Research Facilities at ISTM

Facilities available in the Institute at its three sites include:

Patient Research facilities

Guy_Hilton_Research_Centre_foyer_200x150 The Guy Hilton Research Centre, at ISTM’s Hartshill site at University Hospital of North Staffordshire, opened in 2006 and the final phases were completed in 2008. The GHRC is linked to and supports existing Keele laboratories and extensive facilities for MSc and PhD students, to create a base for the Institute’s academic and NHS members and their teams, all under one roof.

The Guy Hilton Research Centre provides a specialised patient research suite with consulting rooms, all ancillary services and waiting areas, ideal for hosting a range of studies including clinical trials. For further information contact GHRC Reception on +44 (0)1782 674988 or e-mail Amy Chell: a.chell1@keele.ac.uk.

Guy_Hilton_Research_Centre_laboratory_200x150  GHRC laboratories now house the facilities for successful current programmes such as:

  •  development of SIFT-MS technology for breath analysis,
  •  development of magnetic nanotechnology in therapeutics and diagnostics,
  •  upgrade facilities to include GMP and MCA approved facilities for human cell therapy for the tissue engineering programme,
  •  a class 100 clean room for supporting sample materials research,
  •  molecular facilities which further provide support for the Genomics suite.

 Plus generic laboratories for multi-disciplinary expansion with new staff members in Keele's Schools of Medicine and Pharmacy.

Human Genomics facilities

General_ISTM_lab_a_200x150   The Institute has a dedicated Human Genomics facility for:

  • Whole-genome analysis and expression to be characterised through an Affymetrix workstation and microarray facility in addition to equipment for real-time PCR analysis.
  • High-throughput sequencing (ABI) and mutation analysis based on Wave (Transgenomics) and Pyrosequencing technologies.
  • Cell sorting and cell cycle (FACS) analysis.

For further information on research based in this facility see the pages of the Human Genomics group.

Entomology and Parasitology facilities

ISTM_Fruit_fly_with_fluorescent_eyes_200x150   New and refurbished laboratories for Keele's Centre for Applied Entomology and Parasitology

These include category 3 culture suites, secure insectaries, fluorescence microscopy unit and dark rooms, dedicated molecular biology and biochemistry laboratories, insect cell culture facilities and a cold room.  Odour separation, identification of components and insect response to them is assisted by laboratories containing a mass spectrometer, facilities for single cell recordings and a wind tunnel.

For details of research carried out in these facilities please see the pages for CAEP.

 

Structural Biology facilities

Protein_3D_image_200x175   Recent refurbishments have provided coherent research facilities and laboratories for structural biology.

The facilities include a new purpose-built X-ray room, a protein biochemistry laboratory, a walk-in cold room, a graphics room (PCs, SGI O2+s, SGI Octane) and a dedicated resource room. They are adjacent to new research laboratories provided for the Keele Medical School with equipment and resources shared between the two. Access to the SRS, ESRF and Diamond is provided through the Midlands UK Protein Crystallography Consortium.

For details of recent research at these facilities see the pages of the Structural Biology Research Group.

PET Scanner and advanced medical imaging

New_PET-CT_Scanner_May2013_190x164

Keele University and the University Hospital of North Staffordshire purchased a state-of-the-art PET/CT Scanner in 2013.

A Service Level Agreement allocates dedicated PET time to ISTM researchers and UHNS clinical trialists.  For information please contact Andrea Clarke, Directorate Manager for Imaging at UHNS (Andrea.Clark@uhns.nhs.uk).

ISTM is developing novel imaging technologies such as 4D Electromagnetic Tomography, which is ready for first trials with stroke patients.

Keele Electron Microscopy Unit

electron microscope The Electron microscope Unit at Keele University aims to offer a high level service in microscopic techniques for anyone interested in exploring the invisible microworld of the small.

Services include visible and electron microscopy, image processing and slide making.

Central Electron Microscope Unit

Keele Proteomic Mass Spectrometry Facility

Applied_Biosystems_3200_QTRAP_+_Dionex_Ultimate_3000_LC_system_200x140 The Proteomics Facility at Keele University offers a range of mass spectrometry equipment now based at Huxley Building on Keele campus.

The equipment includes a 4800 MALDI TOF/TOF and 3200 QTRAP tandem quadrupole mass spectrometers, with nanoflow HPLC interfaces.  Access charges are applied either for an entire project at grant submission, or on an ad hoc basis.

