Professor Anthony A Fryer

Title: Professor of Clinical Biochemistry
Phone: +44 (0)1782 675378
Email: Anthony.Fryer@uhns.nhs.uk
a.a.fryer@keele.ac.uk
Location: Institute for Science & Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research themes: 1. Health Services Research
2. Cell & Molecular Medicine

Contacting me: By e-mail please.
Tony_Fryer_150x190

Prof Tony Fryer completed his PhD at Keele in 1991 following work as a research biochemist in Department of Clinical Biochemistry, at North Staffordshire Hospital NHS Trust. He became a Keele Honorary Lecturer in 1999, Hon Senior Lecturer in 2003, in which year he became a Consultant Clinical Biochemist and was made Head of the Department of Clinical Biochemistry the following year.

Appointed as Keele Professor of Clinical Biochemistry in the Institute for Science & Technology in Medicine in 2008, Prof Fryer has also been chair of the West Midlands Association of Clinical Biochemistry since 2009. His involvement in research and training through Keele and the WM Association includes supervision of higher degrees and trainee Clinical Biochemists, and a wide range of research grants and awards from national and regional funders such National Institute for Health Research, Medical Research Council, Engineering and Physical Sciences Research Council, Cancer Research UK, British Lung Foundation, and the former NHS Locally Organised Research Scheme. Prof Fryer is a member of the  Fetal Epigenetics Group, and has output over 150 peer-reviewed publications and 24 book chapters/reviews.

In October 2012 Prof Fryer succeeded Prof Gordon Ferns as Research & Development Director at the University Hospitals of North Midlands.

ISTM Research themes: 1. Health Services Research
                                      2. Cell & Molecular Medicine

Research Interests:

•    Performing the right test in the right patient at the right time: Assessment of the appropriateness of pathology testing and impact of guidance.
•    The impact of maternal folate supplementation during pregnancy on fetal epigenome..
•    Genetic and environmental risk factors for skin cancer in renal transplant recipients: use of statistical modelling approaches to predict risk.

Proportion of appropriate requests from primary care for the glycosylated haemoglobin test. Figure illustrates that 40% of requests are inappropriate (green/red bars), that this proportion is increasing and that national guidance has had little impact.  

Proportion of appropriate requests from primary care for the glycosylated haemoglobin test. Figure illustrates that 40% of requests are inappropriate (green/red bars), that this proportion is increasing and that national guidance has had little impact.

Association of mean LINE-1 methylation, as a surrogate for global methylation, with cord plasma homocysteine concentration. Figure illustrates a significant inverse relationship (p=0.001, r= -0.69) between markers of global methylation and functional methyl group supply.
 

Association of mean LINE-1 methylation, as a surrogate for global methylation, with cord plasma homocysteine concentration. Figure illustrates a significant inverse relationship (p=0.001, r= -0.69) between markers of global methylation and functional methyl group supply.

Selected Publications

  • Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi>
  • Scargill JJ, Livingston M, Holland D, Khan A, Duff CJ, Fryer AA, Heald AH. 2017. Monitoring thyroid function in patients on levothyroxine: audit findings and suggested change in practice. Int J Clin Pract, vol. 71(1). link> doi>
  • Heald A, Anderson S, Scargill J, Short A, Holland D, Khan A, Fryer A, Donn R, Livingston M. 2017. Social Disadvantage Is Associated With Lower Vitamin D Levels in Older People and There Is No Surrogate for Its Measurement. Gerontology and Geriatric Medicine, vol. 3. doi> link>
  • Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. 2016. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Sim J, Packham JC, Mattey DL, Farrell WE, Fryer AA. 2017. DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, vol. 9(4), 419-428. link> doi>

