Professor Patrik Španel

Title: Professor of Chemical Physics

Phone: +44 (0)1782 674988
Email: p.spanel@keele.ac.uk
patrik.spaneljh-inst.cas.cz
Location: Address 1: Institute for Science & Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Address 2: Department of Chemical Physics, J. Heyrovský Institute of Physical Chemistry, Dolejskova 3, Praha 8, Prague, Czech Republic
Role: ISTM Research theme: Healthcare Technologies
Contacting me: By phone or email please
Prof Patrick Spanel

Patrik Špan?l was born in Prague in the Czech Republic. Just prior to his entry to Charles University, Prague in 1985 where he studied physics, he was placed first at the International Physics Olympiad held in Portorose, Slovenia. He obtained his first doctoral degree (RNDr, 1990) at Charles University researching into low temperature plasma physics. He then entered the Institute for Ion Physics of the University of Innsbruck, Austria, where he obtained his second doctoral degree (Dr., 1994) researching into gas-phase ionic processes.

After conceiving and developing the SIFT-MS analytical method with Prof David Smith FRS at the School of Medicine at Keele University (1995-1997), where he is now a Professor, he moved to the J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences in Prague to continue research into gas phase ion physics and chemistry and the further development and exploitation of SIFT-MS and FA-MS to trace gas analysis of air and exhaled breath.

ISTM Research theme: Healthcare Technologies

Current Research Interests at ISTM:

1. Studies of ion-molecule reactions directed towards the analysis of trace amounts of gases in air and in human breath. The research carried out as a joint project between ISTM, Keele UK and the J Heyrovský Institute of Physical Chemistry, Czech Republic, funded by The Royal Society (1998-2001).

2. SIFT-MS applications in medicine: Clinical and laboratory research - the main fields of concern are nephrology (focusing on dialysis), cancer research and cell biology. In collaboration with Prof David Smith and specialists in medicine and biology (Dr Simon Davies, Prof James B Elder and Prof Alicia El Haj ), this research has been funded by the EPSRC as a Physics in Healthcare project (2000-2002).

3. FA-MS applications in medicine: A major clinical advancement is the development of an on-line method for the determination of total body water from the deuterium abundance in single breath exhalations.

4. SIFT-MS in animal husbandry: In collaboration with Dr R Dewhurst (IGER), Dr J Jones (SILSOE) and Prof David Smith, analyses of samples of porcine excrements and bovine rumen gas have been carried out. A pilot study of molecular emissions from bovine cervical smears has also been carried out in collaboration with Dr T Mottram (SILSOE)

5. Aldehydes in Foods: In collaboration with Prof David Smith and Prof J Van Doren (who visited the J Heyrovsky Institute partially funded by the Fullbright Commission). Results provide kinetic data on ion chemistry of aldehydes relevant to food flavour research.

Current Projects include:

Selected Ion Flow Tube Mass Spectrometry, SIFT-MS

ISTM_smith_spanel_image1_720x260  

Schematic diagram of selected ion flow tube (SIFT) apparatus.

SIFT-MS has been designed and constructed to allow on-line, real time analyses of the trace gases in ambient (polluted) air, exhaled breath and the headspace of aqueous liquids. The SIFT-MS analytical method combines fast flow tube techniques and quantitative mass spectrometry. The air/breath/headspace sample is introduced into fast flowing helium carrier gas where the trace gases in the sample react with embedded reagent ions (H3O+, NO+ or O2+) to produce characteristic product ions that identify the trace gases, and accurate quantification is achieved from knowledge of the kinetics of the ion/trace gas molecule reactions. Unlike other analytical techniques, an important feature of SIFT-MS analyses is that sample collection into bags or onto traps are not required, which can compromise the sample, and time consuming calibration is unnecessary. This allows the direct analysis of single exhalations of breath and provides the scientist/clinician with immediate results. Rapid non-invasive analyses of breath can now be routinely performed in the clinical environment with minimal stress to the patients, which is new route to clinical diagnosis and therapeutic monitoring.

 

Flowing Afterglow Mass Spectrometry (FA-MS)

ISTM_smith_spanel_image2_720x340  

The principle of the FA-MS technique is similar to that of SIFT-MS in that it exploits ion chemistry coupled with fast flow tube techniques and quantitative mass spectrometry. However, FA-MS is specifically used for the on-line determination of the deuterium content of water vapour in exhaled breath and the vapour above aqueous liquids. Thus, for example, the deuterium content of single breath exhalations can be measured following the ingestion of a small known amount of deuterium oxide when, following the principle of isotope dilution, the total body water of the subject can be obtained, which is proving to be particularly useful in nephrology.
ISTM_Smith_Spanel_SIFTimages3+4_720x450  

"Meeting the Canine Challenge to Cancer Detection", news article in Spectroscopy Now, 15 July 2004.

"Sifting through Breath for Cyanide", news article in Spectroscopy Now, 15 March 2005.

Selected Publications

  • Shestivska V, Nemec A, Drevinek P, Sovova K, Dryahina K, Spanel P. 2011. Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 25(17), 2459-2467. link> doi>
  • Chippendale TWE, Spanel P, Smith D. 2011. Time-resolved selected ion flow tube mass spectrometric quantification of the volatile compounds generated by E. coli JM109 cultured in two different media. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 25(15), 2163-2172. link> doi>
  • Spanel P and Smith D. 2011. Comment on 'Influences of mixed expiratory sampling parameters on exhaled volatile organic compound concentrations'. JOURNAL OF BREATH RESEARCH, vol. 5(4), Article ARTN 048001. link> doi>
  • Spanel P, Dryahina K, Rejskova A, Chippendale TWE, Smith D. 2011. Breath acetone concentration; biological variability and the influence of diet. PHYSIOLOGICAL MEASUREMENT, vol. 32(8), N23-N31. link> doi>
  • Smith D and Spanel P. 2011. Direct, rapid quantitative analyses of BVOCs using SIFT-MS and PTR-MS obviating sample collection. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, vol. 30(7), 945-959. link> doi>

