Dr Derek L Mattey

Title: Reader in Rheumatology
Phone: +44 (0)1782 673813
Email: d.l.mattey@keele.ac.uk
derek.mattey@uhns.nhs.uk
Location: Address 1: Staffordshire Rheumatology Centre, Haywood Hospital, Burslem, Stoke-on-Trent, ST6 7AG, United Kingdom
Address 2: Institute for Science & Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB United Kingdom
Role: ISTM Research theme: Diagnostic Engineering & Proteomics
Contacting me: By E-mail please.
Dr Derek Mattey

I have been head of the research laboratory at the Staffordshire Rheumatology Centre (SRC) at the Haywood Hospital since 1989, and have been responsible for initiating and developing the current research programme This includes; studies on the role of genetic factors and gene-environment interactions in rheumatoid arthritis (RA); identification of diagnostic/prognostic markers for inflammatory arthritis, and studies on synovial fibroblast and T cell biology. The unit is well recognised for work on markers of disease outcome in RA.

The main objective of my research is to enable a better understanding of disease mechanisms involved in the development and progression of RA and other inflammatory joint diseases such as ankylosing spondylitis. Research on genetic factors which influence disease susceptibility, severity and drug responses will continue to expand, and increased effort will be focused on identifying how interactions between genes and environmental factors influence the disease phenotype. Our work will also include studies on the role of epigenetic mechanisms in the pathogenesis of RA.

We have established at the SRC a well characterised resource of patient material for studying inflammatory joint diseases, and developed close liaison between laboratory and clinical research, together with a network of national and international collaborators. We have also published regularly in top rheumatology and scientific journals. In particular, I have helped to provide better understanding of the role of gene polymorphisms (e.g. HLA, TNF, TGFβ1, MMP-3, GSTs, MnSOD, etc) in the development and severity of RA. We were the first group to show that genetic factors associated with RA are also associated with increased risk of early mortality in RA patients. We also provided the first evidence that genetic factors modulate the association of smoking with RA severity, and were the first to show that smoking attenuates the response of RA patients to some of the new biologic agents. We are currently using Luminex technology to investigate the profiles of multiple cytokines, matrix metalloproteinases and adhesion molecules in smokers and non-smokers with RA.  

I have had the privilege of presenting talks and posters at major national and international rheumatology conferences (London, Manchester, Birmingham, Glasgow, Amsterdam,Nice, Brussels, Washington, San Diego, San Francisco, San Antonio), and had over 2,500 citations of my research papers. 

ISTM Research theme: Diagnostic Engineering & Proteomics 

My main research interests are:

  1. influence of genetic factors on development and severity of rheumatoid arthritis
  2. predictors of co-morbid disease and survival in RA
  3. gene-environment interactions in rheumatic diseases
  4. biomarker profiling in inflammatory arthritis
  5. role of epigenetic factors in RA.

The equipment and facilities we use include Luminex suspension array technology for biomarker analysis, ELISA, immunofluorescence microscopy, PCR, cell culture, FACS analysis. Our research group consists of a senior scientist, postdoctoral researcher, 2 PhD students, 2 research technicians and 2 research nurses.

TGFß1 induced expression of a smooth muscle actin in RA synovial fibroblasts  

TGFß1 induced expression of a smooth muscle actin in RA synovial fibroblasts 
Haywood_Foundation_logo_192x72  

Selected Publications

  • Chen Y, Yu Z, Packham JC, Mattey DL. 2013. Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability. PLoS One, vol. 8(5), e64862. link> doi>
  • Mattey DL, Nixon NB, Dawes PT. 2012. Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Res Ther, vol. 14(5), R204. link> doi>
  • Mattey DL, Packham JC, Nixon NB, Coates L, Creamer P, Hailwood S, Taylor GJ, Bhalla AK. 2012. Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Res Ther, vol. 14(3), R127. link> doi>
  • Chen Y, Dawes PT, Packham JC, Mattey DL. 2012. Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther, vol. 14(2), R81. link> doi>
  • Chen Y, Dawes PT, Mattey DL. 2012. Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking. Cytokine, vol. 58(3), 390-397. link> doi>

