ISTM

Current Research Interests:

• Research into bioartificial bone tissues and their potential for bone tissue engineering in orthopaedic practice.
• Investigations of menstrual cycle disorders (clinical and genetic.)
• Research into gene transfection techniques using nanoparticles and magnetic fields to delivery foreign DNA into living cells.

Publications in peer-reviewed journals:

Julia L Magnay, Gerrit Schonicke, Tracy M Nevatte, Shaughn O'Brien, Wolfgang Junge.  Validation of a rapid alkaline hematin technique to measure menstrual blood loss on feminine towels containind superabsorbent polymers.  Fertil Steril 2011 (in press) [corresponding author].

NM Whiteley, JL Magnay, SJ McCleary, S Khazraee, AJ El Haj, J Rock.  Characterization of myosin heavy chain gene variants in the fast and slow muscle fibres of gammarid amphipods. Comp Biochem and Physiol A Mol Integr Physiol 2010; 157:116-122.

Janos Kanzler, Harpul Sura, Julia Magnay, Richard Oreffo, David Green, Jon Dobson, Alicia El Haj. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng Part A 2010;16:3241-3250.

Julia L Magnay, Tracy M Nevatte, Vandana Dhingra, Shaughn O’Brien.  Menstrual blood loss measurement: validation of the alkaline hematin technique for feminine hygiene products containing superabsorbent polymers. Fertil Steril 2010;94:2742-2746 [corresponding author].

Julia L Magnay, Maged El Shourbagy, Anthony A Fryer, Shaughn O’Brien, Khaled MK Ismail. Analysis of the serotonin transporter rs25531 polymorphism in premenstrual dysphoric disorder. Am J Obs Gyn 2010; 203:181 e1 - 181 e5. [corresponding author].

J Rock, JL Magnay, S Beech, AJ El Haj, G Goldspink, D Lunt, NM Whiteley.  Linking functional molecular variation with environmental gradient: myosin gene diversity in a crustacean broadly distributed across variable thermal environments.  Gene 2009; 437: 60-70.

Wang QG, Magnay JL, Nguyen B, Thomas CR, Zhang Z, El Haj AJ, Kuiper NJ.  Gene expression profiles of dynamically compressed single chondrocytes and chondrons.  Biochem Biophys Res Commun 2009; 379: 738-42.

Dhingra V, Magnay JL, O’Brien PMS, Chapman G, Fryer AA, Ismail KMK.  Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder. Obstet Gynecol 2007; 110: 788-792. [corresponding author]

Magnay JL, Ismail KMK, Chapman G, Cioni L, Jones P, O’Brien S.  Serotonin  transporter, tryptophan hydroxylase and monoamine oxidase A polymorphisms in premenstrual dysphoric disorder.  Am J Obstet Gynecol 2006; 195: 1254-1259. [corresponding author]

Smith D, Ismail K, Diskin AM, Chapman G, Magnay JL, Spanel P, O'Brien S. Increase of acetone emitted by urine in relation to ovulation. Acta Obstet Gynecol Scand 2006; 85: 1008-1011.

Hughes S, Magnay J, Foreman M, Publicover S, El Haj AJ.  Expression of the mechanosensitive  2PK⁺ channel TREK-1 in human osteoblasts.  J Cell Physiol 2006; 206: 738-748.

Yang Y, Magnay J, Cooling L, Cooper J, El Haj AJ.  Effects of substrate   characteristics on bone cells’ response to their mechanical environment. Med Biol Eng Computing 2004; 42: 22-29. Awarded the Institute of Physics and Engineering in Medicine ‘Nightingale Prize’ for the best scientific paper published in Medical &  Biological  Engineering &  Computing during 2004.

Magnay JL, Holmes JM, Neil DM, El Haj AJ. Temperature-dependent developmental variation in lobster muscle myosin heavy chain isoforms.  Gene 2003, 316: 119-126.

Yang Y, Magnay JL, Cooling L, El Haj AJ.  Development of a ‘mechano-active’ scaffold for tissue engineering. Biomaterials  2002; 10: 2119-2126.

