School of Pharmacy
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I obtained my BSc, MSc and PhD degrees at the Queen’s University of Belfast. I have worked in industry (for Unilever Research) and held a number of academic posts including, most recently, Head of Pharmaceutics at the Hertfordshire School of Pharmacy. I joined the Keele School of Pharmacy in January 2010 and am responsible for aspects of pharmaceutics within the School.
My main research interests are in percutaneous absorption, particularly in the development of quantitative models of skin absorption and in aspects related to language / resource development in teaching and learning. Most recently, I have - at the invitation of the Karolinska Institute, Sweden - presented my research at the 1st International Conference on Modelling of Dermal Absorption, held September 2012 in Beijing, People's Republic of China. In November I was invited to speak at the Royal Society, London, at the first alumni event for the Royal Soceity MP-Scientist Pairing Scheme, which I participated in last year.
Selected Publications
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2012. Modelling of absorption across skin and silicone membranes using non-linear auto-regressive moving average with exogenous input (NARMAX) methods. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 377). link>
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2012. Nanomaterials for the advancement of infection control. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 372). link>
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2012. The application of machine learning methods to identify and classify potential transdermal enhancers. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 377). link>
Full Publications List show
Journal Articles
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2010. The application of Gaussian Processes in the prediction of absorption across mammalian sin and synthetic membranes.
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2008. The effect of language background on teaching and learning on the M.Pharm. Pharmacy Eduction, vol. 8(1), 45-52.
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2008. The effect of language background to teaching and learning on the M.Pharm. Pharmacy Education, vol. 8, 45-52.
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2007. Cosmetic claims: getting under your skin. The Biochemist, vol. 29, 8-10.
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2007. Pharmacy student perceptions of educational media tools. Pharmacy Eduction, vol. 7(1), 77-82. doi>
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2006. A potential anti-implantation and spermicidal strategy: Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity. European Journal of Contraception and Reproductive Healthcare, vol. 11, 258-261. doi>
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2005. Multiple-application dosing: effect on the percutaneous absorptionof aluminium from commercially available products. J Pharmacy & Pharmacology, vol. 57s, 104.
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2005. Synthesis and in vitro v vascular response of a putative captopril methyl ester nitric oxide releasing prodrug, on aortic helical strips. J Pharmacy & Pharmacology, vol. 57s((British Pharmaceutical Conference, Manchester)), 79.
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2004. The role of handouts in the MPharm degree pathway - differentiation between the inquisitive and acquisitive. Pharmacy Eduction, vol. 4(1), 7-12.
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2004. ACE-inhibitory activity of captopril methyl ester prodrug. J Pharmacy & Pharmacology, vol. 56s((British Pharmaceutical Conference, Manchester)), 88.
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2004. Prodrugs for enhanced percutaneous absorption. J Pharmacy & Pharmacology, vol. 56s((British Pharmaceutical Conference, Manchester)), 100.
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2004. The in vitro percutaneous absorption of aluminium from topical products. J Pharmacy & Pharmacology, vol. 56s((British Pharmaceutical Conference, Manchester)), 68.
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2003. Characteristics of the percutaneous penetration of novel anti-varcella zoster virus nucleoside analogues by confocal laser scanning microscopy. J Pharmacy & Pharmacology, vol. 56S(British Pharmaceutical Conference, Harrogate, UK), 25.
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2003. Surface-enhanced Raman spectroscopy if tetracaine deposition in the stratum corneum. J Pharmacy & Pharmacology, vol. 56S(British Pharmaceutical Confernce), 29.
Chapters
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2009. Skin case studies. In Clinical case studies in pharmacy. Dhillon S and Raymond R (Eds.). London: Pharmaceutical Press.
Other
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2012. Modelling of absorption across skin and silicone membranes using non-linear auto-regressive moving average with exogenous input (NARMAX) methods. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 377). link>
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2012. Nanomaterials for the advancement of infection control. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 372). link>
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2012. The application of machine learning methods to identify and classify potential transdermal enhancers. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (vol. 34, p. 377). link>
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2010. Synthesis and ACE-inhibitory potency of captopril branched chain ester prodrugs. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 62, pp. 1374-1375). link>
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2010. Synthesis of NO-releasing peptides and peptoids for stent coating. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 62, p. 1381). link>
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2010. The appication of feature selection to the development of Gaussian Process models for percutaneous absorption. J Pharmacy & Pharmacology. doi>
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2010. The effect of depilation on the percutaneous absorption of aluminium from antiperspirant products. 12th International perspectives in percutameous penetration.
