Professor Josep Sulé-Suso

Title: Associate Specialist and Professor in Oncology
MB ChB - University of Barcelona, Catalonia, PhD - Keele University, Keele, UK

Phone: +44 (0)1782 674384 or 672571
Email: josep.sulesuso@uhns.nhs.uk
jsule@dial.pipex.com
Location: Address 1: Institute for Science & Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill Stoke-on-Trent, ST4 7QB UK
Address 2: Cancer Centre, Royal Stoke University Hospital, University Hospitals of North Midlands, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG UK
Role: ISTM Research theme: Therapeutics
Contacting me: By phone or email please
Dr Josep Sule-Suso

Professor Josep Sulé-Suso qualified in Medicine and Surgery at the University of Barcelona. He trained in oncology at the University Hospitals of North Midlands. He later furthered his research at the Instituto Nazionale dei Tumori in Milan, Italy. He presently combines his clinical duties at the Cancer Centre, University Hospitals of North Midlands with his research at ISTM.

ISTM Research theme: Therapeutics

Research Experience

Cancer immunotherapy, cancer cell biology, translational research, clinical trials, vibrational spectroscopy, synchrotron based FTIR spectroscopy, Analysis of Volatile Organic Compounds for cancer diagnosis.

Research Funding

Funding period

Funding amount

Role of involvement

Project title

Source of funding

2014-2016

£12,300

Principal investigator

Study of volatile organic compounds released by lung cells for early diagnosis of lung cancer

Slater & Gordon Health projects & Research Fund

2013-2016

£231,000

Co-investigator

Clinical Infrared and Raman Spectroscopy (CLIRSPEC)

EPSRC Network Grant, EP/L012952/1

2012

£13,000

Principal investigator

Lung cancer diagnosis through breath analysis

Cancer Research Fund, University Hospitals of North Midlands

2012-2014

£29,100

Principal investigator

Joint PhD studentship

Diamond Light Source

2012-2015

£23,346

Principal investigator

Diagnosis of lung cancer through breath analysis

Breath of Life Charity

2012-2013

£8,400

Principal investigator

3D imaging for radiotherapy planning

The Dott Griffiths Fund

2011-2012

£17,332

Principal investigator

The application of the Selected Ion Flow-Mass Spectrometry (SIFT-MS) in the management of lung cancer

Keele Acorn Studentship

Selected Publications

  • Butcher JB, Rutter AV, Wootton AJ, Day CR, Sule-Suso J. 2017. Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer. In F. Chao, S. Schockaert & Q. Zhang (Eds.). Proceedings of the 17th Annual UK Workshop on Computational Intelligence (vol. 650, pp. 183-190). Springer.
  • Shestivska V, Rutter AV, Sulé-Suso J, Smith D, Španěl P. 2017. Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace. Rapid Commun Mass Spectrom, vol. 31(16), 1344-1352. link> doi>
  • Siddique MR, Rutter AV, Wehbe K, Cinque G, Bellisola G, Sulé-Suso J. 2017. Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning. Analyst, vol. 142(8), 1299-1307. link> doi>
  • Yousef I, Seksek O, Gil S, Prezado Y, Sulé-Suso J, Martínez-Rovira I. 2016. Study of the biochemical effects induced by X-ray irradiations in combination with gadolinium nanoparticles in F98 glioma cells: first FTIR studies at the Emira laboratory of the SESAME synchrotron. The Analyst, vol. 141(7), 2238-2249. doi> link>
  • Sule-Suso J, Finney S, Bisson J, Hammersley S, Jassel S, Knight R, Hicks C, Sargeant S, Lam K-P, Belcher J, Collins D, Bhana R, Adab F, O'Donovan C, Moloney A. 2015. Pilot study on virtual imaging for patient information on radiotherapy planning and delivery. Radiography. doi>