Holmes JM, Whiteley NM, Magnay JL, El Haj AJ.  Comparison of the variable loop regions of myosin heavy chain genes from antarctic and temperate isopods.  Comp Biochem Physiol B Biochem Mol Biol 2002; 131: 349-359.

Gu Y, Preston MR, Magnay J, El Haj AJ, Publicover SJ.  Hormonally regulated expression of voltage-operated Ca(2⁺) channels in osteocytic (MLO-Y4) cells.  Biochem Biophys Res Commun  2001; 30: 536-542.

Magnay JL, Tong J, Drangova R, Baines AD. Production of cysteinyl dopamine during intravenous dopamine therapy. Kidney Int  2001; 59: 1891-1898.

Walker LM, Preston MR, Magnay JL, Thomas PB, EL Haj AJ.  Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture.  Bone  2001; 28: 603-608.

Peake MA, Cooling LM, Magnay JL, Thomas PB, El Haj AJ.  Regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells.  J Appl Physiol  2000; 89: 2498-2507.

Farrell WE, Simpson DJ, Bicknell J, Magnay JL, Kyrodimou E, Thakker RV, Clayton RN.  Sequence analysis and transcript expression of the MEN 1 gene in sporadic pituitary tumours.  Br J Cancer 1999; 80: 44-50.

Simpson DJ, Magnay JL, Bicknell JE, Barkan AL, McNicholl AM, Clayton RN, Farrell WE.  Chromosome 13q deletion mapping in pituitary tumors, infrequent loss of the retinoblastoma susceptibility gene (RB1) locus despite loss of RB1 protein product in somatotrophinomas.  Cancer Res 1999; 59: 1562-6.

Magnay JL, Bayly GR.  Uses and misuses of serum hCG - a clinical audit.  Br J Biomed Sci 1995; 52: 26-30. [corresponding author]. Awarded the Biostat prize for the best Clinical Chemistry Paper published in the British Journal of  Biomedical  Science during 1995.

Book Chapter:

Julia L Magnay and Khaled MK Ismail.  Genetics of Premenstrual Dysphoric Disorder. In: The Premenstrual Dysphoric Disorder: PMS and PMDD. Eds: PM Shaughn O’Brien, Andrea Rapkin, Peter J Schmidt. Informa Healthcare October 2007. ISBN 978-0-415-39974-6

 

 

 

Previous appointments: 

• MSc Biomedical Science, University of Toronto and Toronto Hospital, Canada, (13 month sabbatical) and University of Wolverhampton, UK. Jul 1994 to Jul 1998
• Senior Biomedical Scientist, North Staffordshire Hospital and Keele University, UK Apr 1996 to Jun 1998
• Senior Biomedical Scientist, Clinical Biochemistry, Birmingham City Hospital, UK Aug 1988 to Mar 1996
• Biomedical Scientist, Clinical Biochemistry, Birmingham City Hospital, UK Sep 1980-Aug 1988
• Trainee, then Biomedical Scientist, Clinical Biochemistry, Birmingham Heartlands Hospital, UK Aug 1973-Sep 1980

 

Professional memberships, committees:

• Health Professions Council – State Registered Biomedical Scientist.
• The Science Council – Registered Chartered Scientist.
• Institute of Biomedical Science (IBMS):
  -        Fellow of the Institute of Biomedical Science (FIBMS).
  -        IBMS Continuing Professional Development (CPD) question setter and examiner  in Clinical Biochemistry.
  -        Member of the IBMS Clinical Biochemistry Advisory Panel from 200-2002.
• Association for Clinical Biochemistry – Member.
• Society of Biology – Member (MSB).
• Royal Society of Chemistry – Member (MRSC).

IBMS awards for Continuing Professional Development:

• 1^st Diploma 2001
• 2^nd Diploma 2004
• 3^rd Diploma 2006
• 4^th Diploma 2009
• 5^th Diploma 2010
• 6th Diploma 2011