ISTM
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ISTM Research theme: 1. Bioengineering & Therapeutics - Clinical Lead for B&T theme
Research Interests:Surgical Management of Early Arthritis. This has two arms:
1. Bone conservation in joint replacement, and
2. Tissue Engineering with a long term goal of developing a biological joint replacement.
An image of human cartilage cells (chondrocytes) in tissue culture, where the cells adhere to the culture surface and start to proliferate
Principal external research grants:
Medical Research Council trial grant
Cartilage Repair by Autologous Chondrocyte Transplantation (ACTIVE)
£759,622 (1 January 2004 for 12 years) Trial No: ISRCTN 48911177 (Alpha A Band)
European Commission Framework Programme project grant
European Partnership for Autologous Chondrocyte Cell Implantation (EUROCELL)
658,962 Euros (1 February 2001 for 3 years) (in collaboration with European partners)
Arthritis Research Campaign grant (N Goodstone, J Richardson)
A novel approach for characterising repair cartilage following human autologous chondrocyte implantation (ACI)
£93,231 (April 2004 for 2 years) ARC grant ref: 16181
Arthritis Research Campaign grant (S Roberts, B Caterson, J Richardson, G Edwards)
Biomarker patterns of degenerative joint disease
£187,396 (1 May 2006 for 3 years) ARC grant ref: 17540
European Commission Framework Programme 6 project grant
Growing a New Joint in a Human Back (MYJOINT)
£386,106 (1 January 2007 for 3 years) Partnership between Keele UK and Kiel Germany)
Roberts S, Menage J, Sandell LJ, Evans EH, Richardson JB (2009) Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. Knee 16(5):398-404 October 2009
Bajada S, Mazakova I, Richardson JB and Ashammakhi N (2008) Updates on stem cells and their applications in regenerative medicine. Journal of Tissue Engineering and Regenerative Medicine 2:4 pp169-183 June 2008
Aulakh TS, Robinson EV and Richardson JB (2007) Nine year follow up of Birmingham hip resurfacing in context of survival and complications. Value in Health 10:6 pp A231-A231 Nov-Dec 2007
Khan M, Kuiper JH and Richardson JB (2007) Can cobalt levels estimate in-vivo wear of metal-on-metal bearings used in hip arthroplasty? Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering Medicine 221:H8 pp929-942 November 2007
Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N and Richardson JB (2007) Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. Journal of Bone and Joint Surgery - British Volume 89:10 pp1382-1386 October 2007
Bhosale AM, Myint P, Roberts S, Menage J, Harrison P, Ashton B, Smith T, McCall I and Richardson JB (2007) Combined autologous chondrocyte implantation and allogenic meniscus transplantation: A biological knee replacement. Knee 14:5 pp361-368 October 2007
Richardson JB, Balbouzis T, Cassar-Pullicino V, Kuiper JH, Harrison PE, Bhosale A, Cook F, Haddaway MJ and Ashton B (2006) Clinical application of adult bone marrow mesenchymal stem cells for treatment of fracture nonunions. Tissue Engineering 12 (4): 1023-1023 115 April 2006 ISSN 1076-3279
Bhosale A, Harrison P, Ashton B, Menage J, Myint P, Roberts S, McCall I, Smith T and Richardson J (2006) A new biological method of joint reconstruction in young patients: Combination of autologous chondrocyte implantation with allogenic meniscus transplantation. Tissue Engineering 12 (4): 1022-1023 114 April 2006 ISSN 1076-3279
Khan M Takahashi T Kuiper JH Sieniswska CE Takagi K and Richardson JB (2006) Current in vivo wear of metal-on-metal bearings assessed by exercise related rise in plasma cobalt level Journal of Orthopaedic Research 24 11 2029 – 2035
Smith GD, Knutsen G, and Richardson JB (2005) A Clinical Review of Cartilage Repair Techniques. Journal of Bone and Joint Surgery Br 87-B No 445-449 April 2005 ISSN 0301-620X
Harrison P, Pfeifer P, Turner S, Richardson J, Jones P and Ashton B (2003) Serum from patients anaesthetized with opiates is less effective in the support of chondrocyte growth in vitro. Tissue Engineering 9; 27-41 (2003) ISSN 1076-3279
Roberts S, McCall IW, Darby AJ, Menage J, Evans H, Harrison PE and Richardson JB (2003) Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Research & Therapy 5(1): R60-R73
Bailey A, Goodstone N, Hughes J, Robert S, Van Niekerk L, Richardson J and Rees D (2003) Rehabilitation after Oswestry autologous-chondrocyte implantation: the OsCell protocol. Journal of Sport Rehabilitation 12(2): 104-118
Cassar-Pullicino VN & Richardson JB (2001) Basic sciences for FRCS (Trauma & Orthopaedics): a teaching manual for FRCS (Trauma & Orthopaedics) trainees. Institute of Orthopaedics Publishing Group, Oswestry (contains contributions from 18 Oswestry staff)
Richardson J and Kenwright J (2000) The biology of fracture repair and the role of dynamisation. in De Bastiani G, Apley, AG, Goldberg, A (2000) Orthofix External Fixation in Trauma and Orthopaedics, Berlin, Springer Chap. 2, pp 8-17
Richardson J, Caterson B, Evans EH and Ashton BA (1999) Repair of human articular cartilage after implantation of autologous chondrocytes Journal of Bone and Joint Surgery Nov. 81(6), pp 1064-1068
Selected Publications
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2013. Biomarker discovery for autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, p. A46). link>
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2013. Isolation and characterization of mesenchymal stem cells from different regions of the human umbilical cord. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, pp. A34-A35). link>
Full Publications List show
Journal Articles
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2011. Birmingham hip resurfacing in patients who are seventy years of age or older. Hip Int, vol. 21(2), 217-224. link>
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2011. Physiological normoxia and chondrogenic potential of chondrocytes. Front Biosci (Elite Ed), vol. 3, 1365-1374. link>
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2006. Computational simulation of fracture healing: Influence of interfragmentary movement on the callus growth . Journal of Biomechanics, vol. 40(7), 1467-1476. doi>
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2006. Current in vivo wear of metal-on-metal bearings assessed by exercise-related rise in plasma cobalt level. Journal of Orthopaedic Research, vol. 24(11), 1657. doi>
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2006. Cartilage transplantation. Br J Hosp Med (Lond), vol. 67(6), 286-289. link>
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2005. Arthroscopic Assessment of Cartilage Repair: A Validation Study of 2 Scoring Systems. Athroscopy, vol. 21(12), 1462-1467.
