Dr Jihong Han

Title: Lecturer in Pharmaceutics
Phone: +44 (0)1782 583834
Email: j.han@keele.ac.uk
Location: Institute for Science & Technology in Medicine, School of Pharmacy, Hornbeam Building, Keele University, Staffordshire ST5 5BG United Kingdom
Role: ISTM Research theme: Therapeutics
Lecturer in Pharmaceutics, School of Pharmacy
Contacting me: By e-mail please.
Jihong Han

I joined the School of Pharmacy in 2006. I gained my PhD from Nottingham School of Pharmacy in Oct 2000 and worked as a postdoctoral research fellow in Nottingham and London School of Pharmacy.

My research interests cover formulation and evaluation of colloidal drug delivery systems (including parenteral emulsions and suspensions). I have also worked on the formulation and stability of paediatric formulations. I have used various techniques in my studies, including dynamic light scattering, laser diffraction, single particle optical counting, electrical zone sensing, zeta potential analysis, ultracentrifugation and HPLC.

  • 01/2006 – present   Lecturer in Pharmaceutics, School of Pharmacy, Keele University.
  • 11/2003 –01/2006   Research Fellow, School of Pharmacy, University of London.  
    • Research projects: Evaluation of paediatric formulations in relation to pharmacy practice.
  • 10/2000 – 11/2003   Research Fellow, School of Pharmacy, University of Nottingham. 
    • Research project: physicochemical properties of colloidal drug delivery systems
  • 10/1996 - 9/2000   PhD in Pharmaceutical Sciences, University of Nottingham. 
    • Thesis: Formulation and Evaluation of Intravenous Vitamin E Emulsions for the Delivery of Paclitaxel.
  • 11/1994 - 4/1996   Academic Visitor(with WHO Fellowship), School of Pharmacy, University of Nottingham.
    • Project: to investigate and develop filterable intravenous emulsions (<100nm in diameter).
  • 10/1990-10/1994   Lecturer in Pharmaceutics. Heilongjiang TCMPS University, PR China.
  • 10/1988 -9/1990   Assistant Lecturer in Pharmaceutics, Heilongjiang TCMPS University.

ISTM Research theme: Therapeutics

I have been working on formulation science and drug delivery systems for many years, with strong relation to industrial application. In particular, this covers disperse systems for oral and parenteral applications, including emulsions and suspensions. Fundamental physicochemical principles are applied in the research to solve problems in drug delivery systems.

In my previous post in the Centre for Paediatric Pharmacy Research (the only centre in the UK) at London School of Pharmacy, my work was more closely linked to clinical practice.  I used formulation science to address problems discovered in clinical practice (about unlicensed medicines for children, extemporaneous preparations etc).

My current and future work is on pharmaceutical formulation, initially on disperse systems based on my previous research activities. At the same time, I would like to explore opportunities to collaborate with clinical experts to identify problems in clinical practice which could be addressed using pharmaceutical technology. Later, the research may extend to cover solid oral dosage forms, where my experience on surfactant systems will be useful.

 

Selected Publications

  • Zong L, Li X, Wang H, Cao Y, Yin L, Li M, Wei Z, Chen D, Pu X, Han J. 2017. Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(β-Benzyl-l-aspartate) (PEG-PBLA). Int J Pharm, vol. 531(1), 108-117. link> doi>
  • Guan J, Han J, Zhang D, Chu C, Liu H, Sun J, He Z, Zhang T. 2014. Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO₂ silica dispersion technology. Eur J Pharm Biopharm, vol. 86(3), 376-382. link> doi>
  • Zhang X, Lu S, Han J, Sun S, Wang L, Li Y. 2011. Preparation, characterization and in vivo distribution of solid lipid nanoparticles loaded with syringopicroside. Die Pharmazie, vol. 66(6), 404-407.
  • Xiaohui P, Sun J, Wang Y, Wang Y, Liu X, Zhang P, Tang X, Pan W, Han J, He Z. 2009. Development of a chemically stable 10-hydroxycamptothecin nanosuspension using microprecipotation-high pressure homogenization. International Journal of Pharmaceutics, vol. 379, 167-173.
  • Han J, Washington C, Davis SS. 2007. Design and evaluation of an emulsion vehicle for paclitaxel. II. Suppression of the crystallization of paclitaxel by freeze-drying technique. Drug Dev Ind Pharm, vol. 33(10), 1151-1157. link> doi>

