Dr Jan-Herman Kuiper

Title: Lecturer in Biomechanics



Phone: +44 (0)1691 404581
Email:
Location: Institute for Science and Technology in Medicine
Keele University / The Robert Jones and Agnes Hunt Orthopaedic Hospital
Postal address: Unit for Joint Reconstruction
RJAH Orthopaedic Hospital, Oswestry SY10 7AG, UK
Role: ISTM Research theme: 1. Bioengineering & Therapeutics
Contacting me: By phone or e-mail
Dr Jan-Herman Kuiper

ISTM_jhkuiper_equipment_190x271 Dr Jan-Herman Kuiper was appointed as a Lecturer in Biomechanics at Keele in 2001, but is based at the Robert Jones & Agnes Hunt Orthopaedic Hospital in Oswestry. His research training at MSc and PhD level was at the University of Twente and the University of Nijmegen in the Netherlands.

He has extensive experience in the use of Finite Element-based computer models for design optimization, modelling of hydrated tissues and bone, and biological processes such as adaptive bone remodelling and fracture repair One of his long standing interests is the control of biological processes through mechanical conditions. Most of his work in this area is concentrated on the control of long bone fracture repair by movements at the fracture site, which he has investigated experimentally and theoretically. Findings from these studies have aided his clinical collaborators including Prof James Richardson, an experienced orthopaedic surgeon who heads the Problem Fracture Clinic at the RJAH Orthopaedic Hospital, to develop his treatment regime for bone fractures, in particular non-uniting fractures.

Jan-Herman Kuiper's collaboration with other laboratory based scientists includes joint projects with Prof Alicia El Haj and Dr Ying Yang to control the response of bone cells (osteoblasts) to mechanical strains in order to improve bone formation on resorbable 3-dimensional scaffolds. These studies are supported by substantial joint grants from the Engineering & Physical Sciences Research Council and the European Commission Framework Programme. 

In a collaboration with Dr Carol Evans at Manchester University, Dr Kuiper also receives funding from the AO Foundation in Switzerland to study the influence of fracture site movements on bone formation during limb lengthening.

Other European collaboration includes European Commission Framework VI “New and Emerging Science and Technology” funding in partnership with several European researchers, including Dr Patrick Warnke at the University of Kiel in Germany who has pioneered a clinical procedure to grow a complete new jaw for a patient inside a back muscle. The objective of this new high risk/high benefit "MYJOINT" project is to develop a clinical procedure to grow a complete synovial joint in a patient’s back muscle, similar to the procedure pioneered by Dr Warnke. One of Dr Kuiper's specific tasks is to model the control of articular joint formation by mechanical conditions.  

Summary of previous posts (with dates):

  • Lecturer in Biomechanics (Keele University, 2001-present)
  • Post-graduate researcher (Robert Jones and Agnes Hunt Orthopaedic Hospital, 1997-2001)
  • Post-graduate researcher (Keele University, 1993-1997)
  • Research assistant (University of Nijmegen, 1992-1993)
  • Ph.D. student (University of Nijmegen, 1989-1992)
  • Research assistant (University of Nijmegen,1988-1989)

 

 

ISTM Research theme: 1. Bioengineering & Therapeutics

All my current work is related to orthopaedics and broadly characterised by two interests.

1. Mechanical guidance of skeletal tissue formation.

Mechanical influences on tissue formation and differentiation, in particular with relation to fracture healing and cartilage repair

2 .Development and pre-clinical testing of joint replacement implants, bioresorbable orthopaedic devices and bone substitution products

Examples are the development and testing of impaction grafting for hip and knee revision surgery, and the development and testing of knee ligament repair systems using a composite bioresorbable materials.