Full Publications List show

Journal Articles

  • Murphy D, Mattey D, Hutchinson D. 2017. Anti-citrullinated protein antibody positive rheumatoid arthritis is primarily determined by rheumatoid factor titre and the shared epitope rather than smoking per se. PLoS One, vol. 12(7), e0180655. link> doi>
  • Rump L, Mattey DL, Kehoe O, Middleton J. 2017. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, vol. 97, 133-140. link> doi>
  • Bhalla AK, Bhalla AS, Coates LC, Packham JC, Creamer P, Hailwood S, Chakravarty K, Mulherin D, Taylor G, Mattey DL. 2017. Reply to comment on: Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. Clin Exp Rheumatol, vol. 35(3), 549. link>
  • Glossop JR, Nixon NB, Emes RD, Sim J, Packham JC, Mattey DL, Farrell WE, Fryer AA. 2017. DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. EPIGENOMICS, vol. 9(4), 419-428. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Sim J, Packham JC, Mattey DL, Farrell WE, Fryer AA. 2017. DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, vol. 9(4), 419-428. link> doi>
  • Rump LJ, Mattey DL, Middleton J, Kehoe O. 2016. Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue. Open Journal of Rheumatology and Autoimmune Diseases, vol. 2016(6), 74-78. doi> link>
  • Glossop JR, Emes RD, Nixon NB, Packham JC, Fryer AA, Mattey DL, Farrell WE. 2016. Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes. Epigenomics, vol. 8(2), 209-224. link> doi>
  • Glossop JR, Haworth KE, Emes RD, Nixon NB, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2015. DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, vol. 7(4), 539-551. link> doi>
  • Kerr JR and Mattey DL. 2015. The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia. Reviews in medical virology. doi>
  • Ellerby N, Mattey DL, Packham J, Dawes P, Hider SL. 2014. Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis. Ann Rheum Dis, vol. 73(11), e74. link> doi>
  • Glossop JR, Emes RD, Nixon NB, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2014. Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics, vol. 9(9), 1228-1237. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2013. Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals. Epigenetics, vol. 8(11), 1188-1197. link> doi>
  • Dawes PT, Ryan S, Jorsh M, Mattey DL. 2013. Biology of subjectivity in chronic diseases. Rheumatology (Oxford), vol. 52(10), 1733-1734. link> doi>
  • Chen Y, Yu Z, Packham JC, Mattey DL. 2013. Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability. PLoS One, vol. 8(5), e64862. link> doi>
  • Mattey DL, Nixon NB, Dawes PT. 2012. Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Res Ther, vol. 14(5), R204. link> doi>
  • Chen Y and Mattey DL. 2012. Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes. Clin Exp Rheumatol, vol. 30(6), 894-898. link>
  • Mattey DL, Packham JC, Nixon NB, Coates L, Creamer P, Hailwood S, Taylor GJ, Bhalla AK. 2012. Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Res Ther, vol. 14(3), R127. link> doi>
  • Yu Z, Tan BK, Dainty S, Mattey DL, Davies SJ. 2012. Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients. Nephrol Dial Transplant, vol. 27(12), 4437-4445. link> doi>
  • Chen Y, Dawes PT, Packham JC, Mattey DL. 2012. Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther, vol. 14(2), R81. link> doi>
  • Chen Y, Dawes PT, Mattey DL. 2012. Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking. Cytokine, vol. 58(3), 390-397. link> doi>
  • Mattey DL, Dawson SR, Healey EL, Packham JC. 2011. Relationship between smoking and patient-reported measures of disease outcome in ankylosing spondylitis. J Rheumatol, vol. 38(12), 2608-2615. link> doi>
  • Glossop JR, Dawes PT, Mattey DL. 2011. Antinuclear antibodies are associated with tumor necrosis factor receptor I gene polymorphism in patients with rheumatoid arthritis. Clin Exp Rheumatol, vol. 29(4), 609-615. link>
  • Chen Y, Nixon NB, Dawes PT, Mattey DL. 2012. Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis. Genes Immun, vol. 13(1), 29-37. link> doi>
  • Chen Y, Dawes PT, Packham JC, Mattey DL. 2011. Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis. J Rheumatol, vol. 38(5), 802-809. link> doi>
  • Kapoor SR, Hider SL, Brownfield A, Mattey DL, Packham JC. 2011. Fibromyalgia in patients with rheumatoid arthritis: driven by depression or joint damage?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol. 29(6), S88-S91. link>
  • Mattey DL, Dawes PT, Hassell AB, Brownfield A, Packham JC. 2010. Effect of psychological distress on continuation of anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. J Rheumatol, vol. 37(10), 2021-2024. link> doi>
  • Mattey DL, Brownfield A, Dawes PT. 2010. Irish Smokers with Rheumatoid Arthritis Suffer More Than Their Nonsmoking Counterparts reply. JOURNAL OF RHEUMATOLOGY, vol. 37(5), 1063. link> doi>
  • Zhang L, Gough J, Christmas D, Mattey DL, Richards SCM, Main J, Enlander D, Honeybourne D, Ayres JG, Nutt DJ, Kerr JR. 2010. Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Pathol, vol. 63(2), 156-164. link> doi>
  • Croft L, Bartlett JD, MacLaren DPM, Reilly T, Evans L, Mattey DL, Nixon NB, Drust B, Morton JP. 2009. High-intensity interval training attenuates the exercise-induced increase in plasma IL-6 in response to acute exercise. Appl Physiol Nutr Metab, vol. 34(6), 1098-1107. link> doi>
  • Hider SL, Tanveer W, Brownfield A, Mattey DL, Packham JC. 2009. Depression in RA patients treated with anti-TNF is common and under-recognized in the rheumatology clinic. Rheumatology (Oxford), vol. 48(9), 1152-1154. link> doi>
