Dr Sam Hider

Title: Lecturer in Clinical Rheumatology & Honorary Consultant Rheumatologist
Phone: +44 (0) 1782 734885
Email:
Location: DJW 1.61
Role: As above
Contacting me: Via email
Staff photo

I came to Keele in 2007 as an NIHR Walport Clinical Lecturer in Rheumatology. Following my undergraduate medical training in Nottingham (1996) I undertook postgraduate training in Manchester with an MSc Clinical Rheumatology (2003) and a PhD (2007).

Currently I work as a clinical academic at Keele and an Honorary Consultant Rheumatologist at the Haywood Hospital.

My research interests include

  • Clinical outcomes of sciatica
  • Polymyalgia rheumatica
  • Management of musculoskeletal conditions at the primary/secondary care interface

Selected Publications

  • Hayward RA, Rathod T, Roddy E, Muller S, Hider SL, Mallen CD. 2013. The association of gout with socioeconomic status in primary care: a cross-sectional observational study. Rheumatology (Oxford). link> doi>
  • Muller S, Hider SL, Belcher J, Helliwell T, Mallen CD. 2013. Is cancer associated with polymyalgia rheumatica? A cohort study in the General Practice Research Database. Ann Rheum Dis. link> doi>
  • Helliwell T, Hider SL, Mallen CD. 2013. Polymyalgia rheumatica: diagnosis, prescribing, and monitoring in general practice. Br J Gen Pract, vol. 63(610), e361-e366. link> doi>
  • Ellerby N, Mattey DL, Packham J, Dawes P, Hider SL. 2013. COMORBIDITY AND OBESITY ARE INDEPENDENTLY ASSOCIATED WITH FAILURE TO ACHIEVE REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 71). link>
  • Clarson LE, Hider SL, Belcher J, Heneghan C, Roddy E, Mallen CD. 2013. GOUT IS AN INDEPENDENT RISK FACTOR FOR ALL TYPES OF VASCULAR DISEASE: A RETROSPECTIVE COHORT STUDY IN THE UK GENERAL PRACTICE RESEARCH DATABASE. RHEUMATOLOGY (vol. 52, pp. 38-39). link>

