Prof Gordon A A Ferns BSc (Hons), MSc (Clin Biochem), DSc (Med Sci), MB, BS (Lond), MD, LRCP, MRCS, FRCPath, DiplHlthMgt

Title: Professor of Metabolic Medicine
Consultant in Clinical Biochemistry
Associate Medical Director, North Staffordshire NHS Research & Development
Clinical Director, West Midlands North Clinical Local Research Network
Phone: +44 (0)1782 554718
Email:
Location: Institute for Science & Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB United Kingdom
Role: ISTM Research theme: 1. Neuroscience & Human Metabolism
Contacting me: Please call or e-mail Miss Paula Marsh: +44 (0)1782 554253 / p.marsh@bemp.keele.ac.uk
Prof Gordon A A Ferns

Professor Ferns qualified in Medicine from St Barts, University of London then undertook speciality training in Chemical Pathology at the hospital where he worked on the molecular genetics of diabetes and atherosclerosis supported by a Wellcome Clinical Fellowship.

Following his MD, Gordon spent three years in Seattle, Washington as American Heart Association-British Heart Foundation Fellow developing models of accelerated atherosclerosis. He returned to the UK in 1991 to the post of Senior Scientist in the William Harvey Research Institute. He was appointed to a Senior Lectureship in Chemical Pathology at the University of Leicester (1993-1995), then moved to the University of Surrey as Chair of Metabolic and Molecular Medicine, a post he held for 14 years. In 2007 he was appointed Dean of Medicine at the University and Clinical Director of the NIHR Surrey & Sussex Comprehensive Local Research Network. In November 2009 Gordon moved to Keele University to take up the combined post of Director of the Research Institute for Science & Technology in Medicine in the Faculty of Health and Director of R&D at the University Hospital of North Staffordshire.

Gordon Ferns has published over 300 articles, has received grant support from the MRC, BHF, BBSRC and MAFF, and was awarded a DSc from London University in 2003.

Previous appointments:

Director, Research Institute for Science & Technology in Medicine, Keele University Nov 2009 - present
Director of R&D, University Hospital of North Staffordshire Nov 2009 - present
Clinical Director

Surrey & Sussex Comprehensive Local Research Network

 Nov 2007 - present
Dean and Head of Division

Postgraduate Medical School, University of Surrey

 Feb 2007 - Oct 2009
Vice Dean

Postgraduate Medical School, University of Surrey

 April 2006 - Jan 2007

Professor of Metabolic & Molecular Medicine, Consultant in Clinical Biochemistry
FHMS, University of Surrey, and The Royal Surrey County Hospital, Guildford

 Jan 1996 - Oct 2009

Senior Lecturer and Honorary Consultant in Chemical Pathology
Glenfield General Hospital, University of  Leicester

 Nov 1993 - Dec 1995

Senior Scientist and Honorary Senior Lecturer in Chemical Pathology
The William Harvey Research Institute, St Bartholomew's Hospital Medical College, London

 Oct 1990 - Oct 1993

British Heart Foundation-American Heart Association, reciprocal fellowship and Senior Research Fellow
Dept of Pathology SM-30, University of Washington, Seattle USA

 Jan 1988 - Sept 1990

Locum Consultant in Chemical Pathology
West Essex Health Authority, Princess Alexandra, St Margaret's and the Herts and Essex Hospitals

 Aug 1987 - Dec 1987

Research Fellow/ Hon Senior Registrar in the Dept of Diabetes & Lipid Research,
St Bartholomew's Hospital, London

 Nov 1983 - July 1987
House Posts in Medicine, Surgery and Pathology
Newmarket and London		 Feb 1980-Oct 1983

 

Qualifications:

DSc, London University 2003
Diploma in Health Management, Keele University 1994
Final MRCPath 1987; FRCPath 1997
MD thesis: "Lipoproteins, apoproteins and genetic polymorphisms in disorders related to atherosclerosis," awarded December 1986
MSc (Clinical Biochemistry), London University, 1983
MRCS (Eng.), LRCP (Lond.) 1979; MB, BS (Lond.) 1980 
BSc (Hons) Psychology with Medical Sciences, London University, 1976.
 

ISTM Research theme: 1. Neuroscience & Human Metabolism

Professor Ferns' research and clinical interests include the causes and management of coronary heart disease and other metabolic disorders:

  • Dietary management of coronary risk
  • Cellular mechanisms of atherogenesis
  • Trace elements and antioxidants in disease
  • Clinical management of Dyslipidaemia
  • Insulin resistance

Selected Publications

  • Smith D, Spaněl P, Fryer AA, Hanna F, Ferns GA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?. J Breath Res, vol. 5(2), 022001. doi>
  • Alshammari E, Shafi S, Nurmi-Lawton J, Taylor A, Lanham-New S, Ferns G. 2010. Altered antioxidant and trace-element status in adolescent female gymnasts. Int J Sport Nutr Exerc Metab, vol. 20(4), 291-298.
  • Borai A, Livingstone C, Shafi S, Zarif H, Ferns G. 2010. Insulin sensitivity (Si) assessment in lean and overweight subjects using two different protocols and updated software. Scand J Clin Lab Invest, vol. 70(2), 98-103. doi>
  • Borai A, Livingstone C, Farzal A, Kholeif M, Wang T, Ferns G. 2010. Reproducibility of HOMA and QUICKI among individuals with variable glucose tolerance. Diabetes Metab, vol. 36(3), 247-249. doi>
  • Borai A, Livingstone C, Ghayour-Mobarhan M, Abuosa A, Shafi S, Mehta S, Heidari A, Emadzadeh A, Wark G, Ferns G. 2010. Serum insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation status in subjects with and without ischaemic heart disease. Atherosclerosis, vol. 208(2), 593-598. doi>