Selected Publications

  • Barlow D, Bansal R, Barlow T, Rhee SJ, Kuiper JH, Makwana NK. 2013. Effect of cotton padding on the setting properties of plaster slabs. Ann R Coll Surg Engl, vol. 95(2), 107-109. link> doi>
  • Balain B, Jaiswal A, Trivedi JM, Eisenstein SM, Kuiper JH, Jaffray DC. 2013. The Oswestry Risk Index: an aid in the treatment of metastatic disease of the spine. Bone Joint J, vol. 95-B(2), 210-216. link> doi>
  • Hanifi A, Richardson JB, Kuiper JH, Roberts S, Pleshko N. 2012. Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis Cartilage, vol. 20(9), 988-996. link> doi>
  • Miyazaki T, Uchida K, Sato M, Watanabe S, Yoshida A, Wada M, Shimada S, Kuiper JH, Baba H. 2012. Knee laxity after staircase exercise predicts radiographic disease progression in medial compartment knee osteoarthritis. Arthritis Rheum, vol. 64(12), 3908-3916. link> doi>
  • Johansson A, Kuiper JH, Sundqvist T, Persson F, Speier C, D'Alfonso D, Richardson JB, Öberg Å. 2012. Spectroscopic measurement of cartilage thickness in arthroscopy: ex vivo validation in human knee condyles. Arthroscopy, vol. 28(10), 1513-1523. link> doi>

