Selected Publications

2013

  • Terzaki, K., Kaloudi, E., Mossou, E., Mitchell, E.P., Forsyth,V.T., Rosseeva, E., Simon, P., Vamvakaki, M., Chatzinikolaidou, M., Mitraki, A., Farsari, M., Cell response on mineralized self-assembling peptides on top of a hybrid scaffold: A new route toward ‘scaffold on scaffold’ hard tissue engineering, Biofabrication 5, 045002 (2013).
  • Hellstrand, E. Grey, M. Ainalem, M.-L., Ankner, J., Forsyth, V. T., Fragneto, G., Haertlein, M., Dauvergne, M.-T., Nilsson, H., Brundin, P., Linse, S., Nylander, T., Sparr, E., Adsorption of α-synuclein to supported lipid bilayers– positioning and role of electrostatics, ACS Chemical Neuroscience (2013, in press)
  • D. Sawada, Y. Nishiyama, L. Petridis, R. Parthasarathi, S. Gnanakaran, V. T. Forsyth, M. Wada, P. Langan, Structure and dynamics of a complex of cellulose with EDA: insights into the action of amines on cellulose, Cellulose (2013, in press)
  • M. G. Cuypers, M. Trubitsyna, P. Callow, V. T. Forsyth, J. M. Richardson, Solution conformations of early intermediates in Mos1 transposition, Nucleic Acids Research, 41 (3), 2020-2033 (2013)
  • M.G. Cuypers, S.A. Mason, M. P. Blakeley, E.P. Mitchell, M. Haertlein, and V. T. Forsyth, Near-atomic resolution neutron crystallography on perdeuterated Pyrococcus furiosus rubredoxin implicates hydronium ions and protonation state equilibria in redox changes, Angewandte Chemie 52, 1022-1025 (2013). DOI: 10.1002/anie.201207071
  • L.H. Thomas, V.T. Forsyth, A. Šturcová, C.J. Kennedy, R.P. May, C.M. Altaner, D.C. Apperley, T.J. Wessand M.C. Jarvis. Structure of cellulose microfibrils in primary cell-walls from collenchyma. Plant Physiology, 161, 465-476 (2013).

2012

  • E. Gazit, R. Orbach, I. Mironi-Harpaz, L. Adler-Abramovich, E. Mossou, E.P. Mitchell, V.T. Forsyth, D. Seliktar, The rheological and structural properties of Fmoc peptide based hydrogels: The effect of aromatic molecular architecture on self-assembly and physical characteristics, Langmuir 28, 2015−2022 (2012).
  • Sawada, D., Nishiyama, Y., Langan, P., Forsyth, V.T., Kimura, S., Wada, M., Direct Determination of the Hydrogen Bonding Arrangement in Anhydrous β-chitin by Neutron Fiber Diffraction", Biomacromolecules (2012), 13, 288-291.
  • Kennaway, C.K., Taylor, J.E., Song, C.F., Potrzebowski, W., Nicholson, W., White, J.H., Swiderska, A., Obarska-Kosinska, A., Callow, P., Cooper, L.P., Roberts, G.A., Artero, J.-B., Bujnicki, J.M., Trinick, J., Kneale, G., Dryden, DTF (2012), Structure and operation of the DNA-translocating Type I DNA restriction enzymes. Genes & Development 26, 92-104D.
  • Sawada, D., Nishiyama, Y., Langan, P., Forsyth, V.T., Kimura, S., Wada, M., Water in crystalline fibers of dihydrate beta-chitin results in unexpected absence of intramolecular hydrogen bonding PLoS ONE 7 (6), e39376 (2012).
  • J.E. Taylor, A. Swiderska, J.-B. Artero, P. Callow, G. Kneal, Structural and Functional Analysis of the Symmetrical Type I Restriction Endonuclease R.EcoR124INT, PLoS ONE 7 (4) e35263 (2012).
  • Kovalevsky, A.Y., Hanson, L.,  Mason, S.A., Forsyth, V.T.,  Fisher, S.Z., Mustyakimov, M., Keen, D.A., Langan, P.,  A Joint X-ray/Neutron Structure of D-xylose Isomerase with Sorbitol: Atomic Details of Polyol Inhibitor Binding, Acta Cryst D68, 1201–1206 (2012)
  • S. Ossowski, A. Jackson, M. Obiols-Rabasa, C. Holt, S. Lenton, L. Porcar, M. Paulsson, T. Nylander, Aggregation Behaviour of Bovine Kappa- and Beta- Casein Studied with Small Angle Neutron Scattering and Crogenic Transmission Electron Microscopy, Langmuir 28 (38), 13577-89 (2012).

