ISTM

Prof. Simon Davies is a consultant nephrologist at the University Hospital of North Staffordshire and Professor of Nephrology and Dialysis Medicine in the Institute for Science and Technology in Medicine at Keele University. His principal research interests are in peritoneal dialysis and the evaluation of fluid status in advanced renal failure.

Prof. Davies  is responsible for the Stoke PD Study, now the largest single centre study of long-term membrane function and clinical outcomes in peritoneal dialysis patients and was one of the lead investigators of the European Automated Peritoneal Dialysis Outcome Study (EAPOS). Other international collaborations have included studies evaluating the effects of polyglucose and low sodium solutions on fluid status in PD patients. He is currently developing new techniques in bedside body composition using breath analysis for deuterium abundance with the physicist Prof. David Smith FRS, for application in the haemodialysis unit, intensive care setting and in heart failure. This research is supported by Kidney Research UK, the Wellcome Trust and the Baxter Renal Discoveries Extra-mural grant programme.

Prof. Davies is a member of the UK Renal Registry Dialysis group, the Renal Association standards committee and author of the UK peritoneal dialysis guidelines. He is also chair of the International Society of Peritoneal Dialysis Research Committee and associate editor of Peritoneal Dialysis International.

Previous appointments held:

Education:

ISTM Research themes:

1. Clinical & Diagnostic Science  (clinical theme lead)
2. Infection, Inflamation & Immunity 

Prof Davies' principal research interests are in peritoneal dialysis and the evaluation of fluid status in advanced renal failure.

TEACHING AND EDUCATION:

RECENT PEER REVIEWED GRANTS RECEIVED FOR RESEARCH:

RESEARCH STUDENT SUPERVISION:

Invited Lectures at National and International Academic Meetings (since May 2003):

• International PD Course Vicenza, Italy May 2003
                PD after transplantation
               Measuring comorbidity in PD patients
• International Society of Nephrology, Berlin, June 2003
               Symposium: Alterations in Solute and Water Transport in Ultrafiltration Failure
               CME session: Management of the patient with the failing graft
• Holgar Crawford Symposioum, Lund Sweden. September 2003
               Diffusive transport of tracer H2O (HDO) across the peritoneum
• Inaugural Lecture, Keele University, January 2004
               The peritoneal membrane as artificial kidney: what have we learned?
• British Renal Society, Plenary Session, Harrogate, May 2004
               Integrated Dialysis Therapies
• International Society of Peritoneal Dialysis, Amsterdam, August 2004
               Member of Scientific Programme Committee
               Chair of Symposium on fluid status in PD
               Lecture: Peritoneal sodium and water transport:
               How do theoretical and experimental insights translate into clinical observations?
               Chair and lecturer at Gambro Symposium
• International Society of Blood Purification, London September, 2004
               Can peritoneal dialysis be a long-term treatment option?
• First Meeting of the North American Chapter of the International Society of Peritoneal Dialysis, Chicago, May 2005
               Aspects of Peritoneal Water Transport
• European Peritoneal Dialysis Meeting, Prague 2005
               Chair of the Scientific Programme Committee
               Symposium Chair and Speaker
               Symposium I – What have observational studies in PD told us?
               Membrane function and outcome: lessons from the Stoke PD Study & EAPOS
               Plenary Chair Session: Controversies in PD:  Which is more important in patient management -
               an ultrafiltration or sodium removal target?
               Symposium Speaker
               Mini-Symposium – Modelling the membrane without equations
• American Society of Nephrology, Philadelphia, 2005
               Managing salt and water: physiology and management strategies
• Vicenza Peritoneal Dialysis Course, June, 2006
               Peritoneal Dialysis after transplant failure
• International Society of Peritoneal Dialysis, Hong Kong, August, 2006
               How to manage anuric Peritoneal Dialysis Patients
               UK Model: Why the UK leads the PD utilisation in Europe
• European Peritoneal Dialysis Meeting, Helsinki, July 2007
               Chair of the Scientific Programme Committee

Additional invitations to lecture includes Swiss PD Academy, Geneva, June 2003; PD update meetings in Copenhagen, April 2003, Helsinki, September 2004, Prague April 2005, Madrid, May 2005 and the Middle East PD Academy Jordan, May 2005, Oxford Summer School, September 2004 and 2005, UK PD Academy (x2 courses per year, faculty member and co-organiser), Dialysis Course at Royal Free (annually), Renal SpR Club, March 2004.

