ISTM

I joined the School of Pharmacy in 2006. I gained my PhD from Nottingham School of Pharmacy in Oct 2000 and worked as a postdoctoral research fellow in Nottingham and London School of Pharmacy.

My research interests cover formulation and evaluation of colloidal drug delivery systems (including parenteral emulsions and suspensions). I have also worked on the formulation and stability of paediatric formulations. I have used various techniques in my studies, including dynamic light scattering, laser diffraction, single particle optical counting, electrical zone sensing, zeta potential analysis, ultracentrifugation and HPLC.

• 01/2006 – present   Lecturer in Pharmaceutics, School of Pharmacy, Keele University.
• 11/2003 –01/2006   Research Fellow, School of Pharmacy, University of London.  
  • Research projects: Evaluation of paediatric formulations in relation to pharmacy practice.
• 10/2000 – 11/2003   Research Fellow, School of Pharmacy, University of Nottingham. 
  • Research project: physicochemical properties of colloidal drug delivery systems
• 10/1996 - 9/2000   PhD in Pharmaceutical Sciences, University of Nottingham. 
  • Thesis: Formulation and Evaluation of Intravenous Vitamin E Emulsions for the Delivery of Paclitaxel.
• 11/1994 - 4/1996   Academic Visitor(with WHO Fellowship), School of Pharmacy, University of Nottingham.
  • Project: to investigate and develop filterable intravenous emulsions (<100nm in diameter).
• 10/1990-10/1994   Lecturer in Pharmaceutics. Heilongjiang TCMPS University, PR China.
• 10/1988 -9/1990   Assistant Lecturer in Pharmaceutics, Heilongjiang TCMPS University.

ISTM research theme: Bioengineering & Therapeutics

I have been working on formulation science and drug delivery systems for many years, with strong relation to industrial application. In particular, this covers disperse systems for oral and parenteral applications, including emulsions and suspensions. Fundamental physicochemical principles are applied in the research to solve problems in drug delivery systems.

In my previous post in the Centre for Paediatric Pharmacy Research (the only centre in the UK) at London School of Pharmacy, my work was more closely linked to clinical practice.  I used formulation science to address problems discovered in clinical practice (about unlicensed medicines for children, extemporaneous preparations etc).

My current and future work is on pharmaceutical formulation, initially on disperse systems based on my previous research activities. At the same time, I would like to explore opportunities to collaborate with clinical experts to identify problems in clinical practice which could be addressed using pharmaceutical technology. Later, the research may extend to cover solid oral dosage forms, where my experience on surfactant systems will be useful.

Publications: 

Han, J., Allison, B., Tuleu, C., Long P and Wong, I. Physicochemical and microbiological stability of extemporaneous tacrolimus suspensions (2006).  Journal of Clinical Pharmacy and Therapeutics. 31: 167-172.

Panayiotis, P., Han, J. and Davis, S. S. Advances in the Use of Tocols as Drug Delivery Vehicles (2006). Pharmaceutical Research 23: 243-255.

Han, J. and Washington, C (2005).  Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability. International Journal of Pharmaceutics. 288(2): 263-271

Karimova A, Robertson A, Cross N, Smith L, O'Callaghan M, Tuleu C, Long P, Beeton A, Han J, Ridout D, Goldman A, Brown K. (2005). A wet-primed extracorporeal membrane oxygenation circuit with hollow-fiber membrane oxygenator maintains adequate function for use during cardiopulmonary resuscitation after 2 weeks on standby. Critical care medicine 33 (7): 1572-1576, 2005.

Han, J., Davis, S. S., Melia, C. D. and Washington, C. (2004) Design and evaluation of an emulsion vehicle for paclitaxel. I. Physicochemical properties. Pharmaceutical Research. 22(9): 1573-1580.

Han, J., Melia, C. D. and Washington, C. (2004) A concentric cylinder shear device for the study of stability in intravenous emulsions. European Journal of Pharmaceutical Sciences. 23(3): 253-260.