Full Publications List show

Journal Articles

  • Shestivska V, Rutter AV, Sulé-Suso J, Smith D, Španěl P. 2017. Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace. Rapid Commun Mass Spectrom, vol. 31(16), 1344-1352. link> doi>
  • Siddique MR, Rutter AV, Wehbe K, Cinque G, Bellisola G, Sulé-Suso J. 2017. Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning. Analyst, vol. 142(8), 1299-1307. link> doi>
  • Yousef I, Seksek O, Gil S, Prezado Y, Sulé-Suso J, Martínez-Rovira I. 2016. Study of the biochemical effects induced by X-ray irradiations in combination with gadolinium nanoparticles in F98 glioma cells: first FTIR studies at the Emira laboratory of the SESAME synchrotron. The Analyst, vol. 141(7), 2238-2249. doi> link>
  • Sule-Suso J, Finney S, Bisson J, Hammersley S, Jassel S, Knight R, Hicks C, Sargeant S, Lam K-P, Belcher J, Collins D, Bhana R, Adab F, O'Donovan C, Moloney A. 2015. Pilot study on virtual imaging for patient information on radiotherapy planning and delivery. Radiography. doi>
  • Byrne H, Baranska M, Puppels GJ, Stone N, Wood B, Gough KM, Lasch P, Heraud P, Sule-Suso J, Sockalingum GD. 2015. Spectropathology for the next generation: Quo vadis?. Analyst, vol. 140(7), 2066-2073. doi>
  • Guilbert M, Eklouh-Molinier C, Wehbe K, Sulé-Suso J, Yang Y, Cinque G, Jeannesson P, Sockalingum GD. 2014. Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. J Biomed Opt, vol. 19(11), 111612. link> doi>
  • Baker MJ, Trevisan J, Bassan P, Bhargava R, Butler HJ, Dorling KM, Fielden PR, Fogarty SW, Fullwood NJ, Heys KA, Hughes C, Lasch P, Martin-Hirsch PL, Obinaju B, Sockalingum GD, Sulé-Suso J, Strong RJ, Walsh MJ, Wood BR, Gardner P, Martin FL. 2014. Using Fourier transform IR spectroscopy to analyze biological materials. Nat Protoc, vol. 9(8), 1771-1791. link> doi>
  • Rutter AV, Siddique MR, Filik J, Sandt C, Dumas P, Cinque G, Sockalingum GD, Yang Y, Sulé-Suso J. 2014. Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry A, vol. 85(8), 688-697. link> doi>
  • Sulé-Suso J, Forsyth NR, Untereiner V, Sockalingum GD. 2014. Vibrational spectroscopy in stem cell characterisation: is there a niche?. Trends Biotechnol, vol. 32(5), 254-262. link> doi>
  • Lam KP, Collins DJ, Sule-Suso J, Bhana R, Moloney A. 2013. On evaluation of a multiscale-based CT image analysis and visualisation algorithm. 2013 6th International Conference on Biomedical Engineering and Informatics, 148-153. doi>
  • Wilson SL, Guilbert M, Sulé-Suso J, Torbet J, Jeannesson P, Sockalingum GD, Yang Y. 2014. A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response. FASEB J, vol. 28(1), 14-25. link> doi>
  • Pijanka JK, Stone N, Rutter AV, Forsyth N, Sockalingum GD, Yang Y, Sulé-Suso J. 2013. Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation. Analyst, vol. 138(17), 5052-5058. link> doi>
  • Rutter AV, Chippendale TWE, Yang Y, Španěl P, Smith D, Sulé-Suso J. 2013. Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, vol. 138(1), 91-95. link> doi>
  • Sule-Suso J, Dessombz, A, Bazin, D, Dumas, P, Sandt, C, Daudon, M. 2011. Shedding Light on the Chemical Diversity of Ectopic Calcifications in Kidney Tissues: Diagnostic and Research Aspects. PLoS One, vol. 6(11). doi>
  • Aydin HM, Hu B, Suso JS, El Haj A, Yang Y. 2011. Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 136(4), 775-780. link> doi>