Full Publications List show

Journal Articles

  • Smith D, Spaněl P, Fryer AA, Hanna F, Ferns GA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?. J Breath Res, vol. 5(2), 022001. doi>
  • Alshammari E, Shafi S, Nurmi-Lawton J, Taylor A, Lanham-New S, Ferns G. 2010. Altered antioxidant and trace-element status in adolescent female gymnasts. Int J Sport Nutr Exerc Metab, vol. 20(4), 291-298.
  • Borai A, Livingstone C, Shafi S, Zarif H, Ferns G. 2010. Insulin sensitivity (Si) assessment in lean and overweight subjects using two different protocols and updated software. Scand J Clin Lab Invest, vol. 70(2), 98-103. doi>
  • Borai A, Livingstone C, Farzal A, Kholeif M, Wang T, Ferns G. 2010. Reproducibility of HOMA and QUICKI among individuals with variable glucose tolerance. Diabetes Metab, vol. 36(3), 247-249. doi>
  • Borai A, Livingstone C, Ghayour-Mobarhan M, Abuosa A, Shafi S, Mehta S, Heidari A, Emadzadeh A, Wark G, Ferns G. 2010. Serum insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation status in subjects with and without ischaemic heart disease. Atherosclerosis, vol. 208(2), 593-598. doi>
  • Burut DF, Karim Y, Ferns GA. 2010. The role of immune complexes in atherogenesis. Angiology, vol. 61(7), 679-689. doi>
  • Borai A, Livingstone C, Mehta S, Zarif H, Abdelaal F, Ferns G. 2009. Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance. Clin Biochem, vol. 42(12), 1270-1274. doi>
  • Alissa EM, Bahjri SM, Ahmed WH, Al-Ama N, Ferns GAA. 2009. Chromium Status and Glucose Tolerance in Saudi Men With and Without Coronary Artery Disease. BIOLOGICAL TRACE ELEMENT RESEARCH, vol. 131(3), 215-228. link> doi>
  • Ebrahimi M, Kazemi-Bajestani SMR, Ghayour-Mobarhan M, Moohebati M, Paydar R, Azimi-Nezhad M, Esmaily HO, Ferns GAA. 2009. Metabolic Syndrome May Not be a Good Predictor of Coronary Artery Disease in the Iranian Population: Population-Specific Definitions are Required. THESCIENTIFICWORLDJOURNAL, vol. 9, 86-96. link> doi>
  • Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, Hoseini M, Parizade SMR, Farhoudi F, Hosseininezhad SJ, Tavallaei S, Vejdani A, Azimi-Nezhad M, Shakeri MT, Rad MA, Mobarra N, Kazemi-Bajestani SMR, Ferns GAA. 2009. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. ACTA CARDIOLOGICA, vol. 64(3), 321-327. link> doi>
  • Shafi S, Lamb D, Modjtahedi H, Ferns G. 2010. Periadventitial delivery of anti-EGF receptor antibody inhibits neointimal macrophage accumulation after angioplasty in a hypercholesterolaemic rabbit. Int J Exp Pathol, vol. 91(3), 224-234. doi>
  • Nematy M, Sakhdari A, Ahmadi-Moghaddam P, Aliabadi M, Kimiagar M, Ilaty AA, Azimi-Nezhad M, Shakeri MT, Ghayour-Mobarhan M, Sahebkar A, Ferns GAA. 2009. Prevalence of Obesity and Its Association with Socioeconomic Factors in Elderly Iranians from Razavi-Khorasan Province. THESCIENTIFICWORLDJOURNAL, vol. 9, 1286-1293. link> doi>
  • Alissa EM, Ahmed WH, Al-ama N, Ferns GAA. 2009. Selenium Status and Cardiovascular Risk Profile in Healthy Adult Saudi Males. MOLECULES, vol. 14(1), 141-159. link> doi>
  • Burut DF, Borai A, Livingstone C, Ferns G. 2010. Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study. Cell Stress Chaperones, vol. 15(4), 379-386. doi>
  • Borai A, Livingstone C, Zarif H, Ferns G. 2009. Serum insulin-like growth factor binding protein-1: an improvement over other simple indices of insulin sensitivity in the assessment of subjects with normal glucose tolerance. Ann Clin Biochem, vol. 46(Pt 2), 109-113. doi>
  • Ghayour-Mobarhan M, Rahsepar AA, Tavallaie S, Rahsepar S, Ferns GAA. 2009. THE POTENTIAL ROLE OF HEAT SHOCK PROTEINS IN CARDIOVASCULAR DISEASE: EVIDENCE FROM IN VITRO AND IN VIVO STUDIES. ADVANCES IN CLINICAL CHEMISTRY VOL 48, vol. 48, 27-72. link> doi>
  • Shams S, Shafi S, Bodman-Smith K, Williams P, Mehta S, Ferns GA. 2008. Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clin Chim Acta, vol. 395(1-2), 42-46. doi>
  • Ferns G and Keti V. 2008. HDL-cholesterol modulation and its impact on the management of cardiovascular risk. Ann Clin Biochem, vol. 45(Pt 2), 122-128. doi>
  • Ferns GA. 2008. Multiple step-variable pathway hypothesis: a reason why predictions fail in atherosclerosis. Med Hypotheses, vol. 71(6), 923-926. doi>
  • Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SMR, Abasalti Z, Yaghoobi Z, Yaghoobi F, Esmaeili H, Kazemi-Bajestani SMR, Aghasizadeh R, Saloom KY, Ferns GAA. 2008. Natural honey and cardiovascular risk factors; Effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. THESCIENTIFICWORLDJOURNAL, vol. 8, 463-469. link> doi>