Full Publications List show

Journal Articles

  • Smith D and Španěl P. 2016. Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas. Bioanalysis, vol. 8(11), 1183-1201. link> doi>
  • Smith D, Sovová K, Dryahina K, Doušová T, Dřevínek P, Španěl P. 2016. Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis. J Breath Res, vol. 10(2), 021002. link> doi>
  • Zymak I, Žabka J, Polášek M, Španěl P, Smith D. 2016. A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan. Orig Life Evol Biosph, vol. 46(4), 533-538. link> doi>
  • Gilchrist FJ, Belcher J, Jones AM, Smith D, Smyth AR, Southern KW, Španěl P, Webb AK, Lenney W. 2015. Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Res, vol. 1(2). link> doi>
  • Mochalski P, Unterkofler K, Spanel P, Smith D, Amann A. 2015. Product ion distributions for the reactions of NO+ with some N-containing and O-containing heterocyclic compounds obtained using SRI-TOF-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 386, 42-46. link> doi>
  • Shestivska V, Antonowicz SS, Dryahina K, Kubišta J, Smith D, Španěl P. 2015. Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom, vol. 29(11), 1069-1079. link> doi>
  • Smith D, Bloor R, George C, Pysanenko A, Spanel P. 2015. Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content. ANALYTICAL METHODS, vol. 7(10), 4104-4110. link> doi>
  • Smith D and Spanel P. 2015. Pitfalls in the analysis of volatile breath biomarkers: suggested solutions and SIFT-MS quantification of single metabolites. J Breath Res, vol. 9(2), 022001. link> doi>
  • Shestivska V, Dryahina K, Nunvář J, Sovová K, Elhottová D, Nemec A, Smith D, Španěl P. 2015. Quantitative analysis of volatile metabolites released in vitro by bacteria of the genus Stenotrophomonas for identification of breath biomarkers of respiratory infection in cystic fibrosis. J Breath Res, vol. 9(2), 027104. link> doi>
  • Gilchrist FJ, Spanel P, Smith D, Lenney W. 2015. The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens. ANALYTICAL METHODS, vol. 7(3), 818-824. link> doi>
  • Smith D and Spanel P. 2015. The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 377, 467-478. link> doi>
  • Kumar S, Huang J, Abbassi-Ghadi N, Mackenzie HA, Veselkov KA, Hoare JM, Lovat LB, Španěl P, Smith D, Hanna GB. 2015. Mass Spectrometric Analysis of Exhaled Breath for the Identification of Volatile Organic Compound Biomarkers in Esophageal and Gastric Adenocarcinoma. Ann Surg, vol. 262(6), 981-990. link> doi>
  • Smith D and Španěl P. 2015. SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK. Analyst, vol. 140(8), 2573-2591. link> doi>
  • Smith D, Chippendale TWE, Španěl P. 2014. Reactions of the selected ion flow tube mass spectrometry reagent ions H3O(+) and NO(+) with a series of volatile aldehydes of biogenic significance. Rapid Commun Mass Spectrom, vol. 28(17), 1917-1928. link> doi>
  • Dryahina K, Pospíšilová V, Sovová K, Shestivska V, Kubišta J, Spesyvyi A, Pehal F, Turzíková J, Votruba J, Spaněl P. 2014. Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease. J Breath Res, vol. 8(3), 037109. link> doi>
  • Mochalski P, Unterkofler K, Španěl P, Smith D, Amann A. 2014. Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer. Rapid Commun Mass Spectrom, vol. 28(15), 1683-1690. link> doi>
  • Chippendale TWE, Španěl P, Smith D, El Haj AJ. 2014. Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. Analyst, vol. 139(19), 4903-4907. link> doi>
  • Mochalski P, Unterkofler K, Španěl P, Smith D, Amann A. 2014. Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument. Int J Mass Spectrom, vol. 363, 23-31. link> doi>
  • Smith D, Španěl P, Herbig J, Beauchamp J. 2014. Mass spectrometry for real-time quantitative breath analysis. J Breath Res, vol. 8(2), 027101. link> doi>
  • Davies SJ, Španěl P, Smith D. 2014. Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis. Bioanalysis, vol. 6(6), 843-857. link> doi>
  • Chippendale TWE, Gilchrist FJ, Spanel P, Alcock A, Lenney W, Smith D. 2014. Quantification by SIFT-MS of volatile compounds emitted by Aspergillus fumigatus cultures and in co-culture with Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. ANALYTICAL METHODS, vol. 6(20), 8154-8164. link> doi>
  • Chippendale TWE, Gilchrist FJ, Spanel P, Alcock A, Lenney W, Smith D. 2014. Quantification by SIFT-MS of volatile compounds emitted by in vitro cultures of S. aureus, S. pneumoniae and H. influenzae isolated from patients with respiratory diseases. ANALYTICAL METHODS, vol. 6(8), 2460-2472. link> doi>
  • Smith D, Spanel P, Gilchrist FJ, Lenney W. 2013. Hydrogen cyanide, a volatile biomarker of Pseudomonas aeruginosa infection. JOURNAL OF BREATH RESEARCH, vol. 7(4), Article ARTN 044001. link> doi>
  • Spanel P and Smith D. 2013. Advances in On-line Absolute Trace Gas Analysis by SIFT-MS. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 525-539. link>
  • Davies SJ, Engel B, Chan C, Tan BK, Yu Z, Asghar R, John B, Spanel P, Smith D. 2013. Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution - Applications in the Dialysis Clinic. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 593-599. link>
  • Smith D, Chippendale TWE, Spanel P. 2013. Minimising the Effects of Isobaric Product Ions in SIFT-MS Quantification of Acetaldehyde, Dimethyl Sulphide and Carbon Dioxide. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 550-557. link>
  • Flores M, Olivares A, Dryahina K, Spanel P. 2013. Real Time Detection of Aroma Compounds in Meat and Meat Products by SIFT-MS and Comparison to Conventional Techniques (SPME-GC-MS). CURRENT ANALYTICAL CHEMISTRY, vol. 9, 622-630.
  • Spanel P and Smith D. 2013. Selected Ion Flow Tube Mass Spectrometry, SIFT-MS. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 523-524. link>
  • Smith D, Chippendale TWE, Dryahina K, Spanel P. 2013. SIFT-MS Analysis of Nose-Exhaled Breath; Mouth Contamination and the Influence of Exercise. CURRENT ANALYTICAL CHEMISTRY, vol. 9(4), 565-575. link>
  • Dryahina K, Spanel P, Pospisilova V, Sovova K, Hrdlicka L, Machkova N, Lukas M, Smith D. 2013. Quantification of pentane in exhaled breath, a potential biomarker of bowel disease, using selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 27(17), 1983-1992. link> doi>
  • Gilchrist FJ, Sims H, Alcock A, Jones AM, Bright-Thomas RJ, Smith D, Spanel P, Webb AK, Lenney W. 2013. Is Hydrogen Cyanide a Marker of Burkholderia cepacia Complex?. JOURNAL OF CLINICAL MICROBIOLOGY, vol. 51(11), 3849-3851. link> doi>
  • Sovová K, Čepl J, Markoš A, Španěl P. 2013. Real time monitoring of population dynamics in concurrent bacterial growth using SIFT-MS quantification of volatile metabolites. Analyst, vol. 138(17), 4795-4801. link> doi>
  • Gilchrist FJ, Bright-Thomas RJ, Jones AM, Smith D, Spanel P, Webb AK, Lenney W. 2013. Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection. JOURNAL OF BREATH RESEARCH, vol. 7(2), Article ARTN 026010. link> doi>
  • Kumar S, Huang J, Abbassi-Ghadi N, Spanel P, Smith D, Hanna GB. 2013. Selected Ion Flow Tube Mass Spectrometry Analysis of Exhaled Breath for Volatile Organic Compound Profiling of Esophago-Gastric Cancer. ANALYTICAL CHEMISTRY, vol. 85(12), 6121-6128. link> doi>
  • Spanel P, Dryahina K, Smith D. 2013. A quantitative study of the influence of inhaled compounds on their concentrations in exhaled breath. JOURNAL OF BREATH RESEARCH, vol. 7(1), Article ARTN 017106. link> doi>
  • Huang J, Kumar S, Abbassi-Ghadi N, Spanel P, Smith D, Hanna GB. 2013. Selected Ion Flow Tube Mass Spectrometry Analysis of Volatile Metabolites in Urine Headspace for the Profiling of Gastro-Esophageal Cancer. ANALYTICAL CHEMISTRY, vol. 85(6), 3409-3416. link> doi>
  • Rutter AV, Chippendale TWE, Yang Y, Spanel P, Smith D, Sule-Suso J. 2013. Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. ANALYST, vol. 138(1), 91-95. link> doi>
  • Spanel P and Smith D. 2013. Account On the features, successes and challenges of selected ion flow tube mass spectrometry. EUROPEAN JOURNAL OF MASS SPECTROMETRY, vol. 19(4), 225-246. link> doi>
  • Ajibola OA, Smith D, Spaněl P, Ferns GAA. 2013. Effects of dietary nutrients on volatile breath metabolites. J Nutr Sci, vol. 2, e34. link> doi>
  • Spanel P and Smith D. 2013. On the features, successes and challenges of selected ion flow tube mass spectrometry. Eur J Mass Spectrom (Chichester), vol. 19(4), 225-246. link> doi>
