Prof Paul Eggleston

Title: Professor of Molecular Entomology
Phone: +44 (0)1782 733027
Email:
Location: Huxley Building : 173
Role: Deputy Director, Institute for Science and Technology in Medicine
Contacting me: Arrange an appointment by e-mail
paul eggleston

I was appointed to the Chair of Molecular Entomology in the Centre for Applied Entomology and Parasitology (now part of the Institute for Science and Engineering in Medicine) in 1999. Before that, I obtained a B.Sc. (Hons.) in Biological Sciences from Birmingham University in 1977 and a Ph.D. in Genetics, also from Birmingham University, in 1981. Shortly afterwards, I was appointed to a Lectureship in the Department of Genetics and Microbiology at the University of Liverpool, progressing to a Senior Lectureship in Genetics within the new School of Biological Sciences at Liverpool University in 1993. During this time, I was awarded a Senior Research Fellowship from the Lister Institute of Preventive Medicine, which was held at the Liverpool School of Tropical Medicine from 1987-1995. I was also elected to present the 1990 Balfour Lecture to the Genetics Society, an award that recognizes outstanding achievement by a young Geneticist.

My research interests are in molecular entomology, particularly the molecular genetics of mosquitoes that transmit human disease and their complex interactions with the parasites and viruses that cause disease. Because of their medical importance, the focus of my group is on the malaria vector mosquito, Anopheles gambiae and the yellow fever mosquito, Aedes aegypti. Current projects include the development of technologies for genetic engineering of mosquitoes, the creation of genetically modified mosquitoes that are compromised in their ability to transmit disease and the development of strategies for stage- and tissue-specific gene expression within genetically modified mosquitoes. My research has attracted external funding of just under £4 million since 1982 and this has resulted in over 55 primary publications and 65 published abstracts. I am currently a Fellow of the Royal Entomological Society and a member of the Lister Institute of Preventive Medicine, the British Society for Parasitology and the Genetics Society.

Further details

Selected Publications

  • Paton D, Underhill A, Meredith J, Eggleston P, Tripet F. 2013. Contrasted Fitness Costs of Docking and Antibacterial Constructs in the EE and EVida3 Strains Validates Two-Phase Anopheles gambiae Genetic Transformation System. PLoS One, vol. 6(8), Article e67364. doi>
  • Meredith JM, Underhill A, McArthur CC, Eggleston P. 2013. Next-Generation Site-Directed Transgenesis in the Malaria Vector Mosquito Anopheles gambiae: Self-Docking Strains Expressing Germline-Specific phiC31 Integrase. PLoS One, vol. 8(3). doi>
  • Paton D, Underhill A, Meredith J, Eggleston P, Tripet F. 2013. Contrasted fitness costs of docking and antibacterial constructs in the EE and EVida3 strains validates two-phase Anopheles gambiae genetic transformation system. PLoS One. doi>
  • Carter V, Underhill A, Baber I, Sylla L, Baby M, Larget-Thiery I, Zettor A, Bourgouin C, Langel U, Faye I, Otvos L, Wade JD, Coulibaly MB, Traore SF, Tripet F, Eggleston P, Hurd H. 2013. Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium. PLoS Pathogens.
  • McArthur CC, Meredith JM, Eggleston P. 2013. Transgenic Anopheles gambiae expressing the synthetic Vida3 antimalarial peptide suffer no significant fitness cost. PLoS One.

Full Publications List show

Books

  • EGGLESTON P. EGGLESTON P and Crampton JM (Eds.). 1992. Insect Molecular Science. Academic Press, London..

