Dr Gavin Miller

Title: Lecturer
Phone: (+44) 01782 7 34442
Email: g.j.miller@keele.ac.uk
Location: Lennard-Jones LJ 1.08
Role:
Contacting me: E-mail me for an appointment
Gavin Miller

Gavin Miller was born in Newport, Wales and read Chemistry with Medicinal Chemistry at UMIST where he was awarded an MChem. Continuing his studies at the University of Manchester, Gavin undertook a PhD in carbohydrate chemistry (investigating multivalency). 

He then undertook PDRA positions at Brown University (polyketides) and St Andrews University (inositol mimetics). Gavin then worked in industry, firstly at Ferring Pharmaceuticals, on the design of new treatments for primary dysmenorrhea and secondly at Peakdale Molecular on the design of an anti-nicotine vaccine.

Gavin returned to academia and the University of Manchester in 2009, firstly as a PDRA in the Manchester Institute of Biotechnology developing chemical synthesis approaches to heparan sulfate oligosaccharides and secondly as a fixed-term lecturer, in 2013, within the School of Chemistry. He took up his current lectureship in chemistry at Keele in 2015.

Our research program sits at the chemistry/biology interface. We are interested in further understanding fundamental mammalian biological signaling processes and in exploring unchartered bacterial biosynthetic pathways; all encompassed within the field of glycomics

As a means to achieve this, we are developing and applying new synthetic organic methodologies to construct mimetic carbohydrate building blocks. This technology will facilitate the application of such building blocks, both as individual biological tools/probes, and also for constructing more complex mimetic oligosaccharide and sugar nucleotide targets.

Please see the Research Group Webpage for further information.

A 24 month EPSRC funded PDRA position investigating the design and synthesis of innovative mimetic sugar nucleotides is  now available - closing date 23rd August

Selected Publications

  • Hansen SU, Miller GJ, Cliff MJ, Jaysonc GC, Gardiner JM. 2015. Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer. CHEMICAL SCIENCE, vol. 6(11), 6158-6164. link> doi> link> full text>
  • Jayson GC, Hansen SU, Miller GJ, Cole CL, Rushton G, Avizienyte E, Gardiner JM. 2015. Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. Chem Commun (Camb), vol. 51(72), 13846-13849. link> doi> full text>
  • Takemoto N, Suehara T, Frisco HL, Sato S-I, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. 2013. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc, vol. 135(30), 11032-11039. link> doi>
  • Hansen SU, Miller GJ, Cole C, Rushton G, Avizienyte E, Jayson GC, Gardiner JM. 2013. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat Commun, vol. 4, 2016. link> doi>
  • Miller GJ, Hansen SU, Avizienyte E, Rushton G, Cole C, Jayson GC, Gardiner JM. 2013. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2-and VEGF(165)-mediated endothelial cell functions. CHEMICAL SCIENCE, vol. 4(8), 3218-3222. link> doi> full text>