Full Publications List show

Journal Articles

  • Barlow D, Bansal R, Barlow T, Rhee SJ, Kuiper JH, Makwana NK. 2013. Effect of cotton padding on the setting properties of plaster slabs. Ann R Coll Surg Engl, vol. 95(2), 107-109. link> doi>
  • Balain B, Jaiswal A, Trivedi JM, Eisenstein SM, Kuiper JH, Jaffray DC. 2013. The Oswestry Risk Index: an aid in the treatment of metastatic disease of the spine. Bone Joint J, vol. 95-B(2), 210-216. link> doi>
  • Hanifi A, Richardson JB, Kuiper JH, Roberts S, Pleshko N. 2012. Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis Cartilage, vol. 20(9), 988-996. link> doi>
  • Miyazaki T, Uchida K, Sato M, Watanabe S, Yoshida A, Wada M, Shimada S, Kuiper JH, Baba H. 2012. Knee laxity after staircase exercise predicts radiographic disease progression in medial compartment knee osteoarthritis. Arthritis Rheum, vol. 64(12), 3908-3916. link> doi>
  • Johansson A, Kuiper JH, Sundqvist T, Persson F, Speier C, D'Alfonso D, Richardson JB, Öberg Å. 2012. Spectroscopic measurement of cartilage thickness in arthroscopy: ex vivo validation in human knee condyles. Arthroscopy, vol. 28(10), 1513-1523. link> doi>
  • Fricker RA, Kuiper JH, Gates MA. 2012. Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PLoS One, vol. 7(10), e47169. link> doi>
  • Jaiswal A, Gilbert RE, Sunil Kumar KH, Carrothers AD, Kuiper JH, Richardson JB. 2011. Function and survival after revision of hip resurfacing. Hip Int, vol. 21(5), 610-615. link> doi>
  • Lutianov M, Naire S, Roberts S, Kuiper JH. 2011. A mathematical model of cartilage regeneration after cell therapy. J Theor Biol, vol. 289, 136-150. link> doi>
  • Balain B, Kerin C, Kanes G, Roberts SN, Rees D, Kuiper JH. 2012. Effects of knee compartment, concomitant surgery and smoking on medium-term outcome of microfracture. Knee, vol. 19(4), 440-444. link> doi>
  • Johansson A, Sundqvist T, Kuiper JH, Öberg PÅ. 2011. A spectroscopic approach to imaging and quantification of cartilage lesions in human knee joints. Phys Med Biol, vol. 56(6), 1865-1878. link> doi>
  • Cheung G, Carmont MR, Bing AJ, Kuiper JH, Alcock RJ, Graham NM. 2010. No drain, autologous transfusion drain or suction drain? A randomised prospective study in total hip replacement surgery of 168 patients. Acta Orthop Belg, vol. 76(5), 619-627. link> full text>
  • Aulakh TS, Kuiper JH, Dixey J, Richardson JB. 2011. Hip resurfacing for rheumatoid arthritis: independent assessment of 11-year results from an international register. Int Orthop, vol. 35(6), 803-808. link> doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. JOURNAL OF BIOMECHANICS, vol. 43(4), 733-739. link> doi>
  • Bhosale AM, Kuiper JH, Johnson WE, Harrison PE, Richardson JB. 2009. Midterm to long-term longitudinal outcome of autologous chondrocyte implantation in the knee joint: a multilevel analysis. Am J Sports Med, vol. 37 Suppl 1, 131S-138S. link> doi>
  • Khan M, Kuiper JH, Edwards D, Robinson E, Richardson JB. 2009. Birmingham hip arthroplasty: five to eight years of prospective multicenter results. J Arthroplasty, vol. 24(7), 1044-1050. link> doi>
  • Aulakh TS, Rao C, Kuiper JH, Richardson JB. 2010. Hip resurfacing and osteonecrosis: results from an independent hip resurfacing register. Arch Orthop Trauma Surg, vol. 130(7), 841-845. link> doi>
  • Balain B, Ennis O, Kanes G, Singhal R, Roberts SN, Rees D, Kuiper JH. 2009. Response shift in self-reported functional scores after knee microfracture for full thickness cartilage lesions. Osteoarthritis Cartilage, vol. 17(8), 1009-1013. link> doi>
  • Aulakh TS, Jayasekera N, Kuiper JH, Richardson JB. 2009. Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty. Biomaterials, vol. 30(9), 1732-1738. link> doi>
  • Rethnam U, Kuiper J, Makwana N. 2009. Biomechanical characteristics of three staples commonly used in foot surgery. Journal of Foot and Ankle Research, vol. 2, Article 5. doi> link>
  • John J, Kuiper JH, May PC. 2009. Age at follow-up and mechanical axis are good predictors of function after unicompartmental knee arthroplasty. An analysis of patients over 17 years follow-up. Acta Orthop Belg, vol. 75(1), 45-50. link> full text>
  • Toms AD, Barker RL, McClelland D, Chua L, Spencer-Jones R, Kuiper JH. 2009. Repair of defects and containment in revision total knee replacement: a comparative biomechanical analysis. J Bone Joint Surg Br, vol. 91(2), 271-277. link> doi>