  • Ghayour-Mobarhan M, Taylor A, Kazemi-Bajestani SM, Lanham-New S, Lamb DJ, Vaidya N, Livingstone C, Wang T, Ferns GA. 2008. Serum zinc and copper status in dyslipidaemic patients with and without established coronary artery disease. Clin Lab, vol. 54(9-10), 321-329.
  • Ghayour-Mobarhan M, Taylor A, Lamb DJ, Ferns GA. 2007. Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians. Int J Obes (Lond), vol. 31(1), 197-200. doi>
  • Kazemi-Bajestani SMR, Ghayour-Mobarhan M, Ebrahimi M, Moohebati M, Esmaeili H-A, Ferns GAA. 2007. C-reactive protein associated with coronary artery disease in Iranian patients with angiographically defined coronary artery disease. CLINICAL LABORATORY, vol. 53(1-2), 49-56. link>
  • Alissa EM, Ahmed WH, Al-Ama N, Ferns GAA. 2007. Relationship between indices of iron status and coronary risk factors including diabetes and the metabolic syndrome in Saudi subjects without overt coronary disease. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol. 21(4), 242-254. link> doi>
  • Ghayour-Mobarhan M, Lamb DJ, Tavallaie S, Ferns GA. 2007. Relationship between plasma cholesterol, von Willebrand factor concentrations, extent of atherosclerosis and antibody titres to heat shock proteins-60, -65 and -70 in cholesterol-fed rabbits. Int J Exp Pathol, vol. 88(4), 249-255. doi>
  • Kazemi-Bajestani SMR, Ghayour-Mobarhan M, Ebrahimi M, Moohebati M, Esmaeili HA, Parizadeh MR, Aghacizadeh R, Ferns GAA. 2007. Serum copper and zinc concentrations are lower in Iranian patients with angiographically defined coronary artery disease than in subjects with a normal angiogram. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol. 21(1), 22-28. link> doi>
  • Borai A, Livingstone C, Ferns GA. 2007. The biochemical assessment of insulin resistance. Ann Clin Biochem, vol. 44(Pt 4), 324-342. doi>
  • Walters JF, Hampton SM, Deanfield JE, Donald AE, Skene DJ, Ferns GA. 2006. Circadian variation in endothelial function is attenuated in postmenopausal women. Maturitas, vol. 54(3), 294-303. doi>
  • Ferns G, Shams S, Shafi S. 2006. Heat shock protein 27: its potential role in vascular disease. Int J Exp Pathol, vol. 87(4), 253-274. doi>
  • Alissa EM, Bahjri SM, Al-Ama N, Ahmed WH, Ferns GAA. 2006. High cardiovascular risk in young Saudi males: Cardiovascular risk factors, diet and inflammatory markers. CLINICA CHIMICA ACTA, vol. 365(1-2), 288-296. link> doi>
  • Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA. 2006. The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. Atherosclerosis, vol. 186(1), 38-53. doi>
  • Alissa EM, Bahjri SM, Ahmed WH, Al-ama N, Ferns GAA. 2006. Trace element status in Saudi patients with established atherosclerosis. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol. 20(2), 105-114. link> doi>
  • Ghayour-Mobarhan M, Taylor A, New SA, Lamb DJ, Ferns GA. 2005. Determinants of serum copper, zinc and selenium in healthy subjects. Ann Clin Biochem, vol. 42(Pt 5), 364-375. doi>
  • Ghayour-Mobarhan M, New SA, Lamb DJ, Starkey BJ, Livingstone C, Wang T, Vaidya N, Ferns GA. 2005. Dietary antioxidants and fat are associated with plasma antibody titers to heat shock proteins 60, 65, and 70 in subjects with dyslipidemia. Am J Clin Nutr, vol. 81(5), 998-1004.
  • Lamb DJ, Tickner ML, Hourani SM, Ferns GA. 2005. Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis. Int J Exp Pathol, vol. 86(4), 247-255. doi>
  • Alissa EM, Bahjri SM, Al-Ama N, Ahmed WH, Starkey B, Ferns GAA. 2005. Dietary vitamin A may be a cardiovascular risk factor in a Saudi population. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, vol. 14(2), 137-144. link>
  • Walters JF, Hampton SM, Ferns GAA, Skene DJ. 2005. Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions. CHRONOBIOLOGY INTERNATIONAL, vol. 22(5), 859-872. link> doi>
  • Walters JF, Hampton SM, Ferns GA, Skene DJ. 2005. Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions. Chronobiol Int, vol. 22(5), 859-872. doi>
  • Ghayour-Mobarhan M, Lamb DJ, Vaidya N, Livingstone C, Wang T, Ferns GA. 2005. Heat shock protein antibody titers are reduced by statin therapy in dyslipidemic subjects: a pilot study. Angiology, vol. 56(1), 61-68. doi>
  • Ghayour-Mobarhan M, Lamb DJ, Lovell DP, Livingstone C, Wang T, Ferns GA. 2005. Plasma antibody titres to heat shock proteins-60, -65 and-70: their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals. Scand J Clin Lab Invest, vol. 65(7), 601-614. doi>
