Dr Sheila A Hope

Title: Senior Lecturer in Biochemistry
Phone: +44 (0)1782 733674
Email:
Location: Huxley Building : 305
Role: Programme Director for Biochemistry
Contacting me: Try my office or e-mail for an appointment
sheila hope

I initially read for a B.Sc in Genetics at Glasgow University in 1988.  My first appointment was as a research assistant in the Department of Cancer Studies (now the Birmingham CRUK Institute for Cancer Studies) at Birmingham University, where I had the opportunity to complete my PhD, entitled Esptein Barr virus and Cell Survival.  I remained at Birmingham on a Wellcome funded post doctoral fellowship until I was appointed as a lecturer at Keele university in 1995. I have supervised or co-supervised 5 PhD students and 1 MPhil student.

My main scientific research interest is on the role of viruses in the control of apoptosis and cellular differentiation, although I have side interests in apoptosis in general.  I am a member of ISTM and am currently focusing on the role of proteins encoded by Epstein Barr virus.  My technical expertise lies in molecular and cell biology.  The most successful period of my research career remains my PhD research - 3 of the resulting publications have between them been cited over 2000 times – but there’s still plenty time for me to make that Nobel winning discovery! Since establishing my own independent research programme here at Keele, I have held major grants from the Wellcome Trust and BBSRC and studentships from AICR and LRF, plus 3 Nuffield vacation scholarships.

In the past few years, I have re-focused my research towards pedagogical action research and have developed several projects based around the technological innovations I have made in feedback provision.  My latest pilot project is the production of a student-based blog, aimed at easing the transition between school and university and between levels at university. 

Selected Publications

  • Hope SA. 2011. Making Movies: The Next Big Thing in Feedback?. Bioscience Education Electronic Journal, vol. 18, Article 4. link>
  • Hope SA and Polwart A. 2012. Engagement with Online Pre-exam Formative Tests Improves Exam Performance and Feedback Satisfaction. Bioscience Education, 37-52. link> doi>
  • Hope SA. 2010. Giving audio-visual feedback using Jing and GradeMark. link>
  • Watson D, Kinsey E, Hoskert BS, Hazlewood SA, Scarpello JHB, Loweth AC. 2007. A role for mitochondrial calcium uptake in oxidant-induced beta-cell death. DIABETIC MEDICINE, vol. 24, 34. link>
  • Howell M, Williams T, Hazlewood SA. 2005. Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2. BMC Microbiol, vol. 5, 6. link> doi>

Full Publications List show

Journal Articles

  • Hope SA and Polwart A. 2012. Engagement with Online Pre-exam Formative Tests Improves Exam Performance and Feedback Satisfaction. Bioscience Education, 37-52. link> doi>
  • Hope SA. 2011. Making Movies: The Next Big Thing in Feedback?. Bioscience Education Electronic Journal, vol. 18, Article 4. link>
  • Watson D, Kinsey E, Hoskert BS, Hazlewood SA, Scarpello JHB, Loweth AC. 2007. A role for mitochondrial calcium uptake in oxidant-induced beta-cell death. DIABETIC MEDICINE, vol. 24, 34. link>
  • Howell M, Williams T, Hazlewood SA. 2005. Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2. BMC Microbiol, vol. 5, 6. link> doi>
  • Bellows DS, Howell M, Pearson C, Hazlewood SA, Hardwick JM. 2002. Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. JOURNAL OF VIROLOGY, vol. 76(5), 2469-2479. link> doi>
  • Williams T, Sale D, Hazlewood SA. 2001. BHRF1 is highly conserved in primate virus analogues of Epstein-Barr virus. Intervirology, vol. 44(1), 55-58. link> doi>
  • Johnson RJ, Stack M, Hazlewood SA, Jones M, Blackmore CG, Hu LF, Rowe M. 1998. The 30-base-pair deletion in Chinese variants of the Epstein-Barr virus LMP1 gene is not the major effector of functional differences between variant LMP1 genes in human lymphocytes. J.Virol., vol. 72(5), 4038-4048. link>
  • McCarthy NJ, Hazlewood SA, Huen DS, Rickinson AB, Williams GT. 1996. The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs. Adv Exp Med Biol, vol. 406, 83-97. link>
  • Huen DS, Henderson SA, Croom-Carter D, Rowe M. 1995. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene, vol. 10(3), 549-560. link>
  • Henderson SA, Huen D, Rowe M. 1994. Epstein-Barr-Virus Transforming Protein. Seminars in Virology, vol. 5(5), 391-399. link> doi>
  • Henderson S, Huen D, Rowe M, Dawson C, Johnson G, Rickinson A. 1993. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc.Natl.Acad.Sci.U.S.A, vol. 90(18), 8479-8483. link> doi>
  • Lear AL, Rowe M, Kurilla MG, Lee S, Henderson S, Kieff E, Rickinson AB. 1992. The Epstein-Barr virus (EBV) nuclear antigen 1 BamHI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle. J.Virol., vol. 66(12), 7461-7468. link>
  • Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A. 1991. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell, vol. 65(7), 1107-1115. link> doi>
  • Gregory CD, Dive C, Henderson S, Smith CA, Williams GT, Gordon J, Rickinson AB. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature, vol. 349(6310), 612-614. link>
  • Gregory CD, Dive C, Henderson S, Smith CA, Williams GT, Gordon J, Rickinson AB. 1991. Activation of Epstein-Barr-Virus Latent Genes Protects Human B-Cells from Death by Apoptosis. Nature, vol. 349(6310), 612-614. link> doi>
  • Rowe M, Young LS, Crocker J, Stokes H, Henderson S, Rickinson AB. 1991. Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. J.Exp.Med., vol. 173(1), 147-158. link> doi>

Other

  • Hope SA. 2010. Giving audio-visual feedback using Jing and GradeMark. link>
  • Hope SA and LEE M. BALF1/0 – just another BHRF1?.

Although my home school is Life Sciences, I also contribute to the teaching on the pharmacy and forensic science course.  I am the Life Sciences/Forensic Science liaison person and programme director for Biochemistry

I am keen to develop the use of new technologies in teaching and feedback and in recent years have explored the use of collaborative wiki pages for group work and pioneered the use of audiovisual feedback using screencasting software.  In 2012 I was awarded Keele’s Teaching Excellence Award. 

Year 1

Biochem/BMS

  • LSC-10030      Case Studies in Medicine
  • LSC-10036      Cells and Organelles
  • LSC-10038      Information and Inheritance (Module Manager)

Pharmacy

  • PHA-10014    

Forensic Sciences

  • CHE-10042    Forensic Identification (Module Manager)

Year 2

BMS/Hum Biol/Biol

  • LSC-20050  Human Genetics (Module Manager)

Year 3

Biochem/BMS

  • LSC-30008      Research Project I (Module Manager)
  • LSC-30035      Double Research Project (Module Manager)
  • LSC-30014      Biochemistry research Project (Non-experimental) (Module Manager)
  • LSC-30015      Biology of Disease

Biology/Hum Biol

  • LSC-30007      Dissertation for Biology
  • LSC-30033      Human Biology Dissertation

M.Sc Biomedical Blood Science

  • LSC-40038       Research Methodologies (Module Manager)