  • Malviya A, Kuiper JH, Makwana N, Laing P, Ashton B. 2009. The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. J Orthop Surg Res, vol. 4, 17. link> doi>
  • Khan M, Kuiper JH, Richardson JB. 2008. The exercise-related rise in plasma cobalt levels after metal-on-metal hip resurfacing arthroplasty. J Bone Joint Surg Br, vol. 90(9), 1152-1157. link> doi>
  • Wood MA, Yang Y, Baas E, Meredith DO, Richards RG, Kuiper JH, El Haj AJ. 2008. Correlating cell morphology and osteoid mineralization relative to strain profile for bone tissue engineering applications. J R Soc Interface, vol. 5(25), 899-907. link> doi>
  • Gokhale S, Khan M, Kuiper JH, Richardson JB, Davies JP. 2008. An arthroscopic hip documentation form. Arthroscopy, vol. 24(7), 839-842. link> doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. J Biomech, vol. 43(4), 733-739. link> doi>
  • John J, Kuiper JH, Kelly CP. 2008. Learning assessment at shoulder surgical skills course. Ann R Coll Surg Engl, vol. 90(2), 120-122. link> doi>
  • Baas E and Kuiper JH. 2008. A numerical model of heterogeneous surface strains in polymer scaffolds. J Biomech, vol. 41(6), 1374-1378. link> doi>
  • Khan M, Kuiper JH, Richardson JB. 2007. Can cobalt levels estimate in-vivo wear of metal-on-metal bearings used in hip arthroplasty?. Proc Inst Mech Eng H, vol. 221(8), 929-942. link> doi>
  • Aulakh TS, Robinson EV, Kuiper JH, Richardson JB. 2007. Multilevel analysis: A novel approach for statistical analysis of longitudinal studies in orthopaedics. VALUE IN HEALTH, vol. 10(6), A252-A253. link> doi>
  • John J, Wagner WW, Kuiper JH. 2007. Tension-band wiring of transverse fractures of patella. The effect of site of wire twists and orientation of stainless steel wire loop: a biomechanical investigation. Int Orthop, vol. 31(5), 703-707. link> doi>
  • García-Aznar JM, Kuiper JH, Gómez-Benito MJ, Doblaré M, Richardson JB. 2007. Computational simulation of fracture healing: influence of interfragmentary movement on the callus growth. J Biomech, vol. 40(7), 1467-1476. link> doi>
  • Kakarala G, Toms AD, Kuiper JH. 2006. Stereolithographic models for biomechanical testing. Knee, vol. 13(6), 451-454. link> doi>
  • RICHARDSON JB, Khan M, Kuiper JH, Takahashi T. 2006. Current in vivo wear of metal-on-metal bearings assessed by exercise-related rise in plasma cobalt level. Journal of Orthopaedic Research, vol. 24(11), 1657. doi>
  • Gómez-Benito MJ, García-Aznar JM, Kuiper JH, Doblaré M. 2006. A 3D computational simulation of fracture callus formation: influence of the stiffness of the external fixator. J Biomech Eng, vol. 128(3), 290-299. link> doi>
  • Oakley J and Kuiper JH. 2006. Factors affecting the cohesion of impaction bone graft. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, vol. 88B(6), 828-831. link> doi>
  • KUIPER JH and Oakley J. 2006. Factors affecting the cohesion of impaction bone graft. Journal of Bone and Joint Surgery - British Volume, vol. 88-B(6), 828-831. doi>
  • Barker R, Takahashi T, Toms A, Gregson P, Kuiper JH. 2006. Reconstruction of femoral defects in revision hip surgery. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, vol. 88B(6), 832-836. link> doi>
  • KUIPER JH, Barker R, Takahashi T, Toms A. 2006. Reconstruction of femoral defects in revision hip surgery: risk of fracture and stem migration after impaction bone grafting. Journal of Bone and Joint Surgery - British Volume, vol. 88, 832-836. doi>
  • Bailey CA, Kuiper JH, Kelly CP. 2006. Biomechanical evaluation of a new composite bioresorbable screw. J Hand Surg Br, vol. 31(2), 208-212. link> doi>
  • Gómez-Benito MJ, García-Aznar JM, Kuiper JH, Doblaré M. 2005. Influence of fracture gap size on the pattern of long bone healing: a computational study. J Theor Biol, vol. 235(1), 105-119. link> doi>
  • Toms AD, McClelland D, Chua L, Malefit MD, Verdonschot N, Jones RS, Kuiper JH. 2005. Mechanical testing of impaction bone grafting in the tibia. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, vol. 87B(5), 656-663. link> doi>
  • Toms AD, McClelland D, Chua L, de Waal Malefijt M, Verdonschot N, Spencer Jones R, Kuiper JH. 2005. Mechanical testing of impaction bone grafting in the tibia: initial stability and design of the stem. J Bone Joint Surg Br, vol. 87(5), 656-663. link> doi>