  • Pijanka JK, Kumar D, Dale T, Yousef I, Parkes G, Untereiner V, Yang Y, Dumas P, Collins D, Manfait M, Sockalingum GD, Forsyth NR, Sulé-Suso J. 2010. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells. Analyst, vol. 135(12), 3126-3132. link> doi>
  • Smith D, Spanêl P, Sulé-Suso J. 2010. Advantages of breath testing for the early diagnosis of lung cancer. Expert Rev Mol Diagn, vol. 10(3), 255-257. link> doi>
  • Pijanka J, Sockalingum GD, Kohler A, Yang Y, Draux F, Parkes G, Lam K-P, Collins D, Dumas P, Sandt C, van Pittius DG, Douce G, Manfait M, Untereiner V, Sulé-Suso J. 2010. Synchrotron-based FTIR spectra of stained single cells. Towards a clinical application in pathology. Lab Invest, vol. 90(5), 797-807. link> doi>
  • Sulé-Suso J, Pysanenko A, Spanel P, Smith D. 2009. Quantification of acetaldehyde and carbon dioxide in the headspace of malignant and non-malignant lung cells in vitro by SIFT-MS. Analyst, vol. 134(12), 2419-2425. link> doi>
  • Egot-Lemaire S, Pijanka J, Sulé-Suso J, Semenov S. 2009. Dielectric spectroscopy of normal and malignant human lung cells at ultra-high frequencies. Phys Med Biol, vol. 54(8), 2341-2357. link> doi>
  • Sule-Suso J, Draux, F, Jeannesson, P, Beljebbar, A, Trayli, A, Fourre, N, Manfait, M, Sockalingum, GD. 2008. Raman spectral imaging of single living cancer cells: a preliminary study. Analyst, vol. 134(3), 542-548. doi>
  • Kohler A, Sulé-Suso J, Sockalingum GD, Tobin M, Bahrami F, Yang Y, Pijanka J, Dumas P, Cotte M, van Pittius DG, Parkes G, Martens H. 2008. Estimating and correcting mie scattering in synchrotron-based microscopic fourier transform infrared spectra by extended multiplicative signal correction. Appl Spectrosc, vol. 62(3), 259-266. link> doi>
  • Sule-Suso J, Yang Y, Tobin M, Bahrami F, Sockalingum G, Kohler A, Manfait M, El Haj AJ. 2005. Sensitivity of single, in vitro growing lung cancer cells to gemcitabine measured with synchrotron based fourier transform infrared microspectroscopy. EJC SUPPLEMENTS, vol. 3(2), 51. link>
  • YANG Y, El Haj AJ, Sockalingum GD, Sule-Suso J. 2005. Study of tumor cell invasion by Fourier transform infrared microspectroscopy . Biopolymers, vol. 78(6), 311-317. doi>
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG R. 2004. Monitoring of lung tumour cell growth in artificial membranes. Biosens Bioelectron, vol. 20(3), 442-447. doi>
  • Sulé-Suso J, Forster A, Zholobenko V, Stone N, El Haj A. 2004. Effects of CaCl2 and MgCl2 on Fourier transform infrared spectra of lung cancer cells. Appl Spectrosc, vol. 58(1), 61-67. link> doi>
  • Yang Y, Sule-Suso J, El Haj AJ, Hoban PR, Wang RKK. 2003. Use of OCT to study tumour cell growth in 3D membranes. ALT'03 INTERNATIONAL CONFERENCE ON ADVANCED LASER TECHNOLOGIES: BIOMEDICAL OPTICS, vol. 5486, 154-160. link> doi>
  • Smith D, Wang T, Sule-Suso J, Spanel P, El Haj AJ. 2003. Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Communcations Mass Spectometry, vol. 17(8), 845-850. doi>
  • Sule-Suso J, Zhang S, Yang Y, Forster A, Hand PA, El Haj AJ. 1999. Study of lung cancer cells by Fourier Transform Infrared spectroscopy. THORAX, vol. 54, A83. link>
  • Li WW, Rosa JO, Siddique MR, Bajana B, Sule-Suso J, Richardson A. 2013. Anti-cancer thymoquinone from Nigella sativa. PLANTA MEDICA, vol. 79(13), 1126. link>