Proteomic Mass Spectrometry Facility

Postgraduate training facilities

To create an integrated research training environment ISTM has placed facilities for postgraduates at the heart of its buildings.  

At the Guy Hilton Research Centre there is a large study suite for PhD/MPhil/DM students with 24/7 access and WiFi, and a dedicated room to host MSc students. In addition to meeting all the training requirements for Research Council and industry sponsored research students, ISTM holds Marie Curie Early Stage Training site and Training Network funding from the European Commission, for regular visits of PG students and staff from our collaborators.

News on research facilities at ISTM

istm_xray_diffraction_and_new_cryocooler_jan2014_IMG_5348_90x90  

Ultra-cool addition to Keele research equipment

Posted on 31 January 2014 Keele has invested over £60,000 in state-of-the-art, low temperature and cryo-cooling equipment to upgrade its Xcalibur X-ray Diffraction equipment.
New_SIFT-MS_equipment_Oct2013_IMG_5141_crop_90x90  

New Breath Analysis Equipment

Posted on 14 October 2013 ISTM has purchased new Selected Ion Flow Technique Mass Spectrometry (SIFT-MS) equipment for use by several groups at the Guy Hilton Research Centre.
New_safety_cabinet_at_GHRC_with_visiting_student_Jessica_Bratt_Oct2013_IMG_5128_90x90  

ISTM laboratory upgrades reach £100,000

Posted on 04 October 2013 The Research Institute for Science & Technology in Medicine has invested over £100,000 in laboratory upgrades over the summer, across its three main sites.
biomagnetometer  

Keele team builds new biomagnetometer

Posted on 17 June 2013 ISTM's biomagnetics team has come up with a low cost solution to measure the properties of magnetic nanoparticle suspensions
New_PET-CT_Scanner_May2013_90x90  

Opening for PET CT Scanner

Posted on 24 May 2013 A new PET/CT scanner has been purchased for use by University Hospital of North Staffordshire and Keele University researchers.
Karen_Walker_Dave_Furness_new_EM_Unit_fume_cupboards_Jan2013_IMG_3659_90x90  

New fume cupboards in Keele’s EM Unit

Posted on 05 February 2013 Two brand new fume cupboards have been installed at Keele's Electron Microscope Unit.
Applied_Biosystems_3200_QTRAP_+_Dionex_Ultimate_3000_LC_system_90x90  

Introduction to Mass Spectrometry capabilities at Keele

Posted on 15 November 2012 Dr Elzbieta Piatkowska, newly appointed researcher in mass spectrometry, gave members an outline of the capabilities of the relocated Keele Proteomics facility.

GC-MS_and_TD_capability_with_Dr_Wen-Wu_Li_GHRC_Nov2012_IMG_3002_90x90  

New Analytical Technique for ISTM Laboratories

Posted on 16 November 2012 Keele has invested in the latest Gas Chromatograph Mass Spectrometry (GC-MS) equipment, coupled to Thermal Desorption (TD) capability.
Stereomicroscope_equipment_for_neuroscience_2012_90x90  

Investment in new neuroscience equipment

Posted on 09 November 2012 A new stereomicroscope with imaging equipment has enhanced the facilities for Keele's neuroscientists.
CellIQ_with_Karina_Wright_and_Hannah_Fox_90x90  

Cell-IQ enables high quality images

Posted on 10 October 2012 Members of ISTM based at RJAH Hospital in Oswestry have taken delivery of a Cell-IQ machine.
Catriona_Kelly_and_Alan_Harper_2012_IMG_2140_90x90  

New Spectrophotometer benefits two lecturers’ research

Posted on 29 June 2012 The purchase of a monochromator-based fluorescence spectrophotometer system in April has enabled two Keele lecturers to start a new series of experiments.
Bill_Farrell_and_equipment_90x90  

A new Pyrosequencing facility for Keele

Posted on 15 June 2012 ISTM has purchased a new Pyrosequencer costing over £35,000, for installation in the Guy Hilton Research Centre
Electrophysiology_rig_Dave_Mazzochi-Jones_Mike_Evans_May2012_IMG_2014_90x90  

New Electrophysiology facilities for cellular engineering

Posted on 01 June 2012 Four members of ISTM’s neuroscience research group based in the Huxley Building have together designed and purchased a new set of Electrophysiology equipment.
FlourochemM_Dr_Alan_Richardson_Elizabeth_Robinson_90x90  

ISTM invests in the latest imaging equipment

Posted on 23 May 2012 Fifteen members of the Research Institute now have access to the latest imaging equipment for their experiments on two sites