. 2010. Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS. J Breath Res, vol. 4(1), 017101. link> doi>
  • Chan C, McIntyre C, Smith D, Spanel P, Davies SJ. 2009. Combining near-subject absolute and relative measures of longitudinal hydration in hemodialysis. Clin J Am Soc Nephrol, vol. 4(11), 1791-1798. link> doi>
  • Davies SJ. 2009. Preserving residual renal function in peritoneal dialysis: volume or biocompatibility?. Nephrol Dial Transplant, vol. 24(9), 2620-2622. link> doi>
  • Lambie M, Stompor T, Davies S. 2009. Understanding the variability in ultrafiltration obtained with icodextrin. Perit Dial Int, vol. 29(4), 407-411. link>
  • Mostafa S, Tagboto S, Robinson M, Burden A, Davies S. 2009. Over-representation of diabetic patients with renal anaemia in the primary care setting. Fam Pract, vol. 26(3), 180-182. link> doi>
  • Davies S, Carlsson O, Simonsen O, Johansson A-C, Venturoli D, Ledebo I, Wieslander A, Chan C, Rippe B. 2009. The effects of low-sodium peritoneal dialysis fluids on blood pressure, thirst and volume status. Nephrol Dial Transplant, vol. 24(5), 1609-1617. link> doi>
  • Augustine T, Brown PW, Davies SD, Summers AM, Wilkie ME. 2009. Encapsulating Peritoneal Sclerosis: Clinical Significance and Implications. NEPHRON CLINICAL PRACTICE, vol. 111(2), C149-C154. link> doi>
  • Mushahar L, Lambie M, Tan K, John B, Davies SJ. 2009. Long-term changes in solute and water transport. Contrib Nephrol, vol. 163, 15-21. link> doi>
  • Cian C, Tan K, Lam C, Mcintyre C, Davies SJ. 2009. Validation of Longitudinal Vector Analysis of Body Composition with Deuterium Dilution in Haemodialysis Patients. BLOOD PURIFICATION, vol. 28(4), 300. link>
  • Field M, Pugh J, Asquith J, Davies S, Pherwani AD. 2008. A stuck hemodialysis central venous catheter. J Vasc Access, vol. 9(4), 301-303. link>
  • Davies SJ, Garcia Lopez E, Woodrow G, Donovan K, Plum J, Williams P, Johansson AC, Bosselmann H-P, Heimburger O, Simonsen O, Davenport A, Lindholm B, Tranaeus A, Divino Filho JC. 2008. Longitudinal relationships between fluid status, inflammation, urine volume and plasma metabolites of icodextrin in patients randomized to glucose or icodextrin for the long exchange. Nephrol Dial Transplant, vol. 23(9), 2982-2988. link> doi>
  • Chan C, Smith D, Spanel P, McIntyre CW, Davies SJ. 2008. A non-invasive, on-line deuterium dilution technique for the measurement of total body water in haemodialysis patients. Nephrol Dial Transplant, vol. 23(6), 2064-2070. link> doi>
  • Perl J, Bargman JM, Davies SJ, Jassal SV. 2008. Clinical outcomes after failed renal transplantation - Does dialysis modality matter?. SEMINARS IN DIALYSIS, vol. 21(3), 239-244. link> doi>
  • Asghar RB and Davies SJ. 2008. Pathways of fluid transport and reabsorption across the peritoneal membrane. Kidney Int, vol. 73(9), 1048-1053. link> doi>
  • Engel B and Davies SJ. 2007. Achieving euvolemia in peritoneal dialysis. PERITONEAL DIALYSIS INTERNATIONAL, vol. 27(5), 514-517. link>
  • Davies SJ. 2007. Optimizing automated peritoneal dialysis: increasing nightly dialysate flow vs adding a manual daytime exchange. Nat Clin Pract Nephrol, vol. 3(5), 248-249. link> doi>
  • Davies SJ and Brown EA. 2007. EAPOS: what have we learned?. Perit Dial Int, vol. 27(2), 131-135. link>
  • Davies SJ. 2006. Mitigating peritoneal membrane characteristics in modern peritoneal dialysis therapy. Kidney Int Suppl, S76-S83. link> doi>
  • Davies SJ. 2006. Overfill or ultrafiltration? We need to be clear. Perit Dial Int, vol. 26(4), 449-451. link>
  • Davies SJ, Brown EA, Reigel W, Clutterbuck E, Heimbürger O, Diaz NV, Mellote GJ, Perez-Contreras J, Scanziani R, D'Auzac C, Kuypers D, Divino Filho JC, EAPOS Group. 2006. What is the link between poor ultrafiltration and increased mortality in anuric patients on automated peritoneal dialysis? Analysis of data from EAPOS. Perit Dial Int, vol. 26(4), 458-465. link>
  • Chan C, Smith D, Spanel P, McIntyre C, Davies S. 2006. Deuterium kinetics in haemodialysis patients and the optimal time schedule for breath sampling in the determination of total body water (TBW) using flowing afterglow mass spectrometry (FAMS). NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 21, 422. link>
  • DAVIES SJ, Brown EA, Frandsen NE, Rodriguez AS. 2005. Longitudinal membrane function in functionally anuric patients treated with APD: Data from EAPOS on the effects of glucose and icodextrin prescription. Kidney International, vol. 67(4), 1609-1615. doi>