  • Mattey DL, Brownfield A, Dawes PT. 2009. Relationship between pack-year history of smoking and response to tumor necrosis factor antagonists in patients with rheumatoid arthritis. J Rheumatol, vol. 36(6), 1180-1187. link> doi>
  • Pratt AG, Isaacs JD, Mattey DL. 2009. Current concepts in the pathogenesis of early rheumatoid arthritis. Best Pract Res Clin Rheumatol, vol. 23(1), 37-48. link> doi>
  • Kerr JR, Burke B, Petty R, Gough J, Fear D, Mattey DL, Axford JS, Dalgleish AG, Nutt DJ. 2008. Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes. J Clin Pathol, vol. 61(6), 730-739. link> doi>
  • Kerr JR and Mattey DL. 2008. Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection. Clin Infect Dis, vol. 46(9), e83-e87. link> doi>
  • Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SCM, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. 2008. Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis. J Infect Dis, vol. 197(8), 1171-1184. link> doi>
  • Wild N, Karl J, Grunert VP, Schmitt RI, Garczarek U, Krause F, Hasler F, van Riel PLCM, Bayer PM, Thun M, Mattey DL, Sharif M, Zolg W. 2008. Diagnosis of rheumatoid arthritis: multivariate analysis of biomarkers. Biomarkers, vol. 13(1), 88-105. link> doi>
  • Mattey DL, Glossop JR, Nixon NB, Dawes PT. 2007. Circulating levels of tumor necrosis factor receptors are highly predictive of mortality in patients with rheumatoid arthritis. Arthritis Rheum, vol. 56(12), 3940-3948. link> doi>
  • Mattey DL, Thomson W, Ollier WER, Batley M, Davies PG, Gough AK, Devlin J, Prouse P, James DW, Williams PL, Dixey J, Winfield J, Cox NL, Koduri G, Young A. 2007. Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. Arthritis Rheum, vol. 56(5), 1408-1416. link> doi>
  • Glossop JR, Dawes PT, Mattey DL. 2006. Association between cigarette smoking and release of tumour necrosis factor alpha and its soluble receptors by peripheral blood mononuclear cells in patients with rheumatoid arthritis. Rheumatology (Oxford), vol. 45(10), 1223-1229. link> doi>
  • Mattey DL and Hutchinson D. 2005. Smoking and HLA-DR shared epitope alleles in rheumatoid arthritis: comment on the article by Padyukov et al. Arthritis Rheum, vol. 52(11), 3675-3676. link> doi>
  • Glossop JR, Dawes PT, Hassell AB, Mattey DL. 2005. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. J Rheumatol, vol. 32(9), 1673-1678. link>
  • Smith J, Fritz EL, Kerr JR, Cleare AJ, Wessely S, Mattey DL. 2005. Association of chronic fatigue syndrome with human leucocyte antigen class II alleles. J Clin Pathol, vol. 58(8), 860-863. link> doi>
  • Mattey DL, Nixon N, Dawes PT, Kerr J. 2005. Association of polymorphism in the transforming growth factor {beta}1 gene with disease outcome and mortality in rheumatoid arthritis. Ann Rheum Dis, vol. 64(8), 1190-1194. link> doi>
  • Glossop JR, Dawes PT, Nixon NB, Mattey DL. 2005. Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. Arthritis Res Ther, vol. 7(6), R1227-R1234. link> doi>
  • Shah P, Griffith SM, Shadforth MF, Fisher J, Dawes PT, Poulton KV, Thomson W, Ollier WER, Mattey DL. 2004. Can gold therapy be used more safely in rheumatoid arthritis? Adverse drug reactions are more likely in patients with nodular disease, independent of HLA-DR3 status. J Rheumatol, vol. 31(10), 1903-1905. link>
  • Kerr JR, Cunniffe VS, Kelleher P, Coats AJS, Mattey DL. 2004. Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis. J Med Virol, vol. 74(1), 147-155. link> doi>
  • Mattey DL, Dawes PT, Nixon NB, Goh L, Banks MJ, Kitas GD. 2004. Increased levels of antibodies to cytokeratin 18 in patients with rheumatoid arthritis and ischaemic heart disease. Ann Rheum Dis, vol. 63(4), 420-425. link> doi>
  • Mattey DL, Nixon NB, Dawes PT, Ollier WER, Hajeer AH. 2004. Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis. Genes Immun, vol. 5(2), 147-149. link> doi>
  • Kerr JR, McCoy M, Burke B, Mattey DL, Pravica V, Hutchinson IV. 2003. Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection. J Clin Pathol, vol. 56(10), 725-727. link> doi>
  • Glossop JR, Nixon NB, Dawes PT, Hassell AB, Mattey DL. 2003. No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis. J Rheumatol, vol. 30(7), 1406-1409. link>
  • Gonzalez-Juanatey C, Testa A, Garcia-Castelo A, Garcia-Porrua C, Llorca J, Vidan J, Hajeer AH, Ollier WE, Mattey DL, Gonzalez-Gay MA. 2003. HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis. Am J Med, vol. 114(8), 647-652. link> doi>
  • Glossop JR, Nixon NB, Dawes PT, Hassell AB, Mattey DL. 2003. ASSOCIATION OF POLYMORPHISM IN EXON 1 OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPER FAMILY 1A GENE WITH HAEMOGLOBIN LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY, vol. 42, 84. link>
  • Shah P, Mattey DL, Dawes PT, Hassell AB, Shadforth MF, Griffiths SM, Poulton KV, Fisher J. 2003. CLINICAL PREDICTORS OF ADVERSE DRUG REACTIONS TO GOLD AND D-PENICILLAMINE IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY, vol. 42, 96. link>
  • Kinder AJ, Mattey DL, Brownfield A, Dawes PT. 2003. IS THERE A LINK BETWEEN MICROSCOPIC HAEMATURIA AND IGA LEVELS IN RHEUMATOID ARTHRITIS?. RHEUMATOLOGY, vol. 42, 47. link>
  • Badcock LJ, Clarke S, Jones PW, Dawes PT, Mattey DL. 2003. Abnormal IgA levels in patients with rheumatoid arthritis. Annals of the rheumatic diseases, vol. 62(1), 83-84. doi>
