Professor James B Richardson

Title: Professor of Orthopaedic and Traumatic Surgery
Phone: +44 (0) 01691 404386 (Personal Assistant is Janet Morris)
Email: Janet.Morris@rjah.nhs.uk
Location: Institute for Science and Technology in Medicine, Keele University /
The Robert Jones and Agnes Hunt Orthopaedic Hospital

Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, United Kingdom
Role: ISTM Research theme: Regenerative Medicine
Contacting me: Please contact Janet Morris
Prof James Richardson

Prof James Richardson is one of the team of researchers in the Arthritis Research UK Tissue Engineering Centre, a collaboration between scientists and clinicians at the universities of Aberdeen, Cambridge, Keele, Newcastle and York, and the Robert Jones & Agnes Hunt Orthopaedic Hospital. 

ISTM Research theme: Regenerative Medicine

Research Interests:

Surgical Management of Early Arthritis. This has two arms:

1. Bone conservation in joint replacement, and
2. Tissue Engineering with a long term goal of developing a biological joint replacement. 

An image of human cartilage cells (chondrocytes) in tissue culture, where the cells adhere to the culture surface and start to proliferate  

An image of human cartilage cells (chondrocytes) in tissue culture, where the cells adhere to the culture surface and start to proliferate

Principal external research grants:


Medical Research Council trial grant 
Cartilage Repair by Autologous Chondrocyte Transplantation (ACTIVE)
£759,622 (1 January 2004 for 12 years) Trial No:  ISRCTN 48911177 (Alpha A Band)

European Commission Framework Programme project grant
European Partnership for Autologous Chondrocyte Cell Implantation (EUROCELL)
658,962 Euros (1 February 2001 for 3 years) (in collaboration with European partners) 

Arthritis Research Campaign grant (N Goodstone, J Richardson)
A novel approach for characterising repair cartilage following human autologous chondrocyte implantation (ACI)
£93,231 (April 2004 for 2 years)   ARC grant ref: 16181

Arthritis Research Campaign grant (S Roberts, B Caterson, J Richardson, G Edwards)
Biomarker patterns of degenerative joint disease
£187,396 (1 May 2006 for 3 years)   ARC grant ref:  17540

European Commission Framework Programme 6 project grant
Growing a New Joint in a Human Back (MYJOINT)
£386,106 (1 January 2007 for 3 years)   Partnership between Keele UK and Kiel Germany)
 

Selected Publications

  • Garcia J, Mennan C, McCarthy HS, Roberts S, Richardson JB, Wright KT. 2016. Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem Cells Int, vol. 2016, 6969726. link> doi>
  • Toh WS, Brittberg M, Farr J, Foldager C, Gomoll A, Hoi Po Hui J, Richardson JB, Roberts S, Spector M. 2016. Cellular senescence in aging and osteoarthritis: Implications for cartilage repair. Acta Orthopaedica, vol. 87. doi> link>
  • Dugard MN, Kuiper JH, Parker J, Roberts S, Robinson E, Harrison P, Richardson JB. 2017. Development of a Tool to Predict Outcome of Autologous Chondrocyte Implantation. Cartilage, vol. 8(2), 119-130. link> doi>
  • Bhattacharjee A, McCarthy HS, Tins B, Roberts S, Kuiper JH, Harrison PE, Richardson JB. 2016. Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. Am J Sports Med, vol. 44(5), 1249-1259. link> doi>
  • Khan M, Kuiper JH, Sieniawska C, Richardson JB. 2016. Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty. J Orthop, vol. 13(4), 450-454. link> doi>