Other

  • Butcher JB, Rutter AV, Wootton AJ, Day CR, Sule-Suso J. 2017. Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer. In F. Chao, S. Schockaert & Q. Zhang (Eds.). Proceedings of the 17th Annual UK Workshop on Computational Intelligence (vol. 650, pp. 183-190). Springer.
  • Lam KP, Collins DJ, Sule-Suso J, Bhana R, Moloney A. 2013. On Evaluation of a Multiscale-based CT Image Analysis and Visualisation Algorithm. PROCEEDINGS OF THE 2013 6TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2013), VOLS 1 AND 2 (pp. 148-153). link> doi>
  • Wilson SL, Guilbert M, Sule-Suso J, Torbet J, Jeannesson P, Sockalingum GD, Yang Y. 2012. The effect of collagen ageing on its structure and cellular behaviour. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS IX (vol. 8222). link> doi>
  • Sule-Suso J, Lam KP, Bhana R, Adab F, Sargeant S, Collins D, Patel A, Moloney A. 2011. Three-Dimensional Imaging for Radiotherapy Planning in Prostate Cancer. EUROPEAN JOURNAL OF CANCER (vol. 47, p. S194). link> doi>
  • Pijanka JK, Stone N, Cinque G, Yang Y, Kohler A, Wehbe K, Frogley M, Parkes G, Parkes J, Dumas P, Sandt C, van Pittius DG, Douce G, Sockalingum GD, Sule-Suso J. 2010. FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis. SPECTROSCOPY-AN INTERNATIONAL JOURNAL (vol. 24, pp. 73-78). link> doi>
  • Pijanka JK, Yang Y, Bagnaninchi PO, Debelle L, Sockalingum GD, Sule-Suso J. 2009. Elastin peptides increase lung cancer cell growth in 3D models. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE III (vol. 7179). link> doi>
  • Pijanka JK, Kohler A, Yang Y, Dumas P, Chio-Srichan S, Manfait M, Sockalingum GD, Sulé-Suso J. 2009. Spectroscopic signatures of single, isolated cancer cell nuclei using synchrotron infrared microscopy. Analyst (vol. 134, pp. 1176-1181). link> doi>
  • Egot-Lemaire S, Bagnaninchi P-O, Pijanka J, Sule-Suso J, Semenov S. 2008. Microwave dielectric spectroscopy of low-volume fraction human cancer cells embedded in collagen gels - Experimental feasibility study with an open-ended coaxial probe. BIODEVICES 2008: PROCEEDINGS OF THE FIRST INTERNATIONAL CONFERENCE ON BIOMEDICAL ELECTRONICS AND DEVICES, VOL 2 (pp. 156-+). link>
  • Yang Y, Sule-Suso J, Sockalingum GD. 2008. Study of melanoma invasion by FTIR spectroscopy. IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES VI (vol. 6859). link> doi>
  • Yang Y, Hoban PR, Sule-Suso J, Holley S, El Haj AJ, Bahrami F, Wang RK. 2006. Study cell invasion by optical techniques. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVII (vol. 6084). link> doi>
  • Sule-Suso J, Skingsley D, Sockalingum GD, Kohler A, Kegelaer G, Manfait M, El Haj A. 2005. FT-IR microspectroscopy as a tool to assess lung cancer cells response to chemotherapy. VIBRATIONAL SPECTROSCOPY (vol. 38, pp. 179-184). link> doi>
  • Lam K, Collin, Collins, Sule-Suso. On Evaluation of a Multiscale-based CT Image Analysis and Visualisation Algorithm. Biomedical Engineering and Informatics (BMEI), 2013 6th International Conference on. IEEE. doi>

Education

  • 2003    PhD in Medicine, Institute for Science and Technology in Medicine, Keele University. Thesis: Autologous cell approaches to diagnosis and therapy in oncology.  Date of award: 04-06-2003
  • 1987    Licentiate in Medicine and Surgery, Barcelona, Catalonia.