  • Olivares A, Dryahina K, Spaněl P, Flores M. 2012. Rapid detection of lipid oxidation in beef muscle packed under modified atmosphere by measuring volatile organic compounds using SIFT-MS. Food Chem, vol. 135(3), 1801-1808. link> doi>
  • Gilchrist FJ, Sims H, Alcock A, Belcher J, Jones AM, Smith D, Spanel P, Webb AK, Lenney W. 2012. Quantification of hydrogen cyanide and 2-aminoacetophenone in the headspace of Pseudomonas aeruginosa cultured under biofilm and planktonic conditions. ANALYTICAL METHODS, vol. 4(11), 3661-3665. link> doi>
  • Kumar S, Huang J, Cushnir JR, Spanel P, Smith D, Hanna GB. 2012. Selected Ion Flow Tube-MS Analysis of Headspace Vapor from Gastric Content for the Diagnosis of Gastro-Esophageal Cancer. ANALYTICAL CHEMISTRY, vol. 84(21), 9550-9557. link> doi>
  • Tan BK, Davies SJ, Spanel P, Smith D. 2012. Injection of deuterated water into the pulmonary/alveolar circulation; measurement of HDO in exhaled breath and implications to breath analysis. JOURNAL OF BREATH RESEARCH, vol. 6(3), Article ARTN 036005. link> doi>
  • Gilchrist FJ, Razavi C, Webb AK, Jones AM, Spanel P, Smith D, Lenney W. 2012. An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide. JOURNAL OF BREATH RESEARCH, vol. 6(3), Article ARTN 036004. link> doi>
  • Shestivska V, Spanel P, Dryahina K, Sovova K, Smith D, Musilek M, Nemec A. 2012. Variability in the concentrations of volatile metabolites emitted by genotypically different strains of Pseudomonas aeruginosa. JOURNAL OF APPLIED MICROBIOLOGY, vol. 113(3), 701-713. link> doi>
  • Sovová K, Shestivska V, Španěl P. 2012. Real-time quantification of traces of biogenic volatile selenium compounds in humid air by selected ion flow tube mass spectrometry. Anal Chem, vol. 84(11), 4979-4983. link> doi>
  • Smith D, Sovova K, Spanel P. 2012. A selected ion flow tube study of the reactions of H3O+, NO+ and O-2(+center dot) with seven isomers of hexanol in support of SIFT-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 319, 25-30. link> doi>
  • Kubišta J, Civiš M, Spaněl P, Civiš S. 2012. Combining Fourier transform nuclear quadrupole resonance (FT-NQR) spectroscopy and mass spectrometry (MS) to study the electronic structure of titanocene dichlorides. Analyst, vol. 137(6), 1338-1342. link> doi>
  • Shestivska V, Nemec A, Drevinek P, Sovova K, Dryahina K, Spanel P. 2011. Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 25(17), 2459-2467. link> doi>
  • Chippendale TWE, Spanel P, Smith D. 2011. Time-resolved selected ion flow tube mass spectrometric quantification of the volatile compounds generated by E. coli JM109 cultured in two different media. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 25(15), 2163-2172. link> doi>
  • Spanel P and Smith D. 2011. Comment on 'Influences of mixed expiratory sampling parameters on exhaled volatile organic compound concentrations'. JOURNAL OF BREATH RESEARCH, vol. 5(4), Article ARTN 048001. link> doi>
  • Spanel P, Dryahina K, Rejskova A, Chippendale TWE, Smith D. 2011. Breath acetone concentration; biological variability and the influence of diet. PHYSIOLOGICAL MEASUREMENT, vol. 32(8), N23-N31. link> doi>
  • Smith D and Spanel P. 2011. Direct, rapid quantitative analyses of BVOCs using SIFT-MS and PTR-MS obviating sample collection. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, vol. 30(7), 945-959. link> doi>
  • Boshier PR, Cushnir JR, Mistry V, Knaggs A, Spanel P, Smith D, Hanna GB. 2011. On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study. ANALYST, vol. 136(16), 3233-3237. link> doi>
  • Spanel P and Smith D. 2011. Volatile compounds in health and disease. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, vol. 14(5), 455-460. link> doi>
  • Smith D, Chippendale TWE, Spanel P. 2011. Selected ion flow tube, SIFT, studies of the reactions of H3O+, NO+ and O-2(+) with some biologically active isobaric compounds in preparation for SIFT-MS analyses. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 303(2-3), 81-89. link> doi>
  • Dryahina K, Cunha de Miranda BK, Spanel P, Zabka J, Alcaraz C, Herman Z. 2011. Selected Ion Flow Tube Study of Ion Molecule Reactions of N+(P-3) and Kr+ with C-3 Hydrocarbons Propane, Propene, and Propyne. JOURNAL OF PHYSICAL CHEMISTRY A, vol. 115(25), 7310-7315. link> doi>
  • Smith D, Spanel P, Fryer AA, Hanna F, Ferns GAA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?. JOURNAL OF BREATH RESEARCH, vol. 5(2), Article ARTN 022001. link> doi>
  • Smith D and Spanel P. 2011. Ambient analysis of trace compounds in gaseous media by SIFT-MS. ANALYST, vol. 136(10), 2009-2032. link> doi>
  • Ferus M, Kubelik P, Kawaguchi K, Dryahina K, Spanel P, Civis S. 2011. HNC/HCN Ratio in Acetonitrile, Formamide, and BrCN Discharge. JOURNAL OF PHYSICAL CHEMISTRY A, vol. 115(10), 1885-1899. link> doi>
  • Olivares A, Dryahina K, Navarro JL, Smith D, Spanel P, Flores M. 2011. SPME-GC-MS versus Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) Analyses for the Study of Volatile Compound Generation and Oxidation Status during Dry Fermented Sausage Processing. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59(5), 1931-1938. link> doi>
  • Spanel P and Smith D. 2011. PROGRESS IN SIFT-MS: BREATH ANALYSIS AND OTHER APPLICATIONS. MASS SPECTROMETRY REVIEWS, vol. 30(2), 236-267. link> doi>
  • Civis M, Civis S, Sovova K, Dryahina K, Spanel P, Kyncl M. 2011. Laser Ablation of FOX-7: Proposed Mechanism of Decomposition. ANALYTICAL CHEMISTRY, vol. 83(3), 1069-1077. link> doi>
  • Sovova K, Dryahina K, Spanel P. 2011. Selected ion flow tube (SIFT) studies of the reactions of H3O+, NO+ and O-2(+center dot) with six volatile phytogenic esters. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 300(1), 31-38. link> doi>
  • Gilchrist FJ, Alcock A, Belcher J, Brady M, Jones A, Smith D, Spanel P, Webb K, Lenney W. 2011. Variation in hydrogen cyanide production between different strains of Pseudomonas aeruginosa. EUROPEAN RESPIRATORY JOURNAL, vol. 38(2), 409-414. link> doi>
  • Spanel P, Shestivska V, Chippendale TWE, Smith D. 2011. Determination of the Deuterium Abundances in Water from 156 to 10,000 ppm by SIFT-MS. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 22(1), 179-186. link> doi>
  • John B, Tan BK, Dainty S, Spanel P, Smith D, Davies SJ. 2010. Plasma Volume, Albumin, and Fluid Status in Peritoneal Dialysis Patients. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 5(8), 1463-1470. link> doi>
  • Olivares A, Dryahina K, Luis Navarro J, Flores M, Smith D, Spanel P. 2010. Selected Ion Flow Tube-Mass Spectrometry for Absolute Quantification of Aroma Compounds in the Headspace of Dry Fermented Sausages. ANALYTICAL CHEMISTRY, vol. 82(13), 5819-5829. link> doi>
  • Sovova K, Dryahina K, Spanel P, Kyncl M, Civis S. 2010. A study of the composition of the products of laser-induced breakdown of hexogen, octogen, pentrite and trinitrotoluene using selected ion flow tube mass spectrometry and UV-Vis spectrometry. ANALYST, vol. 135(5), 1106-1114. link> doi>
  • Dryahina K, Smith D, Spanel P. 2010. Quantification of methane in humid air and exhaled breath using selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 24(9), 1296-1304. link> doi>
  • Smith D, Spanel P, Sule-Suso J. 2010. Advantages of breath testing for the early diagnosis of lung cancer. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, vol. 10(3), 255-257. link> doi>
  • Smith D, Pysanenko A, Spanel P. 2010. Kinetics of ethanol decay in mouth- and nose-exhaled breath measured on-line by selected ion flow tube mass spectrometry following varying doses of alcohol. Rapid Commun Mass Spectrom, vol. 24(7), 1066-1074. link> doi>
  • Tan BK, Smith D, Spanel P, Davies SJ. 2010. Dispersal kinetics of deuterated water in the lungs and airways following mouth inhalation: real-time breath analysis by flowing afterglow mass spectrometry (FA-MS). J Breath Res, vol. 4(1), 017109. link> doi>
  • Smith D, Spaněl P, Enderby B, Lenney W, Turner C, Davies SJ. 2010. Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS. J Breath Res, vol. 4(1), 017101. link> doi>
  • Zabka J, Roithová J, Spanel P, Herman Z. 2010. Dynamics of formation of products D2CN+, DCN+, and CD3+ in the reaction of N+ with CD4: a crossed-beam and theoretical study. J Phys Chem A, vol. 114(3), 1384-1391. link> doi>
