ISTM

ISTM Research theme: 1. Neuroscience & Human Metabolism
2. Clinical & Diagnostic Science

Background and Research Interests:

Christine Roffe took up her post as consultant/senior lecturer in October 1996. She has shaped the development of the acute and rehabilitation stroke services in North Staffordshire. Her research interests are acute stroke, stroke rehabilitation and ethics. Ongoing projects include the Stroke Oxygen Study, a clinical trial of oxygen supplementation after acute stroke, a study of the effect of thickeners in drinks on oxygen saturation in dysphagic stroke patients, a questionnaire survey of consumer views of artificial feeding after stroke, and, in collaboration with researchers from the School of Health and Rehabilitation, studies of Botulinum toxin and electrical stimulation early after stroke. She is the Clinical Lead for the West Midlands Stroke Local Research Network.

Research grants held at Keele:

The Stroke Oxygen Study (SO2S): a multi-centre, prospective, randomised, open, blinded-endpoint study of routine oxygen treatment in the first 72 hours after a stroke. C. Roffe, P. Crome, R. Gray, P. Jones, L. Handy/ Strokes R Us. NIHR RfPB £249,500.

Leadership of the West Midlands Local Stroke Research. C. Roffe, RJ McManus, GW Humphries, C Sackley, I. Shannon, S Herron-Marx, P Mayer, S Lamb, F Cappuccio. NIHR Network £3,000,000 (£400,000 per annum, 3 year rolling contract, last renewed in 2009).

A study of the effect swallowing different consistencies of water (plain water or water with thickener) on oxygen saturation in the blood. Investigators: Natarajan I, Roffe C.

Key Publications:

Original Research papers

Ali K, Roffe C, Crome P. What patients want: consumer involvement in the design of a randomized controlled trial of routine oxygen supplementation after acute stroke. Stroke 2006;37:865-71.

Scott F, Beech R, Smedley F, Timmis L, Stokes E, Jones P, Roffe C, Bowling T. A prospective randomized controlled single-blind trial of the costs and consequences of systematic nutrition team follow-up over 12 months after percutaneous endoscopic gastrostomy. Nutrition 2005; 21: 1071-1077.

Arora A, Gray R, Crome P, Roffe C. What do physicians with an interest in stroke consider to be best practice in the diagnosis and treatment of hypoxia after acute stroke? Br J Cardiol 2005;12:456-458.

Arora A, Arora M, Roffe C. Mystery of the missing denture: an unusual cause of respiratory arrest in a nonagenarian. Age and Ageing 005;34: 519-520.

Ali K, Sills S, Roffe C. The effect of different doses and routes of oxygen administration on oxygen saturation in stroke patients. Neurocritical Care 2005;3:24-26.

Srinivasan M, Srinivasan KS, Mansur A, Roffe C. Central nervous system infections in the elderly. Geriatric Medicine 2005;35:15-18.

Arora A, Roffe C, Crome P. An unusual and overlooked complication of nasogastric tube feeding. Age Ageing 2005;34:84-5.

Roffe C, Halim M, Wilde K, Crome P. Feasibility of the Divided Attention Steering Simulator (DASS) for the Assessment of Vigilance in Stroke Patients. Middle-East Journal of Age & Ageing 2004. http://www.me-jaa.com/mejaa2/DASS.htm

Srinivasan M, Roffe C. Cold agglutinin induced anaemia in the elderly. Geriatric Medicine 2004;34:27-30.

Roffe C, Sil ls S, Halim M, Wilde K, Allen MB, Jones PW, Crome P. Unexpected nocturnal hypoxia in patients with acute stroke. Stroke 2003;34:2641-2645.

Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Medical Science Monitor 2002;8(5):CR236-330.

Roffe C, Sills S, Wilde K, Come P. Effect of hemiparetic stroke on pulse oximetry readings on the affected side. Stroke 2001;32:1808-1810.

Roffe C, McDiarmaid-Gordon A, Hollis S, Ohanian V, Heagerty AM. The effect of afterload and angiotensin II on proto-oncogene mRNA levels in the isolated working rat heart. Cardiovascular Research 1996;31:907-916.

Roffe D, Roffe C. Madness and care in the community: a medieval perspective. BMJ 1995; 311:1708-1712.

Roffe C, Fletcher S, Woods KL. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm after acute myocardial infarction. British Heart Journal 1994;71:141-145.

Roffe C, Smith M, Basran GSB. Is anticholinergic premedication necessary for fibreoptic bronchoscopy? Monaldi Archives for Chest Disease 1994;49(2): 101-106.

Woods KL, Fletcher S, Roffe C, Haider Y. A randomised trial of intravenous magnesium sulphas in suspected acute myocardial infarction; results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1992; 339: 1553-58.

Roffe C, Tidmarsh M, Howlett TA. Ketanserin overdose. A case report. Postgrad Med J 1991;67:857.

Roffe C, Czapla K, Patel P, Abbott RJ. Peripheral neuropathy as a complication of neuroleptic malignant syndrome. Journal of Neurology, Neurosurgery and Psychiatry 1991; 54 (3); 378-9.

Roffe C, Cahill MR, Samanta A, Bricknell S, Durrant STS. Aplastic anaemia in systemic lupus erythematosus. A cellular immune mechanism? British Journal of Rheumatology 1991; 30:301-304.

Samanta A, Haider Y, Roffe C. An audit of patients attending a general medical follow-up clinic. JR Coll Physicians London 1991; 25(1) 33-35.

Samanta A, Roffe C. Woods KL, Accidental self administration of xylazine in a veterinary nurse. Postgrad Med J 1990; 66:244-245.

Contributions to Textbooks

Confusion: mental illness in older people. In: Clinical Guidelines 1999, West Mercia Clinical Guidelines Partnership (annual revised reprints to 2005).

Stroke. In: Clinical Guidelines 1999, West Mercia Clinical Guidelines Partnership (Annual revised reprints to 2005).

Roffe C. Drugs in Stroke. In: Drugs and the Older Population, eds Crome P, Ford G. Imperial College Press 2000.

Borriello SP, Roffe C. The normal microflora and antibiotic-associated diarrhoea and colitis. In: Medical importance of the normal microflora. Ed: Tannock GW. Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, pp 371-387.

Review Articles

Roffe C. Hypoxia and stroke. Age and Ageing 2002;3I-S2:1-3.

Roffe C. Hypoxaemia and stroke. Reviews in Clinical Gerontology 2001;11(4):323-335.

Roffe C. Ageing of the heart. Br J Biomed Sci 1998;55:136-148.

Roffe C, Christie L. After the stroke. Midlands Medicine 1998;20(6)108-115.

Roffe C . Biotherapy for antibiotic-associated and other diarrhoeas. Journal of Infection

1996;32(1): 1-10.

MD thesis

The role of afterload and angiotensin II in the generation of early molecular signals of left ventricular hypertrophy, University of Leicester 1999.