  • Lamb DJ, Modjtahedi H, Plant NJ, Ferns GAA. 2004. EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques. ATHEROSCLEROSIS, vol. 176(1), 21-26. link> doi>
  • Lamb DJ, Modjtahedi H, Plant NJ, Ferns GA. 2004. EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques. Atherosclerosis, vol. 176(1), 21-26. doi>
  • Lamb DJ, Tickner ML, Dreux AC, El-Sankary W, Hourani SM, Eales-Reynolds LJ, Ferns GA. 2004. Impairment of vascular function following BCG immunisation is associated with immune responses to HSP-60 in the cholesterol-fed rabbit. Atherosclerosis, vol. 172(1), 13-20. doi>
  • Livingstone C, Al Riyami S, Wilkins P, Ferns GAA. 2004. McArdle's disease diagnosed following statin-induced myositis. ANNALS OF CLINICAL BIOCHEMISTRY, vol. 41, 338-340. link> doi>
  • Abubakar MG, Taylor A, Ferns GA. 2004. Regional accumulation of aluminium in the rat brain is affected by dietary vitamin E. J Trace Elem Med Biol, vol. 18(1), 53-59. doi>
  • Alissa EM, Bahijri SM, Lamb DJ, Ferns GAA. 2004. The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 85(5), 265-275. link> doi>
  • Abubakar MG, Taylor A, Ferns GA. 2003. Aluminium administration is associated with enhanced hepatic oxidant stress that may be offset by dietary vitamin E in the rat. Int J Exp Pathol, vol. 84(1), 49-54. doi>
  • Walters J, Skene D, Hampton SM, Ferns GA. 2003. Biological rhythms, endothelial health and cardiovascular disease. Med Sci Monit, vol. 9(1), RA1-RA8.
  • Ferns GAA. 2003. Differential effects of statins on serum CRP levels: implications of recent clinical trials. ATHEROSCLEROSIS, vol. 169(2), 349-351. link> doi>
  • Ferns GA, O'Dowd D, Wark G, Collins N. 2003. Molecular diagnostics in routine practice: quality issues and application to complex disease. Ann Clin Biochem, vol. 40(Pt 4), 309-312. doi>
  • Lamb DJ, El-Sankary W, Ferns GA. 2003. Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. Atherosclerosis, vol. 167(2), 177-185. doi>
  • Lamb DJ, Avades TY, Allen MD, Anwar K, Kass GE, Ferns GA. 2002. Effect of dietary copper supplementation on cell composition and apoptosis in atherosclerotic lesions of cholesterol-fed rabbits. Atherosclerosis, vol. 164(2), 229-236. doi>
  • Lamb DJ and Ferns GA. 2002. The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. Atherosclerosis, vol. 165(2), 231-240. doi>
  • Lamb DJ, Avades TY, Ferns GA. 2001. Biphasic modulation of atherosclerosis induced by graded dietary copper supplementation in the cholesterol-fed rabbit. Int J Exp Pathol, vol. 82(5), 287-294. doi>
  • Ashmaig ME, Starkey BJ, Ziada AM, Amro A, Sobki S, Ferns GA. 2001. Changes in serum concentration of antioxidants following treadmill exercise testing in patients with suspected ischaemic heart disease. Int J Exp Pathol, vol. 82(4), 243-248. doi>
  • Ferns GA. 2001. C-reactive protein: a central player in atherogenesis or an epiphenomenon?. Clin Sci (Lond), vol. 100(4), 357-358. doi>
  • Lamb DJ, Avades TY, Ferns GA. 2001. Endogenous neutralizing antibodies against platelet-derived growth factor-aa inhibit atherogenesis in the cholesterol-fed rabbit. Arterioscler Thromb Vasc Biol, vol. 21(6), 997-1003.
  • Ferns GA. 2001. The National Service Framework on coronary heart disease: is it sufficiently evidence-based?. Ann Clin Biochem, vol. 38(Pt 3), 159-161. doi>
  • Ferns G, Williams J, Forster L, Tull S, Starkey B, Gershlick A. 2000. Cholesterol standardized plasma vitamin E levels are reduced in patients with severe angina pectoris. Int J Exp Pathol, vol. 81(1), 57-62.
  • Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. 2000. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens, vol. 18(4), 411-415.
  • Ferns GA, Forster LA, Williams JC, Tull SP, Verma PK, Starkey B, Gershlick AH. 2000. Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty. Ann Clin Biochem, vol. 37 ( Pt 5), 649-654. doi>
  • Williams JC, Fotherby MD, Forster LA, Tull SP, Ferns GA. 2000. Mononuclear cell adhesion to collagen ex vivo is related to pulse pressure in elderly subjects. Atherosclerosis, vol. 151(2), 463-469. doi>
  • Ferns GA and Avades TY. 2000. The mechanisms of coronary restenosis: insights from experimental models. Int J Exp Pathol, vol. 81(2), 63-88. doi>
  • Lamb DJ, Reeves GL, Taylor A, Ferns GA. 1999. Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis, vol. 146(1), 33-43. doi>
  • Williams JC, Forster LA, Tull SP, Ferns GAA. 1999. Effects of vitamin E on human platelet and mononuclear cell responses in vitro. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 80(4), 227-234. link> doi>