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2010. The effect of occlusion on the percutaneous absorption of aluminium from antiperspirant products. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 62, p. 799). link>
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2010. Transiently supersaturated solutions from the dissolution of amorphous powders for topical drug delivery. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 62, p. 795). link>
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2010. Characteristisation of the drug release of a novel captopril prodrug from a matrix-type patch device. La Grande Mott, France: 11th International Perspectives in Percutaneous Penetration.
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2010. Novel powder formulation for toical delivery of micronazole nitrate and clotrimazole. La Grande Mott, France: 11th International Perspectives in Percutaneous Penetration.
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2010. Novel venlafaxine prodrugs for enhances percutaneous absorption. Joint meeting: 10th Annual Meeting of Skin Forum, and 3rd APSI Skin & Formulation Symposium.
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2010. Predicting Drug Absorption Rates Through Human Skin. 2010 INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS IJCNN 2010. link>
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2010. The application of machine learning and feature selection methods to the prediction of percutaneous absorption. 12th International perspectives in Percutaneous Penetration.
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2010. Variation of predicted permeability: a comparison of quantitative models for skin absorption. Versailles, France: Joint Meeting: 10th Annual Meeting of Skin Forum, and 3rd APSI Skin & Formulation Symposium.
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2009. Machine learning on barrier function of mammalian skin. Waterville Valley, NH: 11th Gordon Research conference on barrier function of mammalian skin.
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2009. On the utility of machine learning methods to quantify percutaneous absorption. Versailles, France: Joint Meeting: 10th Annual eeting of Skin Forum, and 3rd APSI Skin & Formulation Symposium.
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2009. The effect of amorphouis ad crystalline forms of clotrimazole for topical drug delivery. Versailles, France: Joint meeting: 10th annual meeting of Skin Forum, and 3rd APSI Skin & Formulation Symposium.
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2008. A comparison of quantitative models for skin absorption. London: 9th Annual Meeting of Skin Forum.
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2008. In vitro and in silico ACE-inhibitory activity of metabolically stable captopril ester derivatives for percutaneous absorption. La Grande Mott, France: 11th International Conference: Perspectives in Percutaneous Penetration.
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2008. Non-prametric Gaussian modelling of skin absorption using machine-learning methods. London: 9th Annual Meeting of Skin Forum.
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2008. Prediction of skin penetration using machine learning methods. La Grande Mott, France: 11th International Perspectives in Percutaneoud Penetration.
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2008. Predictions of skin penetration using machine learning methods. In . Giannotti.F, F. Gunopulos, F;Z. Turini, N;W. Ramakrishnan & . X.D;; (Eds.). Pisa, Italy. doi>
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2008. Variation of predicted permiability using calculated and experimental log P values: a comparison of quantitative models for skill absorption. Le Grande Mott, France: 11th International Perspectives in Percutaneous Penetration.
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2007. Formulation studies for prodrugs of captopril for enhances percutaneous absorption. J Pharmacy & Pharmacology (vol. 59s, p. 11).
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2007. Prodrugs for enhances percutaneous absorption - formulation and characterisation of drug-in-adhesive patch formulation. Newport, RI: 10th Gordon Research Conference on Barrier Function of Mammalian Skin.
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2007. Transdermal patch formulation and diffusion studies for captopril ethyl ester prodrug. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 59, p. A11). link>
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2006. A comparison of predicted and experimentally measured descriptors in QSPRs. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 58, p. A10). link>
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2006. A comparison of predicted and experimentally measured descriptors in QSPRs. J Pharmacy & Pharmacology (vol. 58s, p. 104).
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2006. Captopril prodrugs for transclermal delivery: docking and metabolism with CYP4502c1, RNase, and acetylcholinesterase. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 58, p. A33). link>
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2006. Captopril prodrugs for transdermal delivery: docking and metabolism with CYP450cl, RNase, and acetylcholinesterase. J Pharmacy & Pharmacology (vol. 58s, p. 17).
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2006. Synthesis and ACE-inhibitory activity of a captopril nitroxoxyethylamide a novel hybrid prodrug of captopril and itramine. JOURNAL OF PHARMACY AND PHARMACOLOGY (vol. 58, p. A85). link>
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2006. Synthesis and ACE-inhibitory activity of a captopril nitroxoxyethylamide a novel hybrid prodrug of captopril and itramine. J Pharmacy & Pharmacology (vol. 58s, p. 85).
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2005. ACE-inhibitory activity of a captopril propyl ester prodrug. J Pharmacy & Pharmacology (vol. 57s, p. 79).
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2005. Do QSPR models accurately reflect percutraneous absorption?. J Pharmacy & Pharmacology (vol. 57s, p. 18).