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2005. A clinical review of cartilage repair techniques. Journal of Bone and Joint Surgery, vol. 87-B(4), 445-449. doi>
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2005. Variables affecting initial stability of impaction grafting for hip revision. Clin Orthop Relat Res, 174-180. link>
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2005. Autologous Chondrocyte Implantation in Knee Joint: MR Imaging and Histologic Features at 1-year Follow-up. Radiology, vol. 234(2), 501-508. doi>
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2005. Early results of autologous chondrocyte implantation in the talus. journal of Bone & Joint Surgery, vol. 87B(2), 179-183. doi>
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2005. Unexpected long femur in adults with acetabular dysplasia. Acta Orthop Belg, vol. 71(4), 424-428.
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2004. A corrective osteotomy for post-traumatic malrotation and shortening of the femur. Injruy, vol. 35(12), 1248-1254. doi>
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2003. Serum from patients anesthetized with opiates less effective in the support of chondrocyte growth in vitro. Tissue Engineering, vol. 9(1), 37-39. doi>
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2003. Autologous chondrocyte implantation and osteochrondral cylinder transplantation in cartilage repair of the knee joint. The Journal of Bone and Joint Surgery, vol. 85, 185-192.
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2002. Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Research & Therapy, vol. 5(1), R60-R73. doi>
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2003. Rehabilitation after Oswestry autologous chondrocyte implantation: the OsCell protocol. Journal of Sports Rehabilitation.
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2003. Rehabilitation after Oswestry Autologous Chondrocyte Implantation: The OsCell Protocol. Journal of Sports Rehabiliation.
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2003. The behaviour of the periosteum during callotasis. Journal of Pediatric Orthopaedics, vol. 12B(4), 277-283.
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2002. Phenotypic modulation of human articular chondrocytes by bistratene A. Eur Cell Mater, vol. 3, 9-18. link>
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2002. The current state of cartilage transplantation. Hospital Medicine, vol. 63(1), 6-7.
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2001. Fracture Stiffness in Callotasis determined by dual-energy X-ray Absorptiometry Scanning. Journal of Pediatric Orthopaedics, vol. 10(3), 248-254.
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2001. Outcome in fracture healing: a review. Injury, vol. 32(2), 109-114. link>
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2001. Fracture Healing. Surgery, vol. 19(8), 201-208.
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1999. The audit of orthopaedic trainee teaching improves supervision rates. Ann R Coll Surg Engl, vol. 81(3), 195-197. link>
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1999. Experiencing limiting long-standing illness. HEALTH & SOCIAL CARE IN THE COMMUNITY, vol. 7(1), 61-68. link>
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1998. The motivation to learn: efficacy and relevance of the Oswestry postgraduate orthopaedic training programme. Ann R Coll Surg Engl, vol. 80(4), 271-273. link>
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1998. Arthroscopic debridement of external fixator pin tracts. Injury, vol. 29(1), 41-42. link>
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1998. Tibial plateau fracture following allograft anterior cruciate ligament (ACL) reconstruction. Injury, vol. 29(1), 73-74. link>
Chapters
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2004. Stability of impaction-grafted hip and knee prostheses: surgical technique, impant design, and graft compaction. In Impaction Bone Grafting in Revision Arthroplasty. Editor CD and Bannister GC (Eds.). Informa HealthCare.
Other
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2013. Biomarker discovery for autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, p. A46). link>
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2013. Isolation and characterization of mesenchymal stem cells from different regions of the human umbilical cord. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, pp. A34-A35). link>
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2008. Lubricin in biopsies of autologous chondrocyte implantation-treated patients. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A22-A23). link>
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2008. The glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differs from control cartilage. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, p. A23). link>
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2007. Differences in glycosaminoglycan profiles in autologous chondrocyte implantation repair tissue and age-matched cadaveric cartilage. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 88, pp. A61-A62). link>
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2007. Clinical trial of bone marrow stromal stem cell implantation for refractory fracture non-union: Results from the first patients. TISSUE ENGINEERING (vol. 13, p. 1657). link>
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1998. The effect of fluid shear stress on osteoblast precursor cells. Biochem Soc Trans (vol. 26, p. S24). link>
• Editorial Board of Hip International
• Arthritis Research Campaign Research Board
• Action Medical Research
• Board Member of International Cartilage Repair Society
• Medical Research Council - College of Experts
• Scientific Advisory Board (SAB) for Tissue Engineering, Singapore (1 June 2005 – 31 May 2008)
• Director - Institute of Orthopaedics
• Clinical Director of Oscell: cell production unit at Oswestry