  • Galton DJ and Ferns GAA. 1999. Genetic markers to predict polygenic disease: a new problem for social genetics. QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, vol. 92(4), 223-232. link> doi>
  • Lamb DJ, Eales LJ, Ferns GA. 1999. Immunization with bacillus Calmette-Guerin vaccine increases aortic atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis, vol. 143(1), 105-113.
  • Lamb DJ and Ferns GA. 1999. Infection, immunisation and atherosclerosis: is there a link?. Vaccine, vol. 17(6), 559-564. doi>
  • Warwick GL, Waller H, Forster L, Tull S, Ferns GAA. 1999. Plasma anti-oxidant vitamin concentrations in nephrotic syndrome. KIDNEY INTERNATIONAL, vol. 55(5), 2108. link>
  • Fotherby MD, Williams JC, Fishwick C, Forster LA, Ferns GAA. 1998. Monocyte, not platelet adhesion, is related to pulse pressure. JOURNAL OF HYPERTENSION, vol. 16, S219. link>
  • Beckett DJ, Gama R, Wright J, Ferns GAA. 1998. Renal carcinoma presenting with adrenocortical insufficiency due to a pituitary metastasis. ANNALS OF CLINICAL BIOCHEMISTRY, vol. 35, 542-544. link>
  • Fotherby MD, Forster LA, Williams JC, Ferns GAA. 1998. Vitamin C supplementation lowers ambulatory SBP in hypertensives. JOURNAL OF HYPERTENSION, vol. 16, S251. link>
  • Rutherford C, Carrier MJ, Anggard EE, Ferns GAA. 1997. Antibodies to PDGF-BB inhibit fatty streak development, but not neointimal formation after balloon injury to the carotid artery, in cholesterol-fed rabbits. BRITISH JOURNAL OF PHARMACOLOGY, vol. 120, P322. link>
  • Lamb DJ, Reeves GL, Taylor A, Ferns GAA. 1997. Dietary copper supplementation increases monocyte binding to carotid endothelium in the cholesterol-fed rabbit. ATHEROSCLEROSIS, vol. 134(1-2), 330. link> doi>
  • Williams JC, Forster LA, Tull SP, Wong M, Bevan RJ, Ferns GA. 1997. Dietary vitamin E supplementation inhibits thrombin-induced platelet aggregation, but not monocyte adhesiveness, in patients with hypercholesterolaemia. Int J Exp Pathol, vol. 78(4), 259-266. doi>
  • Rutherford C, Martin W, Carrier M, Anggard EE, Ferns GAA. 1997. Endogenously elicited antibodies to platelet derived growth factor-BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol-fed rabbit. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 78(1), 21-32. link> doi>
  • Ferns GA, Lamb DJ, Taylor A. 1997. The possible role of copper ions in atherogenesis: the Blue Janus. Atherosclerosis, vol. 133(2), 139-152. doi>
  • Rutherford C, Martin W, Carrier MJ, Ferns GAA, Anggard EE. 1996. Almost complete inhibition of the neo-intimal response to balloon catheter injury in the rat carotid by a combination of antibodies to PDGF-BB and bFGF. BRITISH JOURNAL OF PHARMACOLOGY, vol. 119, P138. link>
  • Motani A, Forster L, Tull S, Anggard EE, Ferns GAA. 1996. Insulin-like growth factor-I modulates monocyte adhesion to EAhy 926 endothelial cells. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 77(1), 31-35. link> doi>
  • Motani AS, Anggard EE, Ferns GAA. 1996. Recombinant insulin-like growth factor-1 modulates aggregation in human platelets via extracellular calcium. LIFE SCIENCES, vol. 58(15), PL269-PL274. link>
  • Li SR, Forster LA, Anggård EE, Ferns GA. 1996. RT-PCR study on the effects of minimally modified low-density lipoproteins and probucol treatment on gene expressions of interleukin-1 and platelet-derived growth factor B-chain in human peripheral blood mononuclear cells. Biol Signals, vol. 5(5), 263-274.
  • Stewart-Lee AL, Ferns GA, Anggård EE. 1995. Differences in onset of impaired endothelial responses and in effects of vitamin E in the hypercholesterolemic rabbit carotid and renal arteries. J Cardiovasc Pharmacol, vol. 25(6), 906-913.
  • MITROPOULOS K and FERNS G. 1995. EFFECTS OF BALLOON INJURY ON SYSTEMIC PLASMA FACTOR-VII COAGULATION ACTIVITY AND INTIMAL HYPERPLASIA IN THE RABBIT. THROMBOSIS AND HAEMOSTASIS, vol. 73(6), 1404. link>
  • Ferns GA, Konneh M, Rutherford C, Woolaghan E, Anggard EE. 1995. Hyaluronan (HYAL-BV 5200) inhibits neo-intimal macrophage influx after balloon-catheter induced injury in the cholesterol-fed rabbit. Atherosclerosis, vol. 114(2), 157-164. doi>
  • MOTANI A, RUTHERFORD C, ANGGARD E, FERNS G. 1995. INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 INHIBITS ARTERIAL SMOOTH-MUSCLE CELL-PROLIFERATION IN-VITRO BUT DOES NOT REDUCE THE NEOINTIMAL RESPONSE TO BALLOON CATHETER INJURY. ATHEROSCLEROSIS, vol. 118(1), 57-66. link> doi>
  • FERNS G and WOOLAGHAN E. 1995. RECENT INSIGHTS INTO THE MECHANISMS OF IATROGENIC ARTERIOSCLEROSIS. JOURNAL OF PATHOLOGY, vol. 176(4), 331-332. link> doi>
