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EPSRC project to investigate bacterial biosynthesis
Dr Gavin Miller has been awarded a two-year EPSRC Research Grant. The award, of £245,957, is entitled ‘Mimetic sugar nucleotides to probe a strategic bacterial dehydrogenase enzyme’ and will explore essential biosynthetic processes within the infectious bacterium, P. aeruginosa.
The molecular tools required to do this are called sugar nucleotides and their chemical synthesis will enable vital information about enzyme structure and function to be collected, which could contribute towards instigating new approaches to disrupt specific enzyme activity and arrest normal bacterial biofilm development within this opportunistic pathogen.
The award will support a PDRA for two years and will also establish new collaborations between Keele and the John Innes Centre, Norwich and the University of Missouri-Columbia, USA.