Dr Monte Gates

Title: Senior Lecturer in Medicine & Neuroscience
Phone: +44 (0)1782 733875
Email: m.a.gates@keele.ac.uk
Location: Huxley Building : 204a
Role: ISTM Research theme: Therapeutics
Contacting me: Try my office or arrange an appointment by e-mail.
Dr Monte Gates

ROSA TH Z-Series 20x I graduated with a BS in Experimental Psychology, and a BA in Philosophy from Austin Peay State University in the US.  From there, I went on to do my PhD in Anatomy and Neurobiology at the University of Tennessee (UT), where I researched how astrocytes (glial cells) affect the development and repair of neural circuits in the central nervous system.  After successfully completing my degree at UT, I was fortunate to work 2.5 years in the laboratory of Dr. Anders Bjorklund (the innovator of the technique of neural transplantation for Parkinson’s disease) at Lund University in Sweden, where I conducted studies on the possibility of astrocyte phenotypes existing in the brain.  Following my studies there, I went to Harvard University where I became a postdoctoral Fellow, working with Dr. Jeffrey Macklis to study development of cortical projection neurons and axon guidance.  After 3 years at Harvard University, I begin working with Professor Stephen B. Dunnett at Cardiff University, where I conducted work on the emergence and development of dopaminergic neurons in the developing brain.  I then came to Keele University where I have (hopefully) combined this body of work by beginning studies on  what proteins and cells are involved in the development of motor circuitry in the central nervous system.  

ISTM Research theme: Therapeutics

Cerebellum 20x combined adjusted brightened

My lab focuses on the use of proteomics, cell culture, and in vivo models to understand how cells develop and find appropriate targets in the central nervous system.   Over the past 5 years, we have developed a unique device to transplant tissue and constructs into the brain for repair, and have begun to describe changes (at the molecular level) in the brain as it develops, ages, and degenerates.  We have a great deal of interest in Parkinson’s disease, and how dopamine neurons are born, develop and degenerate.  We are particularly interested in how dopamine neurons, and other neurons involved in the motor output of the brain (e.g., cortico-spinal neurons) find their appropriate target / connection during development.  The hope of this research is to find ways to (re) wire the brain to repair diseases and disabilities that affect an individual’s ability to move.

Selected Publications

  • Fuller HR and Gates MA (Eds.). 2016. Recovery of Motor Function Following Spinal Cord Injury. (12 vols.). Intech. link>
  • Fuller HR, Marani L, Holt I, Woodhams PL, Webb MM, Gates MA. Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain. Brain Struct Funct, vol. 222(2), 867-879. link> doi> full text>
  • Fuller HR, Slade R, Jovanov-Milošević N, Babić M, Sedmak G, Šimić G, Fuszard MA, Shirran SL, Botting CH, Gates MA. 2015. Stathmin is enriched in the developing corticospinal tract. Mol Cell Neurosci, vol. 69, 12-21. link> doi> full text>
  • Fuller HR, Hurtado ML, Wishart TM, Gates MA. 2014. The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Sci, vol. 12, 20. link> doi> full text>
  • Jozwiak A, Liu Y, Yang Y, Gates MA. 2014. Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. Biomed Res Int, vol. 2014, 651236. link> doi> full text>

Full Publications List show

Books

  • Fuller HR and Gates MA (Eds.). 2016. Recovery of Motor Function Following Spinal Cord Injury. (12 vols.). Intech. link>