Full Publications List show

Journal Articles

  • Garcia J, Mennan C, McCarthy HS, Roberts S, Richardson JB, Wright KT. 2016. Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem Cells Int, vol. 2016, 6969726. link> doi>
  • Toh WS, Brittberg M, Farr J, Foldager C, Gomoll A, Hoi Po Hui J, Richardson JB, Roberts S, Spector M. 2016. Cellular senescence in aging and osteoarthritis: Implications for cartilage repair. Acta Orthopaedica, vol. 87. doi> link>
  • Dugard MN, Kuiper JH, Parker J, Roberts S, Robinson E, Harrison P, Richardson JB. 2017. Development of a Tool to Predict Outcome of Autologous Chondrocyte Implantation. Cartilage, vol. 8(2), 119-130. link> doi>
  • Bhattacharjee A, McCarthy HS, Tins B, Roberts S, Kuiper JH, Harrison PE, Richardson JB. 2016. Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. Am J Sports Med, vol. 44(5), 1249-1259. link> doi>
  • Khan M, Kuiper JH, Sieniawska C, Richardson JB. 2016. Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty. J Orthop, vol. 13(4), 450-454. link> doi>
  • Wright KT, Mennan C, Fox H, Richardson JB, Banerjee R, Roberts S. 2013. Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regen Med, vol. 8(6), 699-709. link> doi>
  • Mennan C, Wright K, Bhattacharjee A, Balain B, Richardson J, Roberts S. 2013. Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. Biomed Res Int, vol. 2013, 916136. link> doi>
  • Hanifi A, Richardson JB, Kuiper JH, Roberts S, Pleshko N. 2012. Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis Cartilage, vol. 20(9), 988-996. link> doi>
  • Johansson A, Kuiper J-H, Sundqvist T, Persson F, Speier C, D'Alfonso D, Richardson JB, Öberg Å. 2012. Spectroscopic measurement of cartilage thickness in arthroscopy: ex vivo validation in human knee condyles. Arthroscopy, vol. 28(10), 1513-1523. link> doi>
  • Jaiswal A, Gilbert RE, Sunil Kumar KH, Carrothers AD, Kuiper J-H, Richardson JB. 2011. Function and survival after revision of hip resurfacing. Hip Int, vol. 21(5), 610-615. link> doi>
  • Carrothers AD, Gilbert RE, Richardson JB. 2011. Birmingham hip resurfacing in patients who are seventy years of age or older. Hip Int, vol. 21(2), 217-224. link> doi>
  • Kay A, Richardson J, Forsyth NR. 2011. Physiological normoxia and chondrogenic potential of chondrocytes. Front Biosci (Elite Ed), vol. 3, 1365-1374. link>
  • Carrothers AD, Gilbert RE, Jaiswal A, Richardson JB. 2010. Birmingham hip resurfacing: the prevalence of failure. J Bone Joint Surg Br, vol. 92(10), 1344-1350. link> doi>
  • Gilbert RE, Cheung G, Carrothers AD, Meyer C, Richardson JB. 2010. Functional results of isolated femoral revision of hip resurfacing arthroplasty. J Bone Joint Surg Am, vol. 92(7), 1600-1604. link> doi>
  • Aulakh TS, Kuiper JH, Dixey J, Richardson JB. 2011. Hip resurfacing for rheumatoid arthritis: independent assessment of 11-year results from an international register. Int Orthop, vol. 35(6), 803-808. link> doi>
  • Bhosale AM, Kuiper JH, Johnson WEB, Harrison PE, Richardson JB. 2009. Midterm to long-term longitudinal outcome of autologous chondrocyte implantation in the knee joint: a multilevel analysis. Am J Sports Med, vol. 37 Suppl 1, 131S-138S. link> doi>
  • Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WEB. 2009. Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone, vol. 45(4), 726-735. link> doi>
  • Roberts S, Menage J, Sandell LJ, Evans EH, Richardson JB. 2009. Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. Knee, vol. 16(5), 398-404. link> doi>
  • Aulakh TS, Rao C, Kuiper J-H, Richardson JB. 2010. Hip resurfacing and osteonecrosis: results from an independent hip resurfacing register. Arch Orthop Trauma Surg, vol. 130(7), 841-845. link> doi>
  • Caesar BC, Morgan-Jones RL, Warren RE, Wade RH, Roberts PJ, Richardson JB. 2009. Closed double-lumen suction irrigation in the management of chronic diaphyseal osteomyelitis: long-term follow-up. J Bone Joint Surg Br, vol. 91(9), 1243-1248. link> doi>
  • Aulakh TS, Jayasekera N, Kuiper J-H, Richardson JB. 2009. Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty. Biomaterials, vol. 30(9), 1732-1738. link> doi>