  • Aanen MC, Venturoli D, Davies SJ. 2005. A detailed analysis of sodium removal by peritoneal dialysis: comparison with predictions from the three-pore model of membrane function. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 20(6), 1192-1200. link> doi>
  • Davies S. 2005. Are PD patients with or without residual renal function qualitatively different--or are they simply at different stages of the continuum of progressive uraemia?. Nephrol Dial Transplant, vol. 20(2), 270-272. link> doi>
  • DAVIES SJ, Asghar RB, Diskin AM, Smith D. 2005. Influence of Convection on the Diffusive Transport and Sieving of Water and Small Solutes across the Peritoneal Membrane. Journal American Society of Nephrology, vol. 16(2), 437-443. doi>
  • Davies SJ. 2005. Getting to grips with individual variation in membrane function. Perit Dial Int, vol. 25(1), 35-37. link>
  • Davies SJ. 2004. Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients. Kidney Int, vol. 66(6), 2437-2445. link> doi>
  • Asghar RB, Green S, Engel B, Davies SJ. 2004. Relationship of demographic, dietary, and clinical factors to the hydration status of patients on peritoneal dialysis. Perit Dial Int, vol. 24(3), 231-239. link>
  • Asghar RB, Diskin AM, Spanel P, Smith D, Davies SJ. 2003. Measuring transport of water across the peritoneal membrane. Kidney Int, vol. 64(5), 1911-1915. link> doi>
  • DAVIES SJ, Donovan K, Plum J, Woodrow G. 2003. Icodextrin Improves the Fluid Status of Peritoneal Dialysis Patients: Results of a Double-Blind Randomized Controlled Trial. Journal American Society of Nephrology, vol. 14(9), 2338-2344. doi>
  • Davies SJ. 2003. Assessment of comorbidity in peritoneal dialysis patients. Contrib. Nephrol..
  • Davies SJ. 2003. Comment on: Nephron Clin Pract. 2003; 95(1):c9-14 Examine the individual, not the species... Nephron Clin Pract., vol. 95(1), 1-2.
  • Davies SJ. 2003. Examine the individual, not the species... Nephron Clin Pract, vol. 95(1), c1-c2. link> doi>
  • Davies SJ. 2003. Is PD a suitable treatment after an unsuccessful transplant?. Contrib. Nephrol..
  • Asghar RB, Diskin AM, Spanel, P, Smith D, Davies SJ. 2003. Measuring transport of water across the peritoneal membrane. Kidney International.
  • Stompor T, Zdzienicka A, Motyka M, Dembinska-Kiec A, Davies SJ, Sulowicz W. 2003. Selected growth factors in peritoneal dialysis: their relationship to markers of inflammation, dialysis adequacy, residual renal function, and peritoneal membrane transport. Perit. Dial. Int., vol. 22(6), 670-676.
  • Brown EA, Davies SJ, Rutherford P, Meeus F, Borras M, Riegel W, Divino Filho JC, Vonesh E, van Bree M. 2003. Survival of functionally anuric patients on automated peritoneal dialysis: the European APD Outcome Study. J. Am. Soc. Nephrol., vol. 14(11), 2948-2957. doi>
  • Smith D, Engel B, Diskin AM, Spanel P, Davies SJ. 2002. Comparative measurements of total body water in healthy volunteers by online breath deuterium measurement and other near-subject methods. Am J Clin Nutr, vol. 76(6), 1295-1301. link>
  • Asghar RB, Diskin AM, Spanel P, Smith D, Davies SJ. 2002. Diffusion of water across the peritoneal membrane. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, 199A. link>
  • Brown EA, Davies SJ, Rutherford P, Riegel W, Frandsen NE, Boras M, Meeus F, Rodrigues AS, Divino JC, Qureshi T. 2002. European APD outcome study (EAPOS): Ultrafiltration and not solute clearance or solute transport status predicts outcomes at 2 years for APD in anuric patients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, 1A. link>
  • Davies SJ, Woodrow G, Plum J, Heimburger O, Donovan K, Divino J. 2002. Icodextrin improves fluid status in PD patients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, 632A-633A. link>
  • Davies SJ, Phillips L, Naish PF, Russell GI. 2002. Quantifying comorbidity in peritoneal dialysis patients and its relationship to other predictors of survival. Nephrol Dial Transplant, vol. 17(6), 1085-1092. link> doi>
  • DAVIES SJ, Naish PF, Phillips L, Russell GI. 2001. Peritoneal Glucose Exposure and Changes in Membrane Solute Transport with Time on Peritoneal Dialysis. Journal American Society of Nephrology, vol. 12(5), 1046-1051.
  • Davies S, Spanel P, Smith D. 2001. A new 'online' method to measure increased exhaled isoprene in end-stage renal failure. Nephrology Dialsis Transplantation, 836-839. doi>
  • Davies SJ, Van Biesen W, Nicholas J, Lameire N. 2001. Integrated care. Perit Dial Int, vol. 21 Suppl 3, S269-S274. link>
  • Davies SJ. 2001. Monitoring of long-term peritoneal membrane function. Perit Dial Inte, vol. 21(2), 225-230.