Journal Articles

  • Fuller HR, Marani L, Holt I, Woodhams PL, Webb MM, Gates MA. Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain. Brain Struct Funct, vol. 222(2), 867-879. link> doi> full text>
  • Fuller HR, Slade R, Jovanov-Milošević N, Babić M, Sedmak G, Šimić G, Fuszard MA, Shirran SL, Botting CH, Gates MA. 2015. Stathmin is enriched in the developing corticospinal tract. Mol Cell Neurosci, vol. 69, 12-21. link> doi> full text>
  • Fuller HR, Hurtado ML, Wishart TM, Gates MA. 2014. The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Sci, vol. 12, 20. link> doi> full text>
  • Jozwiak A, Liu Y, Yang Y, Gates MA. 2014. Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. Biomed Res Int, vol. 2014, 651236. link> doi> full text>
  • Tailor J, Kittappa R, Leto K, Gates M, Borel M, Paulsen O, Spitzer S, Karadottir RT, Rossi F, Falk A, Smith A. 2013. Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci, vol. 33(30), 12407-12422. link> doi>
  • Fricker RA, Kuiper JH, Gates MA. 2012. Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PLoS One, vol. 7(10), e47169. link> doi> full text>
  • Orme RP, Gates MA, Fricker-Gates RA. 2010. A multiplexed quantitative proteomics approach for investigating protein expression in the developing central nervous system. J Neurosci Methods, vol. 191(1), 75-82. link> doi>
  • Fricker-Gates RA and Gates MA. 2010. Stem cell-derived dopamine neurons for brain repair in Parkinson's disease. Regen Med, vol. 5(2), 267-278. link> doi>
  • Jozwiak A, Gates MA, Liu Y, Yang Y. 2010. A novel technology and stereotactic accessory for implanting engineered tissues, cells, and scaffold materials into the brain. Tissue Eng Part C Methods, vol. 16(3), 469-470. link> doi>
  • Orme R, Fricker-Gates RA, Gates MA. 2009. Ontogeny of substantia nigra dopamine neurons. J Neural Transm Suppl, 3-18. link> doi>
  • Torres M, Monville C, GATES MA, Bagga V, Dunnett SB. 2007. Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease. Neuroscience, vol. 146(4), 1606-1617. doi>
  • GATES MA, Torres E, White A, Fricker-Gates RA, Dunnett SB. 2006. Re-examining the ontogeny of substantia nigra dopamine neurons. European Journal of Neuroscience, vol. 23(5), 1384-1390. doi>
  • GATES MA, Coupe VM, Fricker-Gates RA, Torres EM. 2004. Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit. European Journal of Neuroscience, vol. 19(4), 831-844. doi>
  • Gates MA, Coupe VM, Torres EM, Fricker-Gates RA, Dunnett SB. 2004. Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit. Eur J Neurosci, vol. 19(4), 831-844. link> doi>
  • Fricker-Gates RA, White A, Gates MA, Dunnett SB. 2004. Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors. Eur J Neurosci, vol. 19(3), 513-520. link> doi>
  • Fricker-Gates RA, White A, Gates MA, Dunnett SB. 2004. Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors. Eur J of Neurosci, vol. 19, 513-520.
  • GATES MA and Dunnett SB. 2001. The influence of astrocytes on the development, regeneration and reconstruction of the nigrostriatal dopamine system. Restorative Neurology and Neuroscience , vol. 19(1-2), 67-83.
  • Gates MA, Fricker-Gates RA, Magavi SS, Macklis JD. 2000. Cellular repair of complex cortical circuitry. NEUROSCIENTIST, vol. 6(5), 326-337. link> doi>
  • Eriksson C, Ericson C, Gates MA, Wictorin K. 2000. Long-term, EGF-stimulated cultures of attached GFAP-positive cells derived from the embryonic mouse lateral ganglionic eminence: in vitro and transplantation studies.
  • Gates MA, Tai CC, Macklis JD. 2000. Abnormal differentiation and process elongation by TrKB deficient neocortical neurons in vitro and in vivo. Neurosci, vol. 98, 437-447.
  • Gates MA, Fricker-Gates RA, Macklis JD. 2000. Reconstruction of cortical circuitry. Prog Brain Res, vol. 127, 115-156. link> doi>
  • Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, Björklund A. 1999. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J Neurosci, vol. 19(14), 5990-6005. link> doi>
  • Lanier L, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, KwiatKowski D, Soriano P, Gertler FB. 1999. Mena is required for neurulation and commissure formation. Neuron, vol. 2(22), 313-325.
  • Gates MA, Olsson M, Bjerregaard K, Bjorklund A. 1998. Region-specific migration of embryonic glia grafted to the neonatal brain.
  • Winkler C, Fricker RA, Gates MA, Olsson M, Hammang JP, Carpenter MK, Björklund A. 1998. Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain. Mol Cell Neurosci, vol. 11(3), 99-116. link> doi>
  • Martinez-Serrano A, Olsson M, Gates MA, Bjorklund A. 1998. In utero gene transfer reveals survival effects of nerve growth factor on rat brain cholinergic neurones during development. European Journal of Neuroscience.
  • Olsson M, Bjerregaard K, Winkler C, Gates MA, Bjorklund A, Campbell K. 1998. Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties. European Journal of Neuroscience.
  • Gates MA, Fillmore H, Steindler DA. 1996. Chondroitin sulfate proteoglycan and tenascin in the wounded adult mouse neostriatum in vitro: dopamine neuron attachment and process outgrowth. The Journal of Neuroscience.
  • Gates MA, Laywell ED, Fillmore H, Steindler DA. 1996. Astrocytes and extracellular matrix following intracerebral transplantation of embryonic ventral mesencephalon or lateral ganglionic eminence. Neuroscience.
  • Thomas LB, Gates MA, Steindler DA. 1996. Young neurons from the adult subependymal zone proliferate and migrate along an astrocyte, extracellular matrix-rich pathway. Glia.
  • Gates MA, Thomas LB, Howard EM, Laywell ED, Sajin B, Faissner A, Gotz B, Silver J, Steindler DA. 1995. Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres. Journal of Comparative Neurology.
  • Brodkey JA, Gates MA, Laywell ED, Steindler DA. 1993. The complex nature of interactive neuroregeneration-related molecules. Experimental Neurology.
  • Gates MA, O'Brien TF, Faissner A, Steindler DA. 1993. Neuron-glial interactions during the in vivo and in vitro development of the nigrostriatal circuit. Journal of Chemical Neuroanatomy.

Chapters

  • GATES MA, Dunnett SB, Torres EM, Fricker-Gates RA. 2006. Neural Transplantation. In Handbook of Experimental Neurology: Methods and Techniques in Animal Research. Tatlisumak T and Fisher M (Eds.). Cambridge University Press.
  • GATES MA, Fricker RA, Macklis JD. 2001. Neocortical neural transplantation. In Progress in Brain Research: Functional Neural Transplantation 2nd Edition. Bjorklund A and Dunnett S (Eds.). Elsevier.
  • O'Brien TF, Gates MA, Wilson CJ, Steindler DA. 1995. Glia and glycoconjugates in the neostriatum. In Cellular and Molecular Mechanisms of the Striatum. Surmeier DJ and Ariano M (Eds.). Austin, TX: Springer-Verlag.