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Mechanisms of Toxicity of Nanoparticles
This research was funded under a MRC Highlights Theme of 'Mechanisms of Toxicity of Nanoparticles'. One of the most widely used form of nanoparticle are the particles which constitute aluminium-based adjuvants and these have been used in vaccination for almost 100 years. Surprisingly there is no consensus as to how these adjuvants actually work and so our project will investigate the nanotoxicity of aluminium-based ajuvants with the view to using this information to understand their efficacy as adjuvants in vaccinations. In addition adjuvant-based vaccines are currently a very hot topic in cancer research and we will be trying to understand how an aluminium-based adjuvant might be tailored to be even more effective in attacking brain tumours.
The project is a collaboration between Keele, Malmo University (Professor Hakan Eriksson) and Lund University (Professor Peter Siesjo) and the PDRA on the project is Dr Matthew Mold. We have just held our first Project Group Meeting in Lund (Sweden).