  • Smith HJ, Richardson JB, Tennant A. 2009. Modification and validation of the Lysholm Knee Scale to assess articular cartilage damage. Osteoarthritis Cartilage, vol. 17(1), 53-58. link> doi>
  • Khan M, Kuiper J-H, Richardson JB. 2008. The exercise-related rise in plasma cobalt levels after metal-on-metal hip resurfacing arthroplasty. J Bone Joint Surg Br, vol. 90(9), 1152-1157. link> doi>
  • Gokhale S, Khan M, Kuiper J-H, Richardson JB, Davies JP. 2008. An arthroscopic hip documentation form. Arthroscopy, vol. 24(7), 839-842. link> doi>
  • Bajada S, Mazakova I, Richardson JB, Ashammakhi N. 2008. Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med, vol. 2(4), 169-183. link> doi>
  • Bhosale AM and Richardson JB. 2008. Articular cartilage: structure, injuries and review of management. Br Med Bull, vol. 87, 77-95. link> doi>
  • Khan M, Kuiper JH, Richardson JB. 2007. Can cobalt levels estimate in-vivo wear of metal-on-metal bearings used in hip arthroplasty?. Proc Inst Mech Eng H, vol. 221(8), 929-942. link> doi>
  • Bhosale AM, Myint P, Roberts S, Menage J, Harrison P, Ashton B, Smith T, McCall I, Richardson JB. 2007. Combined autologous chondrocyte implantation and allogenic meniscus transplantation: a biological knee replacement. Knee, vol. 14(5), 361-368. link> doi>
  • Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, Richardson JB. 2007. Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br, vol. 89(10), 1382-1386. link> doi>
  • Sharma A, Wood LD, Richardson JB, Roberts S, Kuiper NJ. 2007. Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage. Arthritis Res Ther, vol. 9(4), R79. link> doi>
  • RICHARDSON JB, Garcia-Aznar JM, Gomez-Benito MJ, Kuiper JH. 2006. Computational simulation of fracture healing: Influence of interfragmentary movement on the callus growth . Journal of Biomechanics, vol. 40(7), 1467-1476. doi>
  • RICHARDSON JB, Khan M, Kuiper JH, Takahashi T. 2006. Current in vivo wear of metal-on-metal bearings assessed by exercise-related rise in plasma cobalt level. Journal of Orthopaedic Research, vol. 24(11), 1657. doi>
  • Gupta A, Bhosale A, Balbouzis T, Smith HJ, Richardson JB. 2006. Cartilage transplantation. Br J Hosp Med (Lond), vol. 67(6), 286-289. link> doi>
  • Takahashi T, Tins B, McCall IW, Richardson JB, Takagi K, Ashton K. 2006. MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome. Skeletal Radiol, vol. 35(1), 16-26. link> doi>
  • RICHARDSON JB, Smith GD, Taylor J, Almqvist KF, Erggelet C, Knutsen G, Carcia Portabello M, Smith T. 2005. Arthroscopic Assessment of Cartilage Repair: A Validation Study of 2 Scoring Systems. Athroscopy, vol. 21(12), 1462-1467.
  • Saweeres ESB, Kuiper JH, Evans RO, Richardson JB, White SH. 2005. Predicting in vivo clinical performance of anterior cruciate ligament fixation methods from in vitro analysis: industrial tests of fatigue life and tolerance limits are more useful than other cyclic loading parameters. Am J Sports Med, vol. 33(5), 666-673. link> doi>
  • RICHARDSON JB, Knutsen G, Smith GD. 2005. A clinical review of cartilage repair techniques. Journal of Bone and Joint Surgery, vol. 87-B(4), 445-449. doi>
  • Gokhale S, Soliman A, Dantas JP, Richardson JB, Cook F, Kuiper J-H, Jones P. 2005. Variables affecting initial stability of impaction grafting for hip revision. Clin Orthop Relat Res, 174-180. link>
  • RICHARDSON JB, McCall IW, Takahashi T, Tins B. 2005. Autologous Chondrocyte Implantation in Knee Joint: MR Imaging and Histologic Features at 1-year Follow-up. Radiology, vol. 234(2), 501-508. doi>
  • RICHARDSON JB, Whittaker JP, Smith G, Makwana N, Laing P, Roberts S, Harrison PE. 2005. Early results of autologous chondrocyte implantation in the talus. journal of Bone & Joint Surgery, vol. 87B(2), 179-183. doi>
  • RICHARDSON JB, Metcalfe J, Banaszkiewicz P, Kapoor B, Jones CW, Kuiper J. 2005. Unexpected long femur in adults with acetabular dysplasia. Acta Orthop Belg, vol. 71(4), 424-428.
  • RICHARDSON JB, Navadgi BC, Cassar-Pullicino VN, Wade RH. 2004. A corrective osteotomy for post-traumatic malrotation and shortening of the femur. Injruy, vol. 35(12), 1248-1254. doi>
