Dr Fiona Leslie

Title: Senior Lecturer
Consultant in Gastroenterology
Phone: +44 (0)1782 556669
Email:
Location: Institute for Science & Technology in Medicine, Keele University, and
Clinical Education Centre, City General Hospital, Newcastle Road, Stoke-on-Trent, ST4 6QG United Kingdom
Role: ISTM Research theme: 1. Infection, Inflamation & Immunity
Contacting me: By phone or e-mail.
Fiona_Leslie_210x275

My clinical interests are in Nutrition and Inflammatory Bowel Disease; as a busy clinician I have only limited time for research and audit although data from recent student projects has been presented at national and local meetings. Currently I am involved in a collaboration with Gordon Dent who is working on interactions between eosinophils and colonic mucosa in inflammation.

During my Specialist Registrar training, I undertook a PhD with Wellcome Trust funding, which I completed at the University of Manchester supervised by Dr John McLaughlin. In GI Science. I undertook my research in the field of the effect of inflammation on enteroendocrine cell function, using infection as a model. This is the area I am hoping to continue.

 

ISTM Research theme: Infection, Inflamation & Immunity

Main current research interests:

• Nutrition and Inflammatory Bowel Disease.

• Enteroendocrine cell function in Crohn’s Disease. A translational study that aims to gain a better understanding of the role of enteroendocrine cells (EEC) in GI inflammation and in particular, in Crohn’s disease. It is hoped that an improved understanding of the basic disease mechanisms involved in inflammatory bowel disease (IBD) may provide novel targets for clinical management strategies.

• Interactions between eosinophils and colonic mucosa in inflammation (collaboration led by Dr Gordon Dent).

• TARGET study, lead UHNS clinician in a multicentre pharmacogenetic study led by Manchester University.

Research track record:

• PhD 2004: 'The Effects of Infection and Inflammation on Enteroendocrine Cell Function and the Relationship to Gastrointestinal Symptoms' (supervised by Dr John McLaughlin, University of Manchester).

• Awarded Wellcome Trust Research Training Fellowship in 2000.

• Awarded Wellcome Trust Entry Level Training Fellowship in 1998.

Selected Publications

  • Harrison E, Dillon J, Leslie FC. 2011. Complications of the Cut-and-Push Technique for Percutaneous Endoscopic Gastrostomy Tube Removal. NUTRITION IN CLINICAL PRACTICE, vol. 26(3), 230-231. link> doi>
  • Leslie FC and Thomas S. 2009. Symposium 9: Competent to care Are all doctors competent in nutrition?. PROCEEDINGS OF THE NUTRITION SOCIETY (vol. 68, pp. 296-299). link> doi> full text>
  • Thomas S and Leslie FC. 2009. HEALTHCARE PROFESSIONALS' KNOWLEDGE ABOUT PERCUTANEOUS GASTROSTOMY FEEDING: HOW WELL ARE WE DOING?. GUT (vol. 58, p. A83). link>
  • LESLIE F, McDermott JR, D'Amato M, Thompson DG, Grencis RK, McLaughlin JT. 2006. Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation. Gut, vol. 55(4), 492-497.
  • LESLIE F, Thompson DG, Varro A, Dockray GJ, Mandal BK, McLaughlin JT. 2003. Plasma cholecystokinin concentrations are elevated in acute upper gastrointestinal infections. QJM, vol. 96(11), 870-871. doi>

Full Publications List show

Journal Articles

  • Harrison E, Dillon J, Leslie FC. 2011. Complications of the Cut-and-Push Technique for Percutaneous Endoscopic Gastrostomy Tube Removal. NUTRITION IN CLINICAL PRACTICE, vol. 26(3), 230-231. link> doi>
  • LESLIE F, McDermott JR, D'Amato M, Thompson DG, Grencis RK, McLaughlin JT. 2006. Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation. Gut, vol. 55(4), 492-497.
  • LESLIE F, Thompson DG, Varro A, Dockray GJ, Mandal BK, McLaughlin JT. 2003. Plasma cholecystokinin concentrations are elevated in acute upper gastrointestinal infections. QJM, vol. 96(11), 870-871. doi>
  • LESLIE F, McDermott JR, Kazmi S, Grencis R, Thompson DG, McLaughlin JT. 2003. Small intestinal inflammation is associated with increased enteroendocrine cell numbers and hypophagia. Gut, vol. 52(suppl 1), A16.
  • LESLIE F, McLaughlin J, Kazmi S, Varro A, Warhurst G, Dockray G, Thompson D. 2002. A cocktail of pro-inflammatory cytokines increases CCK release from STC-1 cells via an effect on intracellular calcium. Gastroenterology, vol. 112(4 Supl 1), A136.
  • LESLIE F, McLaughlin JT, Kazmi S, Varro A, Warhurst G, Dockray GJ, Thompson DG. 2002. A pro-inflammatory cytokine cocktail increases CCK release from STC-1 cells via intracellular calcium. Gut, vol. 50(Supp 11), A27.
  • LESLIE F, Bradley MA, Shaffer JL. 2002. Outcomes in Home Parenteral Nutrition - positive trends for the future. Proceedings of the Nutrition Society, vol. 61, 34A.
  • LESLIE F, Bradley MA, Shaffer JL. 2002. Outcomes in Home Parenteral Nutrition in a National Unit. Gut, vol. 50(Suppl 11), A21.
  • LESLIE F, Kazmi S, McDermott J, Grencis R, Thompson D, McLaughlin J. 2002. Trichinella infection in mice is associated with hypophagia and enteroendocrine cell hyperplasia. Clinical Nutrition, vol. 21(1, suppl 1), 70.
  • LESLIE F, McLaughlin JT, Varro A, Mandal BK, Dockray GJ, Thompson DG. 2001. Plasma Cholecystokinin levels are elevated in Acute Upper Gastrointestinal infections. Digestion, vol. 63(4), 264.
  • Leslie F and Thomas S. Competent to care. Are all doctors competent in nutrition?. Proceedings of the Nutrition Society, vol. 68(3), 296-299. doi>
  • Leslie F, Harrison E, Dillon J. Complications of the cut-and-push technique for percutaneous endoscopic gastrostomy tube removal. Nutrition in Clinical Practive, vol. 26(3), 230-231. doi>

Other

  • Leslie FC and Thomas S. 2009. Symposium 9: Competent to care Are all doctors competent in nutrition?. PROCEEDINGS OF THE NUTRITION SOCIETY (vol. 68, pp. 296-299). link> doi> full text>
  • Thomas S and Leslie FC. 2009. HEALTHCARE PROFESSIONALS' KNOWLEDGE ABOUT PERCUTANEOUS GASTROSTOMY FEEDING: HOW WELL ARE WE DOING?. GUT (vol. 58, p. A83). link>

Module Leader, Year 3 Nutrition, Metabolism and Excretion, Keele Medical School.