ISTM

ISTM Research theme: 1. Bioengineering & Therapeutics - Clinical Lead for B&T theme

Research Interests:

Surgical Management of Early Arthritis. This has two arms:

1. Bone conservation in joint replacement, and
2. Tissue Engineering with a long term goal of developing a biological joint replacement. 

 

An image of human cartilage cells (chondrocytes) in tissue culture, where the cells adhere to the culture surface and start to proliferate

Principal external research grants:

Medical Research Council trial grant 
Cartilage Repair by Autologous Chondrocyte Transplantation (ACTIVE)
£759,622 (1 January 2004 for 12 years) Trial No:  ISRCTN 48911177 (Alpha A Band)

European Commission Framework Programme project grant
European Partnership for Autologous Chondrocyte Cell Implantation (EUROCELL)
658,962 Euros (1 February 2001 for 3 years) (in collaboration with European partners) 

Arthritis Research Campaign grant (N Goodstone, J Richardson)
A novel approach for characterising repair cartilage following human autologous chondrocyte implantation (ACI)
£93,231 (April 2004 for 2 years)   ARC grant ref: 16181

Arthritis Research Campaign grant (S Roberts, B Caterson, J Richardson, G Edwards)
Biomarker patterns of degenerative joint disease
£187,396 (1 May 2006 for 3 years)   ARC grant ref:  17540

European Commission Framework Programme 6 project grant
Growing a New Joint in a Human Back (MYJOINT)
£386,106 (1 January 2007 for 3 years)   Partnership between Keele UK and Kiel Germany) 

Selected publications:Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WE (2009) Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone 45(4):726-735 October 2009

Roberts S, Menage J, Sandell LJ, Evans EH, Richardson JB (2009) Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. Knee 16(5):398-404 October 2009

Bajada S, Mazakova I, Richardson JB and Ashammakhi N (2008) Updates on stem cells and their applications in regenerative medicine. Journal of Tissue Engineering and Regenerative Medicine  2:4  pp169-183   June 2008

Aulakh TS, Robinson EV and Richardson JB (2007) Nine year follow up of Birmingham hip resurfacing in context of survival and complications. Value in Health   10:6   pp A231-A231   Nov-Dec 2007

Khan M, Kuiper JH and Richardson JB (2007) Can cobalt levels estimate in-vivo wear of metal-on-metal bearings used in hip arthroplasty? Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering Medicine 221:H8   pp929-942   November 2007

Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N and Richardson JB (2007)  Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. Journal of Bone and Joint Surgery - British Volume 89:10   pp1382-1386   October 2007

Bhosale AM, Myint P, Roberts S, Menage J, Harrison P, Ashton B, Smith T, McCall I and Richardson JB (2007) Combined autologous chondrocyte implantation and allogenic meniscus transplantation: A biological knee replacement. Knee  14:5   pp361-368   October 2007

Richardson JB, Balbouzis T, Cassar-Pullicino V, Kuiper JH, Harrison PE, Bhosale A, Cook F, Haddaway MJ and Ashton B (2006) Clinical application of adult bone marrow mesenchymal stem cells for treatment of fracture nonunions. Tissue Engineering 12 (4): 1023-1023 115 April 2006     ISSN 1076-3279

Bhosale A, Harrison P, Ashton B, Menage J, Myint P, Roberts S, McCall I, Smith T and Richardson J (2006) A new biological method of joint reconstruction in young patients: Combination of autologous chondrocyte implantation with allogenic meniscus transplantation. Tissue Engineering 12 (4): 1022-1023 114 April 2006          ISSN 1076-3279

Khan M  Takahashi T  Kuiper JH  Sieniswska CE Takagi K  and Richardson JB (2006) Current in vivo wear of metal-on-metal bearings assessed by exercise related rise in plasma cobalt level Journal of Orthopaedic Research  24 11 2029 – 2035

Smith GD, Knutsen G, and Richardson JB (2005) A Clinical Review of Cartilage Repair Techniques. Journal of Bone and Joint Surgery Br 87-B No 445-449  April 2005      ISSN 0301-620X

Harrison P,  Pfeifer P, Turner S, Richardson J, Jones P and Ashton B (2003) Serum from patients anaesthetized with opiates is less effective in the support of chondrocyte growth in vitro.  Tissue Engineering 9;  27-41 (2003)  ISSN 1076-3279
                          
Roberts S, McCall IW, Darby AJ, Menage J, Evans H, Harrison PE and Richardson JB (2003) Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Research & Therapy 5(1): R60-R73

Bailey A, Goodstone N, Hughes J, Robert S, Van Niekerk L, Richardson J and Rees D (2003) Rehabilitation after Oswestry autologous-chondrocyte implantation: the OsCell protocol. Journal of Sport Rehabilitation 12(2): 104-118 

Cassar-Pullicino VN & Richardson JB (2001) Basic sciences for FRCS (Trauma & Orthopaedics): a teaching manual for FRCS (Trauma & Orthopaedics) trainees. Institute of Orthopaedics Publishing Group, Oswestry (contains contributions from 18 Oswestry staff)

Richardson J and Kenwright J (2000) The biology of fracture repair and the role of dynamisation.  in De Bastiani G, Apley, AG, Goldberg, A (2000) Orthofix External Fixation in Trauma and Orthopaedics, Berlin, Springer  Chap. 2, pp 8-17

Richardson J, Caterson B, Evans EH and Ashton BA (1999) Repair of human articular cartilage after implantation of autologous chondrocytes Journal of Bone and Joint Surgery Nov. 81(6), pp 1064-1068

Current external appointments:

 
• Editorial Board of Hip International
• Arthritis Research Campaign Research Board
• Action Medical Research
• Board Member of International Cartilage Repair Society
• Medical Research Council - College of Experts
• Scientific Advisory Board (SAB) for Tissue Engineering, Singapore (1 June 2005 – 31 May 2008)
• Director - Institute of Orthopaedics
• Clinical Director of Oscell: cell production unit at Oswestry