  • Mattey DL, Dawes PT, Fisher J, Brownfield A, Thomson W, Hajeer AH, Ollier WER. 2002. Nodular disease in rheumatoid arthritis: association with cigarette smoking and HLA-DRB1/TNF gene interaction. J Rheumatol, vol. 29(11), 2313-2318. link>
  • Kerr JR, Mattey DL, Thomson W, Poulton KV, Ollier WER. 2002. Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles. J Infect Dis, vol. 186(4), 447-452. link> doi>
  • Mattey DL, Dawes PT, Clarke S, Fisher J, Brownfield A, Thomson W, Hajeer AH, Ollier WER. 2002. Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis. Arthritis Rheum, vol. 47(4), 403-407. link> doi>
  • Chehata JC, Jones PW, Mattey DL, Dawes PT. 2002. Re: Chehata et al. Mortality in rheumatoid arthritis: relationship to single and composite measures of disease activity - Reply. RHEUMATOLOGY, vol. 41(6), 701A. link>
  • Hutchinson D, O'Leary C, Nixon NB, Mattey DL. 2002. Serum complexes of immunoglobulin A-alpha1 proteinase inhibitor in rheumatoid arthritis: association with current cigarette smoking and disease activity. Clin Exp Rheumatol, vol. 20(3), 387-391. link>
  • Kerr JR, Bracewell J, Laing I, Mattey DL, Bernstein RM, Bruce IN, Tyrrell DAJ. 2002. Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. J Rheumatol, vol. 29(3), 595-602. link>
  • Gonzalez-Gay MA, Hajeer AH, Dababneh A, Garcia-Porrua C, Mattey DL, Amoli MM, Thomson W, Ollier WER. 2002. IL-6 promoter polymorphism at position -174 modulates the phenotypic expression of polymyalgia rheumatica in biopsy-proven giant cell arteritis. Clin Exp Rheumatol, vol. 20(2), 179-184. link>
  • Amoli MM, Shelley E, Mattey DL, Garcia-Porrua C, Thomson W, Hajeer AH, Ollier WER, Gonzalez-Gay MA. 2002. Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica. J Rheumatol, vol. 29(3), 502-504. link>
  • González-Gay MA, Hajeer AH, García-Porrúa C, Dababneh A, Thomson W, Ollier WER, Mattey DL. 2002. Patients chosen for treatment with cyclosporine because of severe rheumatoid arthritis are more likely to carry HLA-DRB1 shared epitope alleles, and have earlier disease onset. J Rheumatol, vol. 29(2), 271-275. link>
  • Chehata JC, Jones PW, Mattey DL, Dawes PT. 2002. Mortality in rheumatoid arthritis: relationship to single and composite measures of disease activity - reply. Rheumatology. doi>
  • Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Jones PW, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC. 2002. Smoking and disease severity in rheumatoid arthritis. Association with polymorphism at the gluatathione S-transferase (GST) M1 locus. Arthritis Rheum. doi>
  • Johnson AH, Hassell AB, Jones PW, Mattey DL, Saklatvala J, Dawes PT. 2002. The Mechanical joint score: a new clinical index of joint damage in rheumatoid arthritis. Rheumatology. doi>
  • Kerr JR, Barah F, Mattey DL, Laing I, Hopkins SJ, Hutchinson IV, Tyrrell DA. 2001. Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue. J Gen Virol, vol. 82(Pt 12), 3011-3019. link> doi>
  • Mattey DL, Gonzalez-Gay MA, Garcia-Porrua C, Thomson W, Hajeer AH, Ollier WE. 2001. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. Clin Exp Rheumatol, vol. 19(6), 703-708. link>
  • Chehata JC, Mattey DL, Jones PW, Dawes PT. 2001. Predictors of cardiovascular and neoplastic mortality in patients with rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, vol. 44(9), S53. link>
  • Mattey DL, Hassell AB, Dawes PT, Cheung NT, Poulton KV, Thomson W, Hajeer AH, Ollier WE. 2001. Independent association of rheumatoid factor and the HLA-DRB1 shared epitope with radiographic outcome in rheumatoid arthritis. Arthritis Rheum, vol. 44(7), 1529-1533. link> doi>
  • Amoli MM, Shelley E, Mattey DL, Garcia-Porrua C, Thomson W, Hajeer AH, Ollier WE, Gonzalez-Gay MA. 2001. Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis. J Rheumatol, vol. 28(7), 1600-1604. link>
  • Basu S, Whiteman M, Mattey DL, Halliwell B. 2001. Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases. Ann Rheum Dis, vol. 60(6), 627-631. link> doi>
  • Amoli MM, Mattey DL, Calviño MC, Garcia-Porrua C, Thomson W, Hajeer AH, Ollier WE, Gonzalez-Gay MA. 2001. Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch-Schönlein purpura. J Rheumatol, vol. 28(5), 1014-1018. link>
  • Mattey DL, Dawes PT, Gonzalez-Gay MA, Garcia-Porrua C, Thomson W, Hajeer AH, Ollier WE. 2001. HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis. J Rheumatol, vol. 28(2), 232-239. link>
  • Mattey DL, González-Gay MA, Hajeer AH, Dababneh A, Thomson W, García-Porrúa C, Ollier WE. 2000. Association between HLA-DRB1*15 and secondary Sjögren's syndrome in patients with rheumatoid arthritis. J Rheumatol, vol. 27(11), 2611-2616. link>
  • Mattey DL, Dawes PT, Cheung NT. 2000. Serum matrix metalloproteinase 3 as a predictor of joint destruction in rheumatoid arthritis: comment on the article by Yamanaka et al. Arthritis Rheum, vol. 43(11), 2614-2615. link> doi>
  • Chehata JC, Hassell AB, Clarke SA, Mattey DL, Jones MA, Jones PW, Dawes PT. 2000. Mortality in rheumatoid arthritis: Predictors of death and relationship to disease activity. ARTHRITIS AND RHEUMATISM, vol. 43(9), S183. link>
  • Mattey DL, Hajeer AH, Dababneh A, Thomson W, González-Gay MA, García-Porrúa C, Ollier WE. 2000. Association of giant cell arteritis and polymyalgia rheumatica with different tumor necrosis factor microsatellite polymorphisms. Arthritis Rheum, vol. 43(8), 1749-1755. link> doi>
  • Evans E, Dawes PT, Mattey DL. 2000. An unusual case of adult varicella-associated arthritis. Rheumatology (Oxford), vol. 39(7), 806-808. link> doi>