  • Saweeres ES, Kuiper JH, Evans RO, Richardson JB, White SH. 2005. Predicting in vivo clinical performance of anterior cruciate ligament fixation methods from in vitro analysis: industrial tests of fatigue life and tolerance limits are more useful than other cyclic loading parameters. Am J Sports Med, vol. 33(5), 666-673. link> doi>
  • Gokhale S, Soliman A, Dantas JP, Richardson JB, Cook F, Kuiper JH, Jones P. 2005. Variables affecting initial stability of impaction grafting for hip revision. Clin Orthop Relat Res, 174-180. link>
  • Toms AD, Barker RL, Jones RS, Kuiper JH. 2004. Current concepts review - Impaction bone-grafting in revision joint replacement surgery. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, vol. 86A(9), 2050-2060. link>
  • Toms AD, Barker RL, Jones RS, Kuiper JH. 2004. Impaction bone-grafting in revision joint replacement surgery. J Bone Joint Surg Am, vol. 86-A(9), 2050-2060. link>
  • Saweeres ESB and Kuiper JH. 2003. Untitled (vol 31, pg 325, 2003). AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 31(5), 814. link>
  • Mishra V, Kuiper JH, Kelly CP. 2003. Influence of core suture material and peripheral repair technique on the strength of Kessler flexor tendon repair. J Hand Surg Br, vol. 28(4), 357-362. link> doi>
  • Tselentakis G, Kitano M, Owen PJ, Kuiper JH, Richardson JB, Evans GA. 2003. The behaviour of the periosteum during callotasis. J Pediatr Orthop B, vol. 12(4), 277-283. link> doi>
  • Saweeres E and Kuiper JH. 2003. Fatigue testing of some orthopaedic fixation devices. Am J Sports Med, vol. 31(2), 325-326. link>
  • Saweeres EBS and Kuiper JH. 2003. Untitled. AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 31(2), 325-326. link>
  • Saweeres EB and Kuiper JH. 2003. Letter. The American journal of sports medicine, vol. 31(2), 525-527.
  • Taylor D and Kuiper JH. 2001. The prediction of stress fractures using a 'stressed volume' concept. J Orthop Res, vol. 19(5), 919-926. link> doi>
  • Tselentakis G, Owen PJ, Richardson JB, Kuiper JH, Haddaway MJ, Dwyer JS, Evans GA. 2001. Fracture stiffness in callotasis determined by dual-energy X-ray absorptiometry scanning. J Pediatr Orthop B, vol. 10(3), 248-254. link> doi>
  • Thompson MS, Dawson T, Kuiper JH, Northmore-Ball MD, Tanner KE. 2000. Acetabular morphology and resurfacing design. J Biomech, vol. 33(12), 1645-1653. link> doi>
  • Wade RH, New AM, Tselentakis G, Kuiper JH, Roberts A, Richardson JB. 1999. Malunion in the lower limb. A nomogram to predict the effects of osteotomy. J Bone Joint Surg Br, vol. 81(2), 312-316. link> doi>
  • Kuiper JH and Huiskes R. 1997. The predictive value of stress shielding for quantification of adaptive bone resorption around hip replacements. J Biomech Eng, vol. 119(3), 228-231. link> doi>
  • Kuiper JH and Huiskes R. 1997. Mathematical optimization of elastic properties: application to cementless hip stem design. J Biomech Eng, vol. 119(2), 166-174. link> doi>
  • Prendergast PJ, vanDriel WD, Kuiper JH. 1997. A comparison of finite element codes for the solution of biphasic poroelastic problems. PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, vol. 211(2), 209-211. link>
  • Dwyer JS, Owen PJ, Evans GA, Kuiper JH, Richardson JB. 1996. Stiffness measurements to assess healing during leg lengthening. A preliminary report. J Bone Joint Surg Br, vol. 78(2), 286-289. link>
  • Prendergast PJ, van Driel WD, Kuiper JH. 1996. A comparison of finite element codes for the solution of biphasic poroelastic problems. Proc Inst Mech Eng H, vol. 210(2), 131-136. link>
  • Kuiper JH and Huiskes R. 1996. Friction and stem stiffness affect dynamic interface motion in total hip replacement. J Orthop Res, vol. 14(1), 36-43. link> doi>
  • RICHARDSON J, GARDNER T, HARDY J, EVANS M, KUIPER J, KENWRIGHT J. 1995. DYNAMIZATION OF TIBIAL FRACTURES (VOL 77, PG 412, 1995). JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, vol. 77B(6), 985. link>
  • Richardson JB, Gardner TN, Hardy JR, Evans M, Kuiper JH, Kenwright J. 1995. Dynamisation of tibial fractures. J Bone Joint Surg Br, vol. 77(3), 412-416. link>
  • Meijer HJ, Kuiper JH, Starmans FJ, Bosman F. 1992. Stress distribution around dental implants: influence of superstructure, length of implants, and height of mandible. J Prosthet Dent, vol. 68(1), 96-102. link> doi>
  • Blankevoort L, Kuiper JH, Huiskes R, Grootenboer HJ. 1991. Articular contact in a three-dimensional model of the knee. J Biomech, vol. 24(11), 1019-1031. link> doi>

