ISTM

Research and Clinical Experience:

• Interventional Radiology
• Vascular: diagnostic arteriography via the femoral, brachial and radial artery routes; selective arteriography.
• Biliary/GI: PTC, drainage, balloon dilatation of benign biliary strictures, placement of biliary stents.
• Urological: percutaneous nephrostomy, percutaneous nephrolithotomy, placement of antegrade ureteric stents and dilatation of ureteric strictures.
• Ultrasound: abdominal and small parts Ultrasound; ultrasound guided biopsy and drainage procedures.
• CT scanning: all aspects of diagnostic CT scanning, particularly oncological imaging and neuro-imaging. 
• MRI scanning: oncological imaging, brain and spine imaging.
• Nuclear Medicine: standard techniques: bone scans, V-Q scans, DTPA/MAG3 renography and DMSA scans.

ISTM Research theme: 1. Clinical & Diagnostic Science

Independently reviewed articles:

1.     Absent patella and contra lateral patella alta observed with scoliosis.  Humzah M, Soames R, Munn S, Cowling M.             Anat. Ans. Jena 1988; 167: 63-67.

2.      A further diagnostic test in neonatal/infant solid renal mass: Two cases of mesoblastic nephroma showing uptake of             Tc99mDMSA. Cowling M, Dicks-Mireaux C, Gordon I. Clin. Rad. 1993; 47: 259-261.

3.      A potential pitfall in bronchial artery embolisation. Cowling MG, Belli A-M. Clin Rad. 1995; 50: 105-107.

4.      Benign Chest Wall Lipoblastoma of Infancy Producing Underlying Bone Enlargement.  Cowling MG, Holmes SJK,Adam EJ. Pediatric Radiology 1995; 25: 54-55.

5.      Critical lower limb ischaemia due to aortic dissection relieved by percutaneous transfemoral fenestration.  Cowling MG, Redwood D, Buckenham TM.Clin Rad 1995; 50: 654-6.

6.      Bronchial artery embolisation for the control of recurrent severe haemoptysis with no demonstrable underlying lesion.  Cowling MG, Belli A-M. MITAT 1995; 4: 191-194

7.      Evaluation and complications of direct graft puncture in thrombolysis and other interventional techniques.  Cowling MG, Buckenham TM, Belli, A-M. Cardiovasc Intervent Radiol 1996; 19: 82-84

8.      The role of transradial diagnostic angiography. Cowling MG, Buckenham TM, Belli, A-M. Cardiovasc Intervent Radiol 1997; 20: 103-106

9.      Occlusion of the ulnar artery during diagnostic angiography via the radial artery route.  Cowling MG, Buckenham TM, Belli, A-M. J Intervent Radiol 1997; 12: 89-91

10.  The use of self expanding metal stents in the management of malignant oesophageal strictures. Cowling MG, Hale H, Grundy A. BJS 1998; 85: 264-266

11.  Covered tracheal stent in the palliation of malignant tracheo-oesophageal fistula. Cowling MG, Dussek J, Mason R, Adam A. MITAT 1998; 7: 49-51

12.  Self expanding metallic stents in the treatment of pyloric dysfunction after gastric pull-up operations.  Cowling MG, Goh PY-T, Mason RC, Harper P and Adam AN. European Radiology 1999; 9: 1123-6

13.  Small Bowel Volvulus Related to a Calcified Mesenteric Lymph Node. Qayyum A, Cowling MG and Adam EJ. Clin Rad 2000; 55: 483-4

14.  Epirubicin, Cisplatin and prolonged or brief infusional 5-Fluorouracil in the treatment of carcinoma of unknown primary site. Karapetis CS, Yip D, Virik K, Strickland A, Ryder K, Cowling M and Harper PG. Med Oncol 2001; 18(1): 1423-8

15.  Balloon Dilation for Achalasia of the Cardia: Experience in 76 Patients. Sabharwal T, Cowling M, Dussek J, Owen W and Adam A. Radiology 2002; 224: 719-724

16.  Endovascular stent grafting of a penetrating ulcer in the descending thoracic aorta. Crane JS, Cowling M, Cheshire NJ. Eur J Vasc Endovasc Surg 2003; 25: 178-9

17.  Carotid angioplasty in a pulsatile flow model: factors affecting embolic potential. Eur J Vasc Endovasc Surg 2003; 26:22-31 Bicknell CD, Cowling MG, Clark MW, Delis KT, Jenkins MP, Hughes AD, Thom SA, Wolfe JH, Cheshire NJ.