2011

  • Fernandes, A.N., Thomas, L.M., Altaner, C.M., Callow, P., Forsyth, V.T., Apperley, D.C., Kennedy, C.J., Jarvis, M. C. (2011), Nanostructure of cellulose microfibrils in spruce wood. Proc. Natl. Acad. Sci. USA. 108, E1195–E1203.
  • Russi, S., Juers, D. H., Sanchez-Weatherby, J., Pellegrini, E., Mossou, E., Forsyth, V. T., Huet, J., Gobbo, A., Felisaz, F., Moya, R., McSweeney, S., Cusack, S., Cipriani, F., & Bowler, M. W., Inducing phase changes in crystals of macromolecules: status and perspectives for controlled crystal dehydration. Journal of Structural Biology 175 (2), 236-243 (2011).DOI: 10.1016/j.jsb.2011.03.002
  • Vijayakrishnan, S., Callow, P., Nutley, M.A., McGow, D., Gilbert, D., Kropholler, P., Cooper, A., Byron, O., and Lindsay, J.G., Mammalian pyruvate dehydrogenase complex E2/E3BP core organization: a new variable composition model. Biochemical Journal 437, 565-574 (2011)
  • Grage, S. L., Keleshian, A. M., Turdzeladze, T., Battle, A. R., Tay, W. C., May, R. P., Holt, S. A., Contera, S. A., Haertlein, M., Moulin, M., Pal, P., Rohde, P. R., Forsyth, V. T., Watts, A., Ulrich, A. S. & Martinac, B., Bilayer-Mediated Clustering and Functional Interaction of MscL Channels, Biophysical Journal 100(5) 1252–1260 (2011).
  • Wada, S., Nishiyama, Y., Bellesia, G., Forsyth, V. T., Gnanakataran, S. & Langan, P. (2011, in press). Neutron crystallographic and molecular dynamics studies of the structure of ammonia-cellulose I: rearrangement of hydrogen bonding during the treatment of cellulose with ammonia. Cellulose 18, 191-206 (2011).
  • Tiggelaar, S. M., Mossou, E., Callow, P., Callow, S., Teixeira, S. C. M., Mitchell, E. P., Mitraki, A. & Forsyth, V. T.  Neutron fibre diffraction studies of amyloid using H2O/D2O isotopic replacement,. Acta Crystallographica F67, 332-335 (2011).
  • A. Y. Kovalevsky, B. L. Hanson, S. A. Mason, T. Yoshida, S. Z. Fisher, M. Mustyakimov, V. T. Forsyth, M. P. Blakeley, D. A. Keen, P. Langan, The elusive hydronium ion is found in an enzyme exchanging role with a proton at lower pH, Angewandte Chemie 50, 7520-7523 (2011). [Highlight in Nature Chemistry 3, 662-663 (2011)]
  • Haupt, M., Blakeley, M.P., Teixeira, S.C.M., Mason, S.A., Mitchell, E.P., Cooper, J.B. and Forsyth, V.T., Preliminary neutron crystallographic study of human transthyretin, Acta Crystallographica F67, 1428–1431(2011).
  • Van Eijck, L., Merzel, F., Rolls, S., Olivier, J., Forsyth, V.T., Johnson, M.R., Direct Determination of the Base-Pair Force Constant of DNA from the Acoustic Phonon Dispersion of the Double Helix. Phys. Rev. Lett. 107, 088102 (2011). [Highlight in Nature 477, 372 (2011)]