Journal Articles

  • Paton D, Underhill A, Meredith J, Eggleston P, Tripet F. 2013. Contrasted Fitness Costs of Docking and Antibacterial Constructs in the EE and EVida3 Strains Validates Two-Phase Anopheles gambiae Genetic Transformation System. PLoS One, vol. 6(8), Article e67364. doi>
  • Meredith JM, Underhill A, McArthur CC, Eggleston P. 2013. Next-Generation Site-Directed Transgenesis in the Malaria Vector Mosquito Anopheles gambiae: Self-Docking Strains Expressing Germline-Specific phiC31 Integrase. PLoS One, vol. 8(3). doi>
  • Paton D, Underhill A, Meredith J, Eggleston P, Tripet F. 2013. Contrasted fitness costs of docking and antibacterial constructs in the EE and EVida3 strains validates two-phase Anopheles gambiae genetic transformation system. PLoS One. doi>
  • Carter V, Underhill A, Baber I, Sylla L, Baby M, Larget-Thiery I, Zettor A, Bourgouin C, Langel U, Faye I, Otvos L, Wade JD, Coulibaly MB, Traore SF, Tripet F, Eggleston P, Hurd H. 2013. Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium. PLoS Pathogens.
  • McArthur CC, Meredith JM, Eggleston P. 2013. Transgenic Anopheles gambiae expressing the synthetic Vida3 antimalarial peptide suffer no significant fitness cost. PLoS One.
  • Meredith JM, Basu S, Nimmo DD, Larget-Thiery I, Warr EL, Underhill A, McArthur CC, Carter V, Hurd H, Bourgouin C, Eggleston P. 2011. Site-specific integration and expression of an anti-malarial gene in transgenic Anopheles gambiae significantly reduces Plasmodium infections. PLoS One, vol. 6(1), e14587. link> doi> full text>
  • Meredith JM, Hurd H, Lehane MJ, Eggleston P. 2008. The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes. Insect Mol Biol, vol. 17(2), 103-112. link> doi>
  • Sethuraman N, Jr FMJ, Eggleston P, O'Brochta DA. 2007. Post-integration stability of piggy Bac in Aedes aegypti. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 37(9), 941-951. link> doi>
  • Meredith JM, Munks RJ, Grail W, Hurd H, Eggleston P, Lehane MJ. 2006. A novel association between clustered NF-kappaB and C/EBP binding sites is required for immune regulation of mosquito Defensin genes. Insect Mol Biol, vol. 15(4), 393-401. link> doi>
  • Warr E, Meredith JM, Nimmo DD, Basu S, Hurd H, Eggleston P. 2006. A tapeworm molecule manipulates vitellogenin expression in the beetle Tenebrio molitor. Insect Mol Biol, vol. 15(4), 497-505. link> doi>
  • Nimmo DD, Alphey L, Meredith JM, Eggleston P. 2006. High efficiency site-specific genetic engineering of the mosquito genome. Insect Mol Biol, vol. 15(2), 129-136. link> doi>
  • Meredith JM, Munks RJ, Grail W, Hurd H, Eggleston P, Lehane M. 2006. A novel association between clustered NF-B and C/EBP binding sites is required for immune regulation of mosquito Defensin genes. Insect Molecular Biology, vol. 4(15), 393-401.
  • Hurd H, Taylor PJ, Adams D, Underhill A, Eggleston P. 2005. Evaluating the costs of mosquito resistance to malaria parasites. Evolution, vol. 59(12), 2560-2572. link> doi>
  • Ding YC, Hawkes N, Meredith J, Eggleston P, Hemingway J, Ranson H. 2005. Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress. BIOCHEMICAL JOURNAL, vol. 387, 879-888. link> doi>
  • Warr E, Eggleston P, Hurd H. 2004. Apoptosis in the fat body tissue of the beetle Tenebrio molitor parasitised by Hymenolepis diminuta. J Insect Physiol, vol. 50(11), 1037-1043. link> doi>
  • Cole TJ, Eggleston P, Hurd H. 2003. Juvenile hormone and egg production in \fITenebrio molitor\fP infected by \fIHymenolepis diminuta:\fP effect of male and/or female infection, male age and mating. Journal of Insect Physiology.
  • Cole TJ, Eggleston P, Hurd H. 2003. Juvenile hormone titre and egg production in Tenebrio molitor infected by Hymenolepis diminuta: effect of male and/or female infection, male age and mating. J Insect Physiol, vol. 49(6), 583-590. link> doi>
  • Zhang HJ, Shinmyo Y, Hirose A, Mito T, Inoue Y, Ohuchi H, Loukeris TG, Eggleston P, Noji S. 2002. Extrachromosomal transposition of the transposable element Minos in embryos of the cricket Gryllus bimaculatus. DEVELOPMENT GROWTH & DIFFERENTIATION, vol. 44(5), 409-417. link>
  • Zhang H, Shinmyo Y, Hirose A, Mito T, Inoue Y, Ohuchi H, Loukeris TG, Eggleston P, Sumihare N. 2002. Extrachromosomal transposition of the transposable element \fIMinos\fP of the cricket \fIGryllus bimaculatus\fP. Development, Growth and Differentiation.
  • Alphey L, Beard B, Billingsley P, Coetzee M, Cristanti A, Curtis C, Eggleston P, Godfray C, Hemingway J, Jacobs-Lorena M, James A, Kafatos F, Mukwaya L, Paton M, Powell J, Schneider W, Scott T, Sina B, Sinden R, Sinkins S, et A. 2002. Malaria control with genetically manipulated insect vectors. Science, vol. 298(4 Oct 02), 119-121.
  • Eggleston P and Zhao Y. 2001. A sensitive and rapid assay for homologous recombination in mosquito cells: impact of vector topology and implications for gene targeting. BMC Genet, vol. 2, 21. link>
  • Eggleston P and Zhao Y. 2001. A sensitive and rapid assay for homologous recombination in mosquito cells:impact of vector topology and implications for gene targeting. BMC Genetics, vol. 2(21), 1-9.
  • Eggleston P and Zhao Y. 2001. Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays. BMC Genetics, vol. 2(11), 1-11.
  • Eggleston P and Zhao Y. 2001. Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays. BMC Genet, vol. 2, 11. link>
  • Devenport MP, Blass C, Eggleston P. 2000. Characterization of the Hox gene cluster in the malaria vector mosquito, Anopheles gambiae. EVOLUTION & DEVELOPMENT, vol. 2(6), 326-339. link> doi>
  • Eggleston P, Lu W, Zhao Y. 2000. Genomic organization and immune regulation of the defensin gene from the mosquito, Anopheles gambiae. Insect Mol Biol, vol. 9(5), 481-490. link> doi>
  • Eggleston P. 1980. Hybrid dysgenesis in Drosophila melanogaster: correlation between dysgenic traits. Heredity, 237-249.

Other

  • Eggleston P, Basu S, Meredith J, Medimond. 2006. High efficiency site-directed genetic engineering of the mosquito genome. ICOPA XI: Proceedings of the 11th International Congress of Parasitology (pp. 71-76). link>

  • LSC-10032 Genetics and Evolution (Module Manager)

  • LSC-10031 Cell and Molecular Biology (Module Manager)

  • LSC-30007 Dissertation for Biology

  • LSC-30013 Biology Research Project(non-experimental)

  • LSC-30014 Biochemistry Research Project (non-experimental)

  • LSC-30015 Biology of Disease

  • LSC-30022 Non-experimental Project

  • LSC-30023 Dissertation M.Sc. (Molecular Parasitology and Vector Biology)