  • Hajeer AH, Dababneh A, Makki RF, Thomson W, Poulton K, González-Gay MA, García-Porrúa C, Mattey DL, Ollier WE. 2000. Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients. Tissue Antigens, vol. 55(4), 319-325. link> doi>
  • Cheung NT, Dawes PT, Poulton KV, Ollier WE, Taylor DJ, Mattey DL. 2000. High serum levels of pro-matrix metalloproteinase-3 are associated with greater radiographic damage and the presence of the shared epitope in patients with rheumatoid arthritis. J Rheumatol, vol. 27(4), 882-887. link>
  • Mattey DL, Hassell AB, Dawes PT, Jones PW, Yengi L, Alldersea J, Strange RC, Fryer AA. 2000. Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: evidence for interaction with glutathione S-transferase genes. Arthritis Rheum, vol. 43(4), 859-864. link> doi>
  • Salih AM, Nixon NB, Dawes PT, Mattey DL. 2000. Antibodies to neuroblastoma cells in rheumatoid arthritis: a potential marker for neuropathy. Clin Exp Rheumatol, vol. 18(1), 23-30. link>
  • Mattey DL, Hassell AB, Dawes PT, Ollier WE, Hajeer A. 1999. Interaction between tumor necrosis factor microsatellite polymorphisms and the HLA-DRB1 shared epitope in rheumatoid arthritis: influence on disease outcome. Arthritis Rheum, vol. 42(12), 2698-2704. link> doi>
  • Mattey DL, Hassell AB, Plant MJ, Cheung NT, Dawes PT, Jones PW, Thomson W, Poulton KV, Hajeer AH, Ollier WE. 1999. The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis. Rheumatology (Oxford), vol. 38(12), 1221-1227. link> doi>
  • Mattey DL, Dawes PT, Cheung NT. 1999. Circulating levels of matrix metalloproteinases in rheumatic diseases. J Rheumatol, vol. 26(10), 2281-2282. link>
  • Mattey DL, Hassell AB, Plant M, Dawes PT, Ollier WR, Jones PW, Fryer AA, Alldersea JE, Strange RC. 1999. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Ann Rheum Dis, vol. 58(3), 164-168. link> doi>
  • Salih AM, Nixon NB, Dawes PT, Mattey DL. 1999. Soluble adhesion molecules and anti-endothelial cell antibodies in patients with rheumatoid arthritis complicated by peripheral neuropathy. J Rheumatol, vol. 26(3), 551-555. link>
  • Scott LJ, Russell GI, Nixon NB, Dawes PT, Mattey DL. 1999. Oxidation of alpha1-proteinase inhibitor by the myeloperoxidase-hydrogen peroxidase system promotes binding to immunoglobulin A. Biochem Biophys Res Commun, vol. 255(3), 562-567. link> doi>
  • Layton MA, Jones PW, Alldersea JE, Strange RC, Fryer AA, Dawes PT, Mattey DL. 1999. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology (Oxford), vol. 38(1), 43-47. link> doi>
  • Salih AM, Nixon NB, Dawes PT, Mattey DL. 1998. Prevalence of antibodies to neurofilament polypeptides in patients with rheumatoid arthritis complicated by peripheral neuropathy. Clin Exp Rheumatol, vol. 16(6), 689-694. link>
  • Cheung NT, Dawes PT, Poulton KV, Ollier WER, Taylor DJ, Mattey DL. 1998. High levels of serum proMMP-3 are associated with presence of the shared epitope in patients with rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, vol. 41(9), S64. link>
  • Mattey DL, Hassell AB, Plant MJ, Cheung NT, Dawes PT, Poulton KV, Thomson W. 1998. HLA-DRB1 alleles carrying the DERAA motif are associated with less severe radiological outcome in rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, vol. 41(9), S61. link>
  • Scott LJ, Evans EL, Dawes PT, Russell GI, Mattey DL. 1998. Comparison of IgA-alpha1-antitrypsin levels in rheumatoid arthritis and seronegative oligoarthritis: complex formation is not associated with inflammation per se. Br J Rheumatol, vol. 37(4), 398-404. link>
  • Poulton KV, Griffith SM, Thomson W, Mattey D, Fisher J, Clarke S, Dawes PT, Ollier WER. 1997. Adverse drug reactions in patients with rheumatoid arthritis and HLA-DR3. ARTHRITIS AND RHEUMATISM, vol. 40(9), 391. link>
  • Close DR, Dawes PT, Scott LJ, Mattey DL. 1997. Alpha-1-antitrypsin and the rheumatoid complex of alpha-1-antitrypsin-IgA block transferrin receptors and may contribute to anaemia in rheumatoid disease. ARTHRITIS AND RHEUMATISM, vol. 40(9), 1326. link>
  • Mattey DL, Hassell AB, Plant MJ, Davis MJ, Dawes PT, Ollier WER, Jones PW, Fryer AA, Alldersea J, Strange RC. 1997. Association of radiological outcome in RA with polymorphisms in the glutathione S-transferase supergene family. ARTHRITIS AND RHEUMATISM, vol. 40(9), 1790. link>
  • Mattey DL, Nixon NB, Dawes PT, Scott LJ, Russell GI. 1997. Measurement of IgA-alpha 1-antitrypsin complex in rheumatoid arthritis: a question of specificity?. Ann Rheum Dis, vol. 56(7), 439-440. link> doi>
  • Mattey DL, Dawes PT, Nixon NB, Slater H. 1997. Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor. Ann Rheum Dis, vol. 56(7), 426-431. link> doi>
  • Scott LJ, Dawes PT, Mattey DL. 1997. Comparison of IgA-alpha 1-antitrypsin levels in rheumatoid and reactive arthritis. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 25(2), S370. link>
  • Scott LJ, Dawes PT, Mattey DL. 1997. Comparison of IgA-alpha 1-antitrypsin levels in rheumatoid and reactive arthritis. Biochem Soc Trans, vol. 25(2), 370S. link> doi>
  • Mattey DL. 1997. Interleukin-4 induces myofibroblast differentiation in synovial fibroblasts. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 25(2), S290. link> doi>
  • Mattey DL. 1997. Interleukin-4 induces myofibroblast differentiation is synovial fibroblasts. Biochem Soc Trans, vol. 25(2), 290S. link>
  • Wilkinson SM, Higgins B, Owen S, Mattey DL, Woodcock A. 1997. An assessment of steroid hypersensitivity in asthma. Respir Med, vol. 91(4), 231-233. link> doi>
