Physics & Astrophysics
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I was appointed to a personal Chair in Biophysics in 2004. Prior to that I was a Lecturer and then Senior Lecturer in Physics at Keele. Since 2000 I have been on secondment to the Partnership for Structural Biology at the Institut Laue Langevin (ILL) in Grenoble, France.
The main research interests of my group concern the study of macromolecular systems using physical techniques. Neutron and X-ray scattering techniques at the Institut Laue Langevin (ILL) and the European Synchrotron Radiation Facility (ESRF) are central to this. Current project work includes structural studies of DNA, DNA-drug interactions and DNA-protein complexes, self assembling systems of synthetic and biological origin. We are also deeply involved in methodological developments for neutron and X-ray scattering. The Integrated Macromolecular Structure Research Group is based at the Partnership for Structural Biology (PSB) in Grenoble, France, where a wide variety of techniques are available to complement the capabilities of the Grenoble central facility infrastructures. For further details, see (http://www.ill.fr/deuteration).
See also group publications.
Selected Publications
Full Publications List show
Journal Articles
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2005. Amyloid fibril formation from sequences of a natural beta-structured fibrous protein, the adenovirus fiber. Journal of Biological Chemistry, vol. 280, 2481-2490. doi>
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2004. New Insights into the Structure of Poly(p-phenylene terephthalamide) from Neutron Fiber Diffraction Studies. Macromolecules, vol. 37(25), 9654-9656. doi>
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2004. Water-DNA interactions as studied by X-ray and neutron fibre diffraction. Philosophical Transactions of the Royal Society of London.
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2002. Folding of a fibrous protein and its self-assembling peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 223, D30. link>
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2002. Structural studies of biological & synthetic polymers using x-ray and neutron diffraction. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 223, D26. link>
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2001. Neutron diffraction study of a phenol-nitroxide radical adduct: A structural model for hydrogen atom abstraction by peroxyl radicals from vitamin E and related phenolic antioxidants. Journal of the American Chemical Society, vol. 123, 9164-9165. doi>
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1990. TIME-RESOLVED X-RAY FIBER DIFFRACTION STUDIES OF THE S-REVERSIBLE-B CONFORMATIONAL TRANSITION IN THE POLY [D(G-C)] POLY [D(G-C)] DOUBLE HELIX. INSTITUTE OF PHYSICS CONFERENCE SERIES, 225-236. link>
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1990. X-RAY AND NEUTRON HIGH ANGLE FIBER DIFFRACTION STUDIES IN THE DETERMINATION OF HYDRATION AND IONIC STRUCTURE AROUND DNA. INSTITUTE OF PHYSICS CONFERENCE SERIES, 237-248. link>
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1990. X-RAY AND NEUTRON-DIFFRACTION STUDIES OF THE STRUCTURE OF PEEK. INSTITUTE OF PHYSICS CONFERENCE SERIES, 213-224. link>
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1986. X-ray high-angle fibre diffraction studies of nucleic acid structure using the Daresbury Synchrotron Radiation Source. Biochem Soc Trans, vol. 14(3), 553-557. link>
Other
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2003. The mechanical role of intermediate filaments in cells: Insights from hagfish slime threads. BIOPHYSICAL JOURNAL (vol. 84, p. 440A). link>
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1996. DNA hydration studied by neutron fiber diffraction. Basic Life Sci (vol. 64, pp. 345-358). link>
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1996. Time-of-flight Laue fiber diffraction studies of perdeuterated DNA. Basic Life Sci (vol. 64, pp. 359-367). link>
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1990. TIME-RESOLVED X-RAY FIBER DIFFRACTION STUDIES OF THE S-REVERSIBLE-B CONFORMATIONAL TRANSITION IN THE POLY [D(G-C)] POLY [D(G-C)] DOUBLE HELIX. NEUTRON AND X-RAY SCATTERING : COMPLEMENTARY TECHNIQUES (vol. 101, pp. 225-236). link>
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1990. X-RAY AND NEUTRON HIGH ANGLE FIBER DIFFRACTION STUDIES IN THE DETERMINATION OF HYDRATION AND IONIC STRUCTURE AROUND DNA. NEUTRON AND X-RAY SCATTERING : COMPLEMENTARY TECHNIQUES (vol. 101, pp. 237-248). link>
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1990. X-RAY AND NEUTRON-DIFFRACTION STUDIES OF THE STRUCTURE OF PEEK. NEUTRON AND X-RAY SCATTERING : COMPLEMENTARY TECHNIQUES (vol. 101, pp. 213-224). link>

