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ISTM Research themes: 1. Neuroscience & Human Metabolism
2. Clinical & Diagnostic Science
Research Interests:
- Study of how polymorphic genes interact with environmental factors such as ultraviolet radiation to influence susceptibility and outcome in multiple sclerosis, basal cell carcinoma and prostate cancer.
- Selection of candidate genes, identification of allelic variants and construction of haplotypes. Use of advanced statistics to identify genetic and environmental influences on risk in patient subgroups.
- Work based on multispeciality teams of biochemists, clinicians and statisticians.
Research grants:
|
Project Leaders |
Funder |
Title |
Start date |
Duration (mths) |
Awarded |
|
Monica Spiteri, Richard Strange, Anthony Fryer
|
British Lung Foundation |
Is the I1005V polymorphism at the glutathione S-transferase, GSTP1, locus functionally significant in the development of atopic airway inflammation? |
01/08/99 |
36 |
£89,512 |
|
Richard Strange
|
Smith Kline Beecham |
Genetic studies in Psoriasis |
01/08/1997 |
65 |
67,534 |
|
Peter Croft
|
Medical Research Council |
Establishing North West and Wessex Regional Biobank |
01/04/2004 |
9 |
736,154 |
|
Richard Strange & Warren Lenney
|
North Staffordshire Respiratory Research Foundation. |
Genetics of Asthma |
01/10/2000 |
36 |
£60,000 |
|
Ari Hirvonen (Helsinki)
|
European Union INTAS |
Polymorphic genes in lung cancer. |
01/08/2000 |
36 |
60,000 ECU |
|
Monica Spiteri
|
PPP Healthcare |
Genetic epidemiology of chronic obstructive airway disease. |
01/09/2001 |
24 |
£274,662 |
|
Richard Strange & John Lear (Manchester) |
3M Healthcare Ltd. |
Genetic factors in multiple BCC |
01/01/2001 |
24 |
£54,413 |
|
Clive Hawkins
|
Department of Health Consortium & Serono Pharmaceuticals Ltd. |
Host Genotype, response to Ultraviolet light, general immune factors and clinical outcome in Multiple Sclerosis |
01/09/2002 |
36 |
£
|
|
Richard Strange & Sudashan Ramachandran |
Good Hope Hospital Research and Development Board |
Genetics of Coronary Heart Disease. |
01/01/2005 |
24 |
£32,853 |
|
Anthony Fryer, Paul Hoban & Richard Strange |
Association for International Cancer Research |
Functional analysis of polymorphism in GSTP1 |
2004 |
36 |
£116,769 |
Keele University
