Dr Mark Deakin

Title: Honorary Senior Lecturer and Consultant Surgeon, UHNS
Phone: +44 (0)1782 553828 or 554581
Email:
Location: 1. Institute for Science & Technology in Medicine, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB United Kingdom
2. Keele University School of Medicine, Clinical Education Centre, Stoke-on-Trent, ST5 6QG United Kingdom

Role: ISTM Research theme: 1. Clinical & Diagnostic Science
Contacting me: By phone or e-mail please
Mark_Deakin_150x218

Dr Deakin's research has focussed on creating links between Keele and the patient population in North Staffordshire.  He has worked to create opportunities for the introduction of medical personel into clinical and laboratory research within Keele, largely through associations with the Nuffield Hospital and MD programme.

His research interests include:

  • Molecular epidemiology
  • Molecular Carcinogenesis
  • Metastasis
  • Apoptosis
  • Clinical Oncology
  • Clinical Management of GI Cancer
  • Medical education

ISTM Research theme: 1. Clinical & Diagnostic Science


Research interests:

• Molecular Epidemiology of gastro-intestinal cancers involving GST polymorphisms and VitD receptor polymorphisms (collaboration with Prof RC Strange and Dr AA Fryer)
• Molecular Carcinogenesis relating to gastro-intestinal and pancreatic tumours (collaborations with Prof RC Strange, Dr AA Fryer, Prof WE Farrell, Dr P Hoban and Prof G Williams).
• Metastasis - specifically mechanisms of metastasis (collaboration with Dr P Hoban on E cadherin, polymorphisms, methylation and gastro-intestinal tumours).
• Apoptosis and its association with the reponse to chemoradiotherapy in colorectal cancer (collaboration with Prof G Williams)
• Clinical Oncology Research - specifically clinical management of gastro-intestinal cancer

Clinical Trials:

• REFLUX trial (lead clinician for UHNS, co-ordinated by University of Aberdeen)

Bhogal RH, Athwal R, Durkin D, Deakin M, Cheruvu CN
Comparison between open and laparoscopic repair of perforated peptic ulcer disease
WORLD JOURNAL OF SURGERY 32 (11): 2371-2374 Nov 2008

Al-Sarira AA, David G, Willmott S, Slavin JP, Deakin M and Corless DJ
"Oesophagectomy practice and outcomes in England"
BRITISH JOURNAL OF SURGERY 94 (5): 585-591 May 2007

Bahar A, Whitby P, Holley S, Hoban PR, Elder JB, Deakin M, Hall C, Clayton RN, Williams GT, Farrell WE
"Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis"
GENES CHROMOSOMES & CANCER 46 (2): 202-212 February 2007

Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA
"Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer" 
INTERNATIONAL JOURNAL OF ONCOLOGY 28 (1): 231-236 January 2006

Bassi C, Stocken DD, Olah A, Friess H, Buckels J, Hickey H, Dervenis C, Dunn JA, Deakin M, Carter R, Ghaneh P, Neoptolemos JP, Buchler MW
"Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial" 
DIGESTIVE SURGERY 22 (5): 353-363 2005

Roy SD, Kupp DV, Slavin JP, Corless DJ and Deakin M
"Inequity of upper gastrointestinal cancer distribution and survival with socioeconomic deprivation: A population-based study" 
SURGERY 138 (5): 859-868 November 2005

Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC and Fryer AA
"Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer" 
CARCINOGENESIS 26 (12): 2157-2163 December 2005

Roy SD, Cade D, Deakin M and Corless DJ
"Colorectal cancer trends in various socioeconomic classes: are we targeting the right population?" 
BRITISH JOURNAL OF SURGERY 92: 84-84 Suppl. 1 April 2005

Maharaj S, Elder JB, Deakin M and Williams GT
"Development of a model to investigate the role of Toll-like receptors in H pylori induced apoptosis of gastric cancer cells" 
GUT 54: A89-A89 341 Suppl. 2 April 2005

McCloud J, Sivakumar R, Greenhough A, Jones P, Deakin M, Elder JB, Fryer A, Hoban PR
"p16INK4a polymorphism; associations with tumour progression in patients with sporadic colorectal cancer"
International Journal of Oncology, 25 (5): 1447-1452   November 2004

Roy SD, Jibawi A, Deakin M and Corless DJ
"Variation in gastric cancer incidence and survival trends with deprivation over fifteen years: A population based study"
GASTROENTEROLOGY 126 (4): A314-A314 Suppl. 2 April 2004

Ishaq S, Miller D, Hall C, Green J, Deakin M
"Endoscopic Sphincterotomy for choledocholithiasis in patients younger than 50 years: long term follow up study"
GUT, 53 (1), 168 Suppl 3, A44, April 2004