2010

  • Artero, J.-B., Teixeira, S. C. M., Mitchell, E. P., Kron, M. A., Forsyth, V. T. & Haertlein, M. (2010). Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase. Acta Cryst. F 66, 1521-1524.
  • A. Seyedarabi, T.-T.To, S. Ali, S. Hussain, M. Fries, R. Madsen, M.H. Clausen, S. Teixeira, K. Brocklehurst, R.W. Pickersgill, Structural Insights into Substrate Specificity and the anti Beta-Elimination Mechanism of Pectate Lyase. Biochemistry, 49 (3), 539-546 (2010)
  • Leal, R. M. F., Callow, S., Callow, P., Blakeley, M. P., Cardin, C. J., Denny, W. A., Teixeira, S. C. M., Mitchell, E. P. & Forsyth, V. T. (2010). Combined neutron and X-ray diffraction studies of DNA in crystals and solutions, Acta Crystallographica D 66, 1244-1248.
  • Glusker, J., Kovalevsky, A., Hanson, L., Fisher, Z., Mustkakimov, M., Mason, S. A., Forsyth, V.T., Langan, P. (2010). Using neutron protein crystallography to understand enzyme mechanism. Acta Crystallographica D 66, 1257-1261.
  • Vijayakrishnan, S., Kelly, S. M., Gilbert, R. J. C., Callow, P., Bhella, D., Forsyth, V. T., Lindsay, J. G. & Byron, O. Solution Structure and Characterisation of the Human Pyruvate Dehydrogenase Complex Core Assembly. Journal of Molecular Biology 399, 71-93.
  • Nishiyama, Y., Langan, P., Wada, M. & Forsyth, V. T. (2010). Looking at hydrogen bonds in cellulose. Acta Crystallographica D 66, 1172-1177.
  • Zhu, X., Ng, S. Y., Gupta, A. N., Feng, Y. P., Ho, B., Lapp, A., Egelhaaf, S. U., Forsyth, V. T., Haertlein, M., Moulin, M., Schweins, R. & van der Maarel, J. R. C. Effect of crowding on the conformation of interwound DNA strands from neutron scattering measurements and Monte Carlo simulations. Physical Review E 81, 061905.
  • Teixeira, S. C. M., Blakeley, M. P., Leal, R. M. F., Gillespie, S. M., Mitchell, E. P. & Forsyth, V. T. (2010). Sweet neutron crystallography. Acta Crystallographica D 66, 1139-1143.
  • Kovalevsky, A. Y., Hanson, L., Fisher, S.Z., Mustyakimov, M., Mason, S.A., Forsyth, V.T., Blakeley, M.P., Keene, D., Wagner, T., Carrell, H.L., Katz, A.K., Glusker, J.P., Langan, P. (2010 ). Metal Ion Roles and the Movement of Hydrogen during Reaction Catalyzed by D-Xylose Isomerase: A Joint X-Ray and Neutron Diffraction Study. Structure 18, 688-699.

2009

  • Kasotakis, E., Mossou, E., Adler-Abramovich, L., Mitchell, E. P., Forsyth, V. T., Gazit, E. & Mitraki, A. (2009). Design of metal-binding sites onto self-assembled peptide fibrils. Biopolymers 92, 164-72.
  • Leal, R. M. F., Teixeira, S. C. M., Blakeley, M. P., Mitchell, E. P. & Forsyth, V. T. (2009). A preliminary neutron crystallographic study of an A-DNA crystal. Acta Crystallographica Section F 65, 232-235.
  • Masson,S., Kern, T., Le Gouëllec, A., Simorre, J.-P., Callow, P., Vernet, T., Gabel, F., Zapun, A., The central domain of DivIB caps the C-terminal regions of the DivIC/FtsL coiled-coil rod, J. Biological Chemistry 284, 27687-27700 (2009).
  • Leal, M.F., Teixeira, S.C.M., Blakeley, M., Mitchell, E., Forsyth, V.T., A preliminary neutron crystallographic study of an A-DNA crystal, Acta Cryst F65, 232-235 (2009).