Full Publications List show

Journal Articles

  • Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi>
  • Scargill JJ, Livingston M, Holland D, Khan A, Duff CJ, Fryer AA, Heald AH. 2017. Monitoring thyroid function in patients on levothyroxine: audit findings and suggested change in practice. Int J Clin Pract, vol. 71(1). link> doi>
  • Heald A, Anderson S, Scargill J, Short A, Holland D, Khan A, Fryer A, Donn R, Livingston M. 2017. Social Disadvantage Is Associated With Lower Vitamin D Levels in Older People and There Is No Surrogate for Its Measurement. Gerontology and Geriatric Medicine, vol. 3. doi> link>
  • Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. 2016. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Sim J, Packham JC, Mattey DL, Farrell WE, Fryer AA. 2017. DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, vol. 9(4), 419-428. link> doi>
  • Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA. 2016. Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 0. link> doi>
  • Kitchen MO, Bryan RT, Emes RD, Glossop JR, Luscombe C, Cheng KK, Zeegers MP, James ND, Devall AJ, Mein CA, Gommersall L, Fryer AA, Farrell WE. 2016. Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. Epigenetics, vol. 11(3), 237-246. link> doi>
  • Glossop JR, Emes RD, Nixon NB, Packham JC, Fryer AA, Mattey DL, Farrell WE. 2016. Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes. Epigenomics, vol. 8(2), 209-224. link> doi>
  • Glossop JR, Haworth KE, Emes RD, Nixon NB, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2015. DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, vol. 7(4), 539-551. link> doi>
  • Hanna FWF, Wilkie V, Issa BG, Fryer AA. 2015. Revisiting screening for type 2 diabetes mellitus: the case for and against using HbA1c. Br J Gen Pract, vol. 65(633), e278-e280. link> doi>
  • Haworth KE, Farrell WE, Emes RD, Ismail KMK, Carroll WD, Hubball E, Rooney A, Yates AM, Mein C, Fryer AA. 2014. Methylation of the FGFR2 gene is associated with high birth weight centile in humans. Epigenomics, vol. 6(5), 477-491. link> doi>
  • Driskell OJ, Holland D, Waldron JL, Ford C, Scargill JJ, Heald A, Tran M, Hanna FW, Jones PW, Pemberton RJ, Fryer AA. 2014. Reduced testing frequency for glycated hemoglobin, HbA1c, is associated with deteriorating diabetes control. Diabetes Care, vol. 37(10), 2731-2737. link> doi>
  • Silf K, Woodhead N, Kelly J, Fryer A, Kettle C, Ismail KMK. 2015. Evaluation of accuracy of mediolateral episiotomy incisions using a training model. Midwifery, vol. 31(1), 197-200. link> doi>
  • Glossop JR, Emes RD, Nixon NB, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2014. Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics, vol. 9(9), 1228-1237. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2013. Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals. Epigenetics, vol. 8(11), 1188-1197. link> doi>
  • Haworth KE, Farrell WE, Emes RD, Ismail KMK, Carroll WD, Borthwick H-AD, Yates AM, Hubball E, Rooney A, Khanam M, Aggarwal N, Jones PW, Fryer AA. 2013. Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. Epigenomics, vol. 5(1), 37-49. link> doi>
  • Emes RD, Clifford H, Haworth KE, Farrell WE, Fryer AA, Carroll WD, Ismail KMK. 2013. Antiepileptic drugs and the fetal epigenome. Epilepsia, vol. 54(1), e16-e19. link> doi>
  • Fryer AA and Smellie WSA. 2013. Managing demand for laboratory tests: a laboratory toolkit. J Clin Pathol, vol. 66(1), 62-72. link> doi>
  • Driskell OJ, Holland D, Hanna FW, Jones PW, Pemberton RJ, Tran M, Fryer AA. 2012. Inappropriate requesting of glycated hemoglobin (Hb A1c) is widespread: assessment of prevalence, impact of national guidance, and practice-to-practice variability. Clin Chem, vol. 58(5), 906-915. link> doi>
  • Smith D, Spaněl P, Fryer AA, Hanna F, Ferns GAA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?. J Breath Res, vol. 5(2), 022001. link> doi>
  • Fryer AA, Emes RD, Ismail KMK, Haworth KE, Mein C, Carroll WD, Farrell WE. 2011. Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics, vol. 6(1), 86-94. link> doi>
  • Tahrani AA, Geen J, Hanna FWF, Jones PW, Cassidy D, Bates D, Fryer AA. 2011. Predicting dysglycaemia in patients under investigation for acute coronary syndrome. QJM, vol. 104(3), 231-236. link> doi>
  • Magnay JL, El-Shourbagy M, Fryer AA, O'Brien S, Ismail KMK. 2010. Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder. Am J Obstet Gynecol, vol. 203(2), 181.e1-181.e5. link> doi>
  • Fryer AA and Hanna FW. 2009. Managing demand for pathology tests: financial imperative or duty of care?. Ann Clin Biochem, vol. 46(Pt 6), 435-437. link> doi>
  • Nafee T, Karpova E, Farrell W, Fryer A, Carroll W, Emes R, Ismail K. 2009. DNA methylation in cord blood, fetal plasma homocysteine, and fetal growth - A pilot study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol. 116(10), 1412. link>
  • Fryer AA, Nafee TM, Ismail KMK, Carroll WD, Emes RD, Farrell WE. 2009. LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study. Epigenetics, vol. 4(6), 394-398. link> doi>
  • Urwin HR, Jones PW, Harden PN, Ramsay HM, Hawley CM, Nicol DL, Fryer AA. 2009. Predicting risk of nonmelanoma skin cancer and premalignant skin lesions in renal transplant recipients. Transplantation, vol. 87(11), 1667-1671. link> doi>
  • Ghosh S, Fryer AA, Hoban PR, Wynn-Jones C, Maffulli N. 2009. Fibrillin 1 gene with R2726W mutation is absent in patients with primary protrusio acetabuli and developmental dysplasia of the hip. Med Sci Monit, vol. 15(5), CR199-CR202. link>
  • Hutton HD, Drummond HS, Fryer AA. 2009. The rise and fall of C-reactive protein: managing demand within clinical biochemistry. Ann Clin Biochem, vol. 46(Pt 2), 155-158. link> doi>
  • Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban PR, Rukin N, Alldersea J, Strange RC, Hawkins CP. 2008. Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis. Mult Scler, vol. 14(9), 1280-1283. link> doi>
  • Millard TP, Fryer AA, McGregor JM. 2008. A protective effect of glutathione-S-transferase GSTP1*Val(105) against polymorphic light eruption. J Invest Dermatol, vol. 128(8), 1901-1905. link> doi>
  • Woolmore J, Stone M, Holley S, Jenkinson P, Ike A, Jones P, Fryer A, Strange R, Stephens R, Langdon D, Hawkins C. 2008. Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. Mult Scler, vol. 14(2), 177-182. link> doi>
  • Nafee TM, Farrell WE, Carroll WD, Fryer AA, Ismail KMK. 2008. Epigenetic control of fetal gene expression. BJOG, vol. 115(2), 158-168. link> doi>
  • Holley SL, Fryer AA, Haycock JW, Grubb SEW, Strange RC, Hoban PR. 2007. Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis, vol. 28(11), 2268-2273. link> doi>