Stocken DD, Neoptolemos JP, Friess H, Bassi C, Dunn JA, Hickey H, Imrie C, Deakin M, Buckels J, Dervenis C, Olah A, Fernandez-Cruz L, Lacaine F and Buchler MW
"ESPAC-1: final results of a European, randomized controlled trial to assess the roles of adjuvant chemotherapy and adjuvant chemoradiation in resectable pancreatic cancer" 
BRITISH JOURNAL OF SURGERY 91 (4): 520-520 April 2004

Miller R, Dewar EP, Kapadia CR, (AXIS Collaborators)
"Randomized clinical trial of adjuvant radiotherapy and 5-fluorouracil infusion in colorectal cancer (AXIS)" 
BRITISH JOURNAL OF SURGERY 90 (10): 1200-1212 October 2003

Neoptolemos JP, Stocken DD, Dunn JA, Buckels J, Deakin M, Sutton R, Imrie C, Kerr DJ, Buchler MW
"Influence of the type of surgery and surgical complications in the ESPAC-1 adjuvant trial"
BRITISH JOURNAL OF SURGERY 89: 35-35 Suppl. 1 June 2002

Selected Publications

  • DEAKIN M, Ballal M, David G, Willmott S, Corless DJ, Slavin JP. 2009. Conversion after laparoscopic cholecystectomy in England. Surgical Endoscopy: surgical and interventional techniques, vol. 23(10), 2338-2344. doi>
  • DEAKIN M and Turner P. 2009. Percutaneous endoscopic gastrostomy tube removal and replacement after "buried bumper syndrome": the simple way. Surgical Endoscopy: surgical and interventional techniques, vol. 23(8), 1914-1917. doi>
  • Bhogal RH, Athwal R, Durkin D, Deakin M, Cheruvu CN. 2008. Comparison between open and laparoscopic repair of perforated peptic ulcer disease. World J Surg, vol. 32(11), 2371-2374. link> doi>
  • DEAKIN M, David G, Al-Sarira A, Willmott S, Corless DJ, Slavin JP. 2008. Management of acute gallbladder disease in England. British Journal of Surgery, vol. 95(4), 472-476. doi>
  • Al-Sarira AA, David G, Willmott S, Slavin JP, Deakin M, Corless DJ. 2007. Oesophagectomy practice and outcomes in England. BRITISH JOURNAL OF SURGERY, vol. 94(5), 585-591. link> doi>

Full Publications List show

Books

  • DEAKIN M, BRANT M, STEPHENS M, CHASTY R. Fielding JW, Hallisay M, Springer (Eds.). 2004. Lymphomas. Springer, ..