Employment experience

  • 10/06 – Present Post      Clinical Senior Lecturer, Keele University.
  • 10/04 – 09/06               Clinical Lecturer, Keele University.
  • 11/03 – Present Post      Associate Specialist in Clinical Oncology. University Hospital of North Staffordshire.
  • 06/95 – 11/03                Staff Grade in Clinical Oncology. University Hospital of North Staffordshire.
  • 02/93 – 05/95                Research Fellow. Department of Experimental Oncology “D”, National Cancer Institute, Milan (Italy).
  • 11/88 – 12/92                Senior House Officer. University Hospital of North Staffordshire.

Professional activities

  • Chairman of the Working Group for the Infrared Beamline at DIAMOND synchrotron, Oxfordshire, 2013.
  • Member of the discussion panel: “Microscopy and Imaging in the Synchrotron Light”, organised by the French Embassy in London, at the Royal Society of Medicine, January, 2006
  • Theme leader for the Diagnostics, Proteomics and Imaging theme, Institute for Science and Technology in Medicine, Keele University from January 2013.
  • Member of the Peer Review Committee 5 «Biology-Health» of Soleil, Synchrotron, France. From February, 2012.
  • Expert member of the review panel for SMIS beamline, Soleil Synchrotron, France. October, 2012.
  • Member of the Diamond User committee, 2012-2014.

International advisory board member

  • Spec2014. Shedding new light on disease, Krakow, Poland. August, 2014
  • Spec2012. Shedding new light on disease, Chiang Mai, Thailand. November, 2012.
  • Spec2010, June 2010, Manchester UK, member of the local organising committee.
  • 3rd Diagnostic Applications with Synchrotron Infrared Micro-Spectroscopy Meeting, DASIM-2007. Soleil synchrotron, Paris, France.
  • 4th International Symposium “Shedding Light on Disease: Optical Diagnosis for the New Millennium”. Heidelberg, Germany. June 2006

Examiner

  • External examiner for the PhD thesis: “The development of an infrared method for the characterisation of drug-cell interactions”. The University of Manchester, September 2014.
  • Internal examiner for the PhD thesis: “The aggregation and reduction of iron minerals by the Alzheimer’s disease peptide β-amyloid (1-42): an X-ray absorption study”. Keele University, September, 2014.
  • External examiner for the MSc (by research) thesis: “Investigating the use of Raman spectroscopy as a histopathological tool to identify metastatic brain tumours and their sites of origin”. University of Central Lancaster, Preston, December, 2013.
  • External examiner for the PhD thesis: “Development of a micro fluidic device for single cell analysis using FTIR microscopy”. The University of Manchester, September 2013.
  • External examiner for the PhD thesis: “Metabolic responses to fatty acids studied in vitro by FTIR and NMR spectroscopy”. Århus University, Denmark, October 2011.11.
  • External examiner for the PhD thesis: “Development of Fourier Transform Infrared Spectroscopy for drug response analysis”. The University of Manchester, September 2011.

Invited speaker

  • Does VERT improve patients and relatives treatment satisfaction? 4thInternational VERT User Meeting, LiverpoolUniversity. June 2014.
  • Vibrational Spectroscopy and effects of drugs on cells. Can we identify resistant and sensitive cells in chemotherapy naive populations? Spec2012. Shedding New Light on Disease: optical diagnosis for the new millennium. Chiang Mai, Thailand. November, 2012.
  • Synchrotron based FTIR spectroscopy. Is there a niche in medicine? SOLEIL Users' Meeting Satellite Workshop "Biology and medicine: from fundamental research to diagnosis". Soleil Synchrotron, France, January, 2012.
  • Nanoscale imaging in medicine: is there a niche? CellNano Spec Workshop. Porqueroles, France. September, 2011.

PhD supervision

Application of vibrational spectroscopy in the management of lung cancer. Mr J. K. Pijanka, 2011.

Press interviews

  • “Brightest light in Universe to examine lung cancer cells”, by James Randerson. The Guardian 7th July, 2006.
  • “Research at Diamond Synchrotron”, BBC 10 o’clock News (national news), 11th June, 2010.

Science in school program

 Dr Sulé-Suso has been involved with the British Council in a French program to bring Science to schools since 2010.

Interests

Languages:       Catalan, Spanish, English, Italian, and French.