ISTM

Dr Deakin's research has focussed on creating links between Keele and the patient population in North Staffordshire.  He has worked to create opportunities for the introduction of medical personel into clinical and laboratory research within Keele, largely through associations with the Nuffield Hospital and MD programme.

His research interests include:

• Molecular epidemiology
• Molecular Carcinogenesis
• Metastasis
• Apoptosis
• Clinical Oncology
• Clinical Management of GI Cancer
• Medical education

ISTM Research theme: 1. Clinical & Diagnostic Science

Research interests:

• Molecular Epidemiology of gastro-intestinal cancers involving GST polymorphisms and VitD receptor polymorphisms (collaboration with Prof RC Strange and Dr AA Fryer)
• Molecular Carcinogenesis relating to gastro-intestinal and pancreatic tumours (collaborations with Prof RC Strange, Dr AA Fryer, Prof WE Farrell, Dr P Hoban and Prof G Williams).
• Metastasis - specifically mechanisms of metastasis (collaboration with Dr P Hoban on E cadherin, polymorphisms, methylation and gastro-intestinal tumours).
• Apoptosis and its association with the reponse to chemoradiotherapy in colorectal cancer (collaboration with Prof G Williams)
• Clinical Oncology Research - specifically clinical management of gastro-intestinal cancer

Clinical Trials:

• REFLUX trial (lead clinician for UHNS, co-ordinated by University of Aberdeen)

Bhogal RH, Athwal R, Durkin D, Deakin M, Cheruvu CN
Comparison between open and laparoscopic repair of perforated peptic ulcer disease
WORLD JOURNAL OF SURGERY 32 (11): 2371-2374 Nov 2008

Al-Sarira AA, David G, Willmott S, Slavin JP, Deakin M and Corless DJ
"Oesophagectomy practice and outcomes in England"
BRITISH JOURNAL OF SURGERY 94 (5): 585-591 May 2007

Bahar A, Whitby P, Holley S, Hoban PR, Elder JB, Deakin M, Hall C, Clayton RN, Williams GT, Farrell WE
"Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis"
GENES CHROMOSOMES & CANCER 46 (2): 202-212 February 2007

Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA
"Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer" 
INTERNATIONAL JOURNAL OF ONCOLOGY 28 (1): 231-236 January 2006

Bassi C, Stocken DD, Olah A, Friess H, Buckels J, Hickey H, Dervenis C, Dunn JA, Deakin M, Carter R, Ghaneh P, Neoptolemos JP, Buchler MW
"Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial" 
DIGESTIVE SURGERY 22 (5): 353-363 2005

Roy SD, Kupp DV, Slavin JP, Corless DJ and Deakin M
"Inequity of upper gastrointestinal cancer distribution and survival with socioeconomic deprivation: A population-based study" 
SURGERY 138 (5): 859-868 November 2005

Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC and Fryer AA
"Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer" 
CARCINOGENESIS 26 (12): 2157-2163 December 2005

Roy SD, Cade D, Deakin M and Corless DJ
"Colorectal cancer trends in various socioeconomic classes: are we targeting the right population?" 
BRITISH JOURNAL OF SURGERY 92: 84-84 Suppl. 1 April 2005

Maharaj S, Elder JB, Deakin M and Williams GT
"Development of a model to investigate the role of Toll-like receptors in H pylori induced apoptosis of gastric cancer cells" 
GUT 54: A89-A89 341 Suppl. 2 April 2005

McCloud J, Sivakumar R, Greenhough A, Jones P, Deakin M, Elder JB, Fryer A, Hoban PR
"p16INK4a polymorphism; associations with tumour progression in patients with sporadic colorectal cancer"
International Journal of Oncology, 25 (5): 1447-1452   November 2004

Roy SD, Jibawi A, Deakin M and Corless DJ
"Variation in gastric cancer incidence and survival trends with deprivation over fifteen years: A population based study"
GASTROENTEROLOGY 126 (4): A314-A314 Suppl. 2 April 2004

Ishaq S, Miller D, Hall C, Green J, Deakin M
"Endoscopic Sphincterotomy for choledocholithiasis in patients younger than 50 years: long term follow up study"
GUT, 53 (1), 168 Suppl 3, A44, April 2004

Stocken DD, Neoptolemos JP, Friess H, Bassi C, Dunn JA, Hickey H, Imrie C, Deakin M, Buckels J, Dervenis C, Olah A, Fernandez-Cruz L, Lacaine F and Buchler MW
"ESPAC-1: final results of a European, randomized controlled trial to assess the roles of adjuvant chemotherapy and adjuvant chemoradiation in resectable pancreatic cancer" 
BRITISH JOURNAL OF SURGERY 91 (4): 520-520 April 2004

Miller R, Dewar EP, Kapadia CR, (AXIS Collaborators)
"Randomized clinical trial of adjuvant radiotherapy and 5-fluorouracil infusion in colorectal cancer (AXIS)" 
BRITISH JOURNAL OF SURGERY 90 (10): 1200-1212 October 2003

Neoptolemos JP, Stocken DD, Dunn JA, Buckels J, Deakin M, Sutton R, Imrie C, Kerr DJ, Buchler MW
"Influence of the type of surgery and surgical complications in the ESPAC-1 adjuvant trial"
BRITISH JOURNAL OF SURGERY 89: 35-35 Suppl. 1 June 2002