Full Publications List show

Journal Articles

  • Hayward RA, Rathod T, Roddy E, Muller S, Hider SL, Mallen CD. 2013. The association of gout with socioeconomic status in primary care: a cross-sectional observational study. Rheumatology (Oxford). link> doi>
  • Muller S, Hider SL, Belcher J, Helliwell T, Mallen CD. 2013. Is cancer associated with polymyalgia rheumatica? A cohort study in the General Practice Research Database. Ann Rheum Dis. link> doi>
  • Helliwell T, Hider SL, Mallen CD. 2013. Polymyalgia rheumatica: diagnosis, prescribing, and monitoring in general practice. Br J Gen Pract, vol. 63(610), e361-e366. link> doi>
  • Roddy E, Zwierska I, Jordan KP, Dawes P, Hider SL, Packham J, Stevenson K, Hay EM. 2013. Musculoskeletal clinical assessment and treatment services at the primary-secondary care interface: an observational study. Br J Gen Pract, vol. 63(607), e141-e148. link> doi>
  • Konstantinou K, Hider SL, Jordan JL, Lewis M, Dunn KM, Hay EM. 2013. The impact of low back-related leg pain on outcomes as compared with low back pain alone: a systematic review of the literature. Clin J Pain, vol. 29(7), 644-654. link> doi>
  • Hancock AT, Mallen CD, Belcher J, Hider SL. 2012. Association between polymyalgia rheumatica and vascular disease: a systematic review. Arthritis Care Res (Hoboken), vol. 64(9), 1301-1305. link> doi>
  • Muller S, Hider S, Helliwell T, Bailey J, Barraclough K, Cope L, Dasgupta B, Foskett R, Hughes R, Mayson Z, Purcell C, Roddy E, Wathall S, Zwierska I, Mallen CD. 2012. The epidemiology of polymyalgia rheumatica in primary care: a research protocol. BMC Musculoskelet Disord, vol. 13, 102. link> doi>
  • Barraclough K, Mallen CD, Helliwell T, Hider SL, Dasgupta B. 2012. Diagnosis and management of giant cell arteritis. Br J Gen Pract, vol. 62(599), 329-330. link> doi>
  • Helliwell T, Hider SL, Barraclough K, Dasgupta B, Mallen CD. 2012. Diagnosis and management of polymyalgia rheumatica. Br J Gen Pract, vol. 62(598), 275-276. link> doi>
  • Owen SA, Hider SL, Martin P, Bruce IN, Barton A, Thomson W. 2013. Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. Pharmacogenomics J, vol. 13(3), 227-234. link> doi>
  • Konstantinou K, Beardmore R, Dunn KM, Lewis M, Hider SL, Sanders T, Jowett S, Somerville S, Stynes S, van der Windt DA, Vogel S, Hay EM. 2012. Clinical course, characteristics and prognostic indicators in patients presenting with back and leg pain in primary care. The ATLAS study protocol. BMC Musculoskelet Disord, vol. 13, 4. link> doi>
  • Muller S, Hider SL, Helliwell T, Mallen CD. 2012. An unorthodox approach to calculating sample size. BMJ, vol. 345, e6586. link> doi>
  • Helliwell T, Muller S, Hider SL. 2012. ESR can be normal in giant cell arthritis and polymyalgia rheumatica. BMJ, vol. 344, e1408.
  • Chandratre P, Mallen C, Richardson J, Rome K, Bailey J, Gill R, Hider SL, Mason J, Mayson Z, Muller S, Purcell C, Titley J, Wathall S, Zwierska I, Roddy E. 2012. Prospective observational cohort study of Health Related Quality of Life (HRQOL), chronic foot problems and their determinants in gout: a research protocol. BMC Musculoskelet Disord, vol. 13(1), 219.
  • Konstantinou K, Hider SL, Vogel S, Beardmore R, Somerville S. 2012. Development of an assessment schedule for patients with low back-associated leg pain in primary care: a Delphi consensus study. Eur Spine J, vol. 21(7), 1241-1249. link> doi>
  • Owen SA, Lunt M, Bowes J, Hider SL, Bruce IN, Thomson W, Barton A. 2013. MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms. Pharmacogenomics J, vol. 13(2), 137-147. link> doi>
  • Kapoor SR, Hider SL, Brownfield A, Mattey DL, Packham JC. 2011. Fibromyalgia in patients with rheumatoid arthritis: driven by depression or joint damage?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol. 29(6), S88-S91. link>
  • Reilly M, Wellcome Trust Case Control Consortium, Hider SL. 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet Infectious Diseases, vol. 377(9763), 383-392.
  • Owen SA, Lunt M, Hider SL, Bruce IN, Barton A, Thomson W. 2010. Testing pharmacogenetic indices to predict efficacy and toxicity of methotrexate monotherapy in a rheumatoid arthritis patient cohort. Arthritis Rheum, vol. 62(12), 3827-3829. link> doi>
  • Roddy E, Zwierska I, Dawes P, Hider SL, Jordan KP, Packham J, Stevenson K, Hay E, SAMBA team. 2010. The Staffordshire arthritis, musculoskeletal, and back assessment (SAMBA) study: a prospective observational study of patient outcome following referral to a primary-secondary care musculoskeletal interface service. BMC Musculoskelet Disord, vol. 11, 67. link> doi>
  • Roddy E, Mallen CD, Hider SL, Jordan KP. 2010. Prescription and comorbidity screening following consultation for acute gout in primary care. Rheumatology (Oxford), vol. 49(1), 105-111. link> doi>