SELECTED RECENT PEER-REVIEWED PUBLICATIONS

1. PERITONEAL DIALYSIS RESEARCH:

Chapters in Textbooks:

DAVIES, S.J., G.A. COLES, N. TOPLEY (2000) Problems of peritoneal membrane failure In: Ed. A MEHTA & N. LAMIERE, Complications of Dialysis - recognition and management(Marcel Dekker, New York). 9: pp. 151-178

DAVIES SJ. Peritoneal Dialysis Solutions. (2004) In: Chronic Kidney Disease, Dialysis and Transplantation – Companion to Brenner and Rector’s The Kidney. Ed: Pereira BJG, Sayegh MH and Blake P. Elsevier Saunders, second edition, pp.534-552

DAVIES SJ & WILLIAMS JD. Complications of Peritoneal Dialysis. In: Ed. RJ Johnson, J Floege & J Feehally, Comprehensive Clinical Nephrology (3nd Edition), 2006 (in press)

DAVIES, S.J., L. PHILLIPS, A. GRIFFITHS, L. RUSSELL, P.F. NAISH AND G.I. RUSSELL. (2000) An analysis of the effects of increasing delivered dialysis treatment to malnourished peritoneal dialysis patients Kidney International  57(4):pp.1743-54

DAVIES, S.J., L. PHILLIPS, P.F. NAISH  AND G.I. RUSSELL. Peritoneal glucose exposure and changes in membrane solute transport with time on Peritoneal Dialysis. (2001) Journal American Society of Nephrology 12(5):pp1046-51

Original Papers and Articles:

DAVIES, S.J., L. PHILLIPS, A. GRIFFITHS, L. RUSSELL, P.F. NAISH AND G.I. RUSSELL. (2000) An analysis of the effects of increasing delivered dialysis treatment to malnourished peritoneal dialysis patients Kidney International  57(4):pp.1743-54

DAVIES, S.J., L. PHILLIPS, P.F. NAISH  AND G.I. RUSSELL. Peritoneal glucose exposure and changes in membrane solute transport with time on Peritoneal Dialysis. (2001) Journal American Society of Nephrology 12(5):pp1046-51

DAVIES, S.J., L. PHILLIPS, P.F. NAISH, G.I. RUSSELL. (2002) Quantifying comorbidity in Peritoneal Dialysis patients and its relationship to other predictors of survival. Nephrology Dialysis Transplantation 17(6):1085-1092

DAVIES, S. J., WOODROW, G., DONOVAN, K. PLUM, J., WILLIAMS, P., JOHANSSON, A. C., BOSSELMANN, H. P., HEIMBURGER, O., SIMONSEN, O., DAVENPORT, A., TRANAEUS, A., AND DIVINO FILHO, J. C. (2003) Icodextrin improves the fluid status of peritoneal dialysis patients: results of a double-blind randomized controlled trial. J Am Soc Nephrol 14: 2338-44.

BROWN EA, DAVIES SJ, RUTHERFORD P, MEEUS F, BORRAS M, RIEGEL W, DIVINO FILHO JC, VONESH E, VAN BREE M: Survival of Functionally Anuric Patients on Automated Peritoneal Dialysis: The European APD Outcome Study. J Am Soc Nephrol 2003;14:2948-57.

ASGHAR RB, GREEN S, ENGEL B, DAVIES SJ. Relationship of demographic, dietary, and clinical factors to the hydration status of patients on peritoneal dialysis. Perit Dial Int. 2004 May-Jun;24(3):231-9

DAVIES SJ: (2004) Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients. Kidney Int; 66(6):2437-45.

