lenney_warren - Keele University

Prof Warren Lenney

Title: Professor of Child Health
Consultant Respiratory Paeditrician
Phone: +44 (0)1782 552667
Email:
Location: Institute for Science & Technology in Medicine, Keele University
Guy Hilton Research Centre, Thornburrow Drive, Hartshill Stoke-on-Trent, ST4 7QB United Kingdom
Role: ISTM Research theme: 1. Clinical & Diagnostic Science
2. Infection, Inflamation & Immunity
Contacting me: By e-mail please.
Prof Warren Lenney

Professor Lenney took up his current post of Consultant Respiratory Paediatrician at the University Hospital of North Staffordshire in 1996. For several years he was Associate Medical Director for Research and Development for North Staffordshire and is Chair of the British Paediatric Respiratory Society’s Research Committee.

Prof Lenney lectures widely on paediatric respiratory issues and was awarded a personal Chair at Keele University in 2005.

In 2006 Prof Lenney was appointed Director of the West Midlands Local Research Network for Medicines for Children (MfC).

Previous appointments:

  • Associate Medical Director, Glaxo Pharmaceuticals UK 1993-5
  • Consultant Paediatrician, Royal Alexandra Hospital, Brighton 1981-93
  • Senior Registrar, Royal Alexandra Hospital, Brighton 1978-81
  • Registrar/Research Fellow, Queens Medical Centre, Nottingham 1975-8

ISTM Research theme: 1. Clinical & Diagnostic Science
                                    2. Infection, Inflamation & Immunity

Current research interests involve the genetics of asthma, surrogate markers of inflammation in children and studies involving the actions and benefits of combination therapy.

Research grants:

1996: £37,000 Impact Study on palivizumab. European representative on the write-up team.
1997: £40,000 Audit of paediatric referrals to A&E NSRI
1998: £20,000
1998: £80,000		 Two Centre study of nebulised Fluticasone – efficacy and safety.
1999: £205,000 Glaxo Wellcome: Asthma Genetics Study (2 years)

One of 9 international research centres
1999: £50,000 Further grant from Zeneca Pharmaceuticals to study genetics in pre-school children with asthma. Development of cold air challenge system, body plethysmography and the interrupter technique.
2000: £13,000 Clinical studies; follow-up of preterm babies with chronic lung disease. Four clinical centres in the UK.
2000-2001: £13,000 Multinational study assessing the efficacy of combination therapy in childhood asthma. Lead Investigator.
2001: £58,000 Health Action Zone grant (in association with Dr Charles Pantin) to develop asthma care pathways and audit the results.
2001: £21,000 Stoke Housing Authority project to assess the association of asthma and poor housing conditions.
2003: £50,000 Educational grant to develop studies in childhood asthma and to continue the previous genetic asthma work.
2003: £5,000 North Staffordshire Medical Institute grant to develop SIFT-MS study of pseudomonas infections in cystic fibrosis.
2003: £2,000 Peel Medical Trust Grant to study pseudomonas genotype in cystic fibrosis.
2004: £40,000 Education grant to cover research fellow’s second year (Dr Will Carroll)
2004: £50,000 Educational grant from GlaxoSmithKline to study tachyphylaxis to Salmeterol in children.
2004: £60,000 Educational grant to develop paediatric SIFT-MS in North Staffordshire.
2005: £20,000 Educational grant from Abbott Laboratories for preterm baby follow-up study
2006 £45,000 Educational grant to support SIFT-MS study
2006 £350,000 HTA School aged children with asthma study – outline business case approved. Awaiting result of full business case.
2006 Stoke-on-Trent approved as Local Research Network – Medicines for Children. Infrastructure funding approx. £150,000 / yr
2007: £16,000 Pharmaceutical Profiles Ltd: TOB003 PARI eFlow scinitgraphy study


Selected Recent publications:

Lenney W, and Fryer AA
The genetics of asthma - are the glutathione S-transferases serious players?
Clinical & Experimental Allergy 37 (8): 1124-1126 AUG 2007

Zhu G, Vestbo J, Lenney W, Silverman, M, Whyte, M, Helms, P, Anderson, WH, and Pillai, SG
Association of PTGDR gene polymorphisms with asthma in two Caucasian populations
Genes & Immunity 8 (5): 398-403 July 2007

Pillai SG, Chiano MN, White NJ, Speer M, Barnes KC, Carlsen K, Gerritsen J, Helms P, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Varsani S, Skelding P, Hauser M, Vance J, Pericak-Vance M, Burns DK, Middleton LT, Brewster SR, Anderson WH and Riley JH.

