School of Life Sciences  
 
 
LSC-30039 Regeneration and Repair in the Nervous System  
Co-ordinator: Dr David Mazzocchi-Jones   Tel:33051  
Teaching Team: Dr Dave  Furness, Mrs Janet  Norton, Dr Mark  Skidmore, Mrs Jacqueline  Tickle  
Lecture Time: See Timetable...  
Level: 3 Credits: 15 Study Hours: 150  
School Office: Tel: 01782 734414
 
 
 
Programme/Approved Electives for
None
Available as a Free Standing Elective
No
Barred Combinations
None
Prerequisites
None
Description

The adult nervous system displays quite a remarkable ability to regenerate following degeneration, or trauma. Furthermore, is has been extensively demonstrated that primary neuronal tissue/cells, can be transplanted into the adult nervous system, and given an appropriate time period, can integrate with the host tissue, ultimately restoring neurological function. In this module, we will explore regeneration and repair strategies across the peripheral, and central (Brain and spinal cord) nervous systems, and examine their application in an array of neurological disorders, including; Parkinson's disease, Huntington's disease, spinal cord trauma, multiple sclerosis, and stroke. The module is taught via a series of lectures,and the tutors on this module are drawn from researchers with an active programme in nervous system regeneration and repair. Assessment is via an end of module exam, a grant proposal, and peer-review of grant proposals.







Aims
To provide an in-depth grounding in the mechanisms underlying regeneration and repair in the nervous system, covering application of these mechanisms to a range of neurological disorders including Huntington's &Parkinson's Disease, peripheral nerve injury, multiple sclerosis and spinal cord trauma.
Intended Learning Outcomes
Evaluate current understanding of mechanisms of regeneration &repair in the nervous system, following degeneration/trauma. will be achieved by assessments: 3, 1
Appraise current models of neurological regeneration &repair, and apply this to selected disease models (Huntington's &Parkinson's Disease, Multiple Sclerosis, Stroke and Spinal Cord Trauma). will be achieved by assessments: 3, 1
Evaluate evidence from clinical trials to draw own conclusions regarding the efficacy of neurological cell transplantation. will be achieved by assessments: 3, 1
Discuss the efficacy of emerging sources of transplant tissue (Stem Cells, and Genetically Modified Tissue), in relation to existing and potential neurological disorders. will be achieved by assessments: 3, 1
Able to draft a grant proposal, and an understanding the peer-review process, including the ability to draw a balance between critical and constructive appraisal. will be achieved by assessments: 1,2
Study hours
16 Hours lectures
4 Hours tutorials
29 Hours for in-course assessment (group work, and writing)
98 Hours private study
03 Hours Student Group Talks
Description of Module Assessment
01: Individual Report weighted 30%
2000 word Grant Proposal
Students will produce a 2000 word grant proposal, based on an existing grant proforma.
02: Review weighted 10%
1000 word peer review of Grant Proposals
Students will produce a 500 word peer review of an allocated grant proposal.
03: 2 Hour Unseen Exam weighted 60%
A two-hour essay examination
A two-hour essay examination consisting of two essays chosen from a selection of five.
Version: (1.06B) Updated: 03/Mar/2013

This document is the definitive current source of information about this module and supersedes any other information.