School of Life Sciences  
 
 
LSC-20015 Molecular, Cellular and Structural Immunology  
Co-ordinator: Dr Annette Shrive    Room: HUX212A, Tel:33419  
Teaching Team: Prof T Greenhough, Mrs Janet  Norton Mrs Deborah  Goodall Prof Gwyn  Williams Dr Rhayza  Maingon Mrs Lisa  Smith Mrs Jennifer  Moran Mrs Linda  Flynn Dr David  Watson Dr Mark  Skidmore, Mrs Susan  Andrews, Dr Tara  Sabir,  Shurong  Duan,  John  Greenman  
Lecture Time: See Timetable...  
Level: 2 Credits: 15 Study Hours: 150  
School Office: Tel: 01782 734414
 
 
 
Programme/Approved Electives for
None
Available as a Free Standing Elective
No
Prerequisites
Satisfactory performance in Level 1 Biochemistry or Biomedical Sciences Modules
Barred Combinations
None
Description

This module gives students a consideration of how the mammalian body copes with infection by various pathogens and includes an understanding of the cellular basis of the immune system and the generation and selection of the immune repertoire. It also provides a general qualitative overview of the methods and techniques of protein crystallography, followed by functional insights on immune protein structure.
Aims
The aims of the course are to consider how the mammalian body copes with infection by various pathogens, to understand the cellular basis of the immune system and the generation and selection of the immune repertoire including the role of apoptosis, to provide a general qualitative overview of the methods, techniques and power of protein crystallography, to consider the structure and function of immune proteins, viruses and other pathogens, and to develop subject-based IT skills.
Intended Learning Outcomes
Understand the key concepts of the mammalian immune system repertoire and its role in combating infection.
Describe in detail the cells mediating the immune response.
Understand and critically evaluate the generation and selection of the immune repertoire.
Explain the cell and molecular biology of apoptosis.
Explain key concepts of the structure and function relationship with reference to proteins of the immune system.
Understand the key concepts of the structure, function and immune system recognition of viruses and other pathogens.
Appreciate and explain, in outline, the methodology, advantages and limitations of methods used to determine protein structure.
Explain and critically evaluate analytical methods used on antibodies.
Locate and retrieve scientific information, protein sequences and protein structures, and manipulate and present data retrieved from protein databases.
Study hours
22 Hours Lectures
30 Hours Laboratory classes
30 Hours Report preparation
68 Hours Private study
Description of Module Assessment
1: Report weighted 10%
IT report
2: Practical Assessment weighted 30%
Practical report based on experimental laboratory work
Length 3000 words. The raw data for the laboratory report is from the results of team work. The write-up, analysis and presentation (e.g. tables, graphs etc.) of the data is carried out individually.
3: 2 Hour Unseen Exam weighted 60%
Unseen exam - 2 hours
Version: (1.06B) Updated: 03/Mar/2013

This document is the definitive current source of information about this module and supersedes any other information.