  • Hider SL, Tanveer W, Brownfield A, Mattey DL, Packham JC. 2009. Depression in RA patients treated with anti-TNF is common and under-recognized in the rheumatology clinic. Rheumatology (Oxford), vol. 48(9), 1152-1154. link> doi> full text>
  • Pemberton PW, Ahmad Y, Bodill H, Lokko D, Hider SL, Yates AP, Walker MG, Laing I, Bruce IN. 2009. Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: a cross-sectional study of their association with accelerated atherosclerosis. BMC Res Notes, vol. 2, 83. link> doi>
  • Hider SL, Silman AJ, Thomson W, Lunt M, Bunn D, Symmons DP. 2009. Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis?. Ann Rheum Dis, vol. 68(1), 57-62. link> doi>
  • Hider SL, Thomson W, Mack LF, Armstrong DJ, Shadforth M, Bruce IN. 2008. Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX. Rheumatology (Oxford), vol. 47(8), 1156-1159. link> doi>
  • Hider SL. 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet, vol. 40(6), 768-775.
  • Hider SL. 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's Disease. Nat Genet, vol. 40(6), 710-712.
  • HIDER SL, Thomson W, Bruce IN. 2008. Response to Dr Van der Kooiji et al re: The pharmacogenetics of methotrexate. Rheumatology, vol. 47(4), 557-558.
  • Hider SL, Bruce IN, Thomson W. 2007. The pharmacogenetics of methotrexate. Rheumatology (Oxford), vol. 46(10), 1520-1524. link> doi>
  • Hider SL. 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet, vol. 39(11), 1329-1337.
  • Hider SL. 2007. Rheumatoid arthritis association at 6q23. Nat Genet, vol. 39(12), 1431-1433.
  • Hider SL, Silman A, Bunn D, Manning S, Symmons D, Lunt M. 2006. Comparing the long-term clinical outcome of treatment with methotrexate or sulfasalazine prescribed as the first disease-modifying antirheumatic drug in patients with inflammatory polyarthritis. Ann Rheum Dis, vol. 65(11), 1449-1455. link> doi>
  • Hider SL, Owen A, Hartkoorn R, Khoo S, Back D, Silman AJ, Bruce IN. 2006. Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug. Ann Rheum Dis, vol. 65(10), 1390-1393. link> doi>
  • Hider SL, Woodhead M, Taylor PM, Bruce IN. 2006. Lung fibrosis in systemic sclerosis treated with a combination of ciclosporin and azathioprine. Clin Exp Rheumatol, vol. 24(2), 215. link>
  • Hider SL, Hoggard P, Khoo S, Back D, Bruce IN. 2005. Drug efflux transporters in rheumatoid arthritis: comment on the article by Kremer. Arthritis Rheum, vol. 52(2), 670. link> doi>
  • Hider SL, Bruce IN, Silman AJ, Symmons DP. 2005. Defining response to disease modifying antirheumatic drugs in patients with rheumatoid arthritis. J Rheumatol, vol. 32(1), 6-10. link>
  • Hider SL, Ismail A, Todd B, Rodgers J, Hamilton A, Cook G. 2005. Does a patient-focused approach increase prescribing following a low trauma fracture?. Rheumatology (Oxford), vol. 44(1), 138-139. link> doi>
  • Hider SL, Buckley C, Silman AJ, Symmons DP, Bruce IN. 2005. Factors influencing response to disease modifying antirheumatic drugs in patients with rheumatoid arthritis. J Rheumatol, vol. 32(1), 11-16. link>
  • Hider SL, Roy DK, Augustine T, Parrott N, Bruce IN. 2004. Resolution of diabetic cheiroarthropathy after pancreatic transplantation. Diabetes Care, vol. 27(9), 2279-2280. link> doi>
  • Hider SL, Ismail AA, Cook G, Todd B, Rogers J, Hamilton A. 2004. PRESCRIBING FOLLOWING OSTEOPOROTIC FRACTURE: DOES A PATIENT AND GENERAL PRACTITIONER CENTRED APPROACH INCREASE PRESCRIBING?. RHEUMATOLOGY, vol. 43, 82. link>
  • Dornan T, Boshuizen E, Cordingley L, Hider S, Hadfield J, Scherpier A. 2004. Evaluation of self directed clinical education: validation of an instrument. Medical Education, vol. 38(6), 670-678.
  • Hider SL, Morgan C, Bell E, Bruce IN. 2003. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with RA?. Ann Rheum Dis, vol. 62(6), 591. link> doi>
  • Harrison BJ, Silman AJ, Hider SL, Herrick AL. 2002. Cigarette smoking as a significant risk factor for digital vascular disease in patients with systemic sclerosis. Arthritis Rheum, vol. 46(12), 3312-3316. link> doi>
  • Hider SL, Hilton RC, Hutchinson C. 2002. Chronic exertional compartment syndrome as a cause of bilateral forearm pain. Arthritis Rheum, vol. 46(8), 2245-2246. link> doi>
  • Hider SL, Mulherin D, Ortiz M, Wong M. 2002. Exercise and body image in ankylosing spondylitis. Scandinavian Journal of Rheumatology, vol. 31, 168-171.
  • Hider SL, Lunt M, Herrick AL. 2001. Amputations in systemic sclerosis: the influence of disease subtype, anticentromere antibody and smoking status. RHEUMATOLOGY, vol. 40, 116. link>
  • Hider SL, Mulherin D, Ortiz M, Wong M. 2001. Exercise and body image in ankylosing spondylitis. RHEUMATOLOGY, vol. 40, 40-41. link>
  • Bradbury SL and Scarpello JHB. 1999. Recurrent hypoglycaemia as the presenting symptom of coeliac disease in a patient with type 1 diabetes. Practical Diabetes International 16, vol. 16(3), 89-90.