Full Publications List show

Journal Articles

  • Zong L, Li X, Wang H, Cao Y, Yin L, Li M, Wei Z, Chen D, Pu X, Han J. 2017. Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(β-Benzyl-l-aspartate) (PEG-PBLA). Int J Pharm, vol. 531(1), 108-117. link> doi>
  • Guan J, Han J, Zhang D, Chu C, Liu H, Sun J, He Z, Zhang T. 2014. Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO₂ silica dispersion technology. Eur J Pharm Biopharm, vol. 86(3), 376-382. link> doi>
  • Zhang X, Lu S, Han J, Sun S, Wang L, Li Y. 2011. Preparation, characterization and in vivo distribution of solid lipid nanoparticles loaded with syringopicroside. Die Pharmazie, vol. 66(6), 404-407.
  • Xiaohui P, Sun J, Wang Y, Wang Y, Liu X, Zhang P, Tang X, Pan W, Han J, He Z. 2009. Development of a chemically stable 10-hydroxycamptothecin nanosuspension using microprecipotation-high pressure homogenization. International Journal of Pharmaceutics, vol. 379, 167-173.
  • Han J, Washington C, Davis SS. 2007. Design and evaluation of an emulsion vehicle for paclitaxel. II. Suppression of the crystallization of paclitaxel by freeze-drying technique. Drug Dev Ind Pharm, vol. 33(10), 1151-1157. link> doi>
  • Han J, Beeton A, Long PF, Wong I, Tuleu C. 2006. Physical and microbiological stability of an extemporaneous tacrolimus suspension for paediatric use. J Clin Pharm Ther, vol. 31(2), 167-172. link> doi>
  • Han J, Wang L, Su D. A study of the chemical stability of FT-207 intravenous fat emulsion by HPLC method. Journal of Shenyang Pharmaceutical University, vol. 3(10), 171-175.
  • Zhao N, Liu X, Sun Y, Wang Y, Pu X, Qin Y, Han J, Sun J, He Z. Factors affecting particle size of an intravenous fat emulsions. Asian Journal of Pharmaceutical Sciences, vol. 5(4), 161-167.
  • Han J and Su D. Physical properties of an anticancer drug FT-207 fat emulsion. Journal of Shenyang Pharmaceutical University, vol. 1(8), 14-17.
  • Ning X, Wu Y, Han X, Yan Z, Han J, He Z, Sun J. Strategies to improve dissolution and oral absorption of glimepiride tablets: solid dispersion versus micronization techniques (2011). Drug Development and Industrial Pharmacy, vol. 37, 727-736. doi>
  • Han J and Su D. The properties of the interface between soybean oil and water. Chinese Pharmaceutical Journal, vol. 9(26), 539-542.