  • Sulé-Suso J, Pysanenko A, Spanel P, Smith D. 2009. Quantification of acetaldehyde and carbon dioxide in the headspace of malignant and non-malignant lung cells in vitro by SIFT-MS. Analyst, vol. 134(12), 2419-2425. link> doi>
  • Chan C, McIntyre C, Smith D, Spanel P, Davies SJ. 2009. Combining near-subject absolute and relative measures of longitudinal hydration in hemodialysis. Clin J Am Soc Nephrol, vol. 4(11), 1791-1798. link> doi>
  • Enderby B, Lenney W, Brady M, Emmett C, Spaněl P, Smith D. 2009. Concentrations of some metabolites in the breath of healthy children aged 7-18 years measured using selected ion flow tube mass spectrometry (SIFT-MS). J Breath Res, vol. 3(3), 036001. link> doi>
  • Dryahina K, Pehal F, Smith D, Spanel P. 2009. Quantification of methylamine in the headspace of ethanol of agricultural origin by selected ion flow tube mass spectrometry. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 286(1), 1-6. link> doi>
  • Pysanenko A, Spanel P, Smith D. 2009. Analysis of the isobaric compounds propanol, acetic acid and methyl formate in humid air and breath by selected ion flow tube mass spectrometry, SIFT-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 285(1-2), 42-48. link> doi>
  • Sovova K, Matulkova I, Kamas M, Dryahina K, Spanel P, Juha L, Civis S. 2009. SIFT-MS Analysis of Molecular Gas Mixtures Exposed to High-Power Laser Plasmas: Laboratory Simulation of High-Energy-Density Events in Early Earth's Atmospheres. ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, vol. 39(3-4), 249-250. link>
  • Civis S, Civis M, Rasin R, Kamas M, Dryahina K, Spanel P, Juha L, Ferus M. 2009. Spectroscopic Investigations of High-Power Laser Sparks in Gas Mixtures Containing Methane: A Laboratory Model of Energetic Events in Strongly Reduced Planetary Atmospheres. ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, vol. 39(3-4), 217. link>
  • Smith D, Pysanenko A, Spanel P. 2009. The quantification of carbon dioxide in humid air and exhaled breath by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom, vol. 23(10), 1419-1425. link> doi>
  • Pysanenko A, Wang T, Spanel P, Smith D. 2009. Acetone, butanone, pentanone, hexanone and heptanone in the headspace of aqueous solution and urine studied by selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 23(8), 1097-1104. link> doi>
  • Smith D, Pysanenko A, Spanel P. 2009. Ionic diffusion and mass discrimination effects in the new generation of short flow tube SIFT-MS instruments. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 281(1-2), 15-23. link> doi>
  • Spanel P and Smith D. 2009. Influence of weakly bound adduct ions on breath trace gas analysis by selected ion flow tube mass spectrometry (SIFT-MS). INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 280(1-3), 128-135. link> doi>
  • Pysanenko A, Spanel P, Smith D. 2008. A study of sulfur-containing compounds in mouth- and nose-exhaled breath and in the oral cavity using selected ion flow tube mass spectrometry. JOURNAL OF BREATH RESEARCH, vol. 2(4), Article ARTN 046004. link> doi>
  • Bloor RN, Wang TS, Spanel P, Smith D. 2008. Ammonia release from heated 'street' cannabis leaf and its potential toxic effects on cannabis users. ADDICTION, vol. 103(10), 1671-1677. link> doi>
  • Cáp P, Dryahina K, Pehal F, Spanel P. 2008. Selected ion flow tube mass spectrometry of exhaled breath condensate headspace. Rapid Commun Mass Spectrom, vol. 22(18), 2844-2850. link> doi>
  • Chan C, Smith D, Spanel P, McIntyre CW, Davies SJ. 2008. A non-invasive, on-line deuterium dilution technique for the measurement of total body water in haemodialysis patients. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 23(6), 2064-2070. link> doi>
  • Kushch I, Schwarz K, Schwentner L, Baumann B, Dzien A, Schmid A, Unterkofler K, Gastl G, Spaněl P, Smith D, Amann A. 2008. Compounds enhanced in a mass spectrometric profile of smokers' exhaled breath versus non-smokers as determined in a pilot study using PTR-MS. J Breath Res, vol. 2(2), 026002. link> doi>
  • Wang T, Spanel P, Smith D. 2008. Selected ion flow tube mass spectrometry of 3-hydroxybutyric acid, acetone and other ketones in the headspace of aqueous solution and urine. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 272(1), 78-85. link> doi>
  • Van Doren JM, Miller TM, Viggiano AA, Spanel P, Smith D, Bopp JC, Troe J. 2008. Experimental and theoretical investigation of electron attachment to SF(5)Cl. J Chem Phys, vol. 128(9), 094309. link> doi>
  • Smith D, Wang T, Pysanenko A, Spanel P. 2008. A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 22(6), 783-789. link> doi>
  • Sovova K, Ferus M, Matulkova I, Spanel P, Dryahina K, Dvorak O, Civis S. 2008. A study of thermal decomposition and combustion products of disposable polyethylene terephthalate (PET) plastic using high resolution fourier transform infrared spectroscopy, selected ion flow tube mass spectrometry and gas chromatography mass spectrometry. MOLECULAR PHYSICS, vol. 106(9-10), 1205-1214. link> doi>
  • Turner C, Parekh B, Walton C, Spanel P, Smith D, Evans M. 2008. An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 22(4), 526-532. link> doi>
  • Wang T, Pysanenko A, Dryahina K, Spanel P, Smith D. 2008. Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity. JOURNAL OF BREATH RESEARCH, vol. 2(3), Article ARTN 037013. link> doi>
  • Španěl P and Smith D. 2008. Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. J. Breath Res., vol. 2, 046003. doi>
  • Spanel P, Dryahina K, Smith D. 2007. Microwave plasma ion sources for selected ion flow tube mass spectrometry: Optimizing their performance and detection limits for trace gas analysis. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 267(1-3), 117-124. link> doi>
  • Spaněl P, Dryahina K, Smith D. 2007. Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4-83 years. J Breath Res, vol. 1(1), 011001. link> doi>
  • Amann A, Spanĕl P, Smith D. 2007. Breath analysis: the approach towards clinical applications. Mini Rev Med Chem, vol. 7(2), 115-129. link> doi>
  • Spanĕl P and Smith D. 2007. Selected ion flow tube mass spectrometry for on-line trace gas analysis in biology and medicine. Eur J Mass Spectrom (Chichester), vol. 13(1), 77-82. link> doi>
  • Smith D and Spanel P. 2007. The challenge of breath analysis for clinical diagnosis and therapeutic monitoring. Analyst, vol. 132(5), 390-396. link> doi>
  • Spanel P, Dryahina K, Smith D. 2007. The concentration distributions of some metabolites in the exhaled breath of young adults. J Breath Res, vol. 1(2), 026001. link> doi>
  • Smith D, Turner C, Španěl P. 2007. Volatile metabolites in the exhaled breath of healthy volunteers: their levels and distributions. J. Breath Res., 014004. link> doi>
  • Turner C, Spanel P, Smith D. 2006. A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS. PHYSIOLOGICAL MEASUREMENT, vol. 27(7), 637-648. link> doi>
  • Bloor RN, Spanel P, Smith D. 2006. Quantification of breath carbon disulphide and acetone following a single dose of disulfiram (Antabuse) using selected ion flow tube mass spectrometry (SIFT-MS). ADDICTION BIOLOGY, vol. 11(2), 163-169. link> doi>
  • Bloor RN, Spanĕl P, Smith D. 2006. Quantification of breath carbon disulphide and acetone following a single dose of disulfiram (Antabuse) using selected ion flow tube mass spectrometry (SIFT-MS). Addict Biol, vol. 11(2), 163-169. link> doi>
  • Smith D, Wang T, Spanel P, Bloor R. 2006. The increase of breath ammonia induced by niacin ingestion quantified by selected ion flow tube mass spectrometry. Physiol Meas, vol. 27(6), 437-444. link> doi>
  • Turner C, Spanel P, Smith D. 2006. A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS. PHYSIOLOGICAL MEASUREMENT, vol. 27(4), 321-337. link> doi>
  • Julak J, Stranska E, Rosova V, Geppert H, Spanel P, Smith D. 2006. Bronchoalveolar lavage examined by solid phase microextraction, gas chromatography-mass spectrometry and selected ion flow tube mass spectrometry. JOURNAL OF MICROBIOLOGICAL METHODS, vol. 65(1), 76-86. link> doi>
  • Spanel P, Dryahina K, Smith D. 2006. A general method for the calculation of absolute trace gas concentrations in air and breath from selected ion flow tube mass spectrometry data. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 249, 230-239. link> doi>
