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LSC-30039 - Module Specification
School of Life Sciences
Faculty of Natural Sciences

For academic year: 2024/25 Last Updated: 18 April 2024

LSC-30039 - Regeneration and Repair in the Nervous System
Coordinator: Christopher Adams Room: N/A Tel: +44 1782 7 33943
Lecture Time: See Timetable...
Level: Level 6
Credits: 15
Study Hours: 150
School Office: 01782 734414

Programme/Approved Electives for 2024/25

None

Available as a Free Standing Elective

No

Co-requisites

None

Prerequisites

LSC-20076 Learning and Memory

Barred Combinations

None

Description for 2024/25

The adult nervous system displays quite a remarkable ability to regenerate following degeneration, or trauma. Furthermore it has been extensively demonstrated that primary neuronal tissue/cells can be transplanted into the adult nervous system, and given an appropriate time period can integrate with the host tissue, ultimately restoring neurological function. In this module, we will explore regeneration and repair strategies across the peripheral, and central (Brain and spinal cord) nervous systems, and examine their application in an array of neurological disorders, including; Parkinson's disease, Huntington's disease, spinal cord trauma, multiple sclerosis, and stroke.
The module is taught via a series of lectures, and the tutors on this module are drawn from researchers with an active programme in nervous system regeneration and repair.

Aims
To provide an in-depth grounding in the mechanisms underlying regeneration and repair in the nervous system, covering the application of these mechanisms to a range of neurological disorders.

Intended Learning Outcomes

define and explain the molecular and cellular mechanisms involved in repair and regeneration of the central and peripheral nervous system: 1
evaluate evidence from experimental and clinical trials draw own conclusions regarding the efficacy of neurological cell transplantation: 1,2,3
discuss the efficacy of emerging sources of transplant tissue (i.e., Stem Cells, Genetically Modified Tissue), in relation to existing neurological disorders: 1,2,3
evaluate and explain current bioengineering approaches used in repairing and regenerating the nervous system: 1,2,3
prepare a grant proposal that in turn will be used in a peer-review process. This will enable students to critically and constructively evaluate both their own aims and methods (in writing the grant) and those presented in a grant written by a current student on the module: 1,2,3

Study hours

46 h active learning:
Active lectures ¿ 10h
Tutorial ¿ 16h
Engaging with asynchronous content ¿ 20h

104 h independent study:
60 hours for in-course assessment:
- Assessment 1 (grant proposal): 30 hours
- Assessment 2 (peer-review): 10 hours
- Assessment 3 (panel): 20 hours
44 hours private study
- 33 h reading around lectures
- 11 h preparation and reflection on tutorials

School Rules

None

Description of Module Assessment

1: Individual Report weighted 60%
2,000 word Research Grant Proposal
Students will produce a 2,000 word grant proposal on a topic applied to regeneration and repair of the nervous system, based on an existing grant proforma.

2: Review weighted 15%
500 word peer review of Grant Proposal
Students will produce a 500 word peer review of an allocated grant proposal generated by other students.

3: Group Report weighted 25%
1000 word justification of funding decision, submitted as a group
Once the grant and peer review exercise have been completed, a grant panel meeting will take place. Here, students will be assigned randomly to groups of 6. They will then present their peer review to the group and summarise the strengths and weaknesses of their reviewed grant. Each student will do this and then the group will have to rank the proposals. A 1000 word justification for the ranking will then have to be submitted as a group. This should include strengths of the top proposals and weaknesses of the bottom proposals, based on knowledge acquired in the module. A group mark will be awarded. However, this mark can be modulated +/- 10% based on peer assessment of engagement with the group.

Please note that for the 2022/23 Academic Year programmes may be adapted to operate in accordance with a flexible, digital approach. This means that there may be some changes made to how modules are delivered and assessed. The latest information will be provided to you by your School in module handbooks. We endeavour to give you as much notice as possible of any changes and details about the circumstance in which changes are made to programmes can be found in the Student Agreement, available at: https://www.keele.ac.uk/student-terms-and-conditions/

Last Updated: 18 April 2024