ISTM
Explore this Section
- ISTM >
- Staff >
- Clive Hawkins
Professor Hawkins is Professor of Clinical Neurology at Keele University, and Consultant Neurologist to the Regional Neuroscience Centre, University Hospital of North Staffordshire, Stoke-on-Trent.
He trained as Research fellow, registrar and Lecturer in Clinical Neurology at the Institute of Neurology, National Hospital and University College Hospitals, London. Subsequently he was appointed Senior Lecturer in 1992 and Reader in 2000, to the School of Postgraduate Medicine at Keele.
ISTM Research theme: 1. Neuroscience & Human Metabolism - Clinical Lead for NHM theme
Research Interests:
1. Molecular genetics in MS, with regard to susceptibility and outcome/disability. A database has been established of over 1,400 MS patients in the North-West of England (Stoke, Liverpool, Manchester) with blood samples for DNA and disability measurements. Over 80 genetic polymorphisms have been analysed (with Prof Richard Strange, Keele and Prof Bill Ollier / Prof Jane Worthington, Manchester). Current work is focusing on haplotype interactions of candidate genes involved in the process of inflammation and axonal loss. We are currently collaborating with the Broad Institute, Harvard/MIT, Boston, USA and Cambridge, UK.
2. Vision studies to compare functional deficit by psychophysics with pathophysiology (evoked potential) and Magnetic Resonance Imaging of the optic nerve and visual pathway in the brain (with Prof David Foster, University of Manchester). Current work includes studying two types of bilateral optic neuritis using psychophysics.
3. The Keele Multiple Sclerosis Clinical trial unit is currently involved in ten major multi-centre International research trials in Relapsing and Progressive MS. There are 3 post-graduate research students, Lecturer/research registrars studying for a PhD/MD thesis in molecular genetics or vision studies.
Selected Publications
Full Publications List show
Books
-
2000. Principles of Treatments in Multiple Sclerosis. Butterworth-Heinemann.
Journal Articles
-
2007. Encephalitis: an overview. Neurophychological Rehabilitation, vol. 17(4-5), 429-449.
-
2006. A randomised, placebo-controlled trial of Natalizumab for relapsing multiple sclerosis. New England Journal of Medicine, vol. 354, 899-910.
-
2006. Evaluation of patients treated with Natalizumab for progressive multifocal leukoencephalopathy. New England Journal of Medicine, vol. 354, 924-933.
-
2005. Association between the PTPN22 gene, rheumatoid arthritis and autoimmune disease in the UK population. Arthritis Rheumatism, vol. 52, 1694-1699.
-
2005. Novel polymorphisms in the promoter region of the human nerve growth factor gene. International Journal of Immunogenetics, vol. 32, 379-382.
-
2004. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, vol. 127(8), 1717-1722. doi>
-
2004. Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes. Neurology, vol. 62(12), 2323-2325. link>
-
2003. Does trauma trigger multiple sclerosis? 2: A medicolegal view. HOSPITAL MEDICINE, vol. 64(11), 651-653. link>
-
2003. Does trauma trigger multiple sclerosis? 1: A controversy. HOSPITAL MEDICINE, vol. 64(10), 581-584. link>
-
2003. A controlled trial of Natalizumab for relapsing multiple sclerosis. New England Journal of Medicine, vol. 348, 15-23.
-
2003. The role of the PTPRC (CD45) mutation in the development of Multiple Sclerosis in the North West region of the United Kingdom. Journal of Neurology, Neurosurgery and Psychiatry, vol. 74, 944-945.
-
2002. A comparison of bilateral simultaneous and bilateral sequential optic neuritis using visual psychophysics. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 73(2), 235. link>
-
2002. Chemokine receptor 5 delta 32 polymorphism: susceptibility to and outcome from multiple sclerosis. Journal of Neurology, vol. 249, 173-174.
-
2001. Epistasis: a potentially important concept in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 70(2), 283. link>
-
2001. European/Canadian multi-centre, double-blind, randomised, placebo-controlled study of the effects of glatiramer acetate on the magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis. Annals of Neurology, vol. 49, 290-297.
-
2001. Glatiramer acetate (copolymer 1) in relapsing multiple sclerosis. Drug and Therapeutic Bulletin, vol. 39(6), 41-43.