  • Spanĕl P, Turner C, Wang T, Bloor R, Smith D. 2006. Generation of volatile compounds on mouth exposure to urea and sucrose: implications for exhaled breath analysis. Physiol Meas, vol. 27(2), N7-17. link> doi>
  • Turner C, Spanel P, Smith D. 2006. A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS). PHYSIOLOGICAL MEASUREMENT, vol. 27(1), 13-22. link> doi>
  • Turner C, Spanel P, Smith D. 2006. A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 20(1), 61-68. link> doi>
  • Kubista J, Spanel P, Dryahina K, Workman C, Smith D. 2006. Combined use of gas chromatography and selected ion flow tube mass spectrometry for absolute trace gas quantification. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 20(4), 563-567. link> doi>
  • Chan C, Smith D, Spanel P, McIntyre C, Davies S. 2006. Deuterium kinetics in haemodialysis patients and the optimal time schedule for breath sampling in the determination of total body water (TBW) using flowing afterglow mass spectrometry (FAMS). NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 21, 422. link>
  • Smith D, Ismail KMK, Diskin AM, Chapman G, Magnay JL, Spanel P, O'Brien S. 2006. Increase of acetone emitted by urine in relation to ovulation. Acta Obstet Gynecol Scand, vol. 85(8), 1008-1011. link> doi>
  • Smith D and Spanel P. 2005. Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom Rev, vol. 24(5), 661-700. link> doi>
  • Spanel P, Wang T, Smith D. 2005. Coordinated FA-MS and SIFT-MS analyses of breath following ingestion of D2O and ethanol: total body water, dispersal kinetics and ethanol metabolism. Physiol Meas, vol. 26(4), 447-457. link> doi>
  • Dryahina K and Spanel P. 2005. A convenient method for calculation of ionic diffusion coefficients for accurate selected ion flow tube mass spectrometry, SIFT-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 244(2-3), 148-154. link> doi>
  • Carroll W, Lenney W, Wang T, Spanel P, Alcock A, Smith D. 2005. Detection of volatile compounds emitted by Pseudomonas aeruginosa using selected ion flow tube mass spectrometry. Pediatr Pulmonol, vol. 39(5), 452-456. link> doi>
  • DAVIES SJ, Asghar RB, Diskin AM, Smith D. 2005. Influence of Convection on the Diffusive Transport and Sieving of Water and Small Solutes across the Peritoneal Membrane. Journal American Society of Nephrology, vol. 16(2), 437-443. doi>
  • Wang TS, Spanel P, Smith D. 2004. A selected ion flow tube study of the reactions of H3O+, NO+ and O-2(+center dot) with some phenols, phenyl alcohols and cyclic carbonyl compounds in support of SIFT-MS and PTR-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 239(2-3), 139-146. link> doi>
  • Dryahina K, Polasek M, Spanel P. 2004. A selected ion flow tube, SIFT, study of the ion chemistry of H3O+, NO+ and O-2(+center dot) ions with several nitroalkanes in the presence of water vapour. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 239(1), 57-65. link> doi>
  • Wang TS, Spanel P, Smith D. 2004. A selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O-2(center dot+) ions with several N- and O-containing heterocyclic compounds in support of SIFT-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 237(2-3), 167-174. link> doi>
  • Spanel P, Hall EFH, Workman CT, Smith D. 2004. A directly coupled monolithic rectangular resonator forming a robust microwave plasma ion source for SIFT-MS. PLASMA SOURCES SCIENCE & TECHNOLOGY, vol. 13(2), 282-284. link> doi>
  • Wang TS, Smith D, Spanel P. 2004. Selected ion flow tube, SIFT, studies of the reactions of H-3,O+ NO+ and O-2(+) with compounds released by Pseudomonas and related bacteria. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 233(1-3), 245-251. link> doi>
  • Cheng P, Chu YN, Zhang WJ, Spanel P, Smith D. 2004. Analysis of exhaust gas from a car using selected ion flow tube mass spectrometry. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, vol. 32(1), 113-118. link>
  • Smith D, Spanĕl P, Dabill D, Cocker J, Rajan B. 2004. On-line analysis of diesel engine exhaust gases by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom, vol. 18(23), 2830-2838. link> doi>
  • SPANEL P, WANG T, SMITH D. 2004. Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry. doi>
  • Asghar RB, Diskin AM, Spanel P, Smith D, Davies SJ. 2003. Measuring transport of water across the peritoneal membrane. Kidney Int, vol. 64(5), 1911-1915. link> doi>
  • Wang TS, Spanel P, Smith D. 2003. Selected ion flow tube, SIFT, studies of the reactions of H3O+, NO+ and O2(+) with eleven C10H16 monoterpenes. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 228(1), 117-126. link> doi>
  • Diskin AM, Spanel P, Smith D. 2003. Increase of acetone and ammonia in urine headspace and breath during ovulation quantified using selected ion flow tube mass spectrometry. Physiological Measurement, vol. 24(1), 191-199. doi>
  • Diskin AM, Spanel P, Smith D. 2003. Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. Physiol Meas, vol. 24(1), 107-119. link> doi>
  • Smith D, Wang TS, Spanel P. 2003. A SIFT study of the reactions of H2ONO+ ions with several types of organic molecules. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 230(1), 1-9. link> doi>
  • Spanel P, Diskin AM, Wang T, Smith D. 2003. A SIFT study of the reactions of H3O+, NO+ and O-2(+) with hydrogen peroxide and peroxyacetic acid. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 228(2-3), 269-283. link> doi>
  • Smith D, Wang TS, Spanel P. 2003. Analysis of ketones by selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 17(23), 2655-2660. link> doi>
  • Cheng P, Zhang WJ, Chu YN, Spanel P, Smith D. 2003. Analysis of petrol and diesel vapor using selective ion flow tube/mass, spectrometry. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, vol. 31(5), 548-551. link>
  • Smith D, Wang T, Sule-Suso J, Spanel P, El Haj AJ. 2003. Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Communcations Mass Spectometry, vol. 17(8), 845-850. doi>
  • Abbott SM, Elder JB, Spanel P, Smith D. 2003. Quantification of acetonitrile in exhaled breath and urinary headspace using selected ion flow tube mass spectrometry. International Journal of Mass Spectrometry, vol. 228(2-3), 655-665. doi>
  • Trunec D, Spanel P, Smith D. 2003. The influence of electon-electron collisions on electron thermalisation in He and Ar afterglow plasmas. Chemical Physics Letters. doi>
  • Smith D, Engel B, Diskin AM, Spanel P, Davies SJ. 2002. Comparative measurements of total body water in healthy volunteers by online breath deuterium measurement and other near-subject methods. Am J Clin Nutr, vol. 76(6), 1295-1301. link>
  • Asghar RB, Diskin AM, Spanel P, Smith D, Davies SJ. 2002. Diffusion of water across the peritoneal membrane. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, 199A. link>
  • Smith D, Wang T, Spanĕl P. 2002. On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol. Physiol Meas, vol. 23(3), 477-489. link> doi>
  • Diskin AM, Wang TS, Smith D, Spanel P. 2002. A selected ion flow tube (SIFT), study of the reactions of H3O+, NO+ and O-2(+) ions with a series of alkenes; in support of SIFT-MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 218(1), 87-101. link> doi>
  • Cheng P, Wang HM, Li JQ, Zhang WJ, Ji YF, Wang ZY, Sheng LS, Spanel P, Smith D, Cao DZ, Chu YN. 2002. Ion Formation in Microwave Discharge through Moist Air. Acta Physico-Chimica Sinica. doi>
  • Spanel P, Van Doren JM, Smith D. 2002. A selected ion flow tube study of the reactions of H(3)O(+), NO(+), and O(2)(+) with saturated and unsaturated aldehydes and subsequent hydration of the product ions. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 213(2-3), 163-176. link> doi>
  • Spanel P, Wang TS, Smith D. 2002. A selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O-2(+) ions with a series of diols. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 218(3), 227-236. link> doi>
  • Smith D, Cheng P, Spanel P. 2002. Analysis of petrol and diesel vapour and vehicle engine exhaust gases using selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 16(11), 1124-1134. link> doi>
  • Smith D, Wang T, Spanel P. 2002. Kinetics and isotope patterns of ethanol and acetaldehyde emissions from yeast fermentations of glucose and glucose-6,6-d2 using selected ion flow tube mass spectrometry: a case study. Rapid Commun Mass Spectrom, vol. 16(1), 69-76. link> doi>
