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- hurd hilary
I was originally trained in Zoology, obtaining a degree from the University of Wales, Swansea in 1968. After studying for a Post Graduate Certificate in Education I spent 5 years teaching Biology in the UK and in Uganda. I took a career gap whilst my son and daughter were pre-school age and then returned to higher education, obtaining a PhD in Parasitology in 1985 under the supervision of Prof. Chris Arme, Keele University. The focus of my thesis was on interaction between the rat tapeworm and its beetle intermediate host. I was one of the first recipients of a Daphne Jackson Fellowship for Women Returners to Science in 1988 and was appointed to a lectureship at Keele University in 1990. After promotions to Senior Lecture and Reader I was appointed to a chair in Parasitology in 2002. I acted as Director of the Centre of Applied Entomology and Parasitology, Keele University from 1996 to 2007 and was President of the British Society for Parasitology 2004-2006. I also served on the Membership Committee of the American Society of Parasitologists and was a past Council member of the Royal Society for Tropical Medicine and Hygiene.
I took partial retirement in August 2011 and now work half time.
My research interests are in the field of Parasite-Insect Interactions and mosquito stages of the malaria parasite and currently include: the involvement of apoptosis in malaria / mosquito interactions, the fitness effects of malaria parasites upon both susceptible and refractory mosquitoes, the identification and deployment of peptides that kill the human malaria parasite and the development of transgenic mosquitoes that are incompetent malaria vectors.
Selected Publications
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2010. Choosing anti-Plasmodium molecules for genetically modifying mosquitoes: focus on peptides. Trends Parasitol, vol. 26(12), 582-590. doi>
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2010. Naturally occurring triggers that induce apoptosis-like programmed cell death in Plasmodium berghei ookinetes. PLoS One, vol. 5(9). doi>
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2009. Evolutionary drivers of parasite-induced changes in insect life-history traits from theory to underlying mechanisms. Adv Parasitol, vol. 68, 85-110. doi>
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2009. Malaria ookinetes exhibit multiple markers for apoptosis-like programmed cell death in vitro. Parasit Vectors, vol. 2(1), 32. doi> full text>
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2007. Minimum requirements for ookinete to oocyst transformation in Plasmodium. International Journal for Parasitology , vol. 37(11), 1221-1232. doi>
Full Publications List show
Journal Articles
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2011. Site-specific integration and expression of an anti-malarial gene in transgenic Anopheles gambiae significantly reduces Plasmodium infections. PLoS One, vol. 6(1), e14587. doi> full text>
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2010. Choosing anti-Plasmodium molecules for genetically modifying mosquitoes: focus on peptides. Trends Parasitol, vol. 26(12), 582-590. doi>
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2010. Hydric stress-dependent effects of Plasmodium falciparum infection on the survival of wild-caught Anopheles gambiae female mosquitoes. Malar J, vol. 9, 243. doi>
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2010. Naturally occurring triggers that induce apoptosis-like programmed cell death in Plasmodium berghei ookinetes. PLoS One, vol. 5(9). doi>
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2009. Evolutionary drivers of parasite-induced changes in insect life-history traits from theory to underlying mechanisms. Adv Parasitol, vol. 68, 85-110. doi>
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2009. Malaria ookinetes exhibit multiple markers for apoptosis-like programmed cell death in vitro. Parasit Vectors, vol. 2(1), 32. doi> full text>
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2009. Review of "Insect Pathogens Molecular Approaches and techniques" by S. P. Stock, J. Vandenberg, I. Glazer and N. Boemare. Parasites and Vectors. doi>
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2009. Transmission dynamics of malaria in four selected ecological zones of Nigeria in the rainy season. Ann Afr Med, vol. 8(1), 1-9.