  • Spanel P and Smith D. 2001. Quantitative selected ion flow tube mass spectrometry: the influence of ionic diffusion and mass discrimination. Journal of American Mass Spectrometry Society, 863-872.
  • Davies, S, Spanel P, Smith D. 2001. Rapid measurement of deuterium content of breath following oral ingestion to determine body water. Physiol Meas, 651-659. doi>
  • Davies SJ. 2000. Peritoneal solute transport - we know it is important, but what is it?. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 15(8), 1120-1123. link> doi>
  • Davies SJ, Phillips L, Griffiths AM, Naish PF, Russell GI. 2000. Analysis of the effects of increasing delivered dialysis treatment to malnourished peritoneal dialysis patients. Kidney Int, vol. 57(4), 1743-1754. link> doi>
  • Spanel P, Davies S, Smith D. 2000. Breath ammonia dips after feeding independently of the protein content of the meat. FASEB JOURNAL, vol. 14(4), A490. link>
  • Smith D, Davies S, Spanel P. 2000. SIFT-MS analysis of breath isoprene: a marker of treatment stress in haemodialysis patients?. FASEB JOURNAL, vol. 14(4), A573. link>
  • Smith D, Spanel P, Davies S. 1999. Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. J Appl Physiol (1985), vol. 87(5), 1584-1588. link>
  • Davies SJ, Philips L, Griffiths A, Naish PF, Russell GI. 1999. Analysis of increasing delivered dialysis dose in malnourished peritoneal dialysis patients. KIDNEY INTERNATIONAL, vol. 55(6), 2556-2557. link>
  • Naish PF, Davies SJ, Russell GI, Pryce A, Pendleton E, Kennedy H. 1999. Factors influencing decision for dialysis selection: a prospective audit. KIDNEY INTERNATIONAL, vol. 55(5), 2111. link>
  • Davies SJ. 1999. How to maintain fluid balance in long-term peritoneal dialysis. Perit Dial Int, vol. 19 Suppl 2, S332-S336. link>
  • Griffiths A, Russell L, Breslin M, Russell G, Davies S. 1999. A comparison of two methods of dietary assessment in peritoneal dialysis patients. J Ren Nutr, vol. 9(1), 26-31. link> doi>
  • Nicholas JC, Dawes PT, Davies SJ, Freemont AJ. 1999. Persisting aluminium-related bone disease after cadaveric renal transplantation. Nephrol Dial Transplant, vol. 14(1), 202-204. link> doi>
  • Spanel P, Davies S, Smith D. 1999. Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method. Rapid Commun Mass Spectrom, vol. 13(17), 1733-1738. link> doi>
  • Davies SJ, Phillips L, Griffiths AM, Russell LH, Naish PF, Russell GI. 1998. What really happens to people on long-term peritoneal dialysis?. Kidney Int, vol. 54(6), 2207-2217. link> doi>
  • Little J, Phillips L, Russell L, Griffiths A, Russell GI, Davies SJ. 1998. Longitudinal lipid profiles on CAPD: their relationship to weight gain, comorbidity, and dialysis factors. J Am Soc Nephrol, vol. 9(10), 1931-1939. link>
  • Davies SJ, Phillips L, Russell GI. 1998. Peritoneal solute transport predicts survival on CAPD independently of residual renal function. Nephrol Dial Transplant, vol. 13(4), 962-968. link> doi>
  • Fielding RE, Hawkins CP, Hand MF, Heath PD, Davies SJ. 1998. Seizures complicating adult Henoch-Schönlein purpura. Nephrol Dial Transplant, vol. 13(3), 761-762. link> doi>
  • Spanĕl P, Davies S, Smith D. 1998. Quantification of ammonia in human breath by the selected ion flow tube analytical method using H30+ and 02+ precursor ions. Rapid Commun Mass Spectrom, vol. 12(12), 763-766. link> doi>
  • Davies SJ, Phillips L, Naish PF, Russell GI. 1997. An analysis of effective peritoneal surface area (EPSA), fluid removal and survival in CAPD. KIDNEY INTERNATIONAL, vol. 52(4), 1127. link>
  • Davies SJ, Phillips L, Griffiths A, Naish PP, Russell GI. 1997. Impact of increasing KT/V in malnourished CAPD patients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 8, A1207. link>
  • Davies SJ, Phillips L, Naish PF, Russell GI. 1997. Peritoneal ultrafiltration and survival in CAPD patients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 8, A1208. link>
  • Davies S, Spanel P, Smith D. 1997. Quantitative analysis of ammonia on the breath of patients in end-stage renal failure. Kidney Int, vol. 52(1), 223-228. link> doi>
  • Davies SJ, Phillips L, Russell GI. 1996. Peritoneal solute transfer is an independent predictor of survival on CAPD. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7(9), A0978. link>
  • Davies SJ, Spanel P, Smith D. 1996. Quantitative analysis of metabolites on the breath of patients in renal failure. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7(9), A0352. link>