  • Trunec D, Spanel P, Smith D. 2002. Monte Carlo simulations of the influence of ion-neutral collisions on the ion currents collected by electrostatic probes. Contributions to Plasma Physics. doi>
  • Spanel P, Diskin AM, Abbott SM, Wang T, Smith D. 2002. Quantification of volatile compounds in the headspace of aqueous liquids using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom, vol. 16(22), 2148-2153. link> doi>
  • Wang TS, Smith D, Spanel P. 2002. Selected ion flow tube studies of the reactions of H(3)0(+), NO+ and O-2(+) with the anaesthetic gases halothane, isoflurane and sevoflurane. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 16(19), 1860-1870. link> doi>
  • Spanel P and Smith D. 2001. Quantitative selected ion flow tube mass spectrometry: the influence of ionic diffusion and mass discrimination. J Am Soc Mass Spectrom, vol. 12(7), 863-872. link> doi>
  • Dewhurst RJ, Evans RT, Mottram TT, Spanel P, Smith D. 2001. Assessment of rumen processes by selected-lon-flow-tube mass spectrometric analysis of rumen gases. JOURNAL OF DAIRY SCIENCE, vol. 84(6), 1438-1444. link> doi>
  • Davies S, Spanel P, Smith D. 2001. A new 'online' method to measure increased exhaled isoprene in end-stage renal failure. NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 16(4), 836-839. link> doi>
  • Spanel P and Smith D. 2001. Product ion distributions and rate coefficients for the attachment reactions of electrons with CHCl2Br, CCl2Br2, and CHClBr2. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 205(1-3), 243-252. link> doi>
  • Spanel P and Smith D. 2001. Accuracy and precision of flowing afterglow mass spectrometry for the determination of the deuterium abundance in the headspace of aqueous liquids and exhaled breath water. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 15(11), 867-872. link> doi>
  • Smith D, Diskin AM, Yufeng JI, Spanel P. 2001. Concurrent use of H30+, No+and 02+ precursor ions for the detection and quantification of diverse trace gases in the presence of air and breath by selected on flow tube mass spectrometry. International Journal of Mass Spectrometry, 81-97. doi>
  • Smith D and Spanel P. 2001. On-line determination of the deuterium abundance in breath water vapour by flowing afterglow mass spectrometry, FA-MS with appliants to measurements of total body water. Rapid Communications in mass spectrometry, 25-32. doi>
  • Smith D and Spanel P. 2001. On-line measurement of the absolute humidity of air,breath and liquid headspace samples by selected ion flow tube mass spectrometry. Rapid Communications in mass spectrometry, 563-569. doi>
  • Davies, S, Spanel P, Smith D. 2001. Rapid measurement of deuterium content of breath following oral ingestion to determine body water. Physiol Meas, 651-659. doi>
  • Smith D, Spanel P, Jones JB. 2000. Analysis of volatile emissions from porcine faeces and urine using selected ion flow tube mass spectrometry. BIORESOURCE TECHNOLOGY, vol. 75(1), 27-33. link> doi>
  • Spanel P and Smith D. 2000. Selected ion flow tube mass spectrometry analyses of stable isotopes in water: isotopic composition of H3O+ and H3O+ (H2O)3 ions in exchange reactions with water vapor. J Am Soc Mass Spectrom, vol. 11(10), 866-875. link> doi>
  • Smith D, Suzor-Weiner A, Larsson M, Spanel P, Mitchell JBA. 2000. Experimental studies of the dissociative recombination of H-3(+) - Discussion. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, vol. 358(1774), 2443-2444. link>
  • Spanel P, Davies S, Smith D. 2000. Breath ammonia dips after feeding independently of the protein content of the meat. FASEB JOURNAL, vol. 14(4), A490. link>
  • Smith D, Davies S, Spanel P. 2000. SIFT-MS analysis of breath isoprene: a marker of treatment stress in haemodialysis patients?. FASEB JOURNAL, vol. 14(4), A573. link>
  • Spanel P and Smith D. 2000. An investigation of the reactions of H3O+ and O-2(+) with NO, NO2, N2O and HNO2 in support of selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 14(8), 646-651. link> doi>
  • Spanĕl P and Smith D. 2000. Influence of water vapour on selected ion flow tube mass spectrometric analyses of trace gases in humid air and breath. Rapid Commun Mass Spectrom, vol. 14(20), 1898-1906. link> doi>
  • Spanel P and Smith D. 2000. Quantification of hydrogen sulphide in humid air by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom, vol. 14(13), 1136-1140. link> doi>
  • Smith D, Spanel P, Davies S. 1999. Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. J Appl Physiol (1985), vol. 87(5), 1584-1588. link>
  • Fairley DA, Milligan DB, Freeman CG, McEwan MJ, Spanel P, Smith D. 1999. Competitive association and charge transfer in the reactions of NO+ with some ketones: a selected ion flow drift tube study. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 193(1), 35-43. link> doi>
  • Spanel P and Smith D. 1999. Selected ion flow tube studies of the reactions of H3O+, NO+, and O-2(+) with several aromatic and aliphatic monosubstituted halocarbons. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 189(2-3), 213-223. link> doi>
  • Spanel P and Smith D. 1999. Selected ion flow tube studies of the reactions of H3O+, NO+, and O-2(+) with eleven amine structural isomers of C5H13N. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 185, 139-147. link> doi>
  • Spanel P and Smith D. 1999. Selected ion flow tube studies of the reactions of H3O+, NO+, and O-2(+) with some chloroalkanes and chloroalkenes. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 184(2-3), 175-181. link> doi>
  • Spanel P, Smith D, Holland TA, Al Singary W, Elder JB. 1999. Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 13(14), 1354-1359. link> doi>
  • Spanel P, Davies S, Smith D. 1999. Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method. Rapid Commun Mass Spectrom, vol. 13(17), 1733-1738. link> doi>
  • Spanel P and Smith D. 1999. Selected ion flow tube - Mass spectrometry: Detection and real-time monitoring of flavours released by food products. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 13(7), 585-596. link> doi>
  • Smith D, Spanĕl P, Holland TA, al Singari W, Elder JB. 1999. Selected ion flow tube mass spectrometry of urine headspace. Rapid Commun Mass Spectrom, vol. 13(8), 724-729. link> doi>
  • Spanel P and Smith D. 1998. Selected ion flow tube studies of the reactions of H3O+ NO+, and O-2(+) with several aromatic and aliphatic hydrocarbons. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 181, 1-10. link> doi>
  • Spanel P and Smith D. 1998. The influences of gas and electron temperatures on electron attachment in gas electrical discharges. CZECHOSLOVAK JOURNAL OF PHYSICS, vol. 48(10), 1119-1134. link> doi>
  • Spanel P and Smith D. 1998. Selected ion flow tube studies of the reactions of H3O+, NO+ and O-2(+) with several amines and some other nitrogen-containing molecules. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 176(3), 203-211. link> doi>
  • Spanel P and Smith D. 1998. Selected ion flow tube studies of the reactions of H3O+, NO+ and O-2(+) with some organosulphur molecules. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 176(3), 167-176. link> doi>
  • Spanel P and Smith D. 1998. SIFT studies of the reaction of H3O+, NO+ and O-2(+) with several ethers. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 172(3), 239-247. link> doi>
  • Spanĕl P, Davies S, Smith D. 1998. Quantification of ammonia in human breath by the selected ion flow tube analytical method using H30+ and 02+ precursor ions. Rapid Commun Mass Spectrom, vol. 12(12), 763-766. link> doi>
  • Spanel P and Smith D. 1998. SIFT studies of the reactions of H3O+, NO+ and O-2(+) with a series of volatile carboxylic acids and esters. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 172(1-2), 137-147. link> doi>
  • Spanel P, Smith D, Matejcik S, Kiendler A, Mark TD. 1997. A coordinated flowing afterglow and crossed beam study of electron attachment to CCl(3)Br. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 167, 1-12. link> doi>
  • Spanel P and Smith D. 1997. SIFT studies of the reactions of H3O+, NO+ and O-2(+) with a series of alcohols. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 167, 375-388. link> doi>