Han J, Beeton A, Long P, Karimova A, Robertson A, Cross N, Smith L, O'Callaghan M, Goldman A, Brown K and Tuleu C(2004). Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits. International Journal of Pharmaceutics. 254(1-2): 157-159

Bistrussu S, Beeton A, Castaldo G, Han J, Wong I, Tuleu C, Long PF, Brown K, Cross N, Cope J, Goldman AP, Karimova A, O'Callaghan M, Robertson A, Smith L (2004). Are extracorporeal membrane oxygenation (ECMO) circuits stored 'wet-primed' a likely source of infection? Journal of Clinical Microbiology. 42(8):3906.

Han, J., Davis, S. S. and Washington, C. (2001) Physical properties and stability of two emulsion formulations of propofol. International Journal of Pharmaceutics. 215(1-2): 207-220.

Han, J., Davis S. S. and Washington, C. (2000) Comparative Physical stability of propofol with EDTA versus sulfite-containing propofol.  American Journal of Anesthesiology Supp 1(6): 16-18.

Washington, C., Davis S. S. and Han, J. (2000) Stability studies of propofol intravenous emulsions. American Journal of Anesthesiology Supp 2(3): A1137.

Han, J., Wang, L. and Su, D. (1993).  A study on the chemical stability of FT-207 intravenous fat emulsion by HPLC method.  Journal of Shenyang Pharmaceutical University, 10(3): 171-175.

Han, J. and Su, D. (1991).  Physical properties of an anticancer drug FT-207 fat emulsion. Journal of Shenyang Pharmaceutical University 8(1): 14-17.

Han, J. and Su, D. (1991).  The properties of the interface between soybean oil and water.  Chinese Pharmaceutical Journal. 26(9): 539-542.

Han, J., Tuleu, C. and Wong, I. A study on the physicochemical stability of an extemporaneous tacrolimus suspension by laser diffraction and HPLC method (paper in preparation).

Han, J., Tuleu, C. and Wong, I. A dose uniformity study of extemporaneous tacrolimus suspensions (Paper in Preparation).

Han, J., Davis, S. S. and Washington, C.  Design and evaluation of an emulsion vehicle for paclitaxel.  II. Freeze-drying (submitted, addressing reviewers comments).

Patent:

Davis, S. S. and Han, J. (1999). Taxol emulsion, PCT WO 99/04787.

Conferences:

Han, J., Wong, I. Tuleu, C. (Oral presentation).  Extemporaneous tacrolimus suspensions.
3rd International Workshop on Paediatric Clinical Trials.
Organised by Paediatric and Perinatal Drug Therapy and The Association of Clinical Research Professionals.
11th & 12th July 2005, Catalis Centre, Derby, UK

Han, J. and Tuleu, C. (Poster presentation). Stability study of a sugar-free sildenafil suspension under simulated user conditions.
Neonatal and Paediatric Pharmacists Group Conference 2005
28-30 October 2005.  Europa Hotel, Belfast, UK 

Tuleu C., Han J., Bingen C., Hardyal G., Shah J., Cope J. (Poster presentation). ‘In use’ stability testing of paediatric CIVAS pre-filled syringes of morphine sulphate in glucose.
Neonatal and Paediatric Pharmacists Group Conference 2005
28-30 October 2005.  Europa Hotel, Belfast, UK

Research grants:

• Ian Wong, Glennis S Haworth, Catherine Peckham, Nigel Klein, Catherine Tuleu, Macey Murray, Vincent Yeung, Jihong Han (participants from Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London).  : Task Force in Europe for Drug Development for the Young – Network of Excellence in Europe.  (486,000 Euro out of the 2 million Euro for the total network. A networking fund, not research grant).  The first official network in Europe involving, multi-centre in different countries in Europe, approved by European Commission. (2006).
• Dr Catherine Tuleu, Dr Jihong Han, Mr Ian Costello, Dr Paul Long, Dr Ian Wong. Tacrolimus Oral Paediatric Preparation Evaluation Research 2 (TOPPER 2). A grant (60.5 K) awarded by Fujisawa (UK) Ltd.  December 2004 to December 2005.
• A WHO Fellowship for research training in the UK (1994 -1996).
• A full University Overseas Studentship, University of Nottingham (1996 – 2000).
• 1990 -1994, a research grant (Chinese Yuan, 20k) from Zhaodong Pharmaceutical Ltd., PR China to develop a herbal product, covering manufacturing technique, physicochemical characterization and quality control.