  • Davies SJ, Russell L, Bryan J, Phillips L, Russell GI. 1996. Impact of peritoneal absorption of glucose on appetite, protein catabolism and survival in CAPD patients. Clin Nephrol, vol. 45(3), 194-198. link>
  • Davies SJ, Bryan J, Phillips L, Russell GI. 1996. Longitudinal changes in peritoneal kinetics: the effects of peritoneal dialysis and peritonitis. Nephrol Dial Transplant, vol. 11(3), 498-506. link> doi>
  • Davies SJ, Bryan J, Phillips L, Russell GI. 1996. The predictive value of KT/V and peritoneal solute transport in CAPD patients is dependent on the type of comorbidity present. Perit Dial Int, vol. 16 Suppl 1, S158-S162. link>
  • Davies SJ, Reichardt-Pascal SY, Vaughan D, Russell GI. 1995. Differential effect of ischaemia-reperfusion injury on anti-oxidant enzyme activity in the rat kidney. Exp Nephrol, vol. 3(6), 348-354. link>
  • Davies SJ, Russell L, Bryan J, Phillips L, Russell GI. 1995. Comorbidity, urea kinetics, and appetite in continuous ambulatory peritoneal dialysis patients: their interrelationship and prediction of survival. Am J Kidney Dis, vol. 26(2), 353-361. link> doi>
  • DAVIES SJ, FROOM L, PHILLIPS L, BRYAN J, RUSSELL GI. 1994. CO-MORBIDITY, UREA KINETICS AND DIETARY-INTAKE AS PREDICTORS OF MORTALITY IN CAPD. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 5(3), 441. link>
  • DAVIES SJ, BRYAN J, RUSSELL GI. 1994. DIALYSATE NEUTROPHIL COUNT AND CHANGES IN PERITONEAL KINETICS FOLLOWING PERITONITIS. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 5(3), 441. link>
  • Davies SJ, D'Sousa R, Philips H, Mattey D, Hiley C, Hayes JD, Aber GM, Strange RC. 1993. Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase. Biochim Biophys Acta, vol. 1157(2), 204-208. link> doi>
  • Davies SJ, Brown B, Bryan J, Russell GI. 1993. Clinical evaluation of the peritoneal equilibration test: a population-based study. Nephrol Dial Transplant, vol. 8(1), 64-70. link> doi>
  • Clayton L, Hiley C, D'Souza RJ, Jones PW, Davies SJ, Strange RC, Aber GM. 1993. Oxidant stress and glomerular prostanoid production: influence of angiotensin converting enzyme inhibition. Free Radic Res Commun, vol. 18(2), 107-113. link> doi>
  • Clayton L, Hiley C, Davies S, D'Souza R, Jones P, Strange R, Aber G. 1992. Glomerular injury induced by hydrogen peroxide: modifying influence of ACE inhibitors. Free Radic Res Commun, vol. 17(4), 271-278. link> doi>
  • Davies SJ, Yewdall VM, Ogg CS, Cameron JS. 1990. Peritoneal defence mechanisms and Staphylococcus aureus in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Int, vol. 10(2), 135-140. link>
  • Davies SJ. 1990. Peritoneal lymphocyte populations in CAPD patients. Contrib Nephrol, vol. 85, 16-23. link>
  • Davies SJ, Suassuna J, Ogg CS, Cameron JS. 1989. Activation of immunocompetent cells in the peritoneum of patients treated with CAPD. Kidney Int, vol. 36(4), 661-668. link> doi>
  • Davies SJ, Ogg CS, Cameron JS, Poston S, Noble WC. 1989. Staphylococcus aureus nasal carriage, exit-site infection and catheter loss in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Int, vol. 9(1), 61-64. link>
  • Tan BK, Yu Z, Fang W, Lin A, Ni Z, Qian J, Woodrow G, Jenkins SB, Wilkie ME, Davies SJ. 2016. Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients. Kidney Int, vol. 89(2), 487-497. link> doi>
  • Winterbottom AE, Gavaruzzi T, Mooney A, Wilkie M, Davies SJ, Crane D, Tupling K, Baxter PD, Meads DM, Mathers N, Bekker HL. 2016. Patient Acceptability of the Yorkshire Dialysis Decision Aid (YoDDA) Booklet: A Prospective Non-Randomized Comparison Study Across 6 Predialysis Services. Perit Dial Int, vol. 36(4), 374-381. link> doi>
  • Davies SJ and Davenport A. 2015. The authors reply. Kidney Int, vol. 87(1), 240. link> doi>
  • Mehrotra R, Devuyst O, Davies SJ, Johnson DW. 2016. The Current State of Peritoneal Dialysis. J Am Soc Nephrol, vol. 27(11), 3238-3252. link> doi>
  • Perl J, Davies SJ, Lambie M, Pisoni RL, McCullough K, Johnson DW, Sloand JA, Prichard S, Kawanishi H, Tentori F, Robinson BM. 2016. The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS): Unifying Efforts to Inform Practice and Improve Global Outcomes in Peritoneal Dialysis. Perit Dial Int, vol. 36(3), 297-307. link> doi>
  • Lambie M and Davies SJ. 2015. Transition between home dialysis modalities: another piece in the jigsaw of the integrated care pathway. Nephrol Dial Transplant, vol. 30(11), 1781-1783. link> doi>
  • Davies SJ. 2015. What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Volume Expansion in Peritoneal Dialysis Patients. Semin Dial, vol. 28(3), 239-242. link> doi>