Full Publications List show

Journal Articles

  • Ahmadipour S and Miller GJ. 2017. Recent advances in the chemical synthesis of sugar-nucleotides. Carbohydr Res, vol. 451, 95-109. link> doi> full text>
  • Avizienyte E, Cole CL, Rushton G, Miller GJ, Bugatti A, Presta M, Gardiner JM, Jayson GC. 2016. Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo. PLoS One, vol. 11(8), e0159739. link> doi> full text>
  • Cheallaigh A, Potter G, Gardiner J, Miller GJ. 2016. Preparation of Methyl 1,2,3,4-tetra-O-acetyl-B-D-glucopyranuronate. Organis Syntheses, vol. 93, 200-209. doi> full text>
  • Hansen SU, Miller GJ, Cliff MJ, Jaysonc GC, Gardiner JM. 2015. Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer. CHEMICAL SCIENCE, vol. 6(11), 6158-6164. link> doi> link> full text>
  • Miller GJ, Broberg KR, Rudd C, Helliwell MR, Jayson GC, Gardiner JM. A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides. Org. Biomol. Chem.. doi> full text>
  • Potter GT, Jayson GC, Miller GJ, Gardiner JM. 2015. Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids. TETRAHEDRON LETTERS, vol. 56(37), 5153-5156. link> doi> full text>
  • Jayson GC, Hansen SU, Miller GJ, Cole CL, Rushton G, Avizienyte E, Gardiner JM. 2015. Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. Chem Commun (Camb), vol. 51(72), 13846-13849. link> doi> full text>
  • Hansen SU, Dalton CE, Baráth M, Kwan G, Raftery J, Jayson GC, Miller GJ, Gardiner JM. 2015. Synthesis of L-iduronic acid derivatives via [3.2.1] and [2.2.2] L-iduronic lactones from bulk glucose-derived cyanohydrin hydrolysis: a reversible conformationally switched superdisarmed/rearmed lactone route to heparin disaccharides. Journal of Organic Chemistry, vol. 80(8), 3777-3789. link> doi>
  • Baráth M, Hansen SU, Dalton CE, Jayson GC, Miller GJ, Gardiner JM. 2015. Modular synthesis of heparin-related tetra-, hexa- and octasaccharides with differential o-6 protections: programming for regiodefined 6-o-modifications. Molecules, vol. 20(4), 6167-6180. link> doi> full text>
  • Miller GJ, Hansen SU, Baráth M, Johannessen C, Blanch EW, Jayson GC, Gardiner JM. 2014. Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy. Carbohydr Res, vol. 400, 44-53. link> doi>
  • Jayson GC, Miller GJ, Hansen SU, Barath M, Gardiner JM, Avizienyte E. 2014. The development of anti-angiogenic heparan sulfate oligosaccharides. Biochem Soc Trans, vol. 42(6), 1596-1600. link> doi>
  • Pryde DC, Jones LH, Gervais DP, Stead DR, Blakemore DC, Selby MD, Brown AD, Coe JW, Badland M, Beal DM, Glen R, Wharton Y, Miller GJ, White P, Zhang N, Benoit M, Robertson K, Merson JR, Davis HL, McCluskie MJ. 2013. Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PLoS One, vol. 8(10), e76557. link> doi> full text>
  • Takemoto N, Suehara T, Frisco HL, Sato S-I, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. 2013. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc, vol. 135(30), 11032-11039. link> doi>
  • Hansen SU, Miller GJ, Cole C, Rushton G, Avizienyte E, Jayson GC, Gardiner JM. 2013. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat Commun, vol. 4, 2016. link> doi>
  • Miller GJ, Hansen SU, Avizienyte E, Rushton G, Cole C, Jayson GC, Gardiner JM. 2013. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2-and VEGF(165)-mediated endothelial cell functions. CHEMICAL SCIENCE, vol. 4(8), 3218-3222. link> doi> full text>
  • Hansen SU, Miller GJ, Jayson GC, Gardiner JM. 2013. First gram-scale synthesis of a heparin-related dodecasaccharide. Org Lett, vol. 15(1), 88-91. link> doi>
  • Hansen SU, Miller GJ, Baráth M, Broberg KR, Avizienyte E, Helliwell M, Raftery J, Jayson GC, Gardiner JM. 2012. Synthesis and scalable conversion of L-iduronamides to heparin-related di- and tetrasaccharides. J Org Chem, vol. 77(18), 7823-7843. link> doi>
  • Miller GJ and Gardiner JM. 2011. A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation. TETRAHEDRON LETTERS, vol. 52(25), 3216-3218. link> doi> full text>
  • Miller GJ and Gardiner JM. 2010. Adaptable synthesis of C-glycosidic multivalent carbohydrates and succinamide-linked derivatization. Org Lett, vol. 12(22), 5262-5265. link> doi>
  • Florence GJ, Aslam T, Miller GJ, Milne GDS, Conway SJ. 2009. Thieme Chemistry Journal Awardees - Where are They Now? Synthesis of the Marine Glycolipid Dioctadecanoyl Discoside. SYNLETT, 3099-3102. link> doi>
  • Conway SJ and Miller GJ. 2007. Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives. Nat Prod Rep, vol. 24(4), 687-707. link> doi>

In 2015/16 I am teaching on the following modules: Topics in Chemistry (che-30037), and Topics in Medicinal Chemistry (che-30044)