Dr Oksana Kehoe

Title: Research Fellow and Acting Head of Rheumatology Research Laboratory at RJAH Orthopaedic Hospital
Phone: +44 (0)1691 404149
Email:
Location: Leopold Muller Arthritis Research Centre
Keele University at Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust
Oswestry, Shropshire SY10 7AG United Kingdom
Role: ISTM Research theme: Bioengineering & Therapeutics
Contacting me: By phone or e-mail please.
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Research Career

2006 - present:  Research  Fellow and Acting Head of Rheumatology Research Laboratory, Institute for Science & Technology in Medicine at RJAH Orthopaedic Hospital, Oswestry, UK. 

2002 – 2005: Postdoctoral Research Associate, Faculty of Life Sciences, University of Manchester, UK. Investigation into role of an immunoglobulin-like cell adhesion molecule nectin-1 in palatal shelf fusion and desmosome assembly.

2000, December- 2002:  Postdoctoral Research Associate, Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Cardiff University, Wales. Investigation into role of Angiopoietin-1/Tie-2 system in pericyte survival and recruitment in diabetic retinopathy.

2000, February – 2000, November:  Postdoctoral Research Associate, Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales. Studying the biophysics of corneal transparency under varying ambient anion concentration.

Research interests:

  •     Role of heparan sulphate proteoglycan syndecan-3 in inflammation.

Heparan sulphate proteoglycans (HSPG) form part of the glycocalyx which comprises a network of membrane-bound proteoglycans and glycoproteins at the cell surface of endothelial cells. We show that syndecan-3 appears to play a dual role in inflammation depending on the tissue. In the joint it is pro-inflammatory since its deletion leads to reduced leukocyte recruitment and the severity of arthritis. However, in the skin and cremaster it is anti-inflammatory since its deletion leads to enhanced leukocyte interaction with the endothelium and recruitment. This is the first study to show a role for sdc-3 in inflammation and reveals its function is tissue-selective.

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Reduced chemokine presentation by synovial endothelial cells. CXCL1 emerged as variously-sized granules within the synovial endothelial cells (arrows show examples) (A) and no CXCL1 granules were present in the endothelial cells of controls (arrows)(B). 

  •   Therapeutic potential of mesenchymal stem cells in rheumatoid arthritis.

 

ISTM Research theme: Bioengineering & Therapeutics

Selected Publications

  • Rump-Goodrich L, Mattey D, Kehoe O, Middleton J. 2013. DIFFERENTIAL GENERATION OF CC CHEMOKINES AT MICROVASCULAR ENDOTHELIAL CELLS OF BLOOD AND LYMPHATIC VESSELS UNDER INFLAMMATORY CONDITIONS. RHEUMATOLOGY (vol. 52, pp. 136-137). link>
  • Kehoe O, Cartwright A, Askari A, El Haj A, Middleton J. 2013. INTRA-ARTICULAR INJECTION OF MESENCHYMAL STEM CELLS LEADS TO REDUCED INFLAMMATION IN ANTIGEN-INDUCED ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 78). link>
  • Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J. 2013. A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. J Immunol, vol. 190(4), 1725-1736. link> doi>
  • Cartwright A, King S, Middleton J, Kehoe O. 2012. Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency in CCR9 in a Murine Model of Antigen-Induced Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 77-84. doi>
  • Cai J, Kehoe O, Smith GM, Hykin P, Boulton ME. 2008. The angiopoietin/tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 49(5), 2163-2171. link> doi>

Full Publications List show

Journal Articles

  • Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J. 2013. A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. J Immunol, vol. 190(4), 1725-1736. link> doi>
  • Cartwright A, King S, Middleton J, Kehoe O. 2012. Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency in CCR9 in a Murine Model of Antigen-Induced Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 77-84. doi>
  • Cai J, Kehoe O, Smith GM, Hykin P, Boulton ME. 2008. The angiopoietin/tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 49(5), 2163-2171. link> doi>
  • Kostyuk O, Nalovina O, Mubard TM, Regini JW, Meek KM, Quantock AJ, Elliott GF, Hodson SA. 2002. Transparency of the bovine corneal stroma at physiological hydration and its dependence on concentration of the ambient anion. JOURNAL OF PHYSIOLOGY-LONDON, vol. 543(2), 633-642. link> doi>
  • Kostyuk O, Nalovina O, Mubard TM, Regini JW, Meek KM, Quantock AJ, Elliott GF, Hodson SA. 2002. Transparency of the bovine corneal stroma at physiological hydration and its dependence on concentration of the ambient anion. J Physiol, vol. 543(Pt 2), 633-642. link>
  • Ostapchenko LI, Nalevina OE, Kucherenko NE. 1999. [The use of nontraditional approaches to the analysis of the effects of radiation on the system of protein phosphorylation in spleen lymphocytes]. Radiats Biol Radioecol, vol. 39(2-3), 334-340. link>
  • Ostapchenko LI, Nalevina OE, Tomachinskaia LI, Kucherenko NE. 1998. [Effect of x-irradiation on the properties of cyclic AMP-dependent protein kinases from rat spleen lymphocytes]. Radiats Biol Radioecol, vol. 38(5), 650-656. link>

Other

  • Rump-Goodrich L, Mattey D, Kehoe O, Middleton J. 2013. DIFFERENTIAL GENERATION OF CC CHEMOKINES AT MICROVASCULAR ENDOTHELIAL CELLS OF BLOOD AND LYMPHATIC VESSELS UNDER INFLAMMATORY CONDITIONS. RHEUMATOLOGY (vol. 52, pp. 136-137). link>
  • Kehoe O, Cartwright A, Askari A, El Haj A, Middleton J. 2013. INTRA-ARTICULAR INJECTION OF MESENCHYMAL STEM CELLS LEADS TO REDUCED INFLAMMATION IN ANTIGEN-INDUCED ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 78). link>
  • Hykin PG, Smith GM, Nalovina O, Cai J, Boyd S, Boulton M. 2004. Angiopoietin-1 promotes pericyte survival and activation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (vol. 45, p. U736). link>
  • Nalovina O, Cai J, Hykin P, Boulton M. 2002. The role of the angiopoietin/Tie-2 system in retinal neovascularisation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (vol. 43, p. U298). link>

MSc  Cell & Tissue Engineering - Human Anatomy and Physiology Module (Musculoskeletal component).

Research Funding:

Arthritis Research UK - equipment grant (Wright K., Cartwright A., Kehoe O., Mennan C., Richardson J., Roberts S., Turner S., Wright H.)
£100,000  December 2012
'BD FACSVerse Flow Cytometer (3 Laser 4-2-2)' 

Oswestry Rheumatology Association - consumables for MSCs project
£7,500  December 2012

The EPSRC Centre for Innovative Manufacturing in Regenerative Medicine – Research grant(with Professor Alicia El  Haj and Professor James Richardson)
£119,510  September 2011
'Establishing stem cell population with consistent and reproducible therapeutic  behaviours' 

Institute of Orthopaedics Ltd, Oswestry - research grant
£50,000 May 2011
'The Therapeutic Potential of Mesenchymal Stem Cells in Rheumatoid  Arthritis'.