  • Mattey DL, Scott LJ, Dawes PT, Nixon NB. 1997. Recognition of complement factor H by a monoclonal antibody used for "specifically" measuring IgA-alpha 1 antitrypsin complexes. Clin Exp Rheumatol, vol. 15(1), 117-118. link>
  • HAJEER A, JOHN S, OLLIER WE, SILMAN AJ, DAWES P, HASSALL A, MATTEY D, FRYER AA, STRANGE R, WORTHINGTON J. 1997. Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, vol. 24, 217-219.
  • Scott LJ, Dawes PT, Mattey DL. 1996. Comparison of IgA-alpha 1-antitrypsin levels in RA and reactive arthritis. IMMUNOLOGY, vol. 89, OG386. link>
  • Mattey DL. 1996. IL-4 induces myofibroblast differentiation in synovial fibroblasts. IMMUNOLOGY, vol. 89, OZ259. link>
  • Salih AM, Nixon NB, Dawes PT, Mattey DL. 1996. A 65 kD neuroblastoma cell antigen is predictive of peripheral neuropathy in rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, vol. 39(9), 1277. link>
  • Cheung NT, Taylor DJ, Clarke S, Fisher J, Jones PW, Mattey DL, Dawes PT. 1996. Effect of 6 months treatment on serum stromelysin and collagenase levels in rheumatoid arthritis (RA) patients. ARTHRITIS AND RHEUMATISM, vol. 39(9), 1529. link>
  • Salih AM, Nixon NB, Dawes PT, Mattey DL. 1996. The significance of autoantibodies to peripheral nerve antigens in rheumatoid neuropathy. ARTHRITIS AND RHEUMATISM, vol. 39(9), 1278. link>
  • Salih AM, Nixon NB, Gagan RM, Heath P, Hawkins CP, Dawes PT, Mattey DL. 1996. Anti-ganglioside antibodies in patients with rheumatoid arthritis complicated by peripheral neuropathy. Br J Rheumatol, vol. 35(8), 725-731. link> doi>
  • Cheung NT, Mattey DL, Dawes PT, Taylor DJ. 1996. Serum pro-matrix metalloproteinase 3 in rheumatoid arthritis: a reflection of local or systemic inflammation?. Arthritis Rheum, vol. 39(5), 884-886. link> doi>
  • CHEUNG NT, WISEMAN M, ROLFE P, JONES PW, TAYLOR DJ, MATTEY DL, DAWES PT. 1995. CYCLICAL PRESSURE AND PROMETALLOPROTEINASE-3 RELEASE FROM HUMAN ARTICULAR-CARTILAGE. ARTHRITIS AND RHEUMATISM, vol. 38(9), 959. link>
  • EVANS E, HASSELL A, MATTEY D, GASTON H, DAWES PT. 1995. IS THE CAUSATIVE ORGANISM IN REACTIVE ARTHRITIS CHANGING. ARTHRITIS AND RHEUMATISM, vol. 38(9), 1169. link>
  • PLANT MJ, BORG AA, SAKLATVALA J, CLARKE D, MATTEY D, DAWES PT. 1995. WRIST PREDOMINANCE IN SERONEGATIVE RHEUMATOID-ARTHRITIS - FACT FICTION OR NATURAL-HISTORY. ARTHRITIS AND RHEUMATISM, vol. 38(9), 1061. link>
  • Wilkinson SM, Mattey DL, Beck MH. 1994. IgG antibodies and early intradermal reactions to hydrocortisone in patients with cutaneous delayed-type hypersensitivity to hydrocortisone. Br J Dermatol, vol. 131(4), 495-498. link>
  • Borg AA, Nixon NB, Dawes PT, Mattey DL. 1994. Increased IgA antibodies to cytokeratins in the spondyloarthropathies. Ann Rheum Dis, vol. 53(6), 391-395. link> doi>
  • Mattey DL, Evans E, Dawes PT. 1994. The effects of Tenidap on cytokine induced proliferation of human synovial fibroblasts in vitro. Ann Rheum Dis, vol. 53(4), 250-255. link> doi>
  • Borg AA, Dawes PT, Mattey DL. 1993. Autoantibodies to nuclear lamins and to intermediate filament proteins. J Rheumatol, vol. 20(11), 1988-1990. link>
  • Wilkinson SM, English JS, Mattey DL. 1993. In vitro evidence of delayed-type hypersensitivity to hydrocortisone. Contact Dermatitis, vol. 29(5), 241-245. link> doi>
  • Wilkinson SM, Smith AG, Davis MJ, Mattey DL, Dawes PT. 1993. Suspected cutaneous drug toxicity in rheumatoid arthritis--an evaluation. Br J Rheumatol, vol. 32(9), 798-803. link> doi>
  • Mattey DL, Nixon N, Wynn-Jones C, Dawes PT. 1993. Demonstration of cytokeratin in endothelial cells of the synovial microvasculature in situ and in vitro. Br J Rheumatol, vol. 32(8), 676-682. link> doi>
  • Davies SJ, D'Sousa R, Philips H, Mattey D, Hiley C, Hayes JD, Aber GM, Strange RC. 1993. Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase. Biochim Biophys Acta, vol. 1157(2), 204-208. link> doi>
  • WARDLE TD, MATTEY DL, DAWES PT, STANWORTH DR. 1993. IS IMMUNOGLOBULIN A-ALPHA-1 ANTITRYPSIN COMPLEX PATHOGENIC OR A MARK OF DISEASE-ACTIVITY IN PATIENTS WITH CHRONIC INTESTINAL INFLAMMATION. GASTROENTEROLOGY, vol. 104(4), A798. link>
  • BORG AA, FISHER J, CLARKE S, MATTEY DL, DAWES PT. 1993. IGA ANTIBODIES TO CYTOKERATIN-18 AND MEASURES OF DISEASE-ACTIVITY IN RHEUMATOID-ARTHRITIS. BRITISH JOURNAL OF RHEUMATOLOGY, vol. 32, 9. link>
  • BORG AA, FITZGERALD DA, HEAGARTY AHM, DAWES PT, MATTEY DL. 1993. IGA ANTIBODIES TO CYTOKERATINS AND PATTERNS OF PSORIATIC-ARTHRITIS. BRITISH JOURNAL OF RHEUMATOLOGY, vol. 32, 26. link>
  • Borg AA, Dawes PT, Mattey DL. 1993. Increased levels of IgA antibodies to cytokeratin-18 and epidermal keratin in rheumatoid arthritis. Arthritis Rheum, vol. 36(2), 229-233. link> doi>
  • Mattey DL, Nixon N, Alldersea JE, Cotton W, Fryer AA, Zhao L, Jones P, Strange RC. 1993. Alpha, mu and pi class glutathione S-transferases in human synovium and cultured synovial fibroblasts: effects of interleukin-1 alpha, hydrogen peroxide and inhibition of eicosanoid synthesis. Free Radic Res Commun, vol. 19(3), 159-171. link> doi>
  • BORG AA, DAWES PT, WILKINSON M, MATTEY DL. 1992. ANTIBODIES TO CYTOKERATINS IN PSORIATIC-ARTHRITIS. ARTHRITIS AND RHEUMATISM, vol. 35(9), S297. link>
  • Wilkinson SM, Smith AG, Davis MJ, Mattey D, Dawes PT. 1992. Pityriasis rosea and discoid eczema: dose related reactions to treatment with gold. Ann Rheum Dis, vol. 51(7), 881-884. link> doi>
  • BORG AA, DAWES PT, MATTEY DL. 1992. ANTIBODIES TO CYTOKERATIN-18 IN RHEUMATOID-ARTHRITIS (RA). BRITISH JOURNAL OF RHEUMATOLOGY, vol. 31, 14. link>