2008

  • Nishiyama, Y., Johnson, G.P., French, A.D., Forsyth, V.T., Langan, P. (2008), Neutron Crystallography, Molecular Dynamics, and Quantum Mechanics Studies of the Nature of Hydrogen Bonding in Cellulose I, Biomacromolecules 9, 3133-3140.
  • Andre, A., Fontaine-Vive, F., Forsyth, V. T., Maoller, H., Fischer, T., Maret, G. and Gisler, T. (2008), Force-induced structural transitions in cross-linked DNA films, Eur. Biophys. J. 37, 749-757.
  • Laux, V., Callow, P., Svergun, D.I., Timmins, P.A., Forsyth, V.T., Haertlein, M. (2008), Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering, Eur. Biophys. J. 37, 815-822.
  • Teixeira, SCM, et al, New sources and Instrumentation for Neutrons in Biology, Chem. Phys. 345 (2-3), 133-151 (2008)
  • Teixeira, S.C.M., Blakeley, M.P., Leal, R.M., Mitchell, E.P., Forsyth, V.T. (2008), A preliminary neutron crystallographic study of thaumatin, Acta Cryst. F64, 378-381.
  • Callow, J., Artero, P., Weidenhaupt, J.-B., Smoller, M., Byron, O., Lindsay, G., Teixeira, S.C.M., Moulin, M., Haertlein, M., Forsyth, V.T. (2007), Deuteration protocols for low resolution neutron scattering studies of biological macromolecules, in preparation for Eur. Biophys. J.
  • Leal, R., Teixeira, S., Rey, V., Forsyth, V.T., Mitchell, E. (2008), Absorption correction based on a 3D model reconstruction from visual images, J. Appl. Cryst. 41, 729-737.
  • Kapp, U., Macedo, S., Hall, D.R., Leiros, I.L., McSweeny, S., Mitchell, E. (2008), Structure of Deinococcus radiodurans tunicamycin resistance protein (TmrD), a phosphotransferase, Acta Cryst. F64, 479-486.

2007

  • Parrot, I.M., Haertlein, M., Forsyth, V.T. (2007), Selective deuteration of repetitive sequence DNA samples for neutron fibre diffraction experiments, in preparation for Eur. Biophys.
  • Obarska-Kosinska, A., Taylor, J.E., Callow, P., Orlowski, J., Bujnicki, J.M., Kneale, G. (2008), HsdR subunit of the Type I restriction-modification enzyme EcoR124I: biophysical characterisation and structural modelling, J. Mol. Biol. 376, 438-452.
  • Teixeira, S., Todd, A., Thorpe, J., Denny, W., Cardin, C. (2007). “Crystallographic studies on the structure of d[CGTACG]2 with 5-Br-9-amino-DACA”, submitted for publication.
  • Callow P, Sukhodub, A, Taylor, J, Kneale, G (2007), Shape and subunit organisation of the DNA methyltransferase M.Ahdl, J. Mol. Biol. 69, 177-185.
  • Varga, J. K., Aslimovska, L., Parrot, I., Dauvergne, M.-T., Haertlein, M., Forsyth, V.T. and Watts, A. (2007), NMR crystallography: The effect of deuteration on high resolution 13C solid state NMR spectra of a 7-TM protein, Biochim. Biophys. Acta 1768, 3029-3035.