  • Konneh MK, Rutherford C, Anggard E, Ferns GA. 1995. Tissue distribution of alpha-tocopherol following dietary supplementation in the rat: effects of concomitant cholesterol feeding. Proc Soc Exp Biol Med, vol. 210(2), 156-161.
  • Konneh MK, Rutherford C, Li SR, Anggård EE, Ferns GA. 1995. Vitamin E inhibits the intimal response to balloon catheter injury in the carotid artery of the cholesterol-fed rat. Atherosclerosis, vol. 113(1), 29-39. doi>
  • MOTANI A, COX G, MCDERMOTT M, ANGGARD E, FERNS G. 1994. BIFUNCTIONAL EFFECTS OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 (BP-1) ON MITOGENIC RESPONSES OF RAT VASCULAR SMOOTH-MUSCLE CELLS (RASMC). JOURNAL OF CELLULAR BIOCHEMISTRY, 286. link>
  • Matz J, Andersson TL, Ferns GA, Anggård EE. 1994. Dietary vitamin E increases the resistance to lipoprotein oxidation and attenuates endothelial dysfunction in the cholesterol-fed rabbit. Atherosclerosis, vol. 110(2), 241-249. doi>
  • Nourooz-Zadeh J, Gopaul NK, Forster LA, Ferns GA, Anggård EE. 1994. Measurement of plasma probucol levels by high-performance liquid chromatography. J Chromatogr B Biomed Appl, vol. 654(1), 55-60.
  • Katsura M, Forster LA, Ferns GA, Anggård EE. 1994. Oxidative modification of low-density lipoprotein by human polymorphonuclear leucocytes to a form recognised by the lipoprotein scavenger pathway. Biochim Biophys Acta, vol. 1213(2), 231-237. doi>
  • Li SR, Forster L, Anggård E, Ferns G. 1994. The effects of LPS and probucol on interleukin 1 (IL-1) and platelet-derived growth factor (PDGF) gene expression in the human monocytic cell line U-937. Biochim Biophys Acta, vol. 1225(3), 271-274.
  • Andersson TL, Matz J, Ferns GA, Anggård EE. 1994. Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation. Atherosclerosis, vol. 111(1), 39-45. doi>
  • STEWARTLEE A, FORSTER L, NOUROOZZADEH J, FERNS G, ANGGARD E. 1994. VITAMIN-E PROTECTS AGAINST IMPAIRMENT OF ENDOTHELIUM-MEDIATED RELAXATIONS IN CHOLESTEROL-FED RABBITS. ARTERIOSCLEROSIS AND THROMBOSIS, vol. 14(3), 494-499. link>
  • KLEMSDAL O, ANDERSSON T, MATZ J, FERNS G, GJESDAL K, ANGGARD E. 1994. VITAMIN-E RESTORES ENDOTHELIUM-DEPENDENT VASODILATATION IN CHOLESTEROL-FED RABBITS - IN-VIVO MEASUREMENTS BY PHOTOPLETHYSMOGRAPHY. CARDIOVASCULAR RESEARCH, vol. 28(9), 1397-1402. link>
  • Li SR, Wu KK, Anggard E, Ferns G. 1993. Localization of prostaglandin G/H synthase gene expression in rat brain by in situ hybridization. Biol Signals, vol. 2(2), 77-83.
  • Ferns GA, Forster L, Stewart-Lee A, Nourooz-Zadeh J, Anggård EE. 1993. Probucol inhibits mononuclear cell adhesion to vascular endothelium in the cholesterol-fed rabbit. Atherosclerosis, vol. 100(2), 171-181. doi>
  • Ferns GA, Konneh M, Anggård EE. 1993. Vitamin E: the evidence for an anti-atherogenic role. Artery, vol. 20(2), 61-94.
  • Ferns GA, Stewart-Lee AL, Anggård EE. 1992. Arterial response to mechanical injury: balloon catheter de-endothelialization. Atherosclerosis, vol. 92(2-3), 89-104. doi>
  • FERNS G, FORSTER L, STEWARTLEE A, KONNEH M, NOUROOZZADEH J, ANGGARD E. 1992. PROBUCOL INHIBITS NEOINTIMAL THICKENING AND MACROPHAGE ACCUMULATION AFTER BALLOON INJURY IN THE CHOLESTEROL-FED RABBIT. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 89(23), 11312-11316. link> doi>
  • STEWARTLEE A, FERNS G, NOUROOZZADEH J, LI S, FORSTER L, ANGGARD E. 1992. VITAMIN-E PROTECTS AGAINST IMPAIRMENT OF ENDOTHELIUM-MEDIATED RELAXATION IN THE CHOLESTEROL-FED RABBIT CAROTID-ARTERY. BRITISH JOURNAL OF PHARMACOLOGY, vol. 107, P405. link>
  • Ferns GA, Reidy MA, Ross R. 1991. Balloon catheter de-endothelialization of the nude rat carotid. Response to injury in the absence of functional T lymphocytes. Am J Pathol, vol. 138(4), 1045-1057.
  • Ferns GA, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science, vol. 253(5024), 1129-1132. doi>
  • Ferns GA, Motani AS, Anggård EE. 1991. The insulin-like growth factors: their putative role in atherogenesis. Artery, vol. 18(4), 197-225.
  • Ferns GA and Austin D. 1990. Laboratory medicine--an American system: discussion paper. J R Soc Med, vol. 83(8), 502-505.
  • Ferns GA, Sprugel KH, Seifert RA, Bowen-Pope DF, Kelly JD, Murray M, Raines EW, Ross R. 1990. Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF. Growth Factors, vol. 3(4), 315-324.
  • Ferns GA and Ross R. 1990. StyI RFLP of the human platelet derived growth factor (PDGF) A-chain gene. Nucleic Acids Res, vol. 18(1), 208. doi>
  • Ferns G, Reidy M, Ross R. 1990. Vascular effects of cyclosporine A in vivo and in vitro. Am J Pathol, vol. 137(2), 403-413.