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p
European Journal of Human Genetics 15 (6): 714-714 JUN 2007

Webb BT, van den Oord E, Akkari A, Wilton S, Ly T, Duv R, Barnes KC, Carlsen K, Gerritsen J, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Blumenthal M, Vestbo J, Middleton L, Helms PJ, Anderson WH and Pillai SG
Quantitative linkage genome scan for atopy in a large collection of Caucasian families
Human Genetics 121 (1): 83-92 March 2007

Editorial Paediatric Respiratory Reviews 2006; 7 (4): 229-229

Gray A, Stewart H, Pravica V, Fryer AA, Lenney W, Hutchinson IV, Arkwright PD
Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis
Pediatric Allergy & Immunology 17 (8): 578-582 December 2006

Greenough A, Alexander J, Burgess S, Bytham J, Chetcuti PAJ, Hagan J, Lenney W, Melville S, Shaw NJ, Boorman J, Coles S, Pang F and Turner J
Preschool healthcare utilisation related to home oxygen status
Archives of Disease in Childhood - Fetal and Neonatal Edition 91 (5): 337-341 September 2006

Carroll WD, Lenney W, Child F Strange RC, Jones PW, Whyte MK, Primhak RA and Fryer AA
Asthma severity and atopy: how clear is the relationship?
Archives of Disease in Childhood 2006; 91: 405-409

Arkwright PD, Gray A, Stewart H, Pravica V, Fryer AA, Lenney W, Hutchinson IV
Polymorphisms of the Bcl-2 family member bfl-1 and the genetic predisposition to atopic dermatitis
Journal of Allergy & Clinical Immunology 117 (2): S234-S234 903 Suppl. S February 2006

Pillai SG, Chiano MN, White NJ, Speer M, Barnes KC, Carlsen K, Gerritsen J, Helms P, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Varsani S, Skelding P, Hauser M, Vance J, Pericak-Vance M, Burns DK, Middleton LT, Brewster SR, Anderson WH and Riley JH
A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p
European Journal of Human Genetics 14 (3): 307-316 March 2006

Holley S, Fryer A, Carroll W, Strange R, Hoban P and Lenney W
Functional analysis of GSTP1 haplotypes on cell growth and apoptosis in NIH3T3 fibroblasts
Thorax 60: II22-II23 Suppl. 2 DEC 1 2005

Carroll WD, Lenney W, Wang T et al.
Detection of volatile compounds emitted by pseudomonas aeruginosa using selected ion flow tube mass spectrometry.
Pediatr Pulmonol 2005; 39: 452-456

Carroll WD, Lenney W, Child F et al.
Maternal glutathione S-transferase GSTPI genotype is a specific predictor of phenotype in children with asthma.
PAI 2005; 16(1): 32-35

Carroll WD, Anderson M, Lenney W et al.
Vascular access in cystic fibrosis – does size matter?
Journal of Vascular Access 2005; 2: 72-75

Editorial Paediatric Respiratory Reviews 2005; 6 (2): 75

Editorial Paediatric Respiratory Reviews 2005; 6 (1): 28

Carroll WD, Lenney W, Child F et al.
Maternal glutathione S-transferase GSTPI genotype is a specific predictor of phenotype in children with asthma.
PAI 2005; 16: 32-36

Greenough A, Alexander J, Lenney W et al.
Health care utilisation of prematurely born, preschool children related to hospital admission for RSV infection. Archives of Disease in Childhood 2004; 89 (7)

Carroll WD, Lenney W, Wang T et al.
A study of the volatile compounds emitted by pseudomonas bacteria in vitro using selected ion flow tube mass spectrometry.
Pediatr Pulmonol 2005; 39: 452-6

Carroll WD, Lenney W, Child F et al.
Regional variation of airway hyper-responsiveness in children with asthma.
Respir Med 2005; 99: 403-7

Saglani S, Lenney W.
Difficult asthma in the preschool child.
Paediatr Respir Rev 2004; 5: 199-206

Lenney W.
Neumopatía crónica/displasia broncopulmonar en el lactante: ¿cuál es el tratamiento? (Editorial)
Anales De Pediatría 2004; 60 (2): 113-116

Hariprakash S, Alexander J, Lenney W.
Randomised controlled trial of nebulaised adrenaline in acute bronchiolitis.
Ped All and Immunol 2003; 14: 134-139

Child F, Lenney W, Clayton S et al.
The association of maternal but not paternal genetic variation in GSTPI with asthma phenotypes in children. Respir Med 2003; 97: 1247-1256

Child F, Lenney W, Clayton S et al.
Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children.
Ped All and Immunol 2003; 14: 193-200.

Greenough A, Alexander J, Lenney W et al.
High versus restricted use of home oxygen therapy, healthcare utilisation and the cost of care in CLD infants.
Eur J Pediatr 2004; 163 (6): 292-296.

Peach J, Lenney W.
Can the use of an objective clinical scoring system improve the assessment of response to treatment in wheezing children under 2 years old?
The Asthma Journal 2002; Dec: 193-196.

Professional memberships, committees, editorial boards:

  • Respiratory Paediatrics (RCPCH) - Specialist Advisory Committee Member
  • Medicines for Children (RCPCH) - Editorial Board
  • North Staffs Drugs and Therapeutics Committee
  • Royal Society of Medicine, Respiratory Division - Council Member
  • British Lung Foundation - Trustee
  • British Thoracic Society -
    - Paediatric member, External Relations Committee
    - Education Committee Member
    - Scientific Meetings Committee Member