18.  Multislice CT angiography in renal artery stent evaluation: prospective comparison with intra-arterial digital subtraction angiography. Raza SA, Chugtai AR, Wahba M, Cowling MG, Taube D, Wright AR CVIR 2004; 27: 9-15

19.  Renal artery embolisation for end-stage hydronephrotic kidneys. Mitra K, Prabhudesai V, James RL, Jones RWA, French ME, Cowling M, West DJ CVIR 2004; 27: 204-207

20.  Relationship of matrix metalloproteinases and macrophages to embolization during endoluminal carotid interventions. Bicknell CD, Peck D, Alkhamesi NA, Cowling MG, Clark MW, Goldin R, Foale R, Jenkins MP, Wolfe JH, Darzi AW, Cheshire NJ  J Endovasc Ther. 2004 Jul-Aug;11(4):483-93.

21.  The relationship between plasma MMP-1,-7,-8 and-13 levels and embolic potential during endoluminal carotid intervention. Bicknell CD, Peck D, Lau NM, Alkhamesi NA, Cowling MG, Clark MW, Jenkins MP, Wolfe JH, Darzi AW, Cheshire NJ. Eur J Vasc Endovasc Surg 2004; 28: 500-7

22.  The potential role for optical coherence tomography in the assessment of vulnerable atheromatous plaques: A pilot study. Prabhudesai V, Phelan C, Yang Y, Wang RK, Cowling MG. CVIR 2006; 29:1039-45 

Books written/edited:

Vascular Interventional Radiology: current evidence in endovascular surgery. Ed. Cowling MG. Springer, Berlin 2006.

Book Chapters:

1.      Sedation in Interventional Radiology. MG Cowling and A Adam. In: Principles and Practice of sedation. Whitwam and McCloy Eds. Blackwell Science, Oxford 1998 pp 182-187

2.      Self expanding metal stents in the gastrointestinal tract. RC Mason, MG Cowling and A Adam In: Recent Advances in Surgery. Taylor and Johnson Eds, Chuchill Livingstone 1999, pp 99-108 

3.      Cowling MG and Adam A.  Stents in the Gastrointestinal Tract.  In: Non-Surgical Therapies for the Gut and Abdominal Cavity.  Eds. Brandon JC and Teplick SK.  Thieme, New York 2001 pp 35-49 

4.      Cowling M and Monaghan C. Cardiovascular system. In: Medical Imaging; Techniques, reflection and Evaluation. Eds. Carver E and Carver B. Elsevier, London 2006 pp 449-456 

5.      Cowling M. Interventional and Therapeutic procedures. In: Medical Imaging; Techniques, reflection and Evaluation. Eds. Carver E and Carver B. Elsevier, London 2006 pp 457-480 

6.      The aetiology of vascular disease. Wells RD and Cowling MG. In:Vascular Interventional Radiology: current evidence in endovascular surgery. Ed. Cowling MG. Springer, Berlin 2006 pp1-6 

7.      Assessment of peripheral vascular disease. Cowling MG . In:Vascular Interventional Radiology: current evidence in endovascular surgery. Ed. Cowling MG. Springer, Berlin 2006 pp7-12 

8.      Management of renal and visceral arterial stenoses. Cowling MG  . In:Vascular Interventional Radiology: current evidence in endovascular surgery. Ed. Cowling MG. Springer, Berlin 2006 pp 81-90.

Teaching:

• Problem based learning tutor for Keele Medical School.
• Radiology tutorials for medical students.
• Weekly tutorials for radiology SpRs.

Research Grants:

• Medtronic Corporation (£5,000) to support the study of multislice CT vs DSA for the evaluation of stenoses within renal arterial stents
• Philips Medical Systems (equipment and software support value approx £100,000) to support the evaluation of 3D rotational angiography for use in peripheral arterial intervention, with particular reference to renal arterial stenting, iliac angioplasty/stenting, and iliac aneurysm stent grafting.
• Royal College of Radiologists pump priming grant (£500) to support project entitled “The potential role of Optical Coherence Tomography in the assessment of vulnerable carotid atheromatous plaques”.