  • Dhingra V, Magnay JL, O'Brien PMS, Chapman G, Fryer AA, Ismail KMK. 2007. Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder. Obstet Gynecol, vol. 110(4), 788-792. link> doi>
  • Ramsay HM, Reece SM, Fryer AA, Smith AG, Harden PN. 2007. Seven-year prospective study of nonmelanoma skin cancer incidence in U.K. renal transplant recipients. Transplantation, vol. 84(3), 437-439. link> doi>
  • Lenney W and Fryer AA. 2007. The genetics of asthma: are the glutathione S-transferases serious players?. Clin Exp Allergy, vol. 37(8), 1124-1126. link> doi>
  • Woolmore JA, Stone M, Pye EM, Partridge JM, Boggild M, Young C, Jones PW, Fryer AA, Hawkins CP, Strange RC. 2007. Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation. Mult Scler, vol. 13(3), 369-375. link> doi>
  • Rukin NJ, Luscombe C, Moon S, Bodiwala D, Liu S, Saxby MF, Fryer AA, Alldersea J, Hoban PR, Strange RC. 2007. Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene. Cancer Lett, vol. 247(2), 328-335. link> doi>
  • Rukin N, Blagojevic M, Luscombe CJ, Liu S, Saxby MF, Ramachandran S, Fryer AA, Jones PW, Strange RC. 2007. Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer. Cancer Detect Prev, vol. 31(6), 443-449. link> doi>
  • Kapoor B, Dunlop C, Wynn-Jones C, Fryer AA, Strange RC, Maffulli N. 2007. Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli--a preliminary study. J Negat Results Biomed, vol. 6, 7. link> doi>
  • Gray A, Stewart H, Pravica V, Fryer AA, Lenney W, Hutchinson IV, Arkwright PD. 2006. Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis. Pediatr Allergy Immunol, vol. 17(8), 578-582. link> doi>
  • Salim A, Reece SM, Smith AG, Harrison D, Ramsay HM, Harden PN, Fryer AA. 2006. Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant. J Am Acad Dermatol, vol. 55(5), 878-881. link> doi>
  • Madan V, Hoban PR, Strange RC, Fryer AA, Lear JT. 2006. Prognostic factors for a subsequent basal cell carcinoma: implications for follow-up. Br J Dermatol, vol. 155(1), 217-218. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Whyte MK, Primhak RA, Fryer AA. 2006. Asthma severity and atopy: how clear is the relationship?. Arch Dis Child, vol. 91(5), 405-409. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2006. Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. Ann Hum Genet, vol. 70(Pt 2), 226-236. link> doi>
  • Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2006. Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. Int J Oncol, vol. 28(1), 231-236. link>
  • Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2005. Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer. Carcinogenesis, vol. 26(12), 2157-2163. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation, vitamin D and risk of prostate cancer and other diseases. Photochem Photobiol, vol. 81(6), 1252-1260. link> doi>
  • Carroll WD, Lenney W, Jones PW, Strange RC, Child F, Whyte MK, Primhak RA, Fryer AA. 2005. Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clin Exp Allergy, vol. 35(9), 1155-1161. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer A, Strange RC. 2006. Associations between G/A(1229), A/G(3944), T/C-30875 C/T-48200 and C/T-65013 genotypes and haplotype in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. ANNALS OF HUMAN GENETICS, vol. 70, 226-236. link> doi>
  • Lovatt T, Alldersea J, Lear JT, Hoban PR, Ramachandran S, Fryer AA, Smith AG, Strange RC. 2005. Polymorphism in the nuclear excision repair gene ERCC2/XPD: association between an exon 6-exon 10 haplotype and susceptibility to cutaneous basal cell carcinoma. Hum Mutat, vol. 25(4), 353-359. link> doi>
  • Carroll WD, Lenney W, Proctor A, Whyte MC, Primhak RA, Cliffe I, Jones PW, Strange RC, Fryer AA, Child F. 2005. Regional variation of airway hyperresponsiveness in children with asthma. Respir Med, vol. 99(4), 403-407. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers. Mutat Res, vol. 571(1-2), 207-219. link> doi>
  • Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CEM, Samarasinghe V, Roebuck J, Ramachandran S, Smith AG, Jones PW, Fryer AA, Strange RC. 2005. Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors. J Am Acad Dermatol, vol. 52(3 Pt 1), 468-473. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Fryer AA. 2005. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatr Allergy Immunol, vol. 16(1), 32-39. link> doi>
  • Holley SL, Matthias C, Jahnke V, Fryer AA, Strange RC, Hoban PR. 2005. Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. Oral Oncol, vol. 41(2), 156-160. link> doi>
  • Lear JT, Hoban P, Strange RC, Fryer AA. 2005. Basal cell carcinoma: from host response and polymorphic variants to tumour suppressor genes. Clin Exp Dermatol, vol. 30(1), 49-55. link> doi>
  • Alam M, Pravica V, Fryer AA, Hawkins CP, Hutchinson IV. 2005. Novel polymorphism in the promoter region of the human nerve growth-factor gene. Int J Immunogenet, vol. 32(6), 379-382. link> doi>
  • Fryer AA, Ramsay HM, Lovatt TJ, Jones PW, Hawley CM, Nicol DL, Strange RC, Harden PN. 2005. Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis, vol. 26(1), 185-191. link> doi>
  • McCloud JM, Sivakumar R, Greenhough A, Elder J, Jones PW, Deakin M, Elder JB, Fryer AA, Hoban PR. 2004. p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer. Int J Oncol, vol. 25(5), 1447-1452. link>
  • Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Lear JT, Wong C, Jones PW, Ichii-Jones F, Hoban PR. 2004. Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. Ann Hum Genet, vol. 68(Pt 6), 536-545. link> doi>
  • Brind AM, Hurlstone A, Edrisinghe D, Gilmore I, Fisher N, Pirmohamed M, Fryer AA. 2004. The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. Alcohol Alcohol, vol. 39(6), 478-483. link> doi>
  • Barton A, Woolmore JA, Ward D, Eyre S, Hinks A, Ollier WER, Strange RC, Fryer AA, John S, Hawkins CP, Worthington J. 2004. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, vol. 127(Pt 8), 1717-1722. link> doi>
  • Howells REJ, Dhar KK, Hoban PR, Jones PW, Fryer AA, Redman CWE, Strange RC. 2004. Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 14(2), 242-250. link> doi>
  • Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CEM, Ramachandran S, Smith AG, Salim A, Fryer AA, Jones PW, Strange RC. 2004. Associations between UVR exposure and basal cell carcinoma site and histology. Cancer Lett, vol. 216(2), 191-197. link> doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2004. Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer. Environ Mol Mutagen, vol. 43(2), 121-127. link> doi>
  • Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Lear JT, Ichii-Jones F, Jones PW, Hoban PR. 2004. PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype. Environ Mol Mutagen, vol. 44(5), 469-476. link> doi>
