ISTM

Following surgical training, from October 1991 Dr John Slavin spent a year working as a Smith & Nephew Research Fellow with Professor Hunt, Professor of Surgery, at the University of California, San Francisco, and a major figure in the field of wound healing. His work from that period principally examined the role of TGF-b in tissue repair, and formed the basis for publications and a Mastership in Surgery from London University It led to an interest in the role that the inflammatory response plays in surgical disease.

Whilst at Liverpool as a Clinical Senior Lecturer in the Department of Surgery, most of Dr Slavin’s research activity was in the area of acute pancreatitis. Laboratory studies investigated the role that inflammatory mediators play in the pathogenesis of this condition and the possible use of antagonists to ameliorate distant organ injury. Clinical studies examined the use plasma levels of inflammatory mediators as an aid to early severity prediction. The Royal Liverpool University Hospital is a tertiary referral centre for patients with pancreatic necrosis. A technique of minimally invasive pancreatic necrosectomy; originally pioneered in Glasgow was introduced in Liverpool. Dr Slavin described the initial results with this technique at national meetings and has been involved in seven external research project grants at Liverpool.

In March 2002 he moved to Leighton Hospital (Mid Cheshire NHS Hospitals Foundation Trust), but has continued with a clinical research interest, and has become interested in the use of administrative health service databases as a means of analysing surgical outcome.

ISTM Research theme: 1. Neuroscience & Human Metabolism

Recent Publications (last ten years):

G David, JP Slavin, S Willmott, DJ Corless, AU Khan, CR Selvasekar. Loop ileostomy following anterior resection: is it really
temporary? Colorectal Disease. 2009.

M Ballal, G David, A, S Willmott, DJ Corless, M Deakin, JP Slavin. Conversion following laparoscopic cholecystectomy in
England. Surgical Endoscopy. 2009;23(10):2338-44.

G David, A Al-Sarira , S Willmott, D Cade, D J Corless, JP Slavin Use of Hartmann’s procedure in England. Colorectal Disease. 2009;11(3):308-12.

G David, A Al-Sarira, S Willmott, DJ Corless, M Deakin, J Slavin. Management of acute gall bladder disease in England. British Journal of
Surgery. 2008; 95(4): 585-91.

A Al-Sarira, G. David, S Willmott , J Slavin, M Deakin, DJ Corless. Oesophagectomy practice and outcomes in England. British Journal of Surgery. 2007; 94(5): 472-6.

K Ayub, R Imada, J Slavin. Endoscopic retrograde cholangiopancreatography in gallstone-associated acute pancreatitis. Cochrane Database
Syst Rev. 2004: 4.

M Bhatia, J Slavin, YQ Cao, AI Basbaum, JP Neoptolemos. Preprotachykinin-A (PPT-A) gene knockout affords protection against acute pancreatitis associated lung injury. American Journal of Physiology Gastrointestinal and Liver Physiology 2003; 284:G830-6.

M Bhatia, AEI Proudfoot, M Brady, JP Neoptolemos, TNC Wells, S Christmas, J Slavin. Treatment with met-RANTES reduces lung injury in caerulein-induced pancreatitis in mice. British Journal of Surgery 2003; 90:698-70444.

J Slavin. Acute pancreatitis. Surgery International. 2002: ;227-230.

S Shokuhi, M Bhatia, S Christmas, R Sutton, JP Neoptolemos, J Slavin. Levels of the chemokines growth related oncogene alpha and epithelial neutrophil. British Journal of Surgery. 2002: 5;566-72.

M Brady, M Bhatia, S Christmas, MT Boyd, JP Neoptolemos, J Slavin. Expression of the chemokines MCP-1/JE and CINC in early acute pancreatitis. Pancreas. 2002: 10; 260-9.

C M. Halloran, J Slavin. Pathophysiology of wound healing. Surgery International. 2002.

Mayer J, Raraty M, J Slavin, Kemppainen E, Fitzpatrick J, Beger H, Hietaranta A, Puolakkainen A, JP Neoptolemos. Severe acute pancreatitis is related to increased early levels of the activation peptide of pancreatic phospholipase A2 (PROP). Pancreatology 2002: 2; 535-42

JM Mayer, M Raraty, J Slavin, E Kemppainen, J Fitzpatrick, A Hietaranta, P Puolakkainen, HG Beger, JP Neoptolemos. Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis. British Journal of Surgery. 2002: 2; 163-71.

M Bhatia, M Brady, E Costello, Y Kang, JP Neoptolemos, J Slavin. Chemokine production by pancreatic acini in response to caerulein: The role of NF-?B. American Journal of Physiology. 2002: 281; G77-85.

P Ghaneh, J Slavin, R Sutton, JP Neoptolemos. Adjuvant therapy for pancreatic cancer. Surgical Oncology. 2002.

EA Kemppainen, JM Mayer, PA Puolakkainen, MGT Raraty, J Slavin, JM Fitzpatrick, AJ Hietaranta, H-G Beger, JP Neoptolemos. Trypsinogen activation peptide (TAP) in plasma of patients with acute pancreatitis. British Journal of Surgery. 2001: 88: 697-890.

P Ghaneh, J Slavin, R Sutton, JP Neoptolemos. Adjuvant therapy for pancreatic cancer. World Journal of Gastroenterology. 2001: 7; 482-489.

J Slavin, P Ghaneh, R Sutton, M Hartley, P Rowlands, C Garvey, M Hughes, J Neoptolemos. Management ofpancreatic necrosis. World Journal of Gastroenterology. 2001: 7; 476-481.

R Sutton, J Slavin, J Neoptolemos. Internal stenting in malignant biliary obstruction. Invited commentary. World Journal of Surgery. 2001: 25: 3.

M Bhatia, J Neoptolemos, J Slavin. Inflammatory mediators as therapeutic targets in acute pancreatitis. Current Opinion in Investigational Drugs. 2001; 2: 490-5.

J Slavin, JP Neoptolemos. Antibiotic prophylaxis in severe pancreatitis-What are the facts? Langenbecks Archives of Surgery. 2001; 386: 155-9.

J Taylor, J Slavin. Pathophysiology of the response to trauma. Surgery 2001; 19: 40-4.

S Shokuhi, J Slavin. Sepsis/SIRS. Surgery 2001; 19: 1-4.

Memberships of Learned Bodies and Professional Associations:

• Association of Upper Gastrointestinal Surgeons

• British Medical Association

• Liverpool and North West Society of Surgeons

• Pancreatic Society of Great Britain and Ireland

• Association of Laparoscopic Surgeons