2006

  • Callow, P., Timmins, P.A., Kneale, G. (2006). “The Subunit Arrangement of the Type I Restriction-Modification Enzyme M.AhdI”, Physica B 385-386, 853.
  • Forsyth, V.T., and Parrot, I.M. (2006). “High-Angle Neutron Fibre Diffraction in the Study of Biological systems”, J. Fitter, Gutberlet, T. and Katsaras, J (Eds), Neutrons in Biology - Techniques and Applications, (Springer Publ. Biophysical Studies Series).
  • Krisch, M., Mermet, A., Grimm, H., Forsyth, V.T., Rupprecht, A. (2006). “Phonon dispersion of oriented DNA by inelastic x-ray scattering”, Phys Rev E 73, 6-10.
  • Miles, S., Callow, P., Teixeira, S.C.M., Gan, Y., Denny, W., Cardin, C., Forsyth, V.T.,(2006). “Structural studies on acridine derivatives binding to telomeric DNA”, Physica B 385-386, 845.
  • Parrot, I.M., Laux, V., Urban, V., Haertlein, M., Forsyth, V.T. (2006). “X-rays and neutrons for the study of DNA structure, transitions and hydration”, Physica B 385-386, 848.

2005

  • Artero, J.B., Hartlein, M., McSweeny, S., Timmins, P.A. (2005). “A comparison of refined X-ray structures of hydrogenated and perdeuterated ray gamma E crystallin in H2O and D2O”, Acta Cryst. D61, 1541-1549.
  • Forsyth, V.T. and Parrot, I. M. (2005). “Etudes par diffraction de fibres de l’ADN double brin”, J. Phys. IV France 130, 63-74.
  • Papanikolopoulou, K., Schoehn, G.,Forge, V., Forsyth, V.T., Riekel, C., Hernandez, J.-F., R Uigrok, R.W.H., Mitraki, A. (2005). “Peptides from the fibrous shaft of a natural  beta-structured protein, the adenovirus fiber, self-assemble into amyloid-type fibrils”, Journal of  Biological Chemistry 280: 2481-2490.
  • Plazanet, M., Fontaine-Vive, F., Gardner, K.H., Forsyth, V.T., Ivanov, A., Ramirez-Cuesta, A.J., Johnson, M.R. (2005) Neutron vibrational spectroscopy gives new insights into the structure of poly (p-phenylene terepthalamide), a model beta-sheet compound, J. Am. Chem. Soc. 127, 6672 - 6678.
  • Retsos, H., Papanikolopoulou, K., FilipiniI, C., Riekel, C., Gardner, K.H., Forsyth, V.T., Mitraki, A. (2005). “Amyloid character of self-assembling proteins based on adenovirus fiber shaft sequences: a fibrous biomaterial revisited”, Nanobiotechnology 1(3), 219-226.
  • Sapede, D., Seydel, T., Forsyth, V.T., Koza, M.M., Schweins, R., Vollrath, F., Riekel, C. (2005), “Nanofibrillar Structure and Molecular Mobility in Spider Dragline Silk”, Macromolecules 38(20) 8447-8453.

2004

  • Detti, S., Forsyth, V.T., Roulet, R., Ros, R., Tassan, A., Schenk, K. (2004), Comparative neutron and X-ray study of [PPN][HIr4(CO)(9)( mu-Ph2PCH2PPh2)], Zeitschrift fur Kristallographie 219, 47-53.
  • Fuller, W., Forsyth, V.T. and A.Mahendrasingam (2004).”Water-DNA interactions by x-ray and neutron fibre diffraction”, Philosophical Transactions of the Royal Society, 359, 1448, 1237-1248.
  • Gardner KH, English AD, Forsyth VT (2004), New insights into the structure of poly (p-phenylene terephthalamide) from neutron fiber diffraction studies, Macromolecules 37 (25), 9654-9656.
  • Papanikilopoulou, K., Teixeira, S., Belrhali, H.,  Forsyth, V.T.,  Mitraki, A.,  Van Raaij, M (2004). “Adenovirus shaft sequences fold into the native triple beta-spiral fold when N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif”, Journal of  Molecular Biology, 342, 1, 219-227.