Programme/Approved Electives for 2025/26
None
Available as a Free Standing Elective
No
This module is an introduction to molecular cell biology. Starting with the cell as the basic unit of life, you will look at the subcellular architecture of prokaryotic and eukaryotic cells. You will explore the diversity of prokaryotic cells and you will also look at the incredible diversity of cells within a multicellular organism and how these cells interact with and communicate with each other. You will find out the important roles of cellular membranes and be introduced to key signalling pathways. You will discover the importance of the genetic material and how the information stored in DNA is processed via RNA intermediates to produce proteins and how this genetic information is passed from one generation to the next (at the cellular and organismal levels). You will look in detail at structures of nucleic acids and compare and contrast the processes of transcription and translation in prokaryotic and eukaryotic cells and how these different types of cells control which genes are expressed. You will be introduced to how we can exploit some of the DNA processing enzymes used by bacterial cells for recombinant DNA technology and will investigate some of the bioethical implications of research used to study our genomes or create new DNA molecules.The module follows a flipped learning approach. Core material (lectures) and supporting materials will be delivered asynchronously via the KLE. This will be supported by live core material consolidation lectures and workshops that enable application of the core knowledge. On this module, the assessments are designed to support your learning not only by testing your knowledge and understanding, but also to help you to develop some of your key communication skills.
Aims
This module introduces students to the fundamentals of molecular cell biology, focusing on the mechanisms involved in the storage, processing and controlling the expression of the genetic information and the subcellular locations thereof. We investigate how cells within a multicellular organism interact with and communicate with each other. The module also looks at the diversity of cells and organisms, showing how genetic diversity is generated and how evolutionary pressures contribute to the wide biodiversity of organisms. The workshop programme aims to equip students with, problem solving, bioethics, communication and analytical skills.
Talis Aspire Reading ListAny reading lists will be provided by the start of the course.http://lists.lib.keele.ac.uk/modules/lsc-10066/lists
Intended Learning Outcomes
describe and compare the architecture of prokaryotic and eukaryotic cells, explaining the roles of cellular organelles and the cellular and molecular interactions involved in the formation of tissues: 1,2explain the fundamental differences between the processes of bacterial cell division and mitosis and meiosis in eukaryotic cells and the implications these different types of cell division have on the genetic diversity of offspring (Mendelian genetics): 2describe the chemical structure and function of the key nucleic acids and the molecular mechanisms of DNA replication, transcription and processing of RNA molecules, explaining how these differ in prokaryotes and eukaryotes: 2compare and contrast the processes of translation and post-translational processing of proteins in prokaryotes and eukaryotes: 2,4describe some of the major mechanisms of controlling gene expression in prokaryotes and eukaryotes and relate phenotypic diversity of cells within a multicellular organism to differences in gene expression: 4describe the major mechanisms for generation of genetic variation at the level of DNA and relate phenotypic diversity of prokaryotes and eukaryotes to the process of evolution by natural selection: 2discuss the structure and properties of biological membranes and describe the general mechanisms by which molecules are transported across them: 4describe the different types of intra- and inter-cellular signalling systems in eukaryotic cells: 4describe the practical applications of some of the naturally occurring DNA processing enzymes in recombinant DNA technology and the ethical implications of their use: 3,4communicate in a variety of different formats to different audiences, e.g. bioethics blog discussing the implications of animal experimentation, oral presentation: 1,3
Active learning hours9 x 1.5 hour live workshops8 x 1 hour lectures (core material consolidation)2 x 1 hour tutorials (assessment preparation)90.5 structured engagement with online activities (9 topics at10 hours per topic)Independent study hours2 x 2 hour completion of online class tests and exam 2 x 65 hour reading and revision for class test and exam52 hours completion of the communication skills portfolio assessments
Description of Module Assessment
1: Presentation weighted 15%Communications Skills Portfolio 1 (narrated powerpoint)Students will prepare and narrate a 2 minute PowerPoint presentation on the structure and function of a eukaryotic organelle.
2: Flexible Class Test weighted 25%Online Class Test IMid-semester, online class test covering the core materials from the first part of the module, comprising MCQ/SAQs testing core knowledge and understanding. Duration will be 1 hour expected active working time with an assessment window of 2 hours . Formative tests will be provided to support preparation.
3: Group Assessment weighted 10%Communications skills portfolio 2 (blog)Students will be allocated into group of up to 15, ensuring representation from the multiple cohorts taking the module. They will be expected to contribute approx. 300 words to a blog on the ethics of animal experimentation.
4: Exam weighted 50%1-hour closed book, invigilated exam within a 2-hour window (SEM2)The unseen exam will consist of multiple-choice and short-answer questions assessing lecture-based material. While the exam is designed to take approximately 1 hour, all students will be allocated 2 hours to ensure an inclusive and accessible assessment experience. Students will be permitted to take a double-sided A4 memory prompt of notes with them to the exam. Formative test will be provided to support preparation.