| |
|
|
| School of Physical and Geographical Sciences |
|
| |
| CHE-30031 |
Biologically Important Molecules |
|
| Co-ordinator: |
Dr Graeme Jones Room: LJ1.34, Tel:34173 |
|
| Teaching Team: |
|
|
| Lecture Time: |
See Timetable... |
|
| Level: |
3 |
Credits: |
15 |
Study Hours: |
150 |
|
| School Office: |
|
| |
| |
Medicinal Chemistry
Minor (Level 3)
|
No
|
Satisfactory progression from Year 2 of the BSc Medicinal Chemistry or equivalent
|
None
|
|
The module covers the structures, methods of synthesis and significant properties of the most important biological building blocks (sugars, nucleosides, amino acids). The module builds on basic principles covered in Level I and II modules and aims to develop an understanding of the important properties, synthetic challenges and methods of structure determination associated with these multifunctional biomolecules. The module content leads to a discussion of macromolecules (e.g. starch, DNA, proteins) formed from these building blocks, methods of determining their structures (e.g. X-ray crystallography) and their important structural features.
|
Analyse and interpret the structures and functions of various biomolecules and related pharmaceutical species, and their relationship to on-going biological processes.
will be achieved by assessments: 1,3
Solve problems relating to the structures of sugars, nucleosides, amino acids.
will be achieved by assessments: 1,3
Describe and explain the principles of protecting group chemistry for the OH, NH2 and CO2H groups and how these protecting groups can be applied in the synthesis of simple biomolecules. will be achieved by assessments: 1,3
Design the synthesis of selected sugars, nucleosides and peptides. will be achieved by assessments: 1,3
Critically evaluate the use of modern methods, such as X-ray crystallography, to determine the structures of biomolecules. will be achieved by assessments: 2,3
Locate and extract information from databases to analyse and interpret the structures and functions of various biomolecules.
will be achieved by assessments: 2
|
Lectures: 18 hours
Problem classes and directed study: 6 hours
Class Tests: 1 hour
Independent study: 125 hours
|
|
| 01: Class Test weighted 15% |
In-class Test
In-class test (~1 hour) employing a variety of question styles
|
| 02: Exercise weighted 15% |
Information Retrieval exercise
Information retrieval exercise using publicly available chemistry databases.
|
| 03: 2 Hour Unseen Exam weighted 70% |
2-hour Unseen written examination
2-hour unseen written examination. Students answer 3 questions from a choice of 4.
|
|
Version: (1.06B) Updated: 02/Oct/2013
This document is the definitive current source of information about this module and supersedes any other information. |