  • FERNS G, LANHAM J, DIEPPE P, GALTON D. 1988. A DNA POLYMORPHISM OF AN APOPROTEIN GENE ASSOCIATES WITH THE HYPERTRIGLYCERIDEMIA OF PRIMARY GOUT. HUMAN GENETICS, vol. 78(1), 55-59. link> doi>
  • FERNS G, ROBINSON D, GALTON D. 1988. DNA HAPLOTYPES OF THE HUMAN APOPROTEIN-B GENE IN CORONARY ATHEROSCLEROSIS. HUMAN GENETICS, vol. 81(1), 76-80. link> doi>
  • LENOXSMITH A, SMITH W, FERNS G, MONIZ C. 1988. OLIGOSYMPTOMATIC HYPOCALCEMIA IN A PATIENT WITH IMPAIRED PARATHYROID-HORMONE ACTIVITY. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, vol. 81(12), 732-733. link>
  • FERNS G and GALTON D. 1987. DNA HAPLOTYPES OF THE APOPROTEIN-B GENE IN MYOCARDIAL-INFARCTION SURVIVORS. ATHEROSCLEROSIS, vol. 68(3), 274. link> doi>
  • THOMAS D, MILNE J, STOCKS J, FERNS G, REES R, GALTON D. 1987. HDL SUBFRACTIONS AND ANGIOGRAPHICALLY DEFINED CORONARY-ARTERY DISEASE. BRITISH JOURNAL OF CLINICAL PRACTICE, vol. 41(5), 741-742. link>
  • ROBINSON D, FERNS G, BEVAN E, STOCKS J, WILLIAMS P, GALTON D. 1987. HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS AND CORONARY RISK-FACTORS IN NORMAL MEN. ARTERIOSCLEROSIS, vol. 7(4), 341-346. link>
  • FERNS G, SHELLEY C, STOCKS J, REES A, PAUL H, BARALLE F, GALTON D. 1986. A DNA POLYMORPHISM OF THE APOPROTEIN-AII GENE IN HYPERTRIGLYCERIDEMIA. HUMAN GENETICS, vol. 74(3), 302-306. link>
  • FERNS G, STOCKS J, GALTON D. 1986. C-III DNA RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND MYOCARDIAL-INFARCTION. LANCET, vol. 1(8472), 94. link>
  • FERNS G, HITMAN G, TREMBATH R, WILLIAMS L, TARN A, GALE E, GALTON D. 1986. DNA POLYMORPHIC HAPLOTYPES ON THE SHORT ARM OF CHROMOSOME-11 AND THE INHERITANCE OF TYPE-I DIABETES-MELLITUS. JOURNAL OF MEDICAL GENETICS, vol. 23(3), 210-216. link> doi>
  • FERNS G and GALTON D. 1986. FREQUENCY OF XBAI POLYMORPHISM IN MYOCARDIAL INFARCT SURVIVORS. LANCET, vol. 2(8506), 572. link>
  • FERNS G, SHELLEY C, STOCKS J, REES A, PAUL H, BARALLE F, GALTON D. 1986. GENETIC POLYMORPHISMS OF HDL APOPROTEINS IN HYPERTRIGLYCERIDEMIA. QUARTERLY JOURNAL OF MEDICINE, vol. 61(235), 1076. link>
  • FERNS G, STOCKS J, GALTON D. 1986. GENETIC-MARKER IN APOLIPOPROTEIN-AI-CIII GENE-COMPLEX ASSOCIATED WITH HYPERCHOLESTEROLEMIA. LANCET, vol. 2(8518), 1286-1287. link>
  • FERNS G, TREMBATH R, HITMAN G, GALTON D. 1986. GENETICS OF TYPE-1 (INSULIN-DEPENDENT) DIABETES - REPLY. DIABETOLOGIA, vol. 29(3), 204. link>
  • FERNS G and GALTON D. 1986. HAPLOTYPES OF THE HUMAN APOPROTEIN AI-CIII-AIV GENE-CLUSTER IN CORONARY ATHEROSCLEROSIS. HUMAN GENETICS, vol. 73(3), 245-249. link> doi>
  • FERNS G, ROBINSON D, STOCKS J, BEVAN E, WILLIAMS P, GALTON D. 1986. HDL-CHOLESTEROL SUBFRACTIONS IN HEALTHY-MALES - RELATION TO SERUM TRIGLYCERIDE LEVELS AND AGE. ANNALS OF CLINICAL BIOCHEMISTRY, vol. 23, 504-508. link>
  • FERNS G, RITCHIE C, STOCKS J, GALTON D. 1985. GENETIC POLYMORPHISMS OF APOLIPOPROTEIN C-III AND INSULIN IN SURVIVORS OF MYOCARDIAL-INFARCTION. LANCET, vol. 2(8450), 300-303. link>
  • FERNS G, LANHAM J, STOCKS J, RITCHIE C, KATZ J, GALTON D. 1985. THE MEASUREMENT OF HIGH-DENSITY LIPOPROTEIN SUBFRACTIONS IN PATIENTS WITH PRIMARY GOUT USING A SIMPLE PRECIPITATION METHOD. ANNALS OF CLINICAL BIOCHEMISTRY, vol. 22(SEP), 526-532. link>
  • FERNS G, HITMAN G, TREMBATH R, WILLIAMS L, TARN A, GALE E, GALTON D. 1986. A COMPARISON OF MARKERS ON CHROMOSOME-11 AND CHROMOSOME-6 IN THE INHERITANCE OF TYPE-1 DIABETES. CLINICAL SCIENCE, vol. 70, P32. link>
  • FERNS G, SHELLEY S, STOCKS J, PAUL H, VELLA M, KESSLING A, GALTON D. 1986. A RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM (RFLP) OF APO-AII IN HYPERLIPEMIA AND ATHEROSCLEROSIS. CLINICAL SCIENCE, vol. 70, P92. link>
  • FERNS G and GALTON D. 1987. AN XBAI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM (RFLP) OF THE APO B-GENE AND SERUM-LIPID LEVELS IN POST-MI SUBJECTS. CLINICAL SCIENCE, vol. 72, P13. link>
  • FERNS G and GALTON D. 1987. DNA HAPLOTYPES OF THE APOPROTEIN-B GENE IN MYOCARDIAL-INFARCTION SURVIVORS. CLINICAL SCIENCE, vol. 73, P30. link>
  • FERNS G, ROBINSON D, BEVAN E, GALTON D. 1987. EFFECTS OF PIPE AND CIGAR SMOKING ON HDL-CHOLESTEROL AND ITS SUBFRACTIONS. CLINICAL SCIENCE, vol. 72, P55. link>
  • TREMBATH R, FERNS G, LI S, GALTON D. 1987. GLUCOSE TRANSPORTER GENE - RELATION TO NONINSULIN DEPENDENT DIABETES-MELLITUS. CLINICAL SCIENCE, vol. 73, P50. link>
  • WILLIAMS L, FERNS G, REES A, TREMBATH R, OHUCHI Y, GALTON D. 1986. THE HETEROGENEITY OF THE CLASS-1 INSULIN GENE ALLELE IN CAUCASIAN AND JAPANESE POPULATIONS. CLINICAL SCIENCE, vol. 70, P31. link>

