Programme/Approved Electives for 2020/21
Available as a Free Standing Elective
This module will introduce you to a broad range of core biochemistry concepts that will underpin a lot of what you will be studying throughout your course. Starting from an overview of basic concepts of chemical bonding, reactivity, kinetics and thermodynamics, you will look at their application to the study of protein structure and how this relates to protein and enzyme function. Great progress has been made in understanding the molecular structure of proteins, and we are now able to visualise many of them in great detail. Knowing the structure helps us to understand how a protein functions, and the content of the first part of the module reflects this. Our exploration of the function of enzymes will look at their underlying kinetic behaviour and why this is important in terms of the control and regulation of biochemical processes, including the generation of energy in cellular metabolism; something that will be explored in more detail in future modules in the consideration of metabolic disorders, including those as seemingly diverse as obesity and neurological conditions. The second part of the module will look specifically in more detail at the biochemical processes that underpin energy generation in the body and will cover the major metabolic pathways responsible for the processing of carbohydrates, fatty acids and protein/amino acids. Overall this module will provide a solid grounding in core biochemistry and develop an appreciation of the relationship between the chemical and biological sciences that underpin our understanding of human biological and biochemical processes.
Talis Aspire Reading ListAny reading lists will be provided by the start of the course.http://lists.lib.keele.ac.uk/modules/lsc-10064/lists
The module aims to provide students with an understanding of core chemical concepts and their application to the biological sciences. These concepts are applied to lectures on our understanding of protein and enzyme structure:function, the progress of biochemical reactions and the major metabolic pathways for the generation of energy. Supporting tutorials and laboratory-related virtual workbook activities will align with lecture content and will introduce students to a range of essential biochemical techniques for the study of enzyme kinetics. Further supporting workshops and tutorials are designed to support the development of key transferable skills in data analysis, presentation and communication of information, whilst other sessions will further support core concepts being developed in the lectures.
Intended Learning Outcomes
explain the basis of the layout of the periodic table and how this relates to atomic and molecular structure and properties including Lewis notation applied to bonding in simple organic molecules: 2explain basic concepts of chemical bonding, kinetics, reactivity and thermodynamics and their application to the study of protein structure, biochemical reactions and metabolic processes: 2describe the macromolecular structure of proteins in terms of primary, secondary, tertiary and quaternary structure and the common structural motifs adopted by folded proteins: 2explain the effect of environmental changes, substrate concentration and the binding of non-substrate ligands on protein and enzyme structure and function: 1,2describe the central role of metabolism in homeostasis and explain the progress and control of key metabolic pathways involving carbohydrates, fatty acids and protein/amino acids: 2describe oxidative metabolic processes for the production of ATP, including enzyme complexes in the mitochondria: 2analyse and interpret experimental data from the results of experimental investigations and communicate these effectively in written form in a scientific laboratory report: 1
38 1-hour lectures33 hours of laboratory classes20 hours of tutorials/workshops2 hour examination103 hours preparation of in-course assessments and formative class tests104 hours independent study: examination
1: Report weighted 30%
Description of Module Assessment
Laboratory reportStudents will produce a laboratory report (~2,000 words) assessing scientific content/insight and graphical data presentation/analysis based on data generated using interactive worksheets and/or provided for analysis, supported with a number of online tutorials and group discussion.2: Open Book Examination weighted 70%
Online seen examThe paper will be released on the KLE as a Word document at 9am on the morning of the exam and will comprise compulsory short answer questions (60% contribution to exam component) and one essay from a choice of three (40% contribution to the exam component). Students should answer each question using Word, clearly labelling each question as they provide their answers. Work will be submitted to Turnitin no later than 5pm on the day of release. International students will be asked to notify the School if they need an extension due to different time zones.
Although students have been given significant time to complete this exam script, we expect most students to spend no more than 2 hours. Answers should be as accurate and concise as possible.
For short-answer questions, students should pay careful attention to the number of points that each question is worth. In general, we would expect only one or two sentences for each point.
For essay-based questions, typical answers would be in the range of 500-750 words per question. We recommend that students do not exceed 750 words.