Chapters

  • Warnock DG, Hebbar S, Bargman J, Burkart J, Davies S, Finkelstein FO, Mehrotra R, Ronco C, Teitelbaum I, Urakpo K, Chertow GM. 2012. Prospective Safety Study of Bardoxolone Methyl in Patients with Type 2 Diabetes Mellitus, End-Stage Renal Disease and Peritoneal Dialysis. (vol. 178). link> doi>
  • Williams JD and Davies S. 2003. Complications of peritoneal dialysis. In Therapy in Nephrology and Hypertension. Brady, HR, Wilcox, CS (Eds.). Saunders, ..
  • Davies SJ and Williams J. 2003. Complications of peritoneal dialysis. In Comprehensive (2nd Edition) Clinical Nephrology. Johnson RJ and Freehally J (Eds.). Mosby, ..
  • Davies SJ and Williams JD. 2003. Peritoneal dialysis: principles, techniques and adequacy. In Comprehensive (2nd Edition) Clinical Nephrology. Johnson, RJ, Freehally J (Eds.). Mosby, ..

Other

  • Zelek W, Harri CL, Topley N, Weeks I, Lambie M, Davies SJ, Morgan BP. 2016. Complement biomarkers in the management of peritoneal dialysis. IMMUNOBIOLOGY (vol. 221, p. 1172). link> doi>
  • Davies SJ, Zhao J, Bieber B, Perl J, Wilkie M, Marshall M, Kawanishi H, Tentori F, Grp W. 2016. THE PRESCRIPTION IN PERITONEAL DIALYSIS: INTERNATIONAL COMPARISON FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS). NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 31, pp. 240-241). link>
  • Perl J, Zhao J, Bieber B, Robinson BM, Pisoni RL, Tentori F, Davies SJ, Kawanishi H, Johnson DW, Prevention PDOPPSI. 2016. VARIATION IN THE TREATMENT AND PREVENTION OF PERITONEAL DIALYSIS RELATED INFECTIONS: PRELIMINARY RESULTS FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS). NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 31, pp. 236-237). link>
  • Lambie M, Bankart J, Johnson D, Mactier R, Phillips-Darby L, Topley N, Davies S. 2013. COMPETITIVE RISKS OF ENCAPSULATING PERITONEAL SCLEROSIS AND DEATH IN PERTIONEAL DIALYSIS. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 28, p. 215). link>
  • Lambie M, Chess J, Bankart MJ, Lee HB, Noh H, Do JY, Dorval M, Topley N, Davies SJ. 2013. INTRA-PERITONEAL VERSUS SYSTEMIC INFLAMMATION AND SURVIVAL IN PERITONEAL DIALYSIS: RESULTS FROM THE GLOBAL FLUID STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 28, p. 36). link>
  • Lin C-Y, Roberts GW, Davey MS, Chess JA, Fielding CA, Williams JD, Davies SJ, Johnson DW, Moser B, Topley N, Eberl M. 2010. The HMB-PP producing capacity of the causative pathogen and local gamma delta T cell numbers predict clinical outcome from bacterial peritonitis. IMMUNOLOGY (vol. 131, pp. 81-82). link>
  • Wenzelburger FWG, John B, Lee ES, Tan YT, Heatlie G, Tan KB, Davies SJ, Sanderson JE. 2010. Global Longitudinal Strain and Chamber Stiffness Correlate with Plasma Volume in Chronic Renal Failure. CIRCULATION (vol. 122, p. E75). link>
  • Wenzelburger F, John B, Lee ES, Tan YT, Tan KB, Heatlie G, Davies SJ, Sanderson JE. 2010. Left Atrial Volume Index but not E/E ' Correlates with Plasma Chronic Renal Failure. CIRCULATION (vol. 122, p. E75). link>
  • Rao R, Ansell D, Gilg JA, Davies SJ, Lamb EJ, Tomson CRV. 2009. Effect of change in renal replacement therapy modality on laboratory variables: a cohort study from the UK Renal Registry. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 24, pp. 2877-2882). link> doi>
  • Perl J, Huckvale K, Chellar M, John B, Davies SJ. 2009. Peritoneal protein clearance and not peritoneal membrane transport status predicts survival in a contemporary cohort of peritoneal dialysis patients. Clin J Am Soc Nephrol (vol. 4, pp. 1201-1206). link> doi>
  • Chan C, Davies SJ, McIntyre C, Smith D, Spanel P. 2007. Increased ratio of extracellular to total body water (ECW/TBW) is related to comorbidity and fluid overload rather loss of lean body mass in haemodialysis (HD) patients. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 22, p. 314). link>
  • Udayaraj UP, Lamb E, Steenkamp M, Caskey F, Davies S, Ansell D. 2007. Serum aluminium monitoring in 16,530 dialysis patients in England and Wales: Compliance with national guidelines?. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 22, p. 195). link>
  • Davies SJ. 2006. Exploring new evidence of the clinical benefits of icodextrin solutions. Nephrol Dial Transplant (vol. 21 Suppl 2, pp. ii47-ii50). link> doi>
  • Lambie M, Hunter J, Smith M-A, Pankhurst T, Adkins R, Asghar R, John B, Davies S. 2006. Multi-centre, prospective audit of switching from peritoneal dialysis to haemodialysis. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 21, pp. 494-495). link>
  • John B, Mushahar L, Davies SJ. 2006. Peritoneal dialysis after a failed transplant. Contrib Nephrol (vol. 150, pp. 271-277). link> doi>
  • Rao AVR, van Schalkwyk D, Lamb E, Davies S, Ansell D. 2005. Change in RRT modality and the effect on biochemical and haematological parameters. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 20, pp. V337-V338). link>
  • Brown EA, Davies SJ, Heimburger O, Meeus F, Mellotte G, Rosman J, Rutherford P, Van Bree M, Investigators EAPOS. 2001. Adequacy targets can be met in anuric patients by automated peritoneal dialysis: Baseline data from EAPOS. PERITONEAL DIALYSIS INTERNATIONAL (vol. 21, pp. S133-S137). link>
  • Davies SJ. 2001. Peritoneal dialysis in the patient with a failing renal allograft. Perit Dial Int (vol. 21 Suppl 3, pp. S280-S284). link>
  • Davies SJ, Phillips L, Griffiths AM, Russell LH, Naish PF, Russell GI. 1999. Impact of peritoneal membrane function on long-term clinical outcome in peritoneal dialysis patients. Perit Dial Int (vol. 19 Suppl 2, pp. S91-S94). link>
  • Doos L. Non-Steroidal Anti-Inflammatory Drugs and Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis. doi>
  • Lopez-Anton M, Lambie M, Lopez-Cabrera M, Schmitt CP, Bartosova M, Davies S, Stone T, Taylor PR, Topley N, Bowen T, Fraser DJ. 2015. THE ROLE OF MICRORNAS-21 AND-31 IN PERITONEAL DIALYSIS-ASSOCIATED FIBROGENESIS. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 30). link> doi>