  • Tselentakis G, Kitano M, Owen PJ, Kuiper JH, Richardson JB, Evans GA. 2003. The behaviour of the periosteum during callotasis. J Pediatr Orthop B, vol. 12(4), 277-283. link> doi>
  • Harrison PE, Pfeifer PM, Turner SL, Richardson JB, Jones PW, Ashton BA. 2003. Serum from patients anesthetized with opiates less effective in the support of chondrocyte growth in vitro. Tissue Engineering, vol. 9(1), 37-39. doi>
  • RICHARDSON JB, Smith G, Brittberg M, Erggelet C, Verdonk R, Knutsen G, Ashton BA, Ashton IK, Harrison P. 2003. Autologous chondrocyte implantation and osteochrondral cylinder transplantation in cartilage repair of the knee joint. The Journal of Bone and Joint Surgery, vol. 85, 185-192.
  • ROBERTS S, Darby AJ, McCall IW, Menage J. 2002. Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Research & Therapy, vol. 5(1), R60-R73. doi>
  • Bailey A, Goodstone N, Roberts S, Hughes J, Roberts S, Van Niekerk L, Richardson J, Rees D. 2003. Rehabilitation after Oswestry autologous chondrocyte implantation: the OsCell protocol. Journal of Sports Rehabilitation.
  • Bailey A, Goodstone NJ, Roberts S, Hughes J, Van Niekerk L, Richardson J, Rees D. 2003. Rehabilitation after Oswestry Autologous Chondrocyte Implantation: The OsCell Protocol. Journal of Sports Rehabiliation.
  • RICHARDSON JB, Tselentakis G, Kitano M, Owen PJ, Kuiper JH, Evans GA. 2003. The behaviour of the periosteum during callotasis. Journal of Pediatric Orthopaedics, vol. 12B(4), 277-283.
  • Gargiulo BJ, Cragg P, Richardson JB, Ashton BA, Johnson WE. 2002. Phenotypic modulation of human articular chondrocytes by bistratene A. Eur Cell Mater, vol. 3, 9-18. link>
  • RICHARDSON JB and Taylor J. 2002. The current state of cartilage transplantation. Hospital Medicine, vol. 63(1), 6-7.
  • Roberts S, Hollander AP, Caterson B, Menage J, Richardson JB. 2001. Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation. Arthritis Rheum, vol. 44(11), 2586-2598. link> doi>
  • Tselentakis G, Owen PJ, Richardson JB, Kuiper JH, Haddaway MJ, Dwyer JS, Evans GA. 2001. Fracture stiffness in callotasis determined by dual-energy X-ray absorptiometry scanning. J Pediatr Orthop B, vol. 10(3), 248-254. link> doi>
  • RICHARDSON JB, Tselentakis F, Owen PJ, Kuiper JH, Haddaway MJ, Dwyer JS, Evans GA. 2001. Fracture Stiffness in Callotasis determined by dual-energy X-ray Absorptiometry Scanning. Journal of Pediatric Orthopaedics, vol. 10(3), 248-254.
  • Wade R and Richardson J. 2001. Outcome in fracture healing: a review. Injury, vol. 32(2), 109-114. link> doi>
  • RICHARDSON JB. 2001. Fracture Healing. Surgery, vol. 19(8), 201-208.
  • Harrison PE, Ashton IK, Johnson WE, Turner SL, Richardson JB, Ashton BA. 2000. The in vitro growth of human chondrocytes. Cell Tissue Bank, vol. 1(4), 255-260. link> doi>
  • Cool P, Morgan-Jones RL, Oliver CW, Richardson JB. 1999. The audit of orthopaedic trainee teaching improves supervision rates. Ann R Coll Surg Engl, vol. 81(3), 195-197. link>
  • Ong BN, Jordan K, Richardson J, Croft P. 1999. Experiencing limiting long-standing illness. HEALTH & SOCIAL CARE IN THE COMMUNITY, vol. 7(1), 61-68. link>
  • Morgan-Jones RL, Wade R, Richardson JB. 1998. The motivation to learn: efficacy and relevance of the Oswestry postgraduate orthopaedic training programme. Ann R Coll Surg Engl, vol. 80(4), 271-273. link>
  • Morgan-Jones RL, Burgert S, Richardson JB. 1998. Arthroscopic debridement of external fixator pin tracts. Injury, vol. 29(1), 41-42. link> doi>
  • el-Hage ZM, Mohammed A, Griffiths D, Richardson JB. 1998. Tibial plateau fracture following allograft anterior cruciate ligament (ACL) reconstruction. Injury, vol. 29(1), 73-74. link> doi>
  • Richardson JB, Kenwright J, Cunningham JL. 1992. Fracture stiffness measurement in the assessment and management of tibial fractures. Clin Biomech (Bristol, Avon), vol. 7(2), 75-79. link> doi>
  • Ryd L, Brittberg M, Eriksson K, Jurvelin JS, Lindahl A, Marlovits S, Möller P, Richardson JB, Steinwachs M, Zenobi-Wong M. 2015. Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity. Cartilage, vol. 6(3), 156-165. link> doi>

