Dr Gordon Dent

Title: Senior Lecturer in Pharmacology
Phone: +44 (0)1782 734652
Email: g.dent@keele.ac.uk
Location: School of Medicine
Role: ISTM Research theme: Therapeutics
Director of Admissions (Undergraduate Medicine); Academic Co-Lead for MBChB Module 2 (Integrated Clinical pathology I)
Contacting me: Come to School of Medicine Reception or arrange an appointment by e-mail.
gordon dent

Having completed a BSc in Pharmacology at the University of London in 1985, Gordon undertook a part-time PhD at the National Heart & Lung Institute from 1986 to 1991, investigating the receptor- and enzyme-mediated pharmacological regulation of eosinophil activity. In 1991 he moved to the Großhansdorf Institute for Pneumology and Thoracic Surgery in Germany, where he continued to work on the pharmacology and cell biology of leukocytes (eosinophils, neutrophils and macrophages) and respiratory epithelium. He returned to the UK in 1998, taking up a post as Research Fellow – and later Senior Research Fellow – in the Infection, Inflammation & Repair research division at the University of Southampton School of Medicine. Here, he studied the roles of T-lymphocyte, eosinophil and neutrophil chemoattractants in airway secretions in asthma and chronic obstructive pulmonary disease.

Gordon moved to Keele in August 2003 as a Lecturer in Pharmacology in the School of Medicine, also undertaking teaching in the Schools of Pharmacy and Life Sciences. He was promoted to Senior Lecturer in 2008.

ISTM Research theme: Therapeutics

Gordon's research focuses on the roles of leukocytes and epithelium in inflammatory diseases of the lungs (asthma and COPD) and intestine (ulcerative colitis). He has a particular interest in intracellular signalling pathways in leukocytes and the mechanisms of cell-cell interactions between epithelial cells and leukocytes.

Gordon is also active in the filed of undergraduate medicine admissions, engaging in regional and national groups exploring policies and procedures.

Selected Publications

  • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, vol. 38(5), 443-455. link> doi>
  • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, vol. 219(10), 793-797. link> doi>
  • Dent G. 2014. Eosinophil chemotaxis. Methods Mol Biol, vol. 1178, 101-110. link> doi>
  • Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. 2010. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol, vol. 10(9), 1017-1021. link> doi>
  • Yoshikawa T, Dent G, Ward J, Angco G, Nong G, Nomura N, Hirata K, Djukanovic R. 2007. Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 175(5), 473-479. link> doi>

Full Publications List show

Journal Articles

  • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, vol. 38(5), 443-455. link> doi>
  • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, vol. 219(10), 793-797. link> doi>
  • Dent G. 2014. Eosinophil chemotaxis. Methods Mol Biol, vol. 1178, 101-110. link> doi>
  • Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. 2010. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol, vol. 10(9), 1017-1021. link> doi>
  • Yoshikawa T, Dent G, Ward J, Angco G, Nong G, Nomura N, Hirata K, Djukanovic R. 2007. Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 175(5), 473-479. link> doi>
  • Mishra RK, Scaife JE, Harb Z, Gray BC, Djukanovic R, Dent G. 2005. Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). ALLERGY, vol. 60(9), 1204-1207. link> doi>
  • Dent G, Hadjicharalambous C, Yoshikawa T, Handy R L C, Powell J, Anderson I K, Louis R, Davies D E, Djukanovic R. 2004. Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum. Amercian Journal of Respiratory & Crictical Care Medicine. doi>
  • Hadjicharalambous C, Dent G, May R, Handy R, Anderson I, Davies D, Djukanovic R. 2004. Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma. Journal of Allergy & Clinical Immunology.
  • Dent G. 2003. IgE modulation in asthma. Expert Opinion on Therapeutic Patents, vol. 13(10), 1607-1617.
  • Dent G. 2002. Ciclesonide. Curr Opin Invest Drugs, vol. 3, 78-83.
  • Dent G, Hosking LA, Lordan JL, Steel MD, Cruikshank WW, Center DM, Ellis JH, Holgate ST, Davies DE, Djukanovic R. 2002. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthamatic individuals. J Allergy Clin Immunol, vol. 110, 906-914.
  • Schmidt DT, Dent G, Ruhlmann E, Munoz NM, Leff AR, Rabe KF. 2002. Studying human airway pharmacology in microsections: application of videomicrometry. Eur Respir, vol. 19, 991-996.
  • Dent G. 2001. Protein Kinase A-independent responses to beta-adrenoceptor agonists. Br J Pharmacol, vol. 133, 1199-1200.
  • Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. 2001. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol, vol. 25, 385-391.
  • Lordan JL, Davies DE, Wilson SJ, Dent G, Corkhill A, Jaffar Z, Roberts K, Djukanovic R, Holgate ST. 2001. The role of CD28-B7 costimulation in allergen-induced cytokine release in bronchial mucosa from patients with moderately severe asthma. J Allergy Clin Immunol, vol. 108, 976-981.
  • Hasan AM and Dent G. Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology. doi>

Chapters

  • DENT G. 2006. Airway Inflammation. In The Year in Allergy. (vol. 3). Clinical Publishing, Oxford.
  • Haitchi H M, Krishna M T, Holloway J H, Dent G, Buckley M G, Holgate S T. 2004. Asthma: clinical aspects and mucosal immunity. In Mucosal Immunology (3rd Edition). Mestecky J, Beinenstock J, Lamm M, Strober W, McGhee J, Mayer L (Eds.). Academic Press, San Diego.
  • DENT G, Holgate ST, Buckley MG. Asthma. In Principles of Molecular Medicine. Runge MS and Patterson C (Eds.). Humana Press.

Other

  • Dent G. 2004. BLT-1 leukotriene receptor.
  • Dent G. 2004. BLT-2 leukotriene receptor.
  • Dent G. 2004. CysLT-1 leukotriene receptor.
  • Dent G. 2004. CysLT-2 leukotriene receptor.
  • Dent G, Uddin M, Puddicombe SM, Davies E D, Djukanovic R. 2004. Eosinophils stimulate the secretion of neutrophil chemoattracants by bronichal epithelial cells. European Respiratory Journal.
  • Uddin M, Rytila P, Dent G, Davies D E, Djukanovic R. 2004. Modulation of neutrophil activation and survival by bronchial epithelial cells. European Respiratory Journal.
  • MBChB           Year Leader: Year 2 (Module 2 - Integrated Clinical Pathology I)

  • MBChB           Pharmacology, Physiology and Pathophysiology teaching across years 1, 2 & 3

  • PHA 20009     Pharmacy Level 2

  • PHA 30010     Pharmacy Level 3

  • LSC 10024     Ethical Issues in the Biosciences

  • LSC 30015     Biology of Disease