  • MATTEY DL, NIXON N, WYNNJONES C, DAWES PT. 1992. DEMONSTRATION OF CYTOKERATIN IN ENDOTHELIAL-CELLS OF THE SYNOVIAL MICROVASCULATURE INSITU AND INVITRO. BRITISH JOURNAL OF RHEUMATOLOGY, vol. 31, 14. link>
  • CLOSE DR, NIXON N, BORG AA, DAWES PT, STANWORTH DR, MATTEY DL. 1992. NATURAL-KILLER (NK) CELL IGG FC-GAMMA-III RECEPTOR (CD16) AND MONOCYTE CD-14 EXPRESSION - CORRELATION WITH IGA-ALPHA-1-ANTI-TRYPSIN (IGA-AAT) IN NORMAL AND RHEUMATOID-ARTHRITIS (RA) SERA. BRITISH JOURNAL OF RHEUMATOLOGY, vol. 31, 43. link>
  • MATTEY DL, EVANS E, DAWES PT. 1992. THE EFFECTS OF TENIDAP AND CYTOKINES ON SYNOVIAL FIBROBLAST PROLIFERATION. BRITISH JOURNAL OF RHEUMATOLOGY, vol. 31, 25. link>
  • Mattey DL, Burdge G, Garrod DR. 1990. Development of desmosomal adhesion between MDCK cells following calcium switching. J Cell Sci, vol. 97 ( Pt 4), 689-704. link>
  • Caldwell CJ, Mattey DL, Weller RO. 1990. Role of the basement membrane in the regeneration of skeletal muscle. Neuropathol Appl Neurobiol, vol. 16(3), 225-238. link> doi>
  • Parrish EP, Marston JE, Mattey DL, Measures HR, Venning R, Garrod DR. 1990. Size heterogeneity, phosphorylation and transmembrane organisation of desmosomal glycoproteins 2 and 3 (desmocollins) in MDCK cells. J Cell Sci, vol. 96 ( Pt 2), 239-248. link>
  • Miller K, Mattey D, Measures H, Hopkins C, Garrod D. 1987. Localisation of the protein and glycoprotein components of bovine nasal epithelial desmosomes by immunoelectron microscopy. EMBO J, vol. 6(4), 885-889. link>
  • MATTEY DL, MEASURES HR, GARROD DR. 1987. CALCIUM-INDUCED DESMOSOME FORMATION IN CULTURED KIDNEY EPITHELIAL-CELLS - DIFFERENCES BETWEEN MDBK AND MDCK CELLS IN THEIR REQUIREMENTS FOR RNA AND PROTEIN-SYNTHESIS. CELL BIOLOGY INTERNATIONAL REPORTS, vol. 11(3), 218. link> doi>
  • Mattey DL, Suhrbier A, Parrish E, Garrod DR. 1987. Recognition, calcium and the control of desmosome formation. Ciba Found Symp, vol. 125, 49-65. link>
  • Mattey DL and Garrod DR. 1986. Calcium-induced desmosome formation in cultured kidney epithelial cells. J Cell Sci, vol. 85, 95-111. link>
  • Mattey DL and Garrod DR. 1986. Splitting and internalization of the desmosomes of cultured kidney epithelial cells by reduction in calcium concentration. J Cell Sci, vol. 85, 113-124. link>
  • Parrish EP, Garrod DR, Mattey DL, Hand L, Steart PV, Weller RO. 1986. Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma. Proc Natl Acad Sci U S A, vol. 83(8), 2657-2661. link> doi>
  • Shellswell GB, Mattey DL, Garrod DR. 1986. Hemidesmosome formation by embryonic chick corneal epithelium in vitro. Tissue Cell, vol. 18(5), 659-666. link> doi>
  • Mattey DL and Garrod DR. 1985. Mutual desmosome formation between all binary combinations of human, bovine, canine, avian and amphibian cells: desmosome formation is not tissue- or species-specific. J Cell Sci, vol. 75, 377-399. link>
  • Watt FM, Mattey DL, Garrod DR. 1984. Calcium-induced reorganization of desmosomal components in cultured human keratinocytes. J Cell Biol, vol. 99(6), 2211-2215. link> doi>
  • Docherty RJ, Edwards JG, Garrod DR, Mattey DL. 1984. Chick embryonic pigmented retina is one of the group of epithelioid tissues that lack cytokeratins and desmosomes and have intermediate filaments composed of vimentin. J Cell Sci, vol. 71, 61-74. link>
  • Cowin P, Mattey D, Garrod D. 1984. Identification of desmosomal surface components (desmocollins) and inhibition of desmosome formation by specific Fab'. J Cell Sci, vol. 70, 41-60. link>
  • Mattey DL and Garrod DR. 1984. Organization of extracellular matrix by chick embryonic corneal epithelial cells in culture and the role of fibronectin in adhesion. J Cell Sci, vol. 67, 171-188. link>
  • Mattey DL and Garrod DR. 1984. Role of glycosaminoglycans and collagen in the development of a fibronectin-rich extracellular matrix in cultured embryonic corneal epithelial cells. J Cell Sci, vol. 67, 189-202. link>
  • Cowin P, Mattey D, Garrod D. 1984. Distribution of desmosomal components in the tissues of vertebrates, studied by fluorescent antibody staining. J Cell Sci, vol. 66, 119-132. link>
  • MATTEY DL, MORGAN M, WRIGHT DE. 1980. A SCANNING ELECTRON-MICROSCOPE STUDY OF THE PSEUDOBRANCHES OF 2 MARINE TELEOSTS. JOURNAL OF FISH BIOLOGY, vol. 16(3), 331-343. link> doi>
  • MATTEY DL, MORGAN M, WRIGHT DE. 1979. DISTRIBUTION AND DEVELOPMENT OF RODLET CELLS IN THE GILLS AND PSEUDOBRANCH OF THE BASS, DICENTRACHUS-LABRAX (L). JOURNAL OF FISH BIOLOGY, vol. 15(3), 363-&. link> doi>
  • MATTEY DL, MOATE R, MORGAN M. 1978. COMPARISON OF PSEUDOBRANCH TYPE AND CHLORIDE TYPE CELLS IN PSEUDOBRANCH OF MARINE, FRESHWATER AND EURYHALINE TELEOSTS. JOURNAL OF FISH BIOLOGY, vol. 13(5), 535-&. link> doi>
  • PASCOE D and MATTEY D. 1977. DIETARY STRESS IN PARASITIZED AND NON-PARASITIZED GASTEROSTEUS-ACULEATUS L. ZEITSCHRIFT FUR PARASITENKUNDE-PARASITOLOGY RESEARCH, vol. 51(2), 179-186. link> doi>
  • PASCOE D and MATTEY DL. 1977. STUDIES ON TOXICITY OF CADMIUM TO 3-SPINED STICKLEBACK GASTEROSTEUS-ACULEATUS L. JOURNAL OF FISH BIOLOGY, vol. 11(2), 207-215. link> doi>
  • Coates L, Packham JC, Creamer P, Hailwood S, Bhalla AS, Chakravarty K, Mulherin D, Taylor G, Mattey DL, Bhalla AK. 2017. Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. Clin Exp Rheumatol, vol. 35(3), 445-451. link>
  • Rump-Goodrich L, Askari A, Mattey D, Middleton J. 2014. Dysregulation of CC Chemokines at Microvascular Endothelial Cells of Blood and Lymphatic Vessels Under Inflammatory Conditions. ARTHRITIS & RHEUMATOLOGY, vol. 66, S861. link>