Other

  • Panayiotis P, Han J, Davis SS. 2006. Advances in the use of tocols as drug delivery vehicles.
  • Long PF, Han J, Tuleu C, Wong I. 2006. Microbiological Tests on Oral Pediatric Medicines-Requirements for an Improved Pharmacopoeia Monograph.
  • Karimova A, Robertson A, Cross N, Smith L, O'Callaghan M, Tuleu C, Long P, Beeton A, Han J, Ridout D, Goldman A, Brown K. 2005. A wet-primed extracorporeal membrane oxygenation circuit with hollow-fiber membrane oxygenator maintains adequate function for use during cardiopulmonary resusitation after two weeks on standby.
  • Han J, Wong I, Tuleu C. 2005. Extemporaneous tacrolimus suspensions.
  • Tuleu C, Han J, Bingen C, Hardyal G, Shah J, Cope J. 2005. 'In use' stability testing of paediatric CIV AS pre-filled syringes of morphine sulphate in glucose.
  • Han J and Washington C. 2005. Partition of antimicrobial additives in an intraveneous emulsion and their effect on emulsion physical stability. doi>
  • Han J and Tuleu C. 2005. Stability of a sugar-free sidenafil suspension under simulated user sonditions. Neonatal and Paediatric Pharmacists Group Conference.
  • Han J, Melia CD, Washington C. 2004. A concentric cylinder shear device for the study of stability in intraveneous emulsions. doi>
  • Bistrussu S, Beeton A, Castaldo G, Han J, Wong I, Tuleu C, Long P, Brown K, Cross N, Cope J, Goldman AP, Karimova A, O'Callaghan M, Robertson A, Smith L. 2004. Are extracorporeal membrane oxygenation (ECMO) circuits stored 'wet-primed' a likely source of infection?.
  • Han J, Davis SS, Melia CD, Washington C. 2004. Design and evaluation of an emulsion vehicle for paclitaxel. I. Physicochemical properties.
  • Han J, Beeton A, Long P, Karimova A, Robertson A, Cross N, Smith L, O'Callaghan M, Goldman A, Brown K, Tuleu C. 2004. Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits.
  • Han J, Davis SS, Wash. 2001. Physical properties and stability of two emulsion formulations of propofol. doi>
  • Han J, Davis SS, Washington C. 2000. Comparative physical stability of propofol with EDTA versus sulfite-containing propofol.
  • Han J and Washington C. Adsorption of two model proteins on to emulsions droplets.
  • Davis SS and Han J. Taxol emulsion.

Research grants:

  • Ian Wong, Glennis S Haworth, Catherine Peckham, Nigel Klein, Catherine Tuleu, Macey Murray, Vincent Yeung, Jihong Han (participants from Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London).  : Task Force in Europe for Drug Development for the Young – Network of Excellence in Europe.  (486,000 Euro out of the 2 million Euro for the total network. A networking fund, not research grant).  The first official network in Europe involving, multi-centre in different countries in Europe, approved by European Commission. (2006).
  • Dr Catherine Tuleu, Dr Jihong Han, Mr Ian Costello, Dr Paul Long, Dr Ian Wong. Tacrolimus Oral Paediatric Preparation Evaluation Research 2 (TOPPER 2). A grant (60.5 K) awarded by Fujisawa (UK) Ltd.  December 2004 to December 2005.
  • A WHO Fellowship for research training in the UK (1994 -1996).
  • A full University Overseas Studentship, University of Nottingham (1996 – 2000).
  • 1990 -1994, a research grant (Chinese Yuan, 20k) from Zhaodong Pharmaceutical Ltd., PR China to develop a herbal product, covering manufacturing technique, physicochemical characterization and quality control.

Patent:

Davis, S. S. and Han, J. (1999). Taxol emulsion, PCT WO 99/04787.


Conferences:

Han, J., Wong, I. Tuleu, C. (Oral presentation).  Extemporaneous tacrolimus suspensions.
3rd International Workshop on Paediatric Clinical Trials.
Organised by Paediatric and Perinatal Drug Therapy and The Association of Clinical Research Professionals.
11th & 12th July 2005, Catalis Centre, Derby, UK

Han, J. and Tuleu, C. (Poster presentation). Stability study of a sugar-free sildenafil suspension under simulated user conditions.
Neonatal and Paediatric Pharmacists Group Conference 2005
28-30 October 2005.  Europa Hotel, Belfast, UK 

Tuleu C., Han J., Bingen C., Hardyal G., Shah J., Cope J. (Poster presentation). ‘In use’ stability testing of paediatric CIVAS pre-filled syringes of morphine sulphate in glucose.
Neonatal and Paediatric Pharmacists Group Conference 2005
28-30 October 2005.  Europa Hotel, Belfast, UK