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2008. Ecological immunology of mosquito-malaria interactions. Trends Parasitol, vol. 24(5), 219-227. doi>
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2008. Localisation of laminin within Plasmodium berghei oocysts and the midgut epithelial cells of Anopheles stephensi. Parasit Vectors, vol. 1(1), 33. doi>
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2008. The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes. Insect Mol Biol, vol. 17(2), 103-112. doi>
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2008. The microneme proteins CTRP and SOAP are not essential for Plasmodium berghei ookinete to oocyst transformation in vitro in a cell free system. Malar J, vol. 7, 82. doi>
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2007. Minimum requirements for ookinete to oocyst transformation in Plasmodium. International Journal for Parasitology , vol. 37(11), 1221-1232. doi>
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2007. Nature or nurture in mosquito resistance to malaria?. Trends Parasitol, vol. 23(4), 135-138. doi>
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2006. A novel association between clustered NF-kappaB and C/EBP binding sites is required for immune regulation of mosquito Defensin genes. Insect Mol Biol, vol. 15(4), 393-401. doi>
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2006. A tapeworm molecule manipulates vitellogenin expression in the beetle Tenebrio molitor. Insect Mol Biol, vol. 15(4), 497-505. doi>
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2006. Apoptosis-like death as a feature of malaria infection in mosquitoes. Parasitology, vol. 132 Suppl, S33-S47. doi>
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2006. Programmed cell death and the protozoan parasite. Parasitology, vol. 132(S1). doi>
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2005. Evaluating the costs of mosquito resistance to malaria parasites. Evolution, vol. 59(12), 2560-2572. doi>
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2005. Interactions between malaria and mosquitoes: the role of apoptosis in parasite establishment and vector response to infection. Curr Top Microbiol Immunol, vol. 289, 185-217.
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2005. Parasite manipulation: stretching the concepts. Behav Processes, vol. 68(3), 235-236. doi>
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2004. Apoptosis in the fat body tissue of the beetle Tenebrio molitor parasitised by Hymenolepis diminuta. J Insect Physiol, vol. 50(11), 1037-1043. doi>
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2004. Does environmental stress affect insect-vectored parasite transmission?. Physiological Entomology. doi>
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2004. The role of programmed cell death in \fIPlasmodium\fP-mosquito interactions. International Journal for Parasitology. doi>
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2003. A search for the manipulation molecules that enable the rat tapeworm to inhibit insect reproduction. Proceedings of the 10th International Congress of Parasitology - Volume 2, Issue 3rd Nov. 2003 (Ed Monduzzi).
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2003. In vitro methods for culturing vertebrate and mosquito stages of Plasmodium. Microbes Infect, vol. 5(4), 321-327. doi>
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2003. Infection increases the value of nuptial gifts, and hence male reproductive success, in the Hymenolepis diminuta-Tenebrio molitor association. Proc Biol Sci, vol. 270 Suppl 2, S172-S174. doi>
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2003. Isolation of Plasmodium berghei ookinetes in culture using Nycodenz density gradient columns and magnetic isolation. Malar J, vol. 2(1), 35. doi>
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2003. Juvenile hormone titre and egg production in Tenebrio molitor infected by Hymenolepis diminuta: effect of male and/or female infection, male age and mating. J Insect Physiol, vol. 49(6), 583-590. doi>
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2003. Manipulation of medically important insect vectors by their parasites. Annual Review of Entomology. doi>
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2003. Reproductive aspects of the mosquito \fICulex quinquefasciatus\fP (Diptera:Culcidae) infected with \fIWuchereria bancrofti\fP (Spirurida:Onchocercidae). Memorias do Instituto Oswaldo Cruz.
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2002. \fIAnopheles gambiae:\fP The fitness costs of mounting an immune response. Oikos.
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2002. \fIDrosophila\fP yolk protein produced in \fIE. coli\fP is endocytosed by mosquito ovaries. Insect Molecular Biology, vol. 11(5), 487-496.
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2002. Antimicrobial peptides:design and application towards sporogonic stages of malaria parasites. Antimicrobial Agents and Chemotherapy.
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2002. Apoptosis dependent on a caspase-like enzyme in the protozoan malaria parasite, \fIPlasmodium berghei\fP. International Journal for Parasitology.
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2002. Apoptosis in the malaria protozoan, Plasmodium berghei: a possible mechanism for limiting intensity of infection in the mosquito. Int J Parasitol, vol. 32(9), 1133-1143. doi>
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2002. Complete Development of Mosquito Phases of the Malaria Parasite in Vitro. Science, vol. 295(5555), 677-679. doi>
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2002. Design and activity of antimicrobial peptides against sporogonic-stage parasites causing murine malarias. Antimicrob Agents Chemother, vol. 46(7), 2104-2110. doi>
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2002. Parasite manipulation of vector behaviour. The behavioural ecology of parasites (Ed EE Lewis, JF Cambell, MVK Sukhdeo).