  • Spanel P, Ji YF, Smith D. 1997. SIFT studies of the reactions of H3O+, NO+ and O-2(+) with a series of aldehydes and ketones. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 165, 25-37. link> doi>
  • Davies S, Spanel P, Smith D. 1997. Quantitative analysis of ammonia on the breath of patients in end-stage renal failure. Kidney Int, vol. 52(1), 223-228. link> doi>
  • Spanel P, Cocker J, Rajan B, Smith D. 1997. Validation of the SIFT technique for trace gas analysis of breath using the syringe injection technique. ANNALS OF OCCUPATIONAL HYGIENE, vol. 41(3), 373-382. link> doi>
  • Scott GB, Fairley DA, Freeman CG, McEwan MJ, Spanel P, Smith D. 1997. Gas phase reactions of some positive ions with atomic and molecular hydrogen at 300 K. JOURNAL OF CHEMICAL PHYSICS, vol. 106(10), 3982-3987. link> doi>
  • Spanĕl P, Rolfe P, Rajan B, Smith D. 1996. The selected ion flow tube (SIFT)--a novel technique for biological monitoring. Ann Occup Hyg, vol. 40(6), 615-626. link> doi>
  • Smith D and Spanel P. 1996. Electron attachment to C-60 and C-70 in the gas phase. JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS, vol. 29(21), 5199-5212. link> doi>
  • Spanĕl P and Smith D. 1996. Selected ion flow tube: a technique for quantitative trace gas analysis of air and breath. Med Biol Eng Comput, vol. 34(6), 409-419. link> doi>
  • Davies SJ, Spanel P, Smith D. 1996. Quantitative analysis of metabolites on the breath of patients in renal failure. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7(9), A0352. link>
  • Spanel P and Smith D. 1996. Radiation from the reactions of NO+ with Cl- and I-. CHEMICAL PHYSICS LETTERS, vol. 258(3-4), 477-484. link> doi>
  • Smith D and Spanel P. 1996. Application of ion chemistry and the SIFT technique to the quantitative analysis of trace gases in air and on breath. INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY, vol. 15(1), 231-271. link> doi>
  • Spanel P and Smith D. 1996. A selected ion flow tube study of the reactions of NO+ and O-2(+) ions with some organic molecules: The potential for trace gas analysis of air. JOURNAL OF CHEMICAL PHYSICS, vol. 104(5), 1893-1899. link>
  • Smith D and Spanel P. 1996. The novel selected-ion flow tube approach to trace gas analysis of air and breath. Rapid Commun Mass Spectrom, vol. 10(10), 1183-1198. link> doi>
  • SPANEL P. 1995. AN ONLINE LANGMUIR PROBE TECHNIQUE FOR THE STUDY OF AFTERGLOW PLASMAS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 149, 299-310. link> doi>
  • SPANEL P and SMITH D. 1995. REACTIONS OF HYDRATED HYDRONIUM IONS AND HYDRATED HYDROXIDE IONS, WITH SOME HYDROCARBONS AND OXYGEN-BEARING ORGANIC-MOLECULES. JOURNAL OF PHYSICAL CHEMISTRY, vol. 99(42), 15551-15556. link> doi>
  • SPANEL P, PAVLIK M, SMITH D. 1995. REACTIONS OF H3O+ AND OH- IONS WITH SOME ORGANIC-MOLECULES - APPLICATIONS TO TRACE GAS-ANALYSIS IN AIR. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 145(3), 177-186. link> doi>
  • SPANEL P, MATEJCIK S, SMITH D. 1995. THE VARYING INFLUENCES OF GAS AND ELECTRON TEMPERATURES ON THE RATES OF ELECTRON-ATTACHMENT TO SOME SELECTED MOLECULES. JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS, vol. 28(14), 2941-2957. link> doi>
  • SMITH D, SPANEL P, MATEJCIK S, STAMATOVIC A, MARK TD, JAFFKE T, ILLENBERGER E. 1995. FORMATION OF SF5- IN ELECTRON-ATTACHMENT TO SF6 - SWARM AND BEAM RESULTS RECONCILED. CHEMICAL PHYSICS LETTERS, vol. 240(5-6), 481-488. link> doi>
  • Smith D and Spanel P. 1995. Ions in the terrestrial atmosphere and in interstellar clouds. MASS SPECTROMETRY REVIEWS, vol. 14(4-5), 255-278. link> doi>
  • SPANEL P, SMITH D, HENCHMAN M. 1995. THE REACTIONS OF SOME INTERSTELLAR IONS WITH BENZENE, CYCLOPROPANE AND CYCLOHEXANE. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 141(2), 117-126. link> doi>
  • MATEJCIK S, MARK TD, SPANEL P, SMITH D, JAFFKE T, ILLENBERGER E. 1995. FORMATION AND DECAY OF C-60(-) FOLLOWING FREE-ELECTRON CAPTURE BY C-60. JOURNAL OF CHEMICAL PHYSICS, vol. 102(6), 2516-2521. link>
  • SPANEL P and SMITH D. 1995. RECENT STUDIES OF ELECTRON-ATTACHMENT AND ELECTRON-ION RECOMBINATION AT THERMAL ENERGIES. PLASMA SOURCES SCIENCE & TECHNOLOGY, vol. 4(2), 302-306. link> doi>
  • SPANEL P, SMITH D, CHUDACEK O, KUDRNA P, TICHY M. 1995. THE INFLUENCE OF COLLISIONS IN THE SPACE-CHARGE SHEATH ON THE ION CURRENT COLLECTED BY A LANGMUIR PROBE. CONTRIBUTIONS TO PLASMA PHYSICS, vol. 35(1), 3-14. link> doi>
  • TRUNEC D, SPANEL P, SMITH D. 1995. THE INFLUENCE OF ION-NEUTRAL COLLISIONS IN THE PLASMA SHEATH ON THE ION CURRENT TO AN ELECTROSTATIC-PROBE - MONTE-CARLO SIMULATION. CONTRIBUTIONS TO PLASMA PHYSICS, vol. 35(3), 203-212. link> doi>
  • SPANEL P and SMITH D. 1994. A STUDY OF ELECTRON-ATTACHMENT TO C-70 USING THE FALP TECHNIQUE. CHEMICAL PHYSICS LETTERS, vol. 229(3), 262-266. link> doi>
  • TRUNEC D, SPANEL P, SMITH D. 1994. ELECTRON-TEMPERATURE RELAXATION IN AFTERGLOW PLASMAS - DIFFUSION COOLING. CONTRIBUTIONS TO PLASMA PHYSICS, vol. 34(1), 69-79. link> doi>
  • SMITH D and SPANEL P. 1994. STUDIES OF ELECTRON-ATTACHMENT AT THERMAL ENERGIES USING THE FLOWING AFTERGLOW LANGMUIR PROBE TECHNIQUE. ADVANCES IN ATOMIC, MOLECULAR, AND OPTICAL PHYSICS, VOL 32, vol. 32, 307-343. link>
  • SMITH D, SPANEL P, MILLAR TJ. 1994. THE ROLE OF H+ AND H-3+ IONS IN THE DEGRADATION OF INTERSTELLAR-MOLECULES. MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, vol. 266(1), 31-34. link>
  • SMITH D, GLOSIK J, SKALSKY V, SPANEL P, LINDINGER W. 1993. A FURTHER INVESTIGATION OF THE REACTION OF C2H2+ WITH H-2. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 145-153. link> doi>
  • SPANEL P, DITTRICHOVA L, SMITH D. 1993. FALP STUDIES OF THE DISSOCIATIVE RECOMBINATION COEFFICIENTS FOR O-2(+) AND NO+ WITHIN THE ELECTRON-TEMPERATURE RANGE 300-2000 K. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 183-191. link> doi>
  • SPANEL P, TICHY M, SMITH D. 1993. SIFT STUDIES OF THE REACTIONS OF RARE-GAS ATOMIC IONS WITH CL-2 AND BR-2(1). INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 155-162. link> doi>
  • SMITH D, SPANEL P, MARK TD. 1993. ELECTRON-ATTACHMENT TO C60 AT LOW ENERGIES. CHEMICAL PHYSICS LETTERS, vol. 213(1-2), 202-206. link> doi>
  • SMITH D and SPANEL P. 1993. DISSOCIATIVE RECOMBINATION OF H3+ - EXPERIMENT AND THEORY RECONCILED. CHEMICAL PHYSICS LETTERS, vol. 211(4-5), 454-460. link> doi>
  • SPANEL P, TICHY M, SMITH D. 1993. THE REACTIONS OF POSITIVE AND NEGATIVE HALOGEN IONS WITH CL2 AND BR2. JOURNAL OF CHEMICAL PHYSICS, vol. 98(11), 8660-8666. link>
  • GLOSIK J, FREYSINGER W, HANSEL A, SPANEL P, LINDINGER W. 1993. ENERGY DEPENDENCIES OF FAST REACTIONS OF POSITIVE-IONS X+ WITH HCL FROM NEAR THERMAL TO SIMILAR-OR-EQUAL-TO-2 EV CENTER-OF-MASS COLLISION ENERGY (X+=H+,H-2+,H-3+,N+,N-2+,AR+,C+,CH+,CH-2+,CH-3+,CH-4+,CH-5+). JOURNAL OF CHEMICAL PHYSICS, vol. 98(9), 6995-7003. link> doi>
  • SMITH D and SPANEL P. 1993. DISSOCIATIVE RECOMBINATION OF H-3(+) AND SOME OTHER INTERSTELLAR IONS - A CONTROVERSY RESOLVED. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 163-182. link> doi>
  • SPANEL P and SMITH D. 1993. FALP STUDIES OF ELECTRON-ATTACHMENT AT ELEVATED ELECTRON TEMPERATURES - THE INFLUENCE OF ATTACHMENT ON ELECTRON-ENERGY DISTRIBUTIONS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 193-203. link> doi>
  • GLOSIK J, SMITH D, SPANEL P, FREYSINGER W, LINDINGER W. 1993. SIFDT STUDIES OF THE REACTIONS OF C+, CH+ AND CH2+ WITH HCL AND CO2, AND CH3+ WITH HCL1. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 129, 131-143. link> doi>
  • SMITH D, SPANEL P, MAYHEW CA. 1992. A SELECTED ION-FLOW TUBE STUDY OF THE REACTIONS OF O+, H+ AND HEH+ WITH SEVERAL MOLECULAR GASES AT 300-K. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, vol. 117(1-3), 457-473. link> doi>
  • SMITH D and SPANEL P. 1992. STUDIES OF INTERSTELLAR ION REACTIONS USING THE SIFT TECHNIQUE - ISOTOPE FRACTIONATION. ACCOUNTS OF CHEMICAL RESEARCH, vol. 25(9), 414-420. link> doi>
  • SMITH D, SPANEL P, BEDFORD DK. 1992. SOME REACTIONS OF THE HIGHLY POLAR ION ARH(3+). CHEMICAL PHYSICS LETTERS, vol. 191(6), 587-591. link> doi>
  • Španěl P, Dryahina K, Vicherková P, Smith D. 2015. Increase of methanol in exhaled breath quantified by SIFT-MS following aspartame ingestion. J Breath Res, vol. 9(4), 047104. link> doi>
  • Spesyvyi A, Smith D, Španěl P. 2015. Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath. Anal Chem, vol. 87(24), 12151-12160. link> doi>