ASGHAR RB, DISKIN AM, SPANEL P, SMITH D, DAVIES SJ. Influence of Convection on the Diffusive Transport and Sieving of Water and Small Solutes across the Peritoneal Membrane. J Am Soc Nephrol. 2005 Feb;16(2):437-43

DAVIES SJ, BROWN EA, FRANDSEN NE, RODRIGUES AS, RODRIGUEZ-CARMONA A, VYCHYTIL A, MACNAMARA E, EKSTRAND A, TRANAEUS A, DIVINO FILHO JC, on behalf of the EAPOS group (2005). Longitudinal membrane function in functionally anuric patients treated with APD: data from EAPOS on the effects of glucose and icodextrin prescription. Kidney Int, 67(4):1609-15

AANEN MC, VENTUROLI D, DAVIES SJ. (2005) A detailed analysis of sodium removal by peritoneal dialysis: comparison with predictions from the 3-pore model of membrane function. Nephrol Dial Transplant 2005; Jun;20(6):1192-200

DAVIES SJ.  Are PD patients with or without residual renal function qualitatively different—or are they simply at different stages of the continuum of progressive uraemia?  Nephrol Dial Transplant (2005) 20: 270–272

DAVIES SJ. Getting to grips with individual variation in membrane function Perit Dial Int 2005;25(1):35-7

DAVIES, SJ, Developments in the design of peritoneal dialysis fluid. British Journal of Renal Medicine, 2005, 10(3):6-9

DAVIES SJ,  BROWN EA, REIGEL W, CLUTTERBUCK EA, HEIMBURGER O, VEGA DIAZ N, MELLOTE GJ, PEREZ-CONTRERAS J, SCANZIANI R, D’AUZAC C, KUYPERS D, DIVINO FILHO JC. What is the link between poor ultrafiltration and increased mortality in anuric APD patients? Analysis of data from EAPOS Perit Dial Int, 2006 Jul-Aug;26(4):458-65

DAVIES SJ. Overfill or ultrafiltration? We need to be clear. Perit Dial Int, 2006 Jul-Aug;26(4):449-451

DAVIES SJ, Exploring new evidence of the clinical benefits of icodextrin solutions Nephrol Dial Transplant , 2006;21:Suppl 2:ii47-50

JOHN B., MUSHAHAR L, DAVIES SJ. Peritoneal Dialysis after a Renal Transplant. Contrib Nephrol, 2006;150:271-7

MUSHAHAR, L. JOHN, B, DAVIES, SJ. How does membrane function influence patient outcome and how does dialysis influence the membrane? EDTNA Journal, invited review, 2006

2. BREATH ANALYSIS, BODY COMPOSITION (including SIFT and FA-MS methodologies):

DAVIES, S., P. SPANEL, AND D. SMITH  (1997) Quantitive analysis of ammonia on the breath of patients in end-stage renal failure.  Kidney International 52:pp.223-228

SPANEL. P., S.J. DAVIES AND D. SMITH (1998) Quantification of ammonia in human breath by the SIFT analytical method using H3O+ and O2+ precursor ions. Rapid Communications in Mass Spectrometry.12:pp.763-766

SMITH, D., P. SPANEL, AND S.J. DAVIES  (1999) Trace gases on the breath of healthy volunteers when fasting and following a protein calorie meal Journal of Applied Physiology  87(5):pp.1584-88

SPANEL, P., S. DAVIES, AND D. SMITH (1999) Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method. Rapid Commun Mass Spectrom 13: pp.1733-1738

DAVIES, S., P. SPANEL AND  D. SMITH. A new 'online' method to measure increased exhaled isoprene in end-stage renal failure. (2001) Nephrology Dialysis Transplantation, 16(4):836-839

DAVIES, S., P. SPANEL AND  D. SMITH. Rapid measurement of deuterium content of breath following oral ingestion to determine body water (2001) Physiological Measurement 22(4):pp.651-659

SMITH, D., ENGEL, B., DISKIN, A., M. SPANEL, P., AND DAVIES, S. J. (2002) Comparative measurements of total body water in healthy volunteers by online breath deuterium measurement and other near-subject methods Am J Clin Nutrition 76: 1295-301

ENGEL B, SPANEL P, SMITH D, DISKIN A, DAVIES SJ. (2004) Longitudinal measurements of total body water and body composition in healthy volunteers by online breath deuterium measurement and other near-subject methods Int J Body Comp Res.  2(3):99-106.