Chapters

  • Garrod DR, Parrish EP, Mattey DL, Marston JE, Measures HR, Vilela MJ. 1990. Desmosomes. In Morphoregulatory molecules. Edelman GM, Cunningham BA, Thiery J-P (Eds.). Wiley-Interscience.
  • Mattey DL. 1995. Adhesion molecules and rheumatic diseases. In Arthritis Research Campaign Topical Reviews. (vol. 4).

Other

  • Rashid M, Mattey D, Glossop J, Kamath S, Hider S. 2016. HOW COMMON IS CHRONIC KIDNEY DISEASE IN A COHORT OF PATIENTS WITH ESTABLISHED RHEUMATOID ARTHRITIS?. RHEUMATOLOGY (vol. 55, p. 86). link>
  • Hider S, Konstantinou K, Mattey DL, Hay EM. 2015. ARE SERUM BIOMARKER LEVELS ASSOCIATED WITH SCIATICA?. ANNALS OF THE RHEUMATIC DISEASES (vol. 74, p. 629). link> doi>
  • Glossop J, Nixon N, Emes R, Haworth K, Packham J, Dawes P, Fryer A, Mattey D, Farrell W. 2013. Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals. ARTHRITIS AND RHEUMATISM (vol. 65, pp. S798-S799). link>
  • Ellerby N, Mattey DL, Packham J, Dawes P, Hider SL. 2013. COMORBIDITY AND OBESITY ARE INDEPENDENTLY ASSOCIATED WITH FAILURE TO ACHIEVE REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 71). link>
  • Rump-Goodrich L, Mattey D, Kehoe O, Middleton J. 2013. DIFFERENTIAL GENERATION OF CC CHEMOKINES AT MICROVASCULAR ENDOTHELIAL CELLS OF BLOOD AND LYMPHATIC VESSELS UNDER INFLAMMATORY CONDITIONS. RHEUMATOLOGY (vol. 52, pp. 136-137). link>
  • Glossop JR, Nixon NB, Emes RD, Dawes PT, Farrell WE, Mattey DL. 2013. GENOME-WIDE DNA METHYLATION PROFILING IN T CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 143). link>
  • Chen Y, Packham JC, Dawes PT, Mattey DL. 2011. INTERACTION BETWEEN SMOKING AND POLYMORPHISM IN THE VEGF GENE IS ASSOCIATED WITH ISCHAEMIC HEART DISEASE AND MYOCARDIAL INFARCTION IN RA. RHEUMATOLOGY (vol. 50, pp. 60-61). link>
  • Chen Y, Dawes PT, Mattey DL. 2011. POLYMORPHISM IN THE PROMOTER REGION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR GENE IS ASSOCIATED WITH SERUM VEGF LEVEL AND DISEASE ACTIVITY IN RA. RHEUMATOLOGY (vol. 50, p. 60). link>
  • Mattey DL, Dawson SR, Healey EL, Packham JC. 2011. QUANTITATIVE RELATIONSHIP BETWEEN SMOKING AND MEASURES OF DISEASE ACTIVITY AND SEVERITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS. RHEUMATOLOGY (vol. 50, p. 39). link>
  • Chen Y, Dawes PT, Mattey DL. 2010. A SPECIFIC MMP1-MMP3 HAPLOTYPE IS ASSOCIATED WITH HIGH LEVELS OF MMP-1 AND SHOWS INTERACTION WITH SMOKING IN RELATION TO EROSIVE DISEASE IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 49, pp. I9-I10). link>
  • Mattey DL, Nixon NB, Dawes PT. 2010. ASSOCIATION OF CIRCULATING MATRIX METALLOPROTEINASE-8 LEVELS WITH MORTALITY IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 49, p. I12). link>
  • Judah SM, Nixon N, Dawes P, Mattey DL. 2010. BIOMARKER PROFILES ASSOCIATED WITH DISEASE FEATURES IN PATIENTS WITH EARLY RA. RHEUMATOLOGY (vol. 49, pp. I45-I46). link>
  • Judah SM, Nixon NB, Dawes PT, Mattey DL. 2008. A history of smoking in patients with early rheumatoid arthritis is associated with a distinct profile of cytokines and matrix metalloproteinases. RHEUMATOLOGY (vol. 47, p. II62). link>
  • Tanveer W, Hider SL, Brownfield A, Mattey DL, Packham JC. 2008. Depression in RA patients treated with anti-TNF is common, poorly managed and may influence anti-TNF effectiveness. RHEUMATOLOGY (vol. 47, p. II49). link>
  • Mattey DL, Brownfield A, Packham JC, Dawes PT. 2008. Quantitative relationship between pack year history of smoking and response to anti-TNF therapy in patients with rheumatoid arthritis. RHEUMATOLOGY (vol. 47, p. II14). link>
  • Packham JC, Dowson CM, Datta P, Saklatvala J, Mattey DL, Kirwan M, Menon A. 2008. Rituximab efficacy in active ankylosing spondylitis: A clinical and magnetic resonance imaging pilot study. RHEUMATOLOGY (vol. 47, p. II6). link>
  • Packham JC, Dawes PT, Hassell AB, Mattey DL. 2007. Does depression in rheumatoid arthritis effect the efficacy or side effect profile of anti-TNF therapy?. RHEUMATOLOGY (vol. 46, p. I38). link>
  • Ghelani AM, Gilmour A, Goh L, Samanta A, Jones A, Mattey D, Nixon NB, Mastana SS. 2006. Association of glutathione-S-transferase polymorphisms in South Asian and Caucasian rheumatoid arthritis patients of the East Midlands, UK. ANNALS OF THE RHEUMATIC DISEASES (vol. 65, p. 289). link>
  • Mattey DL, Glossop JR, Nixon NB, Dawes PT. 2006. Circulating levels of tumour necrosis factor receptors are associated with cardiovascular disease in RA independent of activity and severity of rheumatoid disease. ANNALS OF THE RHEUMATIC DISEASES (vol. 65, p. 461). link>
  • Mattey DL, Nixon NB, Dawes PT. 2006. Polymorphism in the MMP-1 gene is associated with development of nodular disease in RA independent of rheumatoid factor and HLA-DRB1 polymorphism. ANNALS OF THE RHEUMATIC DISEASES (vol. 65, p. 294). link>
  • Ghelani AM, Mattey D, Nixon NB, Gilmour A, Goh L, Jones A, Samanta A, Mastana SS. 2006. Association of GSTT(1) and GSTM(1) gene polymorphism in South Asian and Caucasian rheumatoid arthritis patients of the East Midlands, UK. RHEUMATOLOGY (vol. 45, p. I34). link>
  • Glossop JR, Dawes PT, Mattey DL. 2006. Cigarette smoking and release of TNF alpha and its soluble receptors by peripheral blood mononuclear cells in patients with rheumatoid arthritis. RHEUMATOLOGY (vol. 45, pp. I31-I32). link>
  • Glossop JR, Dawes PT, Hassell AB, Mattey DL. 2005. Association of soluble tumour necrosis factor receptor II levels with mortality in rheumatoid arthritis. RHEUMATOLOGY (vol. 44, pp. I11-I12). link>
  • Mattey DL, Thomson W, Ollier WER, Batley M, Koduri G, Young A. 2005. Association of the HLA-DRB1 shared epitope with mortality in rheumatoid arthritis. RHEUMATOLOGY (vol. 44, p. I4). link>
  • Mattey DL, Nixon NB, Hutchinson DG. 2005. Rheumatoid factor and HLA-DRB1*0401, but not cigarette smoking, are independently associated with antibodies to cyclic citrullinated peptides in rheumatoid arthritis. RHEUMATOLOGY (vol. 44, p. I100). link>
  • Mattey DL, Kerr JR, Nixon NB, Dawes PT. 2004. Association of polymorphism in the transforming growth factor beta 1 gene with disease outcome and mortality in rheumatoid arthritis. ARTHRITIS AND RHEUMATISM (vol. 50, p. S355). link>
  • Mattey D, Thomson W, Ollier WER, Koduri G, Young A. 2004. Association of the HLA-DRB1 shared epitope with mortality in rheumatoid arthritis. ARTHRITIS AND RHEUMATISM (vol. 50, p. S381). link>
  • GLOSSOP JR, DAWES PT, HASSELL AB, MATTEY DL. 2004. Polymorphism in the tumour necrosis factor receptor II gene is associated with the soluble receptor levels in rheumatoid arthritis. Arthritis and Rheumatism.
  • KAMATH SN, DAWES PT, GRIFFITHS SM, JONES PW, BROWNFIELD A, FISHER J, MATTEY DL. 2004. Can we predict development of RA in pre-rheumatoid patients. Rheumatology.
  • Glossop JR, Dawes PT, Nixon NB, Hassell AB, Mattey DL. 2003. Association between T-cell production of tumor necrosis factor alpha and the presence of nodular disease in rheumatoid arthritis. Annals of the Rheumatic Diseases.
  • Kamath S, Brownfield A, Jones PW, Griffiths S, Dawes PT, Mattey DL. 2003. Is there a premorbid personality in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases.
  • Mattey DL, Dawes PT, Nixon NB, Banks MJ, Kitas GD. 2002. Increased levels of antibodies to cytokeratin 18 in patients with rheumatoid arthritis and ischaemic heart disease. ARTHRITIS AND RHEUMATISM (vol. 46, p. S129). link>
  • Mattey DL, Hassell AB, Fisher J, Jones PW, Dawes PT. 2002. The mechanical joint score is a powerful predictor of mortality in rheumatoid arthritis. Arthritis Rheumatoid.
  • Jenvey CA, Hider SL, Glossop JR, Packham J, Dawes P, Nixon N, Mattey D. 2014. ASSOCIATION BETWEEN LEVELS OF SERUM HEPATOCYTE GROWTH FACTOR AND JOINT REPLACEMENT OF THE HIP OR KNEE IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 53, p. 102). link>
  • Glossop JR, Haworth KE, Emes RD, Nixon NB, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2015. DNA METHYLATION PROFILING OF SYNOVIAL FLUID-DERIVED FIBROBLAST-LIKE SYNOVIOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS REVEALS COMMON AND DISTINCT CHANGES RELATIVE TO THEIR TISSUE-DERIVED COUNTERPARTS. RHEUMATOLOGY (vol. 54, p. 48). link>
  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2014. GENOME-WIDE DNA METHYLATION PROFILING IDENTIFIES DISTINCT CHANGES IN T- AND B-CELL POPULATIONS FROM PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 53, pp. 157-158). link>

For further information follow the link on Research at the Staffordshire Rheumatology Centre supported by the NHS and The Haywood Foundation.