TEACHING AND EDUCATION:

1997-2000 Deputy chairman of the West Midlands Regional Training Programme for Specialist Registrars in Nephrology, responsible for curriculum development.
2000-2002 Chairman of West Midlands Regional Training Programme for Specialist Registrars in Nephrology, responsible for organisation, delivery and assessment of trainees.
2003-present  Member of the Specialist Advisory Committee (Nephrology) to the Royal College of Physicians Higher Training Committee; Secretary, 2005 onwards

RECENT PEER REVIEWED GRANTS RECEIVED FOR RESEARCH:

Dates

Holder(s)

Type

Title

Body

Amount

Feb 2007

S Davies

Salaries

Cardiac function and near patient analysis of fluid status in dialysis patients with differing fluid removal risk phenotypes

 

£200,000

Feb 2006

S Davies

Consumables

Longitudinal body composition in haemodialysis patients using D breath test and bio-impedance

North Staffs Medical Institute

£30,000

Feb 2005

S Davies
C MacIntyre

Salary and Consumables

Application of body water measurement using deuterium abundance analysis of breath and dialysate headspace in the individualisation of haemodialysis treatment

National Kidney Research Fund

£68,000

May 2002

S Davies

Equipment

Flowing after glow spectrometer dedicated to measurement of deuterium in the breath/aqueous phase

Wellcome Trust

£65,000

June 2001

S Davies

Facilities, equipment and infrastructure

Building and equipping of Clinical Research Facility, Renal Unit, North Staffs Hospital/Keele University

North Staffs Medical Institute

£180,000

May 2001-04

S Davies

Salary and Consumables

Bi-directional Water Flow across the dialysed peritoneum

National Kidney Research Fund

£95,000

Apr 2001-02

S Davies

Salary

Longitudinal Peritoneal Dialysis Research
Database Management

Baxter Renal (UK)

£16,000

August 99-
2002

 

 

Application of SIFT-MS for breath analysis

EPSRC

£260,000

April 2000-02

 

 

A rapid breath test to measure total body water in dialysis patients

West Midlands LORS

£64,000


RESEARCH STUDENT SUPERVISION:

Cian Chan    MD   Completes 2007
Lily Mushahar   Visiting Fellow   2005-6
Ramzana Asghar  MD  Completed 2005
Barbara Engel  PhD Completed 2006
Louise Philips  PhD  Completed 2003
S. Reichart Paschal   M Phil   Completed 1995

Invited Lectures at National and International Academic Meetings (since May 2003):

