Programme/Approved Electives for 2022/23
Available as a Free Standing Elective
Cell to cell communication is fundamental for multi-cellular organisms as cells are required to communicate with their environment and among themselves in order to respond to particular stimuli. Such response is then integrated at the system level for the proper functioning of the organism. Not surprisingly, dysregulation of cellular communication causes many diseases including cancer. Cell to cell communication involves many signalling pathways. These signalling pathways regulate multiple cellular processes by acting through sensors to stimulate molecules that are responsible for controlling different important cellular processes. This module explores these signalling pathways and provides details on their molecular components and their mode of action. The module also places an emphasis on independent study and further develops skills in the acquisition, analysis and written communication of scientific information.
Talis Aspire Reading ListAny reading lists will be provided by the start of the course.http://lists.lib.keele.ac.uk/modules/lsc-20085/lists
The aims of this module are to give students a thorough background in the signalling mechanisms by which mammalian cells are regulated. The module provides a detailed description of the main modes of cell-cell communication, the major classes of signalling molecules and the receptor types upon which they act. It then focuses on the molecular details of these receptors and their associated signal transduction pathways.
Intended Learning Outcomes
explain the main modes of cell-cell communication, the major classes of signalling molecules and the receptor types upon which they act: 1describe the mode of action of receptors and discuss how they can activate major signalling pathways: 1evaluate the involvement of cell signalling pathways in disease processes and how these pathways are targeted for therapeutic intervention in a named disease: 2analyse and critically evaluate the context and results of primary scientific literature related to cell signalling: 2locate and retrieve information from scientific literature: 1,2
12 hours of tutorials/discussion activities supporting asynchronous content1 hour of tutorial related to the literature review assessment14 x 4 hours engagement with asynchronous content2 hours completion of online test40 hours completion of literature review39 hours independent study; test preparation/revision and engaging with directed reading
1: Online Tasks weighted 50%
Description of Module Assessment
Class test (2 hour active working time in a 3 hour assessment window)Online class test to be held in week 10/11 of the semester, comprising a mix of MCQs and SAQs designed to test core knowledge and application of module learning topics.
2: Literature Review weighted 50%
1500 word Literature review1500 word Literature review based on the involvement of cell signalling pathways in disease processes and how these pathways are targeted for therapeutic interventions. Titles will be related to core topics covered in the module and released in week 11/12 of the semester to be submitted in the exam period, with students required to sign-up for specific titles from a list of options.