  • Partridge JM, Weatherby SJM, Woolmore JA, Highland DJ, Fryer AA, Mann CLA, Boggild MD, Ollier WER, Strange RC, Hawkins CP. 2004. Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes. Neurology, vol. 62(12), 2323-2325. link> doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea JE, Strange RC, Fryer AA. 2003. The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children. Respir Med, vol. 97(12), 1247-1256. link> doi>
  • Brind A, Fryer A, Hurlstone A, Fisher N, Pirmohamed M. 2003. The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease. Gastroenterology, vol. 124(7), 2000-2002. link> doi>
  • Carroll RP, Ramsay HM, Fryer AA, Hawley CM, Nicol DL, Harden PN. 2003. Incidence and prediction of nonmelanoma skin cancer post-renal transplantation: a prospective study in Queensland, Australia. Am J Kidney Dis, vol. 41(3), 676-683. link> doi>
  • Matthias C, Jahnke V, Fryer AA, Strange RC. 2003. [First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]. Laryngorhinootologie, vol. 82(1), 25-30. link> doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2003. Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation. Cancer Lett, vol. 200(2), 141-148. link> doi>
  • Ramachandran S, Fryer AA, Lovatt TJ, Smith AG, Lear JT, Jones PW, Strange RC. 2003. Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. Cancer Lett, vol. 189(2), 175-181. link> doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, Fryer AA. 2003. Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children. Pediatr Allergy Immunol, vol. 14(3), 193-200. link>
  • Bodiwala D, Luscombe CJ, Liu S, Saxby M, French M, Jones PW, Fryer AA, Strange RC. 2003. Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sunlight. Cancer Lett, vol. 192(2), 145-149. link> doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003. Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type. Carcinogenesis, vol. 24(4), 711-717. link> doi>
  • Ramachandran S, Fryer AA, Lovatt T, Smith A, Lear J, Jones PW, Strange RC. 2002. The rate of increase in the numbers of primary sporadic basal cell carcinomas during follow up is associated with age at first presentation. Carcinogenesis, vol. 23(12), 2051-2054. link> doi>
  • Ramsay HM, Fryer AA, Hawley CM, Smith AG, Harden PN. 2002. Non-melanoma skin cancer risk in the Queensland renal transplant population. Br J Dermatol, vol. 147(5), 950-956. link> doi>
  • Henrion-Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer AA, Chadelat K, Strange RC, Clement A. 2002. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology, vol. 36(4 Pt 1), 913-917. link> doi>
  • Mann CLA, Davies MB, Stevenson VL, Leary SM, Boggild MD, Ko Ko C, Jones PW, Fryer AA, Strange RC, Thompson AJ, Hawkins CP. 2002. Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. J Neuroimmunol, vol. 129(1-2), 197-204. link> doi>
  • Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2002. An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clin Exp Allergy, vol. 32(7), 994-999. link> doi>
  • Fawole AS, Simpson DJ, Rajagopal R, Elder J, Holland TA, Fryer A, Deakin M, Elder JB, Farrell WE. 2002. Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarcinoma. Int J Cancer, vol. 99(6), 829-833. link> doi>
  • Matthias C, Jahnke V, Fryer AA, Strange RC. 2002. [Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]. Laryngorhinootologie, vol. 81(6), 406-412. link> doi>
  • Child F, Davies S, Clayton S, Fryer AA, Lenney W. 2002. Inhaler devices for asthma: do we follow the guidelines?. Arch Dis Child, vol. 86(3), 176-179. link> doi>
  • Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV. 2002. Association between functional polymorphism in EGF gene and malignant melanoma. Lancet, vol. 359(9304), 397-401. link> doi>
  • Luscombe CJ, French ME, Liu S, Saxby MF, Farrell WE, Jones PW, Fryer AA, Strange RC. 2002. Glutathione S-transferase GSTP1 genotypes are associated with response to androgen ablation therapy in advanced prostate cancer. Cancer Detect Prev, vol. 26(5), 376-380. link> doi>
  • Mapp CE, Fryer AA, De Marzo N, Pozzato V, Padoan M, Boschetto P, Strange RC, Hemmingsen A, Spiteri MA. 2002. Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates. J Allergy Clin Immunol, vol. 109(5), 867-872. link> doi>
  • Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC. 2002. Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus. Arthritis Rheum, vol. 46(3), 640-646. link> doi>
  • Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, Harden PN. 2002. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol, vol. 13(1), 260-264. link>
  • Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Benhamou S, Boffetta P, Bouchardy C, Breskvar K, Brockmoller J, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell'Omo M, Dolzan V, Dresler CM, Fryer A, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh LL, Ingelman-Sundberg M, Kalina I, Kang D, Kihara M, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, van Lieshout EM, London S, Manni JJ, Maugard CM, Morita S, Nazar-Stewart V, Noda K, Oda Y, Parl FF, Pastorelli R, Persson I, Peters WH, Rannug A, Rebbeck T, Risch A, Roelandt L, Romkes M, Ryberg D, Salagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnet D, Strange RC, Stücker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Taioli E. 2001. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev, vol. 10(12), 1239-1248. link>
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. Br J Cancer, vol. 85(10), 1504-1509. link> doi>
  • Simpson DJ, Fryer AA, Grossman AB, Wass JA, Pfeifer M, Kros JM, Clayton RN, Farrell WE. 2001. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. Carcinogenesis, vol. 22(11), 1801-1807. link> doi>
  • Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole A, Gilissen RA, Campbell FC, Coughtrie MW. 2001. Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics, vol. 11(8), 679-685. link> doi>
  • Holland TA, Elder J, McCloud JM, Hall C, Deakin M, Fryer AA, Elder JB, Hoban PR. 2001. Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21(WAF1/CIP1) expression and correlates with patient survival. Int J Cancer, vol. 95(5), 302-306. link> doi>
  • Harden PN, Reece SM, Fryer AA, Smith AG, Ramsay HM. 2001. Skin cancer surveillance in renal transplant recipients: questionnaire survey of current UK practice. BMJ, vol. 323(7313), 600-601. link> doi>
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Outcome in prostate cancer associations with skin type and polymorphism in pigmentation-related genes. Carcinogenesis, vol. 22(9), 1343-1347. link> doi>
  • Luscombe CJ, Fryer AA, French ME, Liu S, Saxby MF, Jones PW, Strange RC. 2001. Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. Lancet, vol. 358(9282), 641-642. link> doi>
  • Ramsay HM, Harden PN, Reece S, Smith AG, Jones PW, Strange RC, Fryer AA. 2001. Polymorphisms in glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis. J Invest Dermatol, vol. 117(2), 251-255. link> doi>