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2002. The costs of mounting an immune response are reflected in the reproductive fitness of the mosquito Anopheles gambiae. Oikos, vol. 97(3), 371-377. doi>
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2002. The role of Plasmodium berghei ookinete proteins in binding to basal lamina components and transformation into oocysts. Int J Parasitol, vol. 32(1), 91-98. doi>
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2001. A parasite that increases host lifespan. Proc Biol Sci, vol. 268(1477), 1749-1753. doi>
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2001. Effects of malaria infection on vitellogenesis in Anopheles gambiae during two gonotrophic cycles. Insect Mol Biol, vol. 10(4), 347-356. doi>
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2001. Host Fecundity reduction: a strategy for damage limitation. Trends in Parasitology, vol. 17(8), 263-268.
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2001. Host fecundity reduction: a strategy for damage limitation?. Trends Parasitol, vol. 17(8), 363-368. doi>
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2001. Malaria-induced apoptosis in mosquito ovaries:a mechanism to control vector egg production. Journal of Experimental Biology.
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2001. The influence of host haematocrit on the blood feeding success of \fIAnopheles stephensi\fP:implications for enhanced malaria transmission. Parasitology.
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1999. Blood digestion in the mosquito, Anopheles stephensi: the effects of Plasmodium yoelii nigeriensis on midgut enzyme activities. Parasitology, vol. 119 ( Pt 6), 535-541. doi>
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1999. Bloodmeal microfilariae density and the uptake and establishment of Wuchereria bancrofti infections in Culex quinquefasciatus and Aedes aegypti. MEMORIAS DO INSTITUTO OSWALDO CRUZ, vol. 94, 591-596. link>
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1999. Direct manipulation of insect reproduction by agents of parasite origin. PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, vol. 266, 1537-1541. link>
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1999. Spermatophore production and spermatheca content in Tenebrio molitor infected with Hymenolepis diminuta. J Insect Physiol, vol. 45(6), 565-569. doi>
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1999. The effect of Plasmodium yoelii nigeriensis infection on the feeding persistence of Anopheles stephensi Liston throughout the sporogonic cycle. PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, vol. 266, 1729-1733. link>
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1998. Effect of Plasmodium yoelii nigeriensis (Haemosporidia: Plasmodiidae) on Anopheles stephensi (Diptera: Culicidae) vitellogenesis. J Med Entomol, vol. 35(6), 956-961.
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1998. Parasite manipulation of insect reproduction: who benefits?. Parasitology, vol. 116 Suppl, S13-S21.
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1998. The effect of metacestodes of Hymenolepis diminuta on the bean-shaped accessory glands in male Tenebrio molitor. Parasitology, vol. 116 ( Pt 2), 191-196. doi>
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1997. Effects of Plasmodium yoelii nigeriensis infection on Anopheles stephensi egg development and resorption. Med Vet Entomol, vol. 11(3), 265-269. doi>
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1997. Haemolymph from female beetles infected with Hymenolepis diminuta metacestodes retards the development of ovarian follicles in recipient Tenebrio molitor (Coleoptera). Parasitology, vol. 114 ( Pt 2), 175-179. doi>
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1997. The effects of infection with Plasmodium yoelii nigeriensis on the reproductive fitness of Anopheles stephensi. Ann Trop Med Parasitol, vol. 91(4), 365-369.
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1997. The effects of natural Plasmodium falciparum infection on the fecundity and mortality of Anopheles gambiae s. l. in north east Tanzania. Parasitology, vol. 114 ( Pt 4), 325-331. doi>
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1997. The Interplay between Patency, Microsomal Na(+)/K(+) ATPase Activity and Juvenile Hormone, in Tenebrio molitor Parasitized by Hymenolepsis diminuta. J Insect Physiol, vol. 43(4), 337-343. doi>
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1996. Carbohydrate titres in the haemolymph and midgut glands of Gammarus pulex infected with the acanthocephalan Pomphorhynchus laevis. JOURNAL OF HELMINTHOLOGY, vol. 70, 103-107. link>
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1996. Comparative fecundity and associated factors for two sibling species of the Anopheles gambiae complex occurring sympatrically in The Gambia. Med Vet Entomol, vol. 10(4), 385-391. doi>
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1996. Hymenolepis diminuta: metacestode-induced reduction in the synthesis of the yolk protein, vitellogenin, in the fat body of Tenebrio molitor. Parasitology, vol. 112 ( Pt 4), 429-436.