Chapters

  • Hider SL, Morgan C, Thomson W, Bruce IN. 2006. Pharmacogenetics in Rheumatology. In Pharmacogenetics. Hall (Ed.).

Other

  • Ellerby N, Mattey DL, Packham J, Dawes P, Hider SL. 2013. COMORBIDITY AND OBESITY ARE INDEPENDENTLY ASSOCIATED WITH FAILURE TO ACHIEVE REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 71). link>
  • Clarson LE, Hider SL, Belcher J, Heneghan C, Roddy E, Mallen CD. 2013. GOUT IS AN INDEPENDENT RISK FACTOR FOR ALL TYPES OF VASCULAR DISEASE: A RETROSPECTIVE COHORT STUDY IN THE UK GENERAL PRACTICE RESEARCH DATABASE. RHEUMATOLOGY (vol. 52, pp. 38-39). link>
  • Muller S, Mallen CD, Belcher J, Helliwell T, Hider SL. 2013. THE RISK OF A SUBSEQUENT CANCER DIAGNOSIS AFTER PMR: A PRIMARY CARE DATABASE STUDY. RHEUMATOLOGY (vol. 52, p. 40). link>
  • Monk HL, Muller S, Mallen C, Hider SL. 2012. ARE RHEUMATOID ARTHRITIS PATIENTS SCREENED FOR CARDIOVASCULAR DISEASE IN PRIMARY CARE?. RHEUMATOLOGY (vol. 51, pp. 37-38). link>
  • Green DJ, Muller S, Mallen C, Hider SL. 2012. FATIGUE AS A PRECURSOR TO POLYMYALGIA RHEUMATICA: A RETROSPECTIVE COHORT STUDY. RHEUMATOLOGY (vol. 51, p. 112). link>
  • Helliwell T, Mallen CD, Hider SL. 2011. Polymyalgia Rheumatica: Diagnosis, Prescribing and Management in Primary Care. Rheumatology.
  • Helliwell T, Mallen CD, Hider SL. 2011. Prescribing of gastric and osteoporosis prophylaxis in the management of Polymyalgia Rheumatica in Primary Care.
  • Hider SL, Whitehurst DG, Thomas E, Foster NE. 2010. PAIN LOCATION MATTERS: THE INFLUENCE OF LEG PAIN ON SOCIETAL VALUATION OF HEALTH STATES FOR PATIENTS WITH LOW BACK PAIN. RHEUMATOLOGY (vol. 49, p. I76). link>
  • Roddy E, Zwierska I, Dawes P, Hider SL, Jordan KP, Packham J, Stevenson K, Hay E. 2010. WHO IS REFERRED TO MUSCULOSKELETAL CLINICAL ASSESSMENT AND TREATMENT SERVICES AT THE PRIMARY-SECONDARY CARE INTERFACE? THE SAMBA STUDY. RHEUMATOLOGY (vol. 49, p. I24). link>
  • Roddy E, Mallen CD, Hider SL, Jordan KP. 2009. HOW IS ACUTE GOUT MANAGED IN PRIMARY CARE?. RHEUMATOLOGY (vol. 48, pp. I101-I102). link>
  • Tanveer W, Hider SL, Brownfield A, Mattey DL, Packham JC. 2008. Depression in RA patients treated with anti-TNF is common, poorly managed and may influence anti-TNF effectiveness. RHEUMATOLOGY (vol. 47, p. II49). link>
  • Pemberton PW, Yates AP, Laing I, Hider SL, Lokko D, Ahmad Y, Bruce IN. 2007. Increased risk of atherosclerosis in women with rheumatoid arthritis: The role of adhesion molecules. ANNALS OF THE RHEUMATIC DISEASES (vol. 66, p. 148). link>
  • Hider SL, Mack LF, Shadforth MF, Thomson W, Bruce IN. 2007. Predicting outcomes of MTX therapy for RA: A combined analysis of clinical and genetic factors. ANNALS OF THE RHEUMATIC DISEASES (vol. 66, p. 329). link>
  • Hider SL, Thomson W, Bunn D, Lunt M, Symmons DP. 2007. Does shared epitope status influence response to methotrexate?. RHEUMATOLOGY (vol. 46, p. I48). link>
  • Bruce IN, Ahmad Y, Lokko D, Hider SL, Pemberton P, Yates A, Laing I. 2007. Plasma interleukin-6 (IL-6) but not CRP or ESR is closely related to clinical measures in the management of rheumatoid arthritis. Ann Rheum Dis.