  • Ramachandran S, Fryer AA, Smith A, Lear J, Bowers B, Jones PW, Strange RC. 2001. Cutaneous basal cell carcinomas: distinct host factors are associated with the development of tumors on the trunk and on the head and neck. Cancer, vol. 92(2), 354-358. link> doi>
  • Child F, Clayton S, Davies S, Fryer AA, Jones PW, Lenney W. 2001. How should airways resistance be measured in young children: mask or mouthpiece?. Eur Respir J, vol. 17(6), 1244-1249. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Hartland AJ, Whiteside JR, Jones PW, Strange RC. 2001. Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype. Pharmacogenetics, vol. 11(3), 247-254. link> doi>
  • Howells RE, Holland T, Dhar KK, Redman CW, Hand P, Hoban PR, Jones PW, Fryer AA, Strange RC. 2001. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival. Int J Gynecol Cancer, vol. 11(2), 107-112. link> doi>
  • Strange RC, Spiteri MA, Ramachandran S, Fryer AA. 2001. Glutathione-S-transferase family of enzymes. Mutat Res, vol. 482(1-2), 21-26. link> doi>
  • Weatherby SJ, Thomson W, Pepper L, Donn R, Worthington J, Mann CL, Davies MB, Fryer AA, Boggild MD, Young CA, Jones PW, Strange RC, Ollier WE, Hawkins CP. 2001. HLA-DRB1 and disease outcome in multiple sclerosis. J Neurol, vol. 248(4), 304-310. link> doi>
  • Jones PW, Strange RC, Ramachandran S, Fryer A. 2002. Models for determining genetic susceptibility and predicting outcome. Methods Mol Biol, vol. 184, 131-142. link>
  • Hemmingsen A, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2001. Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respir Res, vol. 2(4), 255-260. link> doi>
  • Ramachandran S, Fryer AA, Lovatt T, Lear J, Smith AG, Strange RC. 2001. Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype. J Photochem Photobiol B, vol. 63(1-3), 1-7. link> doi>
  • Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, Makki R, Tavernier G, Smilie FI, Custovic A, Woodcock AA, Ollier WE, Hajeer AH. 2000. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun, vol. 1(8), 509-514. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Griffiths CE, Jones PW, Strange RC. 2000. Basal cell carcinoma. Cancer, vol. 89(5), 1012-1018. link> doi>
  • Ramachandran S, Hoban PR, Ichii-Jones F, Pleasants L, Ali-Osman F, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 2000. Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. Pharmacogenetics, vol. 10(6), 545-556. link> doi>
  • Beswick SJ, Garrido MC, Fryer AA, Strange RC, Smith AG. 2000. Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis. Clin Exp Dermatol, vol. 25(5), 381-383. link> doi>
  • Weatherby SJ, Mann CL, Davies MB, Fryer AA, Haq N, Strange RC, Hawkins CP. 2000. A pilot study of the relationship between gadolinium-enhancing lesions, gender effect and polymorphisms of antioxidant enzymes in multiple sclerosis. J Neurol, vol. 247(6), 467-470. link> doi>
  • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. 2000. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med, vol. 161(5), 1437-1442. link> doi>
  • Mattey DL, Hassell AB, Dawes PT, Jones PW, Yengi L, Alldersea J, Strange RC, Fryer AA. 2000. Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: evidence for interaction with glutathione S-transferase genes. Arthritis Rheum, vol. 43(4), 859-864. link> doi>
  • Weatherby SJ, Mann CL, Fryer AA, Strange RC, Hawkins CP, Stevenson VL, Leary SM, Thompson AJ. 2000. No association between the APOE epsilon4 allele and outcome and susceptibility in primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry, vol. 68(4), 532. link> doi>
  • Hajeer AH, Lear JT, Ollier WE, Naves M, Worthington J, Bell DA, Smith AG, Bowers WP, Jones PW, Strange RC, Fryer AA. 2000. Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas. Br J Dermatol, vol. 142(3), 441-445. link> doi>
  • Mann CL, Davies MB, Boggild MD, Alldersea J, Fryer AA, Jones PW, Ko Ko C, Young C, Strange RC, Hawkins CP. 2000. Glutathione S-transferase polymorphisms in MS: their relationship to disability. Neurology, vol. 54(3), 552-557. link> doi>
  • Weatherby SJ, Mann CL, Davies MB, Carthy D, Fryer AA, Boggild MD, Young C, Strange RC, Ollier W, Hawkins CP. 2000. Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis. Mult Scler, vol. 6(1), 32-36. link> doi>
  • Hutchinson PE, Osborne JE, Lear JT, Smith AG, Bowers PW, Morris PN, Jones PW, York C, Strange RC, Fryer AA. 2000. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. Clin Cancer Res, vol. 6(2), 498-504. link>
  • Lear JT, Smith AG, Strange RC, Fryer AA. 2000. Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. Br J Dermatol, vol. 142(1), 8-15. link> doi>
  • Dhar KK, Branigan K, Parkes J, Howells RE, Hand P, Musgrove C, Strange RC, Fryer AA, Redman CW, Hoban PR. 1999. Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells. Br J Cancer, vol. 81(7), 1174-1181. link> doi>
  • Lear J, Sies H, Clairmont A, Ramachandran S, Smith A, Bowers B, Jones P, Fryer A, Strange R. 1999. Association of quinone oxidoreductase genotypes with basal cell carcinomas. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 113(3), 462. link>
  • Matthias C, Jahnke V, Jones PW, Hoban PR, Alldersea JE, Worrall SF, Fryer AA, Strange RC. 1999. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis. Cancer Epidemiol Biomarkers Prev, vol. 8(9), 815-823. link>
  • Clairmont A, Sies H, Ramachandran S, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 1999. Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci. Carcinogenesis, vol. 20(7), 1235-1240. link> doi>
  • Ramsay HM, Fryer A, Strange RC, Smith AG. 1999. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia. Clin Exp Dermatol, vol. 24(4), 281-282. link> doi>
  • Dhar KK, Branigan K, Howells REJ, Musgrove C, Jones PW, Strange RC, Fryer AA, Redman CWE, Hoban PR. 1999. Prognostic significance of cyclin D1 gene (CCND1) polymorphism in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 9(4), 342-347. link> doi>
  • Strange RC, Ellison T, Ichii-Jones F, Bath J, Hoban P, Lear JT, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Fryer AA. 1999. Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma. Pharmacogenetics, vol. 9(3), 269-276. link> doi>
  • Matthias C, Jahnke V, Hand P, Fryer AA, Strange RC. 1999. [Immunohistologic and molecular genetic studies of the effect of glutathione-S-transferases on the development of squamous epithelial carcinomas in the area of the head-neck]. Laryngorhinootologie, vol. 78(4), 182-188. link> doi>
  • Jones FI, Ramachandran S, Lear J, Smith A, Bowers B, Ollier WE, Jones P, Fryer AA, Strange RC. 1999. The melanocyte stimulating hormone receptor polymorphism: association of the V92M and A294H alleles with basal cell carcinoma. Clin Chim Acta, vol. 282(1-2), 125-134. link> doi>