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2005. In vitro metabolism of captopril ester prodrugs: experimental and novel molecular modelling approaches. J Pharmacy & Pharmacology (vol. 57s, p. 41).
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2004. ACE-inhibitory activity of captopril methyl ester prodrug. Portsmouth, UK.
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2004. Development of a drug-in-adhesive patch containing extract of Paullinia Cupana. Portsmouth, UK.
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2004. The in vitro metabolism os captopril carboxy ester prodrugs. La Grande Motte, France: 9th International Conference on Perspectives in Percutaneous Penetration.
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2004. The in vitro pecutaneous absorption of captopril carboxyl ester prodrugs. 9th Internationa Conference on Perspectives in Percutaneous Penetration.
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2004. The in vitro percutaneous absorption of aluminium from topical products. Portsmouth, UK.
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2004. The in vitro percutaneous absorption of captopril carboxyl ester prodrugs: comparison of fresh vs. frozen skin for a series of carboxyl n-esters. Portsmouth, UK.
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2004. The metabolism of captopril carboxyl ester prodrugs: development of in vitro and ex vivo methods. Portsmouth, Uk.
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2003. Synthesis and Characterisation of captopril carboxylate-ester prodrugs. J Pharmacy & Pharmacology (vol. 56S, p. 42).
M.Pharm.
Pharmaceutics:
Level One – Introduction to Dosage Forms and Routes of Administration
Level Two – Various aspects of the formulation, manufacture and testing / QA of pharmaceutical products
Level Three – aspects of dosage form design; Research Methods
Level M – Option topics (percutaneous absorption) and research projects
- Chartered Chemist and Member of the Royal Society of Chemistry, since March 1996.
- Fellow of the Higher Education Academy, July 2004.
- Founding member and current committee member of the EPSRC Drug Delivery Research Network.
- Chairman (2004–2006), treasurer (2004–2005) and committee member (2003 – current date) of the Skin Forum Group (a focus group of the Academy of Pharmaceutical Sciences, initially funded by EPSRC).
- Representative of the EPSRC Skin Forum on the All Party Parliamentary Group on Skin, 2008 – 2010.
- Member of the Editorial Board of the International Journal of Cosmetic Sciences and Journal of Pharmacy and Pharmacology; Editor for Journal of Pharmacy and Pharmacology (Special Themed Edition on Recent Advances in Percutaneous Absorption, published June 2010).
- Member of the International Steering Committee Member, Handbook of Pharmaceutical Excipients.
- Member of the Pharmaceutical Sciences Group of the Royal Pharmaceutical Society of Great Britain.
- Member of the Industrial Pharmacy Group of the Royal Pharmaceutical Society of Great Britain.
- Member of the Academic Pharmacy Group of the Royal Pharmaceutical Society of Great Britain.
- Member of the Academy of Pharmaceutical Sciences.
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External examiner for:- M.Pharm. programme at the Kingston University School of Pharmacy (2013 - 2017)- OSPAP programme at the Kingston University School of Pharmacy (2014 - 2017)- M.Pharm. programme at the University of Ulster School of Pharmacy (2009 - 2013)- M.Res. programme at the University of Brighton School of Pharmacy (2007 - 2012)
§ Chartered Chemist and Member of the Royal Society of Chemistry, since March 1996.
§ Fellow of the Higher Education Academy, July 2004.
§ Founding member and current committee member of the EPSRC Drug Delivery Research Network.
§ Chairman (2004–2006), treasurer (2004–2005) and committee member (2003 – current date) of the Skin Forum Group (a focus group of the Academy of Pharmaceutical Sciences, initially funded by EPSRC).
§ Representative of the EPSRC Skin Forum on the All Party Parliamentary Group on Skin, 2008 – 2010.
§ Member of the Editorial Board of the International Journal of Cosmetic Sciences and Journal of Pharmacy and Pharmacology; Editor for Journal of Pharmacy and Pharmacology (Special Themed Edition on Recent Advances in Percutaneous Absorption, published June 2010).
§ Member of the International Steering Committee Member, Handbook of Pharmaceutical Excipients.
§ Member of the Pharmaceutical Sciences Group of the Royal Pharmaceutical Society of Great Britain.
§ Member of the Industrial Pharmacy Group of the Royal Pharmaceutical Society of Great Britain.
§ Member of the Academic Pharmacy Group of the Royal Pharmaceutical Society of Great Britain.
§ Member of the Academy of Pharmaceutical Sciences.
§ External examiner for the M.Pharm. programme at the University of Ulster and the M.Res. programme at the University of Brighton Schools of Pharmacy.