Journal Articles

  • DEAKIN M, Ballal M, David G, Willmott S, Corless DJ, Slavin JP. 2009. Conversion after laparoscopic cholecystectomy in England. Surgical Endoscopy: surgical and interventional techniques, vol. 23(10), 2338-2344. doi>
  • DEAKIN M and Turner P. 2009. Percutaneous endoscopic gastrostomy tube removal and replacement after "buried bumper syndrome": the simple way. Surgical Endoscopy: surgical and interventional techniques, vol. 23(8), 1914-1917. doi>
  • Bhogal RH, Athwal R, Durkin D, Deakin M, Cheruvu CN. 2008. Comparison between open and laparoscopic repair of perforated peptic ulcer disease. World J Surg, vol. 32(11), 2371-2374. link> doi>
  • DEAKIN M, David G, Al-Sarira A, Willmott S, Corless DJ, Slavin JP. 2008. Management of acute gallbladder disease in England. British Journal of Surgery, vol. 95(4), 472-476. doi>
  • Al-Sarira AA, David G, Willmott S, Slavin JP, Deakin M, Corless DJ. 2007. Oesophagectomy practice and outcomes in England. BRITISH JOURNAL OF SURGERY, vol. 94(5), 585-591. link> doi>
  • Bahar A, Whitby P, Holley S, Hoban PR, Elder JB, Deakin M, Hall C, Clayton RN, Williams GT, Farrell WE. 2007. Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis. Genes Chromosomes Cancer, vol. 46(2), 202-212. link> doi>
  • Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2006. Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. Int J Oncol, vol. 28(1), 231-236. link>
  • Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2005. Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer. Carcinogenesis, vol. 26(12), 2157-2163. link> doi>
  • Roy SD, Kupp DV, Slavin JP, Corless DJ, Deakin M. 2005. Inequity of upper gastrointestinal cancer distribution and survival with socioeconomic deprivation: A population-based study. SURGERY, vol. 138(5), 859-868. link> doi>
  • McCloud JM, Sivakumar R, Greenhough A, Elder J, Jones PW, Deakin M, Elder JB, Fryer AA, Hoban PR. 2004. p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer. Int J Oncol, vol. 25(5), 1447-1452. link>
  • Fawole AS, Simpson DJ, Rajagopal R, Elder J, Holland TA, Fryer A, Deakin M, Elder JB, Farrell WE. 2002. Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarcinoma. Int J Cancer, vol. 99(6), 829-833. link> doi>
  • Fawole AS, Simpson DJ, Rajagopal R, Elder J, Holland TA, Fryer AA, Deakin M, Elder JB, Farrell WE. 2002. Loss of Heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarinoma. International Journal of Cancer, vol. 99(6), 829/833.
  • Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole S, Gilissen R, Campbell FC, Coughtrie MWH. 2001. Phenol sulfotransferase SULT1a1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics. doi>
  • Holland T, Elder J, McCloud J, Hall C, Deakin M, Fryer AA, Elder JB, Hoban PR. 2001. Subcellular Localisation of Cyclin D1 Protein in Colorectal Tumours is Associated with p12 expression and correlates with Patient Survival. International Journal of Cancer, vol. 95(5), 302-306. doi>
  • Neoptolemos JP, Stocken DD, Dunn JA, Almond J, Beger HG, Pederzoli P, Bassi C, Dervenis C, Fernandez-Cruz L, Lacaine F, Buckels J, Deakin M, Adab FA, Sutton R, Imrie C, Ihse I, Tihanyi T, Olah A, Pedrazzoli S, Spooner D, Kerr DJ, W. 2001. Influence of Resection Margins on Survival for Patients with Pancreatic Cancer Treated by Adjuvant Chemoradiation and/or Chemotherapy in the ESPAC-1 Randomized Controlled Trial. Annals of surgery, vol. 234(6), 758-768.
  • Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole S, Gilissen R, Campbell FC, Coughtrie MWH. 2001. Phenol sulfotransferase SULT1a1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics.
  • Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB. 2000. Hereditary non-polyposis colorectal cancer: an updated review. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, vol. 26(7), 635-645. link> doi>
  • Boissy RJ, Watson MA, Umbach DM, Deakin M, Elder J, Strange RC, Bell DA. 2000. A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER, vol. 87(4), 507-511. link> doi>
  • Fawole AS, Elder J, Holland TA, Fryer AA, Anwar S, Rajagopal R, Deakin M, Hall C, Elder JB, Farrell WE. 2000. Region of frequent loss of heterozygosity on long arm of chromosome 10 associated with earlier age of presentation in sporadic colorectal adenocarcinoma. GUT, vol. 46, A53. link>
  • Holland TA, Elder J, Deakin M, Hall C, Fryer AA, Elder JB, Hoban PR. 1999. Protein expression and subcellular localisation of cyclin D1 and p21 in human colorectal carcinoma. BRITISH JOURNAL OF CANCER, vol. 80, 10. link>
  • Holland TA, Elder J, Deakin M, Hall C, Strange RC, Fryer AA, Hoban PR, Elder JB. 1999. Cyclin D1 protein expression in human colorectal carcinoma. GUT, vol. 44, A141. link>
  • Sajjad Z, Oxtoby J, West D, Deakin M. 1999. Biliary imaging by spiral CT cholangiography--a retrospective analysis. Br J Radiol, vol. 72(854), 149-152. link>
  • Anwar S, White J, Hall C, Farrell WE, Deakin M, Elder JB. 1999. Sporadic colorectal polyps: management options and guidelines. Scand J Gastroenterol, vol. 34(1), 4-11. link>
  • Scott N, Hale A, Deakin M, Hand P, Adab FA, Hall C, Williams GT, Elder JB. 1998. A histopathological assessment of the response of rectal adenocarcinoma to combination chemo-radiotherapy: relationship to apoptotic activity, p53 and bcl-2 expression. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, vol. 24(3), 169-173. link> doi>
  • Oke OO, Korsgen S, Holland T, Vadgama B, Deakin M, Hall C, Elder JB. 1997. Epidermal growth factor receptor levels in human colorectal carcinoma. GUT, vol. 41, A250. link>
  • Oke OO, Korsgen S, Hall C, Deakin M, Adab F, Scott N, Elder JB. 1997. The effect of preoperative chemoradiotherapy in locally advanced rectal cancer. GUT, vol. 41, A125. link>
  • Duncan HD, Hodgkinson L, Deakin M, Green JR. 1997. The safety of diagnostic and therapeutic ERCP as a daycase procedure with a selective admission policy. Eur J Gastroenterol Hepatol, vol. 9(9), 905-908. link>
  • Deakin M. 1996. A method to facilitate transcystic exploration of the common bile duct at laparoscopic cholecystectomy. ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, vol. 78(6), 561. link>
  • Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1996. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, vol. 17(4), 881-884. link> doi>
  • Singanayagam J, Oxtoby J, Varghese J, West DJ, Deakin M. 1995. Technical report: percutaneous transperitoneal balloon sphincteroplasty during laparoscopic cholecystectomy for choledocholithiasis. Clin Radiol, vol. 50(12), 867-868. link>
  • BELL D, STEPHENS E, CASTRANIO T, UMBACH D, WATSON M, DEAKIN M, ELDER J, HENDRICKSE C, DUNCAN H, STRANGE R. 1995. POLYADENYLATION POLYMORPHISM IN THE ACETYLTRANSFERASE-1 GENE (NAT1) INCREASES RISK OF COLORECTAL-CANCER. CANCER RESEARCH, vol. 55(16), 3537-3542. link>
  • Nash J, Lambert L, Deakin M. 1994. Histamine H2-receptor antagonists in peptic ulcer disease. Evidence for a prophylactic use. Drugs, vol. 47(6), 862-871. link>
  • Deakin M and Williams JG. 1992. Histamine H2-receptor antagonists in peptic ulcer disease. Efficacy in healing peptic ulcers. Drugs, vol. 44(5), 709-719. link> doi>
  • Strange RC, Matharoo B, Faulder GC, Jones P, Cotton W, Elder JB, Deakin M. 1991. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Carcinogenesis, vol. 12(1), 25-28. link> doi>
  • DEAKIN M, Samee A, Moorthy K, Jaipersad T, Crisp W, Cheruvu C, Elder J. Evaluation of the role of laparoscopic ultrasonography in the staging of oesophagogastric cancers. Surgical Endoscopy: surgical and interventional techniques, vol. 23(9), 2061-2065. doi>