  • Hider SL, Mack LF, Shadforth MF, Armstrong DJ, Bruce IN, Thomson W. 2006. Single nucleotide polymorphisms within adenosine receptor A2a are associated with gastrointestinal (GI) adverse events on MTX therapy. ARTHRITIS AND RHEUMATISM (vol. 54, p. S208). link>
  • Hider SL, Lunt M, Bunn D, Manning S, Symmons DP, Silman AJ. 2006. Can we predict the outcome of methotrexate treatment in inflammatory polyarthritis using clinical variables?. RHEUMATOLOGY (vol. 45, p. I54). link>
  • Hider SL, Mack LF, Armstrong DJ, Shadforth MF, Bruce IN, Thomson W. 2006. Single nucleotide polymorphisms within adenosine receptor A2a are associated with Gastrointestinal (GI) adverse events on MTX therapy. RHEUMATOLOGY (vol. 45, pp. I104-I105). link>
  • Hider SL, Lunt M, Bunn D, Manning S, Symmons DPM, Silman AJ. 2006. Can we predict outcome of treatment with methotrexate?. Rheumatology.
  • Hider SL, Lunt M, Manning S, Bunn D, Silman A, Symmons D. 2005. No difference in outcome between sulfasalazine or methotrexate as the first DMARD in patients with inflammatory polyarthritis. RHEUMATOLOGY (vol. 44, pp. I65-I66). link>
  • Hider SL, Lunt M, Mottram S, Bunn D, Silman AJ, Symmons DPM. 2004. Long-term outcome in inflammatory polyarthritis is not dependent on which disease-modifying drug is used first. ARTHRITIS AND RHEUMATISM (vol. 50, p. S555). link>
  • Hider SL, Hadfield J, Powley D, Brown S, Dornan T. 2004. Can Clerkship Learning Be Horizontally Integrated?. Educacion Medica 7.
  • Ahmad Y, Bodill H, Lokko D, Hider SL, Pemberton P, Yates A, Walker MG, Bruce IN. 2004. The Prevalence and Prediction of Carotid Plaque Development in Rheumatoid Arthritis Patients: A Pilot Study. Poster presentation.
  • Hider SL and Bukhari M. 2004. Variation between DAS28 score between observers: the Manchester experience. Annals of Rheumatic Diseases.
  • Hider SL, Hoggard PG, Khoo S, Back DJ, Silman AJ, Bruce IN. 2003. DMARDs as substrates for drug efflux transporters: A mechanism for drug resistance?. ANNALS OF THE RHEUMATIC DISEASES (vol. 62, p. 188). link>
  • Harrison BJ, Silam AJ, Hider SL, Herrick AL. 2002. Cigarette smoking a risk factor for digital vascular complications in systemic sclerosis. Rheumatology.
  • Hider SL, Morgan C, Bell E. 2002. Methotrexate (MTX) is not a substrate for P-glycoprotein (P-gp) in patients with Rheumatoid arthritis. Annals of Rheumatic Diseases.
  • Harrison BJ, Silman AJ, Hider SL, Herrick AL. 2001. Cigarette smoking: a risk factor for digital vascular complications in systemic sclerosis. Arthritis and Rheumatism.
  • Hider SL and Mulherin D. 2000. Early diagnosis of sacroiliitis by MRI scanning. Journal of Rheumatology.
  • Roddy E, Zwierska I, Jordan KP, Dawes P, Hider SL, Packham J, Stevenson K, Hay EM. Clinical outcome following treatment at a musculoskeletal Clinical Assessment and Treatment Service (CATS): a twelve-month prospective study. Poster presentation. 2011.
  • Undergraduate clinical teaching in Rheumatology
  • Postgraduate teaching on ASPiRE and Musculoskeletal Management at the Interface Modules
  • Assist with organisation of medical undergraduate intercalation programme