Other

  • Ferns GA. 2008. New and emerging risk factors for CVD. Proc Nutr Soc (vol. 67, pp. 223-231). doi> full text>
  • Shams S, Shafi S, Vaidya N, Ghayour-Mobarhan M, Ferns GAA. 2007. Heat shock protein-27 (Hsp27) antibody titres in patient with chest pain. HEART (vol. 93). link>
  • Ghayour-Mobarhan M, Lamb DJ, Taylor A, Vaidya N, Livingstone C, Wang T, Ferns GA. 2005. Effect of statin therapy on serum trace element status in dyslipidaemic subjects. J Trace Elem Med Biol (vol. 19, pp. 61-67). doi>
  • Dreux A, Lamb DJ, Modjtahedi H, Ferns GAA. 2005. Expression and function of the epidermal growth factor receptor (EGFR) on human monocytes. ATHEROSCLEROSIS SUPPLEMENTS (vol. 6, pp. 86-87). link> doi>
  • Ghayour-Mobarhan M, Lamb DJ, Lovel DJ, Livingstone C, Wang T, Vaidya N, Ferns GAA. 2005. Relationship between plasma antibody titres to heat shock proteins-60,-65 and-70, CRP and traditional coronary risk factors including metabolic syndrome. ATHEROSCLEROSIS SUPPLEMENTS (vol. 6, p. 66). link> doi>
  • Ferns GAA, Alissa E, Bahijri S. 2005. Trace element status of Saudi patients with established coronary heart disease and age-matched controls. CLINICA CHIMICA ACTA (vol. 355, p. S84). link>
  • Ferns GA and Lamb DJ. 2004. What does the lipoprotein oxidation phenomenon mean?. Biochem Soc Trans (vol. 32, pp. 160-163). doi>
  • Tickner ML, Lamb DJ, Dreux AC, El-Sankary W, Hourani S, Eales-Reynolds LJ, Ferns GAA. 2003. BCG immunisation impairs vascular relaxation and enhances atherosclerosis in the chronically hypercholesterolaemic rabbit. BRITISH JOURNAL OF PHARMACOLOGY (vol. 140). link>
  • Lamb DJ, Modjtahedi H, Ferns GAA. 2003. Epidermal growth factor: A novel monocyte chemotactic factor and macrophage mitogen. ATHEROSCLEROSIS (vol. 169, pp. 199-200). link>
  • Lamb DJ, Modjtahedi H, Ferns GAA. 2003. Epidermal growth factor: A novel monocyte chemotactic factor and macrophage mitogen. ATHEROSCLEROSIS (vol. 168, pp. 193-194). link>
  • Warwick GL, Waller H, Ferns GAA. 2000. Antioxidant vitamin concentrations and LDL oxidation in nephrotic syndrome. ANNALS OF CLINICAL BIOCHEMISTRY (vol. 37, pp. 488-491). link> doi>
  • Ferns GA. 2000. Cellular mechanisms in atherogenesis: new opportunities in cardiovascular disease risk reduction. Proc Nutr Soc (vol. 59, pp. 435-436). doi>
  • FERNS G and RUTHERFORD C. 1993. ATHEROSCLEROSIS AND PLATELET-DERIVED GROWTH-FACTORS. GROWTH FACTORS AND THE CARDIOVASCULAR SYSTEM (vol. 147, pp. 169-187). link>

Personal awards for research:

Fournier Research Award 

 1997
British Heart Foundation-American Heart Association Reciprocal Fellowship     1988-90
Wellcome Trust Pathology Training Fellowship 1984-87
Aylwen Research Bursary, St Bartholomew's Hospital Medical College 1983-84
BUPA special research award 1981

 


Selected research grants in last ten years:

British Heart Foundation

"The autoimmune response to heat shock protein 27 and its role in atherogenesis"

 £157,522 2009-11

British Heart Foundation PhD studentship (Alyss Dreux)
"EGF receptor on macrophages and their function"

 £66,000 2003-06

British Heart Foundation PhD studentship (Michelle Tickner)
"Copper and macrophage apoptosis"    

 £57,000

2001-04

 

Ministry of Agriculture, Fisheries & Food project grant (with DJ Millward et al)
"Optimising dietary n3/n6-fatty acids"

 £1,200,000 2000-03

Engineering & Physical Sciences Research Council (with Dr S Reddy)
"Development of a biosensor for cholesterol"

 £52,953 1999-2002

British Heart Foundation Project Grant
"Immune response to BCG and its effects on atherogenesis"

 £117,000 1999-2001

Patents:

Ferns G, Vaidya N (2005). Hsp27 a marker of myocardial ischaemia.

Ross R, Raines E, Reidy MA, Lindner V and Ferns GAA (1997). The use of antibodies to prevent re?stenosis after PTCA. USA Patent No 5,648,076

Selected publications:

Lamb DJ, Avades TY, Ferns GAA (2001). Endogenous neutralising antibodies against plateletderived growth factor-AA inhibits atherogenesis in the cholesterol-fed rabbit. Arterioscler Thromb & Vasc Biol 21, 997-1003.

Ferns GAA et al (1992). Probucol inhibits neo-intimal thickening and macrophage accumulation following balloon injury in the cholesterol-fed rabbit. Proc. Natl. Acad. Sci., USA. 89, 11213-11316.

Ferns GAA, et al (1991). Anti-PDGF IgG inhibits intimal smooth muscle cell accumulation in response to arterial injury. Science 253, 1129-1132

Ferns GAA, Reidy MA, Ross R (1990). In-vivo and in-vitro effects of cyclosporin A on rabbit vascular smooth muscle and endothelial cells. Am J Path 137, 403-414

Ferns GAA et al (1985). DNA polymorphisms of genes for apo CIII and insulin in survivors of myocardial infarction. Lancet ii, 300-304.