Chapters

  • Spanel P and Smith D. 2013. Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology. In VOLATILE BIOMARKERS: NON-INVASIVE DIAGNOSIS IN PHYSIOLOGY AND MEDICINE. Amann A and Smith D (Eds.). ELSEVIER SCIENCE BV. doi>
  • Turner C, Welch S, Bellingan G, Singer M, Spanel P, Smith D. 2005. Analysis of breath using SIFT-MS: A comparison of the breath composition of healthy volunteers and seriously-ill ICU patients. link> doi>
  • Bloor R, Wang TS, Spanel P, Smith D. 2005. Applications of selected ion flow tube mass spectrometry, SIFT-MS, in addiction research. Amann A and Smith D (Eds.). doi>
  • Penault C, Spanel P, Smith D. 2005. Detection of H-pylori infection by breath ammonia following urea ingestion. link> doi>
  • Spanel P and Smith D. 2005. Flowing afterglow mass spectrometry (FA-MS) for the determination of the deuterium abundance in breath water vapour and aqueous liquid headspace. link> doi>
  • Smith D and Spanel P. 2005. Selected ion flow tube mass spectrometry, SIFT-MS, for on-line trace gas analysis of breath. link> doi>
  • Wang TS, Spanel P, Smith D. 2005. The combined use of SIFT-MS and FA-MS to investigate first-pass metabolism of ethanol. link> doi>
  • SMITH D and SPANEL P. 1994. FALP STUDIES OF ELECTRON-ION RECOMBINATION AND ELECTRON-ATTACHMENT. (vol. 326). link>

Other

  • Kumar S, Huang J, Abbassi-Ghadi N, Mackenzie H, Hoare J, Spanel P, Smith D, Hanna GB. 2014. SIFT-MS analysis of exhaled breath for volatile organic profiling of oesophago-gastric cancer. BRITISH JOURNAL OF SURGERY (vol. 101, pp. 17-18). link>
  • Gilchrist FJ, Simms H, Alcock A, Jones AM, Smith D, Spanel P, Webb AK, Lenney W. 2012. IS HYDROGEN CYANIDE A MARKER OF BURKHOLDERIA CEPACIA COMPLEX INFECTION?. THORAX (vol. 67, p. A102). link> doi>
  • Chan C, Davies SJ, McIntyre C, Smith D, Spanel P. 2007. Increased ratio of extracellular to total body water (ECW/TBW) is related to comorbidity and fluid overload rather loss of lean body mass in haemodialysis (HD) patients. NEPHROLOGY DIALYSIS TRANSPLANTATION (vol. 22, p. 314). link>
  • Van Doren JM, Spanel P, Smith D. 2003. Real-time analysis of ammonia and volatile organic compounds from cooking meat: Application of the SIFT-MS technique. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 225, p. U120). link>
  • Gilchrist FJ, Belcher J, Jones AM, Smith D, Smyth A, Southern KW, Spanel P, Webb AK, Lenney W. 2014. THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS. THORAX (vol. 69, pp. A162-A163). link> doi>

Useful links on Breath Analysis:

"Meeting the Canine Challenge to Cancer Detection", news article in Spectroscopy Now, 15 July 2004. 

"Sifting through Breath for Cyanide", news article in Spectroscopy Now, 15 March 2005.