  • International PD Course Vicenza, Italy May 2003
                  PD after transplantation
                 Measuring comorbidity in PD patients
  • International Society of Nephrology, Berlin, June 2003
                 Symposium: Alterations in Solute and Water Transport in Ultrafiltration Failure
                 CME session: Management of the patient with the failing graft
  • Holgar Crawford Symposioum, Lund Sweden. September 2003
                 Diffusive transport of tracer H2O (HDO) across the peritoneum
  • Inaugural Lecture, Keele University, January 2004
                 The peritoneal membrane as artificial kidney: what have we learned?
  • British Renal Society, Plenary Session, Harrogate, May 2004
                 Integrated Dialysis Therapies
  • International Society of Peritoneal Dialysis, Amsterdam, August 2004
                 Member of Scientific Programme Committee
                 Chair of Symposium on fluid status in PD
                 Lecture: Peritoneal sodium and water transport:
                 How do theoretical and experimental insights translate into clinical observations?
                 Chair and lecturer at Gambro Symposium
  • International Society of Blood Purification, London September, 2004
                 Can peritoneal dialysis be a long-term treatment option?
  • First Meeting of the North American Chapter of the International Society of Peritoneal Dialysis, Chicago, May 2005
                 Aspects of Peritoneal Water Transport
  • European Peritoneal Dialysis Meeting, Prague 2005
                 Chair of the Scientific Programme Committee
                 Symposium Chair and Speaker
                 Symposium I – What have observational studies in PD told us?
                 Membrane function and outcome: lessons from the Stoke PD Study & EAPOS
                 Plenary Chair Session: Controversies in PD:  Which is more important in patient management -
                 an ultrafiltration or sodium removal target?

                 Symposium Speaker
                
    Mini-Symposium – Modelling the membrane without equations
  • American Society of Nephrology, Philadelphia, 2005
                 Managing salt and water: physiology and management strategies
  • Vicenza Peritoneal Dialysis Course, June, 2006
                 Peritoneal Dialysis after transplant failure
  • International Society of Peritoneal Dialysis, Hong Kong, August, 2006
                 How to manage anuric Peritoneal Dialysis Patients
                 UK Model: Why the UK leads the PD utilisation in Europe
  • European Peritoneal Dialysis Meeting, Helsinki, July 2007
                 Chair of the Scientific Programme Committee

Additional invitations to lecture includes Swiss PD Academy, Geneva, June 2003; PD update meetings in Copenhagen, April 2003, Helsinki, September 2004, Prague April 2005, Madrid, May 2005 and the Middle East PD Academy Jordan, May 2005, Oxford Summer School, September 2004 and 2005, UK PD Academy (x2 courses per year, faculty member and co-organiser), Dialysis Course at Royal Free (annually), Renal SpR Club, March 2004.

SELECTED RECENT PEER-REVIEWED PUBLICATIONS

1. PERITONEAL DIALYSIS RESEARCH:

Chapters in Textbooks:

DAVIES, S.J., G.A. COLES, N. TOPLEY (2000) Problems of peritoneal membrane failure In: Ed. A MEHTA & N. LAMIERE, Complications of Dialysis - recognition and management(Marcel Dekker, New York). 9: pp. 151-178

DAVIES SJ. Peritoneal Dialysis Solutions. (2004) In: Chronic Kidney Disease, Dialysis and Transplantation – Companion to Brenner and Rector’s The Kidney. Ed: Pereira BJG, Sayegh MH and Blake P. Elsevier Saunders, second edition, pp.534-552

DAVIES SJ & WILLIAMS JD. Complications of Peritoneal Dialysis. In: Ed. RJ Johnson, J Floege & J Feehally, Comprehensive Clinical Nephrology (3nd Edition), 2006 (in press)

DAVIES, S.J., L. PHILLIPS, A. GRIFFITHS, L. RUSSELL, P.F. NAISH AND G.I. RUSSELL. (2000) An analysis of the effects of increasing delivered dialysis treatment to malnourished peritoneal dialysis patients Kidney International  57(4):pp.1743-54

DAVIES, S.J., L. PHILLIPS, P.F. NAISH  AND G.I. RUSSELL. Peritoneal glucose exposure and changes in membrane solute transport with time on Peritoneal Dialysis. (2001) Journal American Society of Nephrology 12(5):pp1046-51

Original Papers and Articles:

DAVIES, S.J., L. PHILLIPS, A. GRIFFITHS, L. RUSSELL, P.F. NAISH AND G.I. RUSSELL. (2000) An analysis of the effects of increasing delivered dialysis treatment to malnourished peritoneal dialysis patients Kidney International  57(4):pp.1743-54

DAVIES, S.J., L. PHILLIPS, P.F. NAISH  AND G.I. RUSSELL. Peritoneal glucose exposure and changes in membrane solute transport with time on Peritoneal Dialysis. (2001) Journal American Society of Nephrology 12(5):pp1046-51

DAVIES, S.J., L. PHILLIPS, P.F. NAISH, G.I. RUSSELL. (2002) Quantifying comorbidity in Peritoneal Dialysis patients and its relationship to other predictors of survival. Nephrology Dialysis Transplantation 17(6):1085-1092

DAVIES, S. J., WOODROW, G., DONOVAN, K. PLUM, J., WILLIAMS, P., JOHANSSON, A. C., BOSSELMANN, H. P., HEIMBURGER, O., SIMONSEN, O., DAVENPORT, A., TRANAEUS, A., AND DIVINO FILHO, J. C. (2003) Icodextrin improves the fluid status of peritoneal dialysis patients: results of a double-blind randomized controlled trial. J Am Soc Nephrol 14: 2338-44.