Other

  • Maharaj S, Elder JB, Deakin M, Williams GT. 2005. Development of a model to investigate the role of Toll-like receptors in H pylori induced apoptosis of gastric cancer cells. GUT (vol. 54, p. A89). link>
  • LACY-COLSON J, JONES P, ELDER J, DEAKIN M, HOBAN P, ELDER J. 2004. A Meta analysis of the association between E Cadherin expression and tumour progression in colorectal cancer. Proceedings of the 18th Meeting of the European Association for cancer research.
  • LACY-COLSON J, GREENHOUGH J, ELDER J, JONES P, SAEED M, DEAKIN M, ELDER J, HOBAN. 2004. A Meta comparison of E Cadherin promoter Haplotypes and tumour protein expression as markers of disease progression in colorectal. Proceedings of the 18th Meeting of the European Association for cancer research.
  • DUTTA ROY, JIBAWI A, CURLESS D, DEAKIN M. 2004. A study of deprivation indices and gastro-oesophageal cancer in West Midlands Population (UK) over 15 years. European Journal of Surgical Oncology.
  • ISHAQ S, MILLER D, HALL C, GREEN J, DEAKIN M. 2004. Endoscopic Sphincterotomy for choledocholithiasis in patients younger than 50 years: long term follow up study. Gut.
  • Sivakumar R, Holley SL, Smith V, Deakin M, Hall C, Elder JB, Hoban PR. 2003. Polymorphisms within cyclin D1 gene influence outcome in patients with sporadic colorectal adenocarcinoma. BRITISH JOURNAL OF SURGERY (vol. 90, pp. 134-135). link>
  • Lacy-Colson J, Greenhough A, Sivakumar R, Deakin M, Hall C, Elder J, Hoban P. 2003. E-cadherin promoter polymorphism effects clinical outcome in colorectal cancer. Proceedings of the American Association for Cancer Reseach.
  • Sivakumar R, Elder J, Grrenhough A, Lacy-Colson J, Hall C, Deakin M, Elder J, Hoban P. 2003. Site of intracellular expression of beta-catenin influences the outcome in sporadic colorectal cancer. European Journal of Cancer.
  • Bamber DE, Board PG, Coggan M, Elder JB, Deakin M, Rajagopal R, Fawole AS, Strange RC, Fryer AA. 2001. Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 95-97). link>
  • Rajagopal R, Fawole AS, White J, Holland TA, Deakin M, Elder JB, Strange RC, Fryer AA. 2001. Glutathione S-transferase M1, M3, P1 and T1 in susceptibility to and outcome in patients with colorectal adenocarcinoma. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 109-112). link>