  • Mattey DL, Hassell AB, Plant M, Dawes PT, Ollier WR, Jones PW, Fryer AA, Alldersea JE, Strange RC. 1999. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Ann Rheum Dis, vol. 58(3), 164-168. link> doi>
  • Fryer AA and Jones PW. 1999. Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer. IARC Sci Publ, 303-322. link>
  • Coughtrie MW, Gilissen RA, Shek B, Strange RC, Fryer AA, Jones PW, Bamber DE. 1999. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochem J, vol. 337 ( Pt 1), 45-49. link> doi>
  • Ramachandran S, Lear JT, Ramsay H, Smith AG, Bowers B, Hutchinson PE, Jones PW, Fryer AA, Strange RC. 1999. Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol Biomarkers Prev, vol. 8(1), 61-67. link>
  • Strange RC and Fryer AA. 1999. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ, 231-249. link>
  • Layton MA, Jones PW, Alldersea JE, Strange RC, Fryer AA, Dawes PT, Mattey DL. 1999. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology (Oxford), vol. 38(1), 43-47. link> doi>
  • Lear JT, Harvey I, de Berker D, Strange RC, Fryer AA. 1998. Basal cell carcinoma. J R Soc Med, vol. 91(11), 585-588. link>
  • Howells RE, Redman CW, Dhar KK, Sarhanis P, Musgrove C, Jones PW, Alldersea J, Fryer AA, Hoban PR, Strange RC. 1998. Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin Cancer Res, vol. 4(10), 2439-2445. link>
  • Matthias C, Branigan K, Jahnke V, Leder K, Haas J, Heighway J, Jones PW, Strange RC, Fryer AA, Hoban PR. 1998. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res, vol. 4(10), 2411-2418. link>
  • Worrall SF, Corrigan M, High A, Starr D, Matthias C, Wolf CR, Jones PW, Hand P, Gilford J, Farrell WE, Hoban P, Fryer AA, Strange RC. 1998. Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6. Pharmacogenetics, vol. 8(5), 433-439. link> doi>
  • Ichii-Jones F, Lear JT, Heagerty AH, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Davies E, Ollier WE, Thomson W, Yengi L, Bath J, Fryer AA, Strange RC. 1998. Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J Invest Dermatol, vol. 111(2), 218-221. link> doi>
  • Lear JT, Tan BB, Smith AG, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1998. A comparison of risk factors for malignant melanoma, squamous cell carcinoma and basal cell carcinoma in the UK. Int J Clin Pract, vol. 52(3), 145-149. link>
  • Matthias C, Bockmühl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, Gilford J, Bailey L, Bath J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics, vol. 8(2), 91-100. link>
  • Matthias C, Bockmühl U, Jahnke V, Harries LW, Wolf CR, Jones PW, Alldersea J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. Pharmacogenetics, vol. 8(1), 1-6. link> doi>
  • Matthias C, Bockmühl U, Jahnke V, Petersen I, Dietel M, Fryer A, Strange RC. 1998. [Effect of gene polymorphism on detoxifying glutathione-S-transferase enzymes on chromosomal stability of squamous epithelial carcinomas in the area of the head-neck]. Laryngorhinootologie, vol. 77(4), 201-206. link> doi>
  • Matthias C, Jahnke V, Fryer A, Strange R, Ollier W, Hajeer A. 1998. Influence of tumour necrosis factor microsatellite polymorphisms on susceptibility to head and neck cancer. Acta Otolaryngol, vol. 118(2), 284-288. link> doi>
  • Lear JT, Smith AG, Strange RC, Fryer AA. 1998. Patients with truncal basal cell carcinoma represent a high-risk group. Arch Dermatol, vol. 134(3), 373. link> doi>
  • Strange RC, Lear JT, Fryer AA. 1998. Polymorphism in glutathione S-transferase loci as a risk factor for common cancers. Arch Toxicol Suppl, vol. 20, 419-428. link>
  • Lear JT, Smith A, Bowers W, Heagerty A, Jones P, Gilford J, Alldersea J, Strange R, Fryer A. 1997. Truncal site, detoxifying enzyme genotypes and time to presentation of next basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 109(3), 435. link>
  • Lear JT, Smith AG, Heagerty AH, Bowers B, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma. Carcinogenesis, vol. 18(8), 1499-1503. link> doi>
  • Lear JT, Tan BB, Smith AG, Bowers W, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1997. Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. J R Soc Med, vol. 90(7), 371-374. link>
  • Lear JT, Smith AG, Bowers B, Heagearty AH, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. J Invest Dermatol, vol. 108(4), 519-522. link> doi>
  • Jahnke V, Strange R, Matthias C, Fryer A. 1997. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. Eur Arch Otorhinolaryngol, vol. 254 Suppl 1, S147-S149. link> doi>
  • Lear JT, Strange RC, Fryer AA. 1997. Re: relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst, vol. 89(6), 454-455. link> doi>
  • Hajeer A, John S, Ollier WE, Silman AJ, Dawes P, Hassell A, Mattey D, Fryer A, Strange R, Worthington J. 1997. Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. J Rheumatol, vol. 24(1), 217-219. link>
  • Sarhanis P, Redman C, Perrett C, Brannigan K, Clayton RN, Hand P, Musgrove C, Suarez V, Jones P, Fryer AA, Farrell WE, Strange RC. 1996. Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. Br J Cancer, vol. 74(11), 1757-1761. link> doi>
  • Hand PA, Inskip A, Gilford J, Alldersea J, Elexpuru-Camiruaga J, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, vol. 17(9), 1919-1922. link> doi>
  • Lear JT, Heagerty AH, Smith A, Bowers B, Payne CR, Smith CA, Jones PW, Gilford J, Yengi L, Alldersea J, Fryer AA, Strange RC. 1996. Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, vol. 17(9), 1891-1896. link> doi>
  • Lear JT, Tan BB, Smith AG, Fryer AA, Strange RC, Jones PW. 1996. Non-Hodgkins lymphoma and solar ultraviolet radiation. Basal cell carcinoma may be linked to haematological malignancy. BMJ, vol. 313(7052), 298-299. link> doi>
  • Yengi L, Inskip A, Gilford J, Alldersea J, Bailey L, Smith A, Lear JT, Heagerty AH, Bowers B, Hand P, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Res, vol. 56(9), 1974-1977. link>
  • Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1996. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, vol. 17(4), 881-884. link> doi>
  • Lear J, Heagerty A, Smith A, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange R. 1996. Polymorphism in detoxifying enzymes and susceptibility to skin cancer. Photochem Photobiol, vol. 63(4), 424-428. link> doi>
  • Ollier W, Davies E, Snowden N, Alldersea J, Fryer A, Jones P, Strange R. 1996. Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis Rheum, vol. 39(10), 1763-1764. link> doi>
  • Jahnke V, Matthias C, Fryer A, Strange R. 1996. Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. Am J Surg, vol. 172(6), 671-673. link> doi>
  • Heagerty A, Smith A, English J, Lear J, Perkins W, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange RC. 1996. Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. Br J Cancer, vol. 73(1), 44-48. link> doi>