Other

  • Hampson K, Kuiper JH, El Haj AJ. 2008. The validation of a novel compression bioreactor to ensure the accurate application of loading regimes. TISSUE ENGINEERING PART A (vol. 14, p. 919). link>
  • Bajada S, Harrison P, Kuiper JH, Balbouzis T, Ashton BA, Cassar PV, Ashammakhi N, Richardson JB. 2007. Clinical trial of bone marrow stromal stem cell implantation for refractory fracture non-union: Results from the first patients. TISSUE ENGINEERING (vol. 13, p. 1657). link>
  • Oakley J and Kuiper JH. 2006. Factors affecting the cohesion of impaction bone graft. JOURNAL OF BONE AND MINERAL RESEARCH (vol. 21, p. 1161). link>
  • Bhosale A, Harrison P, Ashton B, Kuiper JH, Davies J, Roberts S, McCall I, Richardson J, Robinson E. 2006. Autologous chondrocyte implantation: 2-to-9 year OsCell experience. TISSUE ENGINEERING (vol. 12, p. 1022). link>
  • Richardson JB, Balbouzis T, Cassar-Pullicino V, Kuiper JH, Harrison PE, Bhosale A, Cook F, Haddaway MJ, Ashton B. 2006. Clinical application of adult bone marrow mesenchymal stem cells for treatment of fracture nonunions. TISSUE ENGINEERING (vol. 12, p. 1023). link>
  • Kuiper JH, Li F, Khan SA, Evans CE. 2006. Dynamic measurement system of interfragmentary movements in patients treated with ilizarov external fixation. BONE (vol. 38, p. S10). link> doi>
  • Hazlehurst ZV, Kitano M, Kuiper JH, Richardson JB, Ashton BA. 1998. The effect of fluid shear stress on osteoblast precursor cells. Biochem Soc Trans (vol. 26, p. S24). link>
  • New AMR, Kloss M, Northmore-Ball MD, Kuiper JH, Tanner KE, Veldkamp E. 1998. Dynamic mechanical testing of prosthetic acetabular components. EXPERIMENTAL MECHANICS, VOLS 1 AND 2 (pp. 839-844). link>
  • KUIPER J and HUISKES R. 1992. NUMERICAL OPTIMIZATION OF HIP-PROSTHETIC STEM MATERIAL. RECENT ADVANCES IN COMPUTER METHODS IN BIOMECHANICS & BIOMEDICAL ENGINEERING (pp. 76-84). link>

Teaching responsibilities:

1. Biomechanics module at MSc courses in Biomedical Engineering and Cell & Tissue Engineering, Keele University

2. Tribology in Joint replacement Implants module at Orthopaedic Science Course, Oswestry

3. Statistics module for ISTM postgraduate research students

4. Regular contributions to Friday afternoon teaching sessions, Oswestry

5. Supervision of BSc, MSc and MPhil-students who do placements and final-year projects. On average, seven students visit us yearly from Universities in The Netherlands, Germany and France.

6. Co-supervision of PhD and MD students.

Supervision of orthopaedic registrars doing biomechanical research.

Dr Kuiper is a reviewer for the EPSRC, several charities and several journals.

He is a member of a Special Interest Group in IPEM (Institute of Physics and Engineering and Medicine), the American Society of Mechanical Engineers, the European Society of Biomechanics and the British Orthopaedic Research Society.