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1995. Hymenolepis diminuta-induced fecundity reduction may be caused by changes in hormone binding to Tenebrio molitor ovaries. Parasitology, vol. 110 ( Pt 5), 565-571.
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1995. Malaria-induced reduction of fecundity during the first gonotrophic cycle of Anopheles stephensi mosquitoes. Med Vet Entomol, vol. 9(2), 176-180. doi>
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1995. Microsomal juvenile hormone binding proteins in the follicle cells of Tenebrio molitor. Insect Biochem Mol Biol, vol. 25(5), 631-637. doi>
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1995. Plasmodium yoelii nigeriensis: the effect of high and low intensity of infection upon the egg production and bloodmeal size of Anopheles stephensi during three gonotrophic cycles. Parasitology, vol. 111 ( Pt 5), 555-562.
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1994. Effect of metacestodes of Hymenolepis diminuta on storage and circulating carbohydrates in the intermediate host, Tenebrio molitor. Parasitology, vol. 108 ( Pt 4), 473-478.
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1994. The effects of Onchocerca lienalis infection on vitellogenesis in the British blackfly, Simulium ornatum. Parasitology, vol. 109 ( Pt 3), 337-343.
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1993. Anthelmintic effects of cyclosporin A on protoscoleces and secondary hydatid cysts of Echinococcus granulosus in the mouse. Int J Parasitol, vol. 23(3), 315-320. doi>
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1993. POMPHORHYNCHUS-LAEVIS (ACANTHOCEPHALA) - ELEVATION OF HEMOLYMPH PROTEIN CONCENTRATIONS IN THE INTERMEDIATE HOST, GAMMARUS-PULEX (CRUSTACEA, AMPHIPODA). PARASITOLOGY, vol. 107, 193-198. link>
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1991. Metacestode-induced depression of the production of, and response to, sex pheromone in the intermediate host Tenebrio molitor. J Invertebr Pathol, vol. 58(1), 82-87. doi>
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1990. Hymenolepis diminuta: an investigation of juvenile hormone titre, degradation and supplementation in the intermediate host, Tenebrio molitor. Parasitology, vol. 100 Pt 3, 445-452.
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1990. Physiological and behavioural interactions between parasites and invertebrate hosts. Adv Parasitol, vol. 29, 271-318. doi>
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1989. ACTION OF CYCLOSPORINE-A ON THE TAPEWORMS HYMENOLEPIS-MICROSTOMA, HYMENOLEPIS-DIMINUTA AND MESOCESTOIDES-CORTI INVIVO. PARASITOLOGY, vol. 98, 291-299. link>
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1989. Echinococcus granulosus: a comparison of free amino acid concentration in hydatid fluid from primary and secondary cysts and host plasma. Parasitology, vol. 98 ( Pt 1), 135-143.
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1987. An evaluation of Locusta migratoria as a model for the study of pathophysiology of Hymenolepis diminuta metacestodes in insects. J Parasitol, vol. 73(5), 1063-1064. doi>
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1987. Evidence against the hypothesis that metacestodes of Hymenolepis diminuta inhibit corpora allata functioning in the intermediate host, Tenebrio molitor. Parasitology, vol. 95 ( Pt 1), 93-96.