Chapters

  • RICHARDSON JB, Kuiper JK, Soliman A, Cheah K. 2004. Stability of impaction-grafted hip and knee prostheses: surgical technique, impant design, and graft compaction. In Impaction Bone Grafting in Revision Arthroplasty. Editor CD and Bannister GC (Eds.). Informa HealthCare.

Other

  • Wright K, Richardson JB, Fuller H, Humphrey E, Jones P, Kerr A, Roberts S. 2013. Biomarker discovery for autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, p. A46). link>
  • Mennan C, Bhattacharjee A, Wright K, Roberts S, Richardson JB. 2013. Isolation and characterization of mesenchymal stem cells from different regions of the human umbilical cord. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, pp. A34-A35). link>
  • Roberts S, Richardson J, Menage J, Evans EH, Jones A, Flannery C. 2008. Lubricin in biopsies of autologous chondrocyte implantation-treated patients. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A22-A23). link>
  • Sharma A, Wood LD, Richardson JB, Roberts S, Kuiper NJ. 2008. The glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differs from control cartilage. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, p. A23). link>
  • Sharma A, Richardson JB, Roberts S, Goodstone N. 2007. Differences in glycosaminoglycan profiles in autologous chondrocyte implantation repair tissue and age-matched cadaveric cartilage. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 88, pp. A61-A62). link>
  • Bajada S, Harrison P, Kuiper JH, Balbouzis T, Ashton BA, Cassar PV, Ashammakhi N, Richardson JB. 2007. Clinical trial of bone marrow stromal stem cell implantation for refractory fracture non-union: Results from the first patients. TISSUE ENGINEERING (vol. 13, p. 1657). link>
  • Hazlehurst ZV, Kitano M, Kuiper JH, Richardson JB, Ashton BA. 1998. The effect of fluid shear stress on osteoblast precursor cells. Biochem Soc Trans (vol. 26, p. S24). link> doi>

Current external appointments:

 Editorial Board of Hip International
• Arthritis Research Campaign Research Board
• Action Medical Research
• Board Member of International Cartilage Repair Society
• Medical Research Council - College of Experts
• Scientific Advisory Board (SAB) for Tissue Engineering, Singapore (1 June 2005 – 31 May 2008)
• Director - Institute of Orthopaedics
• Clinical Director of Oscell: cell production unit at Oswestry