  • Jahnke V, Strange R, Matthias C, Fryer AA. 1995. [Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]. Laryngorhinootologie, vol. 74(11), 691-694. link> doi>
  • OLLIER WER, DAVIES E, SNOWDEN N, ALLDERSEA J, FRYER A, STRANGE R, JONES P. 1995. HOMOZYGOSITY FOR GLUTATHIONE-TRANSFERASE GSTM1 AND GSTT1 NULL ALLELES MAY CONFER RISK FOR ANTI-RO ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE). ARTHRITIS AND RHEUMATISM, vol. 38(9), 183. link>
  • Duncan H, Swan C, Green J, Jones P, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1995. Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. Clin Chim Acta, vol. 240(1), 53-61. link> doi>
  • Perrett CW, Clayton RN, Pistorello M, Boscaro M, Scanarini M, Bates AS, Buckley N, Jones P, Fryer AA, Gilford J. 1995. GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp. Carcinogenesis, vol. 16(7), 1643-1645. link> doi>
  • Warwick A, Sarhanis P, Redman C, Pemble S, Taylor JB, Ketterer B, Jones P, Alldersea J, Gilford J, Yengi L. 1994. Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking. Carcinogenesis, vol. 15(12), 2841-2845. link> doi>
  • Warwick AP, Redman CW, Jones PW, Fryer AA, Gilford J, Alldersea J, Strange RC. 1994. Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. Br J Cancer, vol. 70(4), 704-708. link> doi>
  • Zhao L, Alldersea J, Fryer A, Tighe A, Ollier B, Thomson W, Jones P, Strange R. 1994. Polymorphism at the glutathione S-transferase GSTM1 locus: a study of the frequencies of the GSTM1 A, B, A/B and null phenotypes in Nigerians. Clin Chim Acta, vol. 225(1), 85-88. link> doi>
  • Heagerty AH, Fitzgerald D, Smith A, Bowers B, Jones P, Fryer AA, Zhao L, Alldersea J, Strange RC. 1994. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet, vol. 343(8892), 266-268. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Pearson WR, Strange RC. 1993. Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus. Biochem J, vol. 295 ( Pt 1), 313-315. link> doi>
  • Fryer AA, Jones P, Strange R, Hume R, Bell JE. 1993. Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation. Br J Obstet Gynaecol, vol. 100(9), 850-855. link> doi>
  • Davies MH, Elias E, Acharya S, Cotton W, Faulder GC, Fryer AA, Strange RC. 1993. GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis. Gut, vol. 34(4), 549-553. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Boggild MD, Perrett CW, Clayton RN, Jones PW, Strange RC. 1993. The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis, vol. 14(4), 563-566. link> doi>
  • Mattey DL, Nixon N, Alldersea JE, Cotton W, Fryer AA, Zhao L, Jones P, Strange RC. 1993. Alpha, mu and pi class glutathione S-transferases in human synovium and cultured synovial fibroblasts: effects of interleukin-1 alpha, hydrogen peroxide and inhibition of eicosanoid synthesis. Free Radic Res Commun, vol. 19(3), 159-171. link> doi>
  • Strange RC, Fryer AA, Matharoo B, Zhao L, Broome J, Campbell DA, Jones P, Pastor IC, Singh RV. 1992. The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain. Biochim Biophys Acta, vol. 1139(3), 222-228. link> doi>
  • Bell JE, Fryer AA, Collins M, Marshall T, Jones PW, Strange R, Hume R. 1991. Developmental profile of plasma proteins in human fetal cerebrospinal fluid and blood. Neuropathol Appl Neurobiol, vol. 17(6), 441-456. link> doi>
  • Strange RC, Cotton W, Fryer AA, Jones P, Bell J, Hume R. 1990. Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. J Lab Clin Med, vol. 116(5), 666-673. link>
  • Carder PJ, Hume R, Fryer AA, Strange RC, Lauder J, Bell JE. 1990. Glutathione S-transferase in human brain. Neuropathol Appl Neurobiol, vol. 16(4), 293-303. link> doi>
  • STRANGE RC, FRYER A, BELL J, HUME R. 1990. STUDIES INTO THE ROLE OF REACTIVE OXYGEN SPECIES IN THE PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA. CLINICAL CHEMISTRY, vol. 36(6), 981. link>
  • Carter ND, Fryer A, Grant AG, Hume R, Strange RG, Wistrand PJ. 1990. Membrane specific carbonic anhydrase (CAIV) expression in human tissues. Biochim Biophys Acta, vol. 1026(1), 113-116. link> doi>
  • Carter N, Fryer A, Hume R, Strange R, Wistrand P. 1989. Expression of membrane-bound carbonic anhydrase in developing human lung and kidney. Biochem Soc Trans, vol. 17(6), 1122-1123. link> doi>
  • Hiley C, Fryer A, Bell J, Hume R, Strange RC. 1988. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem J, vol. 254(1), 255-259. link> doi>
  • Strange RC, Cotton W, Fryer AA, Drew R, Bradwell AR, Marshall T, Collins MF, Bell J, Hume R. 1988. Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. Biochim Biophys Acta, vol. 964(2), 260-265. link> doi>
  • Hirrell PA, Hume R, Fryer AA, Collins MF, Drew R, Bradwell AR, Strange RC. 1987. Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. Biochim Biophys Acta, vol. 915(3), 371-377. link> doi>
  • Fryer AA, Hume R, Strange RC. 1986. The development of glutathione S-transferase and glutathione peroxidase activities in human lung. Biochim Biophys Acta, vol. 883(3), 448-453. link> doi>
  • Livingston M, Robinson JC, Brown E, Holland D, Fryer AA, Heald AH. 2015. Are cholesterol levels being checked and managed appropriately in primary care Type 2 diabetes patients?. DIABETIC MEDICINE, vol. 32, 204. link>
  • Livingston M, Robinson JC, Brown CE, Narayanan RP, Holland D, Fryer AA, Heald AH. 2016. Are cholesterol levels being checked and managed appropriately in primary UK care for Type 2 diabetes?. DIABETIC MEDICINE, vol. 33, 84. link>
  • Livingston M, Robinson JC, Brown CE, Narayanan RP, Holland D, Fryer AA, Heald AH. 2015. Are cholesterol levels being checked and managed appropriately in UK primary care type 2 diabetes?. Int J Clin Pract, vol. 69(11), 1389-1391. link> doi>
  • McGinnis R, Child F, Clayton S, Davies S, Lenney W, Illig T, Wjst M, Spurr N, Debouck C, Hajeer AH, Ollier WER, Strange R, Fryer AA. 2002. Further support for the association of CCR5 allelic variants with asthma susceptibility. Eur J Immunogenet, vol. 29(6), 525-528. link> doi>
  • Heald AH, Anderson SG, Scargill JJ, Short AD, Holland D, Livingston M, Fryer AA, Donn RP. 2015. Measuring vitamin D levels: surrogates are insufficient. Int J Clin Pract, vol. 69(1), 131-135. link> doi>
  • Kitchen MO, Bryan RT, Haworth KE, Emes RD, Luscombe C, Gommersall L, Cheng KK, Zeegers MP, James ND, Devall AJ, Fryer AA, Farrell WE. 2015. Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. PLoS One, vol. 10(9), e0137003. link> doi>
  • Mamas MA, Kwok CS, Kontopantelis E, Fryer AA, Buchan I, Bachmann MO, Zaman MJ, Myint PK. 2016. Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights From the UK Myocardial Ischemia National Audit Project Registry. J Am Heart Assoc, vol. 5(11). link> doi>