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1987. The effect of Hymenolepis diminuta upon ecdysteroid activity in the haemolymph of the intermediate host, Tenebrio molitor. Parasitol Res, vol. 74(2), 198-199. doi>
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1986. HYMENOLEPIS-DIMINUTA - INFLUENCE OF METACESTODES ON SYNTHESIS AND SECRETION OF FAT-BODY PROTEIN AND ITS OVARIAN SEQUESTRATION IN THE INTERMEDIATE HOST, TENEBRIO-MOLITOR. PARASITOLOGY, vol. 93, 111-120. link>
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1984. HYMENOLEPIS-DIMINUTA - EFFECT OF METACESTODES ON PROTEIN-METABOLISM OF THE INTERMEDIATE HOST TENEBRIO-MOLITOR (COLEOPTERA). PARASITOLOGY, vol. 89, R47. link>
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1984. PATHO-PHYSIOLOGY OF HYMENOLEPIS-DIMINUTA INFECTIONS IN TENEBRIO-MOLITOR - EFFECT OF PARASITISM ON HEMOLYMPH-PROTEINS. PARASITOLOGY, vol. 89, 253-&. link>
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1984. TENEBRIO-MOLITOR (COLEOPTERA) - EFFECT OF METACESTODES OF HYMENOLEPIS-DIMINUTA (CESTODA) ON HEMOLYMPH AMINO-ACIDS. PARASITOLOGY, vol. 89, 245-251. link>
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1983. THE PATHO-PHYSIOLOGY OF HYMENOLEPIS-DIMINUTA INFECTIONS IN TENEBRIO-MOLITOR. PARASITOLOGY, vol. 87, R68. link>
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1982. CHANGES IN THE HEMOLYMPH COMPOSITION OF TENEBRIO-MOLITOR INFECTED WITH THE CYSTICERCOID LARVAE OF HYMENOLEPIS-DIMINUTA. PARASITOLOGY, vol. 84, R65. link>
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1982. HYMENOLEPIS-DIMINUTA - THE PATHO-PHYSIOLOGY OF INFECTION IN THE INTERMEDIATE HOST, TENEBRIO-MOLITOR. PARASITOLOGY, vol. 85, R63. link>
Chapters
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2010. Parasite-modified vector behavior. In Encyclopedia of Animal Behavior. Breed MD and Moore J (Eds.). (vol. 2). Oxford: Academic Press.
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2005. Interactions Between Malaria and Mosquitoes: The Role of Apoptosis in Parasite Establishment and Vector Response to Infection. In Current Topics in Microbiology and Immunology: Role of apoptosis in infection. Griffin DE (Ed.). Springer Verlag.
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2004. Cestodes. In Encyclopaedia of Entomology. Capinera JL (Ed.). Kluwer Academic Publishers, The Netherlands.
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2002. Parasite manipulation of vector behaviour. In The Behavioural Ecology of Parasites. Lewis EE, Campbell JF, Sukhdeo MVK (Eds.). CABI.
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2001. An example of a vector transmitted parasite. In Practical Exercises in Parasitology. Behnke JM and Marshall I (Eds.). Cambridge University Press.
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2001. Changes in host behaviour as a consequence of parasitic infection. In Practical Exercises in Parasitology. Behnke JM, Marshall I, Halton DW (Eds.). Cambridge University Press.
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2001. Parasite regulation of insect reproduction: similar strategies, different mechanisms?. In Endocrine interactions of insect parasites and pathogens. Edwards JP and Weaver RJ (Eds.). Bios Scientific Publishers Ltd, Oxford.
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1997. The role of endocrinologically active substances in mediating changes in insect hosts and insect vectors. In Parasites and Pathogens - Effects on host hormones and behavior. Beckage NE (Ed.). Springer.
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1993. Reproductive disturbances induced by parasites and pathogens of insects. In Parasites and Pathogens of Insects. Beckag NE, Thompson SA, Federici BA (Eds.). Academic Press.
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1987. Kinetics of molecular transfer acress the regument of protoscoleces and hydatid cysts of Echinococcus granulosus and the relevance of these studies to drug targeting. In Helminth Zoonoses. Geerts S, Kumar V, Brandt J (Eds.). Martinus Nizhoff Publishers.
Other
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2002. A search for the manipulation molecules that enable the rat tapeworm to inhibit insect reproduction. Proceedings of the 10th International Congress of Parasitology.
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1994. Interactions between parasites and insects vectors. Mem Inst Oswaldo Cruz (vol. 89 Suppl 2, pp. 27-30).
My teaching duties are now reduced. I currently teach the majority of a second year module on Symbiotic Relationships and contribute to a third year module on Medical parasitology and the MSc course in Vector Biology and Molecular Parasitology. I also supervise dissertation students.
Keele University