BROWN EA, DAVIES SJ, RUTHERFORD P, MEEUS F, BORRAS M, RIEGEL W, DIVINO FILHO JC, VONESH E, VAN BREE M: Survival of Functionally Anuric Patients on Automated Peritoneal Dialysis: The European APD Outcome Study. J Am Soc Nephrol 2003;14:2948-57.

ASGHAR RB, GREEN S, ENGEL B, DAVIES SJ. Relationship of demographic, dietary, and clinical factors to the hydration status of patients on peritoneal dialysis. Perit Dial Int. 2004 May-Jun;24(3):231-9

DAVIES SJ: (2004) Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients. Kidney Int; 66(6):2437-45.

ASGHAR RB, DISKIN AM, SPANEL P, SMITH D, DAVIES SJ. Influence of Convection on the Diffusive Transport and Sieving of Water and Small Solutes across the Peritoneal Membrane. J Am Soc Nephrol. 2005 Feb;16(2):437-43

DAVIES SJ, BROWN EA, FRANDSEN NE, RODRIGUES AS, RODRIGUEZ-CARMONA A, VYCHYTIL A, MACNAMARA E, EKSTRAND A, TRANAEUS A, DIVINO FILHO JC, on behalf of the EAPOS group (2005). Longitudinal membrane function in functionally anuric patients treated with APD: data from EAPOS on the effects of glucose and icodextrin prescription. Kidney Int, 67(4):1609-15

AANEN MC, VENTUROLI D, DAVIES SJ. (2005) A detailed analysis of sodium removal by peritoneal dialysis: comparison with predictions from the 3-pore model of membrane function. Nephrol Dial Transplant 2005; Jun;20(6):1192-200

DAVIES SJ.  Are PD patients with or without residual renal function qualitatively different—or are they simply at different stages of the continuum of progressive uraemia?  Nephrol Dial Transplant (2005) 20: 270–272

DAVIES SJ. Getting to grips with individual variation in membrane function Perit Dial Int 2005;25(1):35-7

DAVIES, SJ, Developments in the design of peritoneal dialysis fluid. British Journal of Renal Medicine, 2005, 10(3):6-9

DAVIES SJ,  BROWN EA, REIGEL W, CLUTTERBUCK EA, HEIMBURGER O, VEGA DIAZ N, MELLOTE GJ, PEREZ-CONTRERAS J, SCANZIANI R, D’AUZAC C, KUYPERS D, DIVINO FILHO JC. What is the link between poor ultrafiltration and increased mortality in anuric APD patients? Analysis of data from EAPOS Perit Dial Int, 2006 Jul-Aug;26(4):458-65

DAVIES SJ. Overfill or ultrafiltration? We need to be clear. Perit Dial Int, 2006 Jul-Aug;26(4):449-451

DAVIES SJ, Exploring new evidence of the clinical benefits of icodextrin solutions Nephrol Dial Transplant , 2006;21:Suppl 2:ii47-50

JOHN B., MUSHAHAR L, DAVIES SJ. Peritoneal Dialysis after a Renal Transplant. Contrib Nephrol, 2006;150:271-7

MUSHAHAR, L. JOHN, B, DAVIES, SJ. How does membrane function influence patient outcome and how does dialysis influence the membrane? EDTNA Journal, invited review, 2006

2. BREATH ANALYSIS, BODY COMPOSITION (including SIFT and FA-MS methodologies):

DAVIES, S., P. SPANEL, AND D. SMITH  (1997) Quantitative analysis of ammonia on the breath of patients in end-stage renal failure.  Kidney International 52:pp.223-228

SPANEL. P., S.J. DAVIES AND D. SMITH (1998) Quantification of ammonia in human breath by the SIFT analytical method using H3O+ and O2+ precursor ions. Rapid Communications in Mass Spectrometry.12:pp.763-766

SMITH, D., P. SPANEL, AND S.J. DAVIES  (1999) Trace gases on the breath of healthy volunteers when fasting and following a protein calorie meal Journal of Applied Physiology  87(5):pp.1584-88

SPANEL, P., S. DAVIES, AND D. SMITH (1999) Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method. Rapid Commun Mass Spectrom 13: pp.1733-1738

DAVIES, S., P. SPANEL AND  D. SMITH. A new 'online' method to measure increased exhaled isoprene in end-stage renal failure. (2001) Nephrology Dialysis Transplantation, 16(4):836-839

DAVIES, S., P. SPANEL AND  D. SMITH. Rapid measurement of deuterium content of breath following oral ingestion to determine body water (2001) Physiological Measurement 22(4):pp.651-659

SMITH, D., ENGEL, B., DISKIN, A., M. SPANEL, P., AND DAVIES, S. J. (2002) Comparative measurements of total body water in healthy volunteers by online breath deuterium measurement and other near-subject methods Am J Clin Nutrition 76: 1295-301

ENGEL B, SPANEL P, SMITH D, DISKIN A, DAVIES SJ. (2004) Longitudinal measurements of total body water and body composition in healthy volunteers by online breath deuterium measurement and other near-subject methods Int J Body Comp Res.  2(3):99-106.