Other

  • Kwok CS, Mamas AM, Kontopantelis E, Fryer AA, Buchan I, Bachmann MO, Zaman MJ, Myint PK. 2016. THE PREVALENCE, PREDICTORS AND OUTCOMES ASSOCIATED WITH ANAEMIA AMONG PATIENTS THAT PRESENT WITH ACS: INSIGHTS FROM THE UK MINAP REGISTRY. HEART (vol. 102, p. A76). link> doi>
  • Glossop J, Nixon N, Emes R, Haworth K, Packham J, Dawes P, Fryer A, Mattey D, Farrell W. 2013. Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals. ARTHRITIS AND RHEUMATISM (vol. 65, pp. S798-S799). link>
  • Stone MJ, Woolmore JA, Jenkinson P, Stephens R, Mihalova T, Langdon D, Fryer AA, Strange R, Hawkins CP. 2007. Cognitive impairment and polymorphisms of cathepsin D in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 254, p. 163). link>
  • Mihalova T, Eyre S, Barton A, Bowes J, Rukin N, Stone M, Boggild M, Young CA, Fryer A, Hoban P, Worthington J, Strange R, Hawkins CP. 2006. Genetic polymorphism in type III promoter of the major histocompatibility complex class II transactivator gene is associated with susceptibility to multiple sclerosis. MULTIPLE SCLEROSIS (vol. 12, pp. S73-S74). link>
  • Madan V, Hoban P, Strange RC, Fryer AA, Lear JT. 2006. Genetics and risk factors for basal cell carcinoma. Br J Dermatol (vol. 154 Suppl 1, pp. 5-7). link> doi>
  • Holley S, Fryer A, Carroll W, Strange R, Hoban P, Lenney W. 2005. Functional analysis of GSTP1 haplotypes on cell growth and apoptosis in NIH3T3 fibroblasts. THORAX (vol. 60, pp. II22-II23). link>
  • Carroll WD, Fryer AA, Child F, Clayton S, Davies S, Strange RC, Lenney W. 2003. Further evidence supporting an in utero effect of maternal GSTP 1 on asthma phenotype. THORAX (vol. 58, pp. 1-2). link>
  • Carroll WD, Child F, Kwong GNM, Proctor A, Primhak R, Clayton S, Davies S, Strange RC, Whyte M, Fryer A, Lenney W. 2003. Regional variations in phenotype between cohorts 0f asthmatic children and their families. THORAX (vol. 58, pp. 69-70). link>
  • Ramsay HM, Fryer AA, Hawley CM, Smith AG, Nicol DL, Harden PN. 2003. Factors associated with nonmelanoma skin cancer following renal transplantation in Queensland, Australia. J Am Acad Dermatol (vol. 49, pp. 397-406). link> doi>
  • Matthias C, Jahnke V, Hajeer A, Ollier W, Fryer AA, Strange RC. 2001. [Influence of genetic variation in the major histocompatibility complex on head and neck cancer susceptibility]. Laryngorhinootologie (vol. 80, pp. 595-600). link> doi>
  • Ramachandran S, Fryer AA, Strange RC. 2001. Genetic factors determining cutaneous basal cell carcinoma phenotype. Med Pediatr Oncol (vol. 36, pp. 559-563). link> doi>
  • Harden PN, Fryer AA, Reece S, Smith AG, Ramsay HM. 2001. Annual incidence and predicted risk of nonmelanoma skin cancer in renal transplant recipients. Transplant Proc (vol. 33, pp. 1302-1304). link> doi>
  • Holley SL, Parkes G, Matthias C, Bockmühl U, Jahnke V, Leder K, Strange RC, Fryer AA, Hoban PR. 2001. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. Am J Pathol (vol. 159, pp. 1917-1924). link> doi>
  • Child F, Clayton S, Davies S, Fryer AA, Lenney W. 2000. Measurement of Rint, mask or mouthpiece?. THORAX (vol. 55, p. A57). link>
  • Ramsay HM, Fryer AA, Reece S, Smith AG, Harden PN. 2000. Clinical risk factors associated with nonmelanoma skin cancer in renal transplant recipients. Am J Kidney Dis (vol. 36, pp. 167-176). link> doi>
  • Strange RC, Jones PW, Fryer AA. 2000. Glutathione S-transferase: genetics and role in toxicology. Toxicol Lett (vols. 112-113, pp. 357-363). link> doi>
  • Strange RC, Alldersea J, Hoban PR, Fryer AA, Matthias C, Jahnke V, Jones PW. 2000. Genetic polymorphism and clinical outcome: identification of individuals at risk of a poor clinical outcome. Allergy (vol. 55 Suppl 61, pp. 10-14). link> doi>
  • Spiteri MA, Bianco A, Strange RC, Fryer AA. 2000. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy (vol. 55 Suppl 61, pp. 15-20). link> doi>
  • Strange RC, Lear JT, Fryer AA. 1998. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact (vols. 111-112, pp. 351-364). link> doi>
  • Glossop JR, Haworth KE, Emes RD, Nixon NB, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2015. DNA METHYLATION PROFILING OF SYNOVIAL FLUID-DERIVED FIBROBLAST-LIKE SYNOVIOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS REVEALS COMMON AND DISTINCT CHANGES RELATIVE TO THEIR TISSUE-DERIVED COUNTERPARTS. RHEUMATOLOGY (vol. 54, p. 48). link>
  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2014. GENOME-WIDE DNA METHYLATION PROFILING IDENTIFIES DISTINCT CHANGES IN T- AND B-CELL POPULATIONS FROM PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 53, pp. 157-158). link>