This module, focusing on our genetic blueprint, aims to answer a number of questions:
- What is the molecular structure of a gene?
- How is this information inherited during cell division and during fertilisation of higher species?
- How is this information read in order to make the proteins of each cell; how is this process controlled?
- What role does gene mutation play in health and disease?
It consists of lectures, hands on laboratory sessions, problem based small group and class tutorials and substantial KLE based learning resources. Laboratory practical sessions on molecular and microbiology techniques, including a 3D molecular graphics session on DNA structure and function, complement the theory. A Bioethics extraordinary lecture provides an opportunity to become aware of the ethical and legal implications posed by using model organisms in the quest for knowing our genomes.
explain the molecular mechanisms of the main processes involved in information flow from DNA (or RNA for RNA viruses) to make cell proteins. will be achieved by assessments: 01, 04
compare and explain the way information is inherited during cell division, and upon egg fertilisaton in higher organisms. will be achieved by assessments: 01
distinguish amongst the mechanisms of generation of genetic variation including mutations and DNA rearrangements. will be achieved by assessments: 01,04
define the major mechanisms of controlling gene expression in both prokaryotes and in eukaryotes.
will be achieved by assessments: 04
work as part of a team in developing basic molecular biology and microbiology laboratory skills including good practice, biochemical and biological safety. will be achieved by assessments: 02, 03
solve problems, record scientific data, and write individual level 1 laboratory reports that include critical literature and data analysis. will be achieved by assessments: 02, 03
write in a scientific style with emphasis on accurate and appropriate data presentation (Figures and Tables), referencing and avoidance of plagiarism. will be achieved by assessments: 02, 03
analyse the main ethical and legal implications posed by the use of animals in biomedical research. will be achieved by assessments: 01
Laboratory sessions 18 hours
Tutorials 9 hours
Directed private study 40 hours
Private study &assessment 65 hours
In course 40 min mixed class test including MCQ, True/false; matching, short paragraph, calculations, data handling and problem-solving type questions preceded by an on line formative practice test of similar format and level.
Turnitin submitted microbiology proforma on two of the three Microbiology practicals associated with the module. A formative microbiology proforma supports students prior submission of the summative proforma.
A peer-assessed report-structured proforma on a plasmid mapping practical. A tutorial on the exercise is scheduled prior submission of this assignment. Marks are Tutor moderated.
2h examination comprising a short answer section (40%) and an essay choice section (60%). A revision session on solving sample questions of similar level/format to the unseen exam is provided.
This document is the definitive current source of information about this module and supersedes any other information.