-
2001. Multiple Sclerosis: new pathophysiological and therapeutic concepts. Journal of Royal College of Physicians, vol. 31, 134-148.
-
2001. Randomised controlled trial of interferon-beta 1a in secondary progressive multiple sclerosis: clinical results. Neurology, vol. 56, 1496-1504.
-
2001. Randomised controlled trial of interferon-beta 1a in secondary progressive Multiple Sclerosis: MRI results. Neurology, vol. 56, 1505-1513.
-
2000. Glutathione S-transferase polymorphisms in MS - Their relationship to disability. NEUROLOGY, vol. 54(3), 552-557. link>
-
2000. Linomide in the treatment of Multiple Sclerosis: MRI results from phase-III trials. Multiple Sclerosis, vol. 6, 99-104.
-
1998. MRI of optic nerve and postchiasmal visual pathways and visual evoked potentials in secondary progressive multiple sclerosis. Neuroradiology, vol. 40(12), 765-770. link>
-
1996. Anti-ganglioside antibodies in patients with rheumatoid arthritis complicated by peripheral neuropathy. Br J Rheumatol, vol. 35(8), 725-731. link> full text>
-
1996. Cortical plaques visualised by fluid-attenuated inversion recovery imaging in relapsing multiple sclerosis. Neuroradiology, vol. 38 Suppl 1, S10-S13. link>
Chapters
-
2000. Overview of Treatment Strategies for Relapsing and Progressive Multiple Sclerosis. In Principles of Treatments in Multiple Sclerosis. FRCP CPHD and MD JSW (Eds.). Butterworth-Heinemann.
-
2000. Pathogenesis and Clinical Subtypes of Multiple Sclerosis. In Principles of Treatments in Multiple Sclerosis. FRCP CPHD and MD JSW (Eds.). Butterworth-Heinemann.
-
1998. Magnetic Resonance Imaging of Blood-Brain Barrier permeability. In Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology. MD WMP (Ed.). Cambridge University Press.
-
1998. Spinal Features of Multiple Sclerosis. In Spinal Cord Diseases: Diagnosis and Treatment. Engler G (Ed.). Informa HealthCare.
-
1992. Recent Advances in Neurology. In Anasthesia Review. Kaufman L (Ed.). Churchill-Livingstone.
Other
-
2009. Investigation of novel type 1 diabetes loci in multiple sclerosis. MULTIPLE SCLEROSIS (vol. 15, p. S185). link>
-
2008. Colour constancy after optic neuritis associated with multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 79, p. 340). link>
-
2007. Cathepsin D polymorphisms and cognitive impairment in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 78, p. 1037). link>
-
2007. Cognitive impairment and polymorphisms of cathepsin D in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 254, p. 163). link>
-
2006. Elevated urinary excretion of aluminium and iron in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 77, p. 1398). link>
-
2006. Genetic polymorphism in type III promoter of the major histocompatibility complex class II transactivator gene is associated with susceptibility to multiple sclerosis. MULTIPLE SCLEROSIS (vol. 12, pp. S73-S74). link>
-
2006. Elevated urinary excretion of aluminium and iron in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 253, p. 80). link>
-
2005. Neuropsychological outcome and apolipoprotein E epsilon 4 polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 131). link>
-
2005. Neuropsychological outcome and cannabinoid receptor 1 polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 66). link>
-
2005. Ultraviolet radiation and outcome in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 74). link>
-
2005. A role for the protein tyrosine phosphatase N22 (PTPN22) gene in autoimmune disease. RHEUMATOLOGY (vol. 44, p. I5). link>
-
2005. Neuropsychological outcome and APOE polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 76, p. 158). link>
-
2004. Visual psychophysical deficit, visual evoked potentials and magnetic resonance imaging in the treatment of secondary progressive multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 251, p. 151). link>
-
2004. High density single nucleotide polymorphism mapping of protein kinase C alpha gene in a UK population of multiple sclerosis patients. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 75, p. 517). link>
-
2003. The effect of corticosteroid on conduction in the visual pathways: A serial study using visual psychophysics. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 74, p. 408). link>
In August 2010 Prof Hawkins became a Co